[INSERT DATE] [INSERT STREE ADDRESS] Dear [INSERT ... · If you have additional questions related...
5
Page 1 of 4 PID: [PID] GenX Exposure Study North Carolina State University Campus Box 7633 Raleigh, NC 27695-7633 Phone: 855-854-2641 https://chhe.research.ncsu.edu/coec/projects/genx/the-genx-exposure-study/ [INSERT DATE] [INSERT STREE ADDRESS] [INSERT CITY, STATE, ZIP] Dear [INSERT PARTICIPANT/ PARENT NAME], Thank you for participating in the GenX Exposure Study. The purpose of this research study is to see if GenX and related per- and polyfluoroalkyl substances (PFAS) are present in the bodies of New Hanover County residents. PFAS chemicals are a family of fluorochemicals; some of these chemicals, like GenX, are used to make non-stick products. As part of the study, we developed methods to measure GenX and other PFAS chemicals in human blood samples. These tests were done as part of the research project. This report describes the results from the blood tests. We are sharing your PFAS blood results with you on Page 5. Results from all blood samples collected in November 2017 and May 2018 are included. What did we do? • Enrolled 310 participants in November 2017 and 35 in May 2018. • Collected blood samples in November 2017 and May 2018. o 44 participants provided blood samples in both November and May. These samples let us see how long these chemicals stay in the blood. • Tested for 23 different PFAS, including GenX, in the blood samples. o These chemicals were selected based on what we know about Teflon manufacturing processes and chemicals commonly found in US residents. o These testing took place at the US Environmental Protection Agency (USEPA). o The full list of the PFAS tested in blood are on the GenX Exposure Study website (tinyurl.com/GenXstudy).
Transcript of [INSERT DATE] [INSERT STREE ADDRESS] Dear [INSERT ... · If you have additional questions related...
![Page 1: [INSERT DATE] [INSERT STREE ADDRESS] Dear [INSERT ... · If you have additional questions related to the GenX Exposure Study or how we collected and processed the samples, please](https://reader034.fdocuments.in/reader034/viewer/2022042909/5f3c98f698605b34f94f1470/html5/thumbnails/1.jpg)
Page1of4PID:[PID]
GenXExposureStudyNorthCarolinaStateUniversity
CampusBox7633Raleigh,NC27695-7633
Phone:855-854-2641https://chhe.research.ncsu.edu/coec/projects/genx/the-genx-exposure-study/
[INSERTDATE]
[INSERTSTREEADDRESS]
[INSERTCITY,STATE,ZIP]
Dear[INSERTPARTICIPANT/PARENTNAME],
ThankyouforparticipatingintheGenXExposureStudy.ThepurposeofthisresearchstudyistoseeifGenXandrelatedper-andpolyfluoroalkylsubstances(PFAS)arepresentinthebodiesofNewHanoverCountyresidents.PFASchemicalsareafamilyoffluorochemicals;someofthesechemicals,likeGenX,areusedtomakenon-stickproducts.
Aspartofthestudy,wedevelopedmethodstomeasureGenXandotherPFASchemicalsinhumanbloodsamples.Thesetestsweredoneaspartoftheresearchproject.Thisreportdescribestheresultsfromthebloodtests.WearesharingyourPFASbloodresultswithyouonPage5.ResultsfromallbloodsamplescollectedinNovember2017andMay2018areincluded.
Whatdidwedo?
• Enrolled310participantsinNovember2017and35inMay2018.
• CollectedbloodsamplesinNovember2017andMay2018.
o 44participantsprovidedbloodsamplesinbothNovemberandMay.Thesesamplesletusseehowlongthesechemicalsstayintheblood.
• Testedfor23differentPFAS,includingGenX,inthebloodsamples.
o ThesechemicalswereselectedbasedonwhatweknowaboutTeflonmanufacturingprocessesandchemicalscommonlyfoundinUSresidents.
o ThesetestingtookplaceattheUSEnvironmentalProtectionAgency(USEPA).
o ThefulllistofthePFAStestedinbloodareontheGenXExposureStudywebsite(tinyurl.com/GenXstudy).
