Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len...

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Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015

Transcript of Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len...

Page 1: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

Institute for Risk Assessment SciencesVeterinary Public Health

Biosecurity en AB resistentie

Len LipmanIRAS/VPHFaculteit diergeneeskunde4 oktober 2015

Page 2: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

Institute for Risk Assessment SciencesPublic Health and Food Safety Division

Waarom maken we ons druk over AB resistentie?

Eten van vlees veroorzaakt antibioticaresistentie!!!!(Door: Wans Horst)Resistentie tegen antibiotica kan verschrikkelijke gevolgen hebben voor de wereldwijde bevolking. Daarom moet de resistentie bij de wortel worden aangepakt en niet bij de oplossing, zoals de Wereldgezondheidsorganisatie wil.

Page 3: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

Institute for Risk Assessment SciencesPublic Health and Food Safety Division

Page 4: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

Institute for Risk Assessment SciencesPublic Health and Food Safety Division

Page 5: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

Institute for Risk Assessment SciencesPublic Health and Food Safety Division

1 vraag voor publiek via de smartphone:

Ga naar

www.gotovote.at

Code: 41651

Page 6: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

Institute for Risk Assessment SciencesPublic Health and Food Safety Division

Wat is een volksgezondheid risico ikv gebruik AB bij dieren?

1.Er ontstaan AB resistente bacterien in het dier en die komen

daarna op vlees/in millieu.

2.Er komen residuen van AB in het vlees

1 of 2, of beide of beide niet?

Page 7: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

Institute for Risk Assessment SciencesPublic Health and Food Safety Division

In de bestrijding van ABR moeten we?

1. Dus minder AB gebruiken!!!

2. En slachtdieren niet in contact laten komen met

AB resistente bacteriën.

1, 2, beide of beide niet?

En is er een Relatie met biosecurity?

Page 8: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

Associations between biosecurity, herd characteristics, production parameters

and antimicrobial usage in pig production in four EU countries

Merel [email protected]

Unit for Veterinary Epidemiology, Faculty of Veterinary Medicine, Ghent University

MINAPIG consortium – www.minapig.eu21/04/23 8

Annette Backhans, Lucie Collineau, Svenja Lösken, Marie Sjölund, Catherine Belloc, Ulf Emanuelson, Elisabeth Grosse Beilage, Elisabeth Okholm Nielsen, Katharina D.C. Stärk and Jeroen Dewulf

Page 9: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

Objective

21/04/23 9

Which associations can be found between:

Biosecurity level

Herd characteristics

Production parameters

Antimicrobial usage

Best practises for low antimicrobial usage level

with maximum pig health and production

Page 10: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

Materials & Methods

21/04/23 10

227 pig herds, ≥ 70 sows, 500 finishersBelgium, France, Germany, SwedenCross-sectional Dec. 2012 – Dec. 2013

Questionnaire & interviewProduction parametersHerd characteristicsBiosecurity statusAntimicrobial usage

Multivariable modelsCausal path

Page 11: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

Discussion

Multi-country comparison

Causality

Country specific habits/situations

21/04/23 11

Page 12: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

Take home message

Room for improvement Biosecurity & AMU

Better biosecurity more piglets weaned

Better biosecurity lower AMU

Higher weaning age lower AMU

21/04/23 12

Tools to improve animal health & productivity

and to minimise antimicrobial usage

Page 13: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

21/04/23 13

The MINAPIG consortium

MINAPIG consortium – www.minapig.eu

Page 14: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

MRSA and ESBL/AmpC producing Enterobacteriaceae

in vermin on Dutch farmsName: Joeri Baak

Student number: 3580822

Supervisor: dr. S.A. Burt

Sept 2014 – Dec 2014

Page 15: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

Introduction

– Aim: determine whether flies, wild birds, mice and rats may carry antibiotic resistant bacteria in the animal husbandry in the Netherlands.

– MRSA and ESBL/AmpC producing E.coli, Enterobacter spp and Klebsiella spp.

Page 16: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

MRSA

– Van de Giessen et al. 2009 isolated MRSA from five out of 40 black rats(Rattus rattus), 3 negative brown rats (Rattus norvegicus)

– MRSA isolated from mice and urban rats, black and brown rats, in Canada and Belgium (Pletinckx et al. 2013, Himsworth et al. 2014)

Page 17: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

– ESBL producing E.coli isolated from urban brown rats in Berlin and Hong kong (Guenther et al. 2012, Ho et al. 2013)

– Blaak et al. 2014 isolated ESBL producing E.coli from two out of 19 fly pools on two poultry farms

– Veldman et al. 2013 isolated ESBL producing E.coli from one out of 41 non-aquatic wild birds and from 64 out of 373 aquatic wild birds

MacConkey-cefotaxime

ESBL

Page 18: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

Materials and methods

– Sample collection• Wild birds• Flies• Rodents at Tolakker Utrecht

– Isolation of MRSA• MH-6.5% NaCl broth• PHMB (75 mg/L aztreonam and 4 mg/L oxacillin)• MRSA 2 brilliance plate (Oxoid)

– Confirmation tests (MRSA)• Coagulase test• Catalase test

Page 19: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

Materials and methods

– Isolation of ESBL/AmpC producing Enterobacteriaceae

• LB-CTX broth

• TBX-CTX and MacC-CTX plates

– Confirmation tests (ESBL/AmpC)• Indole test

• Oxidase test

Page 20: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

Results: Presumptive MRSA and ESBL/AmpC producing Enterobacteriaceae

Page 21: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

Discussion: MRSA

– MRSA was isolated from a black rat

– In line with results of Van de Giessen et al. 2009 From five out of 40 black rats MRSA was isolated

Page 22: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

Results: ESBL/AmpC producing E.coli Enterobakter

– ESBL producing E. coli isolated from a brown rat

– AmpC producing Enterobacter spp. isolated from two fly pools

– AmpC producing Enterobacter spp. isolated from a brown rat

Page 23: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

Conclusion research

–Vermin may carry MRSA and ESBL/AmpC producing E. coli and Enterobacter spp. in the Dutch animal husbandry

–Biosecurity!!!!!

–Small number of samples investigated

Page 24: Institute for Risk Assessment Sciences Veterinary Public Health Biosecurity en AB resistentie Len Lipman IRAS/VPH Faculteit diergeneeskunde 4 oktober 2015.

Institute for Risk Assessment SciencesPublic Health and Food Safety Division

Is er een Relatie met biosecurity?

Ja dus

Antwoord vraag:

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