Integration of biomedical data and electronic publications

85
Integration of biomedical data and electronic publications Lars Juhl Jensen EMBL Heidelberg

description

10th International Symposium on Electronic Theses and Dissertations, Uppsala University, Uppsala, Sweden, June 13-16, 2007

Transcript of Integration of biomedical data and electronic publications

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Integration of biomedical dataand electronic publications

Lars Juhl JensenEMBL Heidelberg

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printed publications

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dead wood

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electronic publications

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virtual dead wood

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de Lichtenberg et al., Science, 2005

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small font sizes

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“no”

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Jensen et al., Nature Reviews Genetics, 2006

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small font sizes

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hyperlinks

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“no”

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“hell no”

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why?

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archival

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reanalysis

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data mining

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reader interaction

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what?

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raw data

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processed data

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final data

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“facts”

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where?

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part of the document

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too much data

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too coarse grained

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escalates the problem

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institutional repositories

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too many types of data

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lack of standardization

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difficult to download all data

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public databases

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specialization

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standardization

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mandatory deposition

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easy to download all data

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cross references

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examples from biomedicine

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GenBank

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17.9 million sequences

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80 billion nucleotides

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UniProt

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4.7 million sequences

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Ensembl

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35 complete genomes

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PDB

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44000 protein structures

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GEO

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5800 data sets

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152000 samples

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ArrayExpress

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1800 data sets

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BioGRID

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186000 interactions

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129000 proteins

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MINT

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103000 interactions

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28000 proteins

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PubChem

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7.5 million compounds

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PubMed Central

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330 open access journals

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12000 open access papers

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downloadable

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standardized formats

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cross-referenced

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archival

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reanalysis

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data mining

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reader interaction

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thank you!