![Page 2: [INSERT DATE] [INSERT STREE ADDRESS] Dear [INSERT ... · If you have additional questions related to the GenX Exposure Study or how we collected and processed the samples, please](https://reader034.fdocuments.in/reader034/viewer/2022042909/5f3c98f698605b34f94f1470/html5/thumbnails/2.jpg)
Page2of4PID:[PID]
Whatdidwefind?
• WedidnotfindGenXinthebloodsamplesatlevelsgreaterthan2ng/mL.
o Thiswasoneofourkeyresearchquestions.WeusedlaboratorymethodstodetectGenXifitwaspresentinblood.Wehadtheabilitytodetect2ng/mL(2partsperbillion)GenXorgreater.
o OneofthebigunknownsaboutGenXandthenewerPFASchemicalsishowlongtheystayinthebody.BecausewecouldnotdetectGenXinbloodsamples,weknowthatGenXdoesnotstayinthebloodforverylong.
• AnumberofPFASchemicals,bothnewlyidentifiedandhistoricallyusedchemicals,werefoundinthebloodofNewHanoverCountyresidents.
• NewlyidentifiedPFASchemicalscalledNafionby-product2,PFO4DA,PFO5DoDA,andHydro-EVEwerefoundinmostbloodsamples.
• ThebloodlevelsofnewlyidentifiedPFASchemicalsappeartohavedroppedfromNov2017toMay2018amongthe44participantswhoprovidedtwobloodsamples.(Figure1)
• Thehistoricallyused,or“legacy”,chemicalscalledPFOA,PFOS,PFHxS,PFNA,andPFDAwerefoundinmostbloodsamples.
• ThelevelsofhistoricallyusedchemicalsinthebloodofNewHanoverCountyresidentsarehigherthannationalestimates.(Figure2)
o Everyyear,theCDCconductsasurveycalledNHANES(theNationalHealthandNutritionExaminationSurvey).NHANEScollectsbloodsamplesandmedicalinformationfrompeoplefromacrossthecountry.BloodsamplesareanalyzedforthehistoricallyusedPFASchemicals.
o WeusedtheNHANESresultsforPFASchemicalsin2013-2014asacomparisonfortheseresultsfromtheGenXExposureStudy.
Figure1.ChangesinbloodPFASlevelsfromNovember2017toMay2018.Medianconcentration(ng/mL)ofnewlyidentifiedPFASamong44participantswhoprovidedbloodsamplesinNov2017(blackbar)andMay2018(graybar).
Med
ianbloo
dconcen
tration(ng/mL)
NewerPFASChemicals
Nafionbyproduct2
PFO4DA PFO5DoDA
![Page 3: [INSERT DATE] [INSERT STREE ADDRESS] Dear [INSERT ... · If you have additional questions related to the GenX Exposure Study or how we collected and processed the samples, please](https://reader034.fdocuments.in/reader034/viewer/2022042909/5f3c98f698605b34f94f1470/html5/thumbnails/3.jpg)
Page3of4PID:[PID]
WhatarethelimitationsofthePFASbloodsamplingresults?
• TheseresultstellyouhowmuchPFASwaspresentinyourbloodonthedayyouprovidedasample.
o Wedon’tknowhowlevelswillvaryovertime.
o Wedon’tknowhowyouwereexposedorhowlongtheexposurelasted.Someofthesechemicalshavemanysources,sowedon’tknowwhatexposureresultedinthepresenceofthesechemicals.
• Chemicalswhicharenotpresentinbloodmaystillbepresentinthebody.GenXandotherPFASwillalsobeanalyzedfromtheurinesamplesyouprovided.WearelookingforGenXandotherPFASchemicalsintheurinesamplesthatyouprovided.
• TheresultsfortheHydro-EVEareconsideredsemi-quantitative.WeareconfidentthatHydro-EVEispresentinblood.Wedonotknowtheexactamountbecausethetoolsneededtocalculatethiswerenotavailableatthetimeofanalysis.
