Innovations in ICP Sample Introduction Jerry Dulude, Glass Expansion, Inc. 4 Barlows Landing Rd....
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Transcript of Innovations in ICP Sample Introduction Jerry Dulude, Glass Expansion, Inc. 4 Barlows Landing Rd....
![Page 1: Innovations in ICP Sample Introduction Jerry Dulude, Glass Expansion, Inc. 4 Barlows Landing Rd. Pocasset, MA.](https://reader035.fdocuments.in/reader035/viewer/2022062518/56649f425503460f94c62338/html5/thumbnails/1.jpg)
Innovations in ICP Sample Introduction
Jerry Dulude, Glass Expansion, Inc.
4 Barlows Landing Rd.
Pocasset, MA
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Glass Expansion
Summary of Discussion
Low Flow Nebulizers Helix O’ring-free Spray Chambers New Internal Standard Kit Niagara Rapid Rinse Accessory
Innovations in Sample Introduction
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Glass Expansion
Applications of Low-Flow Nebulizers
Limited sample volumes Volatile samples Expensive waste disposal ICP-MS-LC interface
Low-Flow Nebulizers
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Glass Expansion
Range of Low-Flow Nebulizers
MicroMist- Concentric glass nebulizer 0.05 to 0.6 ml/min
PolyCon- Concentric polyimide nebulizer 0.05 to 0.6ml/min
OpalMist- Concentric PFA nebulizer 0.01 to 0.6ml/min
Low-Flow Nebulizers
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Glass Expansion
Transport Efficiency vs. Uptake
%EFFICIENCY
UPTAKE RATE (ML/MIN)
Indirect drain collection method
Low-Flow Nebulizers
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Glass Expansion
Tertiary Flow Rate vs. Uptake
05
101520253035404550
0.03 0.11 0.27 0.5 0.61 1.4 2.1
uptake rate (ml/min)
ul/min
Tertiary Flow Rate (ul/min)
Low-Flow Nebulizers
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Glass Expansion
Corroboration of Tertiary Flow Rates
Uptake rate
(ml/min)
Indirect Method
(mg/min)
Direct Method*
(mg/min)
0.03 15 14
0.11 23 21
Todoli, Hernandis, Canals, and Mermet, JAAS, 1999, 14, 1289-1295Using GE MicroMist nebulizer with U-tube absorption for measurement
Low-Flow Nebulizers
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Glass Expansion
Primary Aerosol Size Distribution Comparison
20
60
100
D32 = 7.1
Nebulizer Gas Flow Rate = 1.0 L/Min Solution Uptake Rate = Natural Aspiration
MicroMist (0.03ml/min)
Diameter (m)10 20 30 40 50 600
D32 = 17.2
Conikal (2ml/min)
20
60
100
No
rmal
ized
Co
un
t
No
rmal
ized
Vo
lum
e
Diameter (m)10 20 30 40 500 60
Low-Flow Nebulizers
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Glass Expansion
Tertiary Aerosol Size Distribution Comparison
No
rmal
ized
Co
un
t
Nebulizer Gas Flow Rate = 1.0 L/Min Solution Uptake Rate = Natural Aspiration
Conikal (2ml/min)
20
60
100D32 = 4.9
Diameter (m)
20
60
100D32 = 5.0
MicroMist (0.03ml/min)
10 20 40300 50
Baffled Cyclonic Spray Chamber
Low-Flow Nebulizers
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Glass Expansion
New Micro-Flow OpalMist
All PFA construction Natural uptake rate of 0.010 ml/min Ultra-high purity applications Ideal for micro samples down to 20 ul volume
Low-Flow Nebulizers
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Glass Expansion
Cyclonic Spray ChambersAdvances in Nebulizer Installation
1984 1993
1996
Helix O’ring free spray chamber
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Glass Expansion
Helix O'ring-Free Spray Chamber
Helix O’ring free spray chamber
Reduced carryover
Faster washout Higher purity Can stand up to
ketones and other solvents
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Glass Expansion
New Internal Standard KitBenefits of Internal Standardization
Compensate for physical interferences Viscosity Surface tension
Compensate for some chemical interferences High salts Mass related effects (ICP-MS)
Improve short term precision (simultaneous detectors)
Decrease long-term drift
Internal Standard Kit
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Glass Expansion
New Modular Internal Standard Kit
Internal Standard Kit
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Glass Expansion
IS Tee with Built-in Mixing Chamber
Internal Standard Kit
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Glass Expansion
New Flared-End Pump Tubing
The final building block of a totally modular system
Internal Standard Kit
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Glass Expansion
IS Schematic
Internal Standard Kit
Sample IS
Peri Pump
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Glass Expansion
Niagara™ Rapid Rinse Accessory
Interfaces between ICP & Autosampler
Reduces required rinse time Programmable delay time Less than 8 inches high Includes adj. height stand
Rapid Rinse Accessory
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Glass Expansion
How Niagara Works
Rapid Rinse Accessory
Analysis Rinse
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Glass Expansion
Niagara Time Saving (30 sec rinse)
Standard System With Niagara
Probe to sample 5 5
Uptake delay 15 15
Stabilization 10 10
Read 15 15
Probe to rinse 5 5
Rinse 30 5
Total (seconds) 80 55
Rapid Rinse Accessory
= Rinse steps
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Glass Expansion
Summary
MicroMist nebulizers Efficient sample consumption Minimum waste generation
Helix spray chambers Eliminate o’ring maintenance and contamination Reduce carryover
Internal standard kit Improved accuracy without the work Easy & inexpensive modular replacement
Niagara Rapid Rinse Accessory More samples per hour Faster sample turnaround time
Rapid Rinse Accessory