• Thisisaresearchstudynotaclinicaltest.o Thechemicalsthatwearereportingrequirednewandsophisticatedmethods
fordetection.
Whatdotheseresultsmeantoyourhealth?
• Forsomeofthechemicalswemeasured(Nafionbyproduct2,PFO4DA,PFO5DoDA,Hydro-EVE),therearenotoxicologydataavailabletoinformaboutpotentialhumanhealtheffects.Therefore,wecannotsaywhattheseresultsmeanforyourhealth.
o Ourfindingswillhelpinformfuturetoxicologystudies.
Figure2.Medianbloodconcentration(ng/mL)oflegacyPFASamong388samplesfrom344GenXExposureStudyparticipants(blackbar).NHANES2013-14data(whitebar)shownforcomparison.
Med
ianbloo
dconcen
tration(ng/mL)
Historically-usedPFASChemicals
![Page 4: [INSERT DATE] [INSERT STREE ADDRESS] Dear [INSERT ... · If you have additional questions related to the GenX Exposure Study or how we collected and processed the samples, please](https://reader034.fdocuments.in/reader034/viewer/2022042909/5f3c98f698605b34f94f1470/html5/thumbnails/4.jpg)
Page4of4PID:[PID]
• WhilescientificresearchonPFASisgrowing,fornowthesePFASbloodresultscannottellyou:
o IfacurrenthealthproblemisrelatedtothePFASlevelsfoundinyourbody.o IfthePFASlevelsinyourbodywillhavenegativehealtheffectsnoworlaterin
life.
Wherethestudyisheading
• WeareworkingtoanalyzetheurinesamplescollectedinthestudyforPFAS.Wewillsendyouthoseresultswhentheyareavailable.
• WaterresultsforMayparticipantswillbesharedlaterthisyear.
YourPFASbloodresults
YourindividualPFASbloodsampleresultsarepresentedonPage5.IfyouprovidedbloodsamplesinNov2017andMay2018,bothresultsareshownonPage5.
Ifyouhavequestionsabouthowtoreadthisreport,pleasegoto“Studyupdates”onourwebsite(tinyurl.com/GenXnc)foravideothatwillwalkyouthroughit.Thereisalsomoreinformationonourwebsiteaboutthesefindings.
WeplantohostacommunitymeetinginWilmingtontodiscusstheseresults.ThismeetingwillbeheldTuesday,November13,2018at7:00PMattheCapeFearCommunityCollegeUnionStation,RoomU-170(502NFrontStreet,Wilmington,NC28401).
IfyouhaveadditionalquestionsrelatedtotheGenXExposureStudyorhowwecollectedandprocessedthesamples,pleasefeelfreetocontactourstudyofficebyphone(855-854-2641)oremail([email protected]).
WethankyouforyourparticipationintheGenXExposureStudy.Yourresults,whencombinedwithothers,mayhelpusbetterunderstandanypotentialhealthrisksfromPFASexposureinthefuture.
Sincerely,
JaneHoppin,ScD GenXExposureStudy,PrincipalInvestigator
![Page 5: [INSERT DATE] [INSERT STREE ADDRESS] Dear [INSERT ... · If you have additional questions related to the GenX Exposure Study or how we collected and processed the samples, please](https://reader034.fdocuments.in/reader034/viewer/2022042909/5f3c98f698605b34f94f1470/html5/thumbnails/5.jpg)
Belowareyourbloodsampleresults(ParticipantID#000).Theunitsareng/mLandNDis“non-detect.”Notethattheconcentrationrangesaredifferentforeachchemical.
WedonotshowconcentrationsforHydro-EVE.Weonlyshowwhereyoursampleisinthedistributionofallbloodsamplesfromstudyparticipants,andwhereitisrelativetothemedian(ormidpoint)ofallparticipants.
Legend
NewerPFAS:
Historically-usedPFAS:
