Innovation by Pre-Commercial Procurement

Advisory Board Meeting THALEA project

Maastricht, February 21st, 2017

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Tele-medicine in Intensive Care

Prof. Dr. P. Roekaerts

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IC – Telemedicine is the use of an off-site

command center in which an intensive care team

is connected with patients in distant ICUs to

provide intensive care through real-time audio,

video and electronic means

What is IC – Telemedicine?

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Why IC – Telemedicine?

Improve access to intensivists’ quality care remote areas

poor countries : humanitarian commitment

demographics: more elderly sick patients and a shortage

of medical/nursing IC teams

cost containment

education

advice

co-management (a second pair of eyes)

extend into departments that are designed to provide an

immediate response to patients

5 The future of ICU care

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• Ageing society

• Ageing workforce

• Foreseeable bottleneck

in health care JAMA, December 6, 2000 – Vol 284, No 21

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Earlier intensivist management

Coordinated timely usage of performance

information

Higher rates of adherence to best practices

Shorter alarm response times

More frequent interdisciplinary rounds

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Benefits of IC – Telemedicine related to :

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The literature

A Multicenter Study of ICU Telemedicine Reengineering of Adult Critical Care Chest 2014; 115(3):500-507

“ICU telemedicine interventions, specifically interventions that

increase early intensivist case involvement, improve adherence

to ICU best practices, reduce response times to alarms, and

encourage the use of performance data, were associated with

lower mortality and length of stay”

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Telemedicine improves ICU outcomes

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The Thalea project

Univ.-Prof. Dr. G. Marx, FRCA

11 The project idea

Problem:

Patient data in Patient Data

Management System (PDMS)

Large data amounts,

no overview possible

Different PDMS do not

communicate

Solution:

Central „Cockpit“

to bundle data

Expert monitors patients

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the relevant information,

at the right time,

in one place

12 The Thalea project

Goal:

save lives!

Mean:

creating a technologically advanced cockpit for remote support and advise for various ICUs

This will lead to: Earlier detection of deterioration, earlier intervention and

more lives saved

Pattern recognition

Tracking workflows thus improving compliance

Standardization of ICU-registry

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13 The Thalea system

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14 The Thalea system

What is the main focus?

Compatibility with patient data management systems already in

use in ICUs

High level of interoperability

Scalability

Manufacturer independency

Enabling remote consultation regionally with telemedicine

solutions

Early detection of ICU patients at increased risk

Effective resource utilization and real-time resource

management

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Innovation Procurement = PCP + PPI 15

PCP to steer the development of solutions towards concrete public sector needs, whilst comparing/validating alternative solution approaches from various vendors

PPI to act as launching customer / early adopter / first buyer of innovative commercial end-solutions newly arriving on the market

Open market consultation

Thalea PCP-process

Prior Information Notice

Development and evaluation of products during three phases

Functional description / Requirements

Call for Tender

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2012 Thalea consortium established

November 2013: Project start

December 2013 - March 2014: Open market consultation

March 2014 – September 2014: Preparation call for tender

November 2014 – June 2015: PCP phase 0: Call for tender

June - September 2015: PCP Phase 1: Selected tenderers develop a solution design

September 2015 – July 2016: PCP Phase 2: Top-3 solution-designs develop into prototype

August – November 2016: PCP Phase 3: Top-3 prototypes develop into pre-series model

Thalea II / PPI Phase 1: deployment of commercial product

Thalea project timeline 17

23 interested companies from 5

different countries

52% are e-specified companies

25% are PDMS manufacturers

82% of companies are familiar with data-safety and

security

Strong interest in forming of consortia

Results market consultation 18

Prior information notice launched

Functional description designed

First call for tender launched in September 2014

Terminated due to administrative issues

Second call for tender launched in March 2015

Open procedure with bidding competition

Timeline has to be adapted

Call for Tender 19

After termination of first call for tender the timeline had

to be adapted

The timeline was extremely challenging

The Thalea consortium managed it

Successful project and great results

Timeline Thalea 20

Final submission of tenders on 02.06.2015

6 tenderers responded

Presentation meeting along with

tenderers (10.-11.06.2015)

Presentation of tenders

Tender evaluation by

Core consortium

5 tenderers were awarded to

phase 1

Results Call for Tender 21

Duration: 15.06.2015 until 16.08.2015

Development of a solution design for the THALEA

challenge

Evaluation of solution designs until 09.06.2015

Pre-defined evaluation matrix

Evaluation by all experts in all test sites

Main evaluation criterion was “value for money”

Phase 1: solution designs 22

5 tenderers developed a solution design

High quality concepts

Evaluation by the Thalea consortium

Three tenderers were awarded to phase 2

Results phase 1: solution design 23

Duration: 14.09.2015 until 03.06.2016

3 tenderers developed prototypes

Different approaches

Workshops with tenderers

21./22.09.2015 in Brussels

Evaluation by the Thalea consortium

Pre-defined evaluation matrix

Evaluation by all experts in all test sites

Three tenderers were awarded to phase 3

Phase 2: prototype development 24

Main advantages:

an impressive ability to extract data from different

source systems

a clear and calm design

low total costs of ownership

Phase 2: prototype Dendrite 25

Main advantages:

the well-structured, graphical display of relevant

data

the modularity of their system

graphical programming

Phase 2: prototype NewCompliance 26

Main advantages:

most comprehensive data presentation

different possibilities to display relevant clinical

information and risk

basic documentation platform for telemedicine in the

ICU (not part of the evaluation)

Phase 2: prototype Philips 27

Duration: 08.08.2016 until 14.10.2016

3 tenderers developed pre-series models

Very narrow time schedule

High dedication of the developers

Evaluation by the Thalea consortium

Pre-defined evaluation matrix

All tenderers improved their prototypes

Three tenderers received a final evaluation

and recommendations

Phase 3: 1st pre-series models 28

Main improvements in:

the amount of presented data

the notification and alarm function

the infection detection

Phase 3: 1st pre-series model Dendrite 29

Main improvements in:

usability of programming due to graphical

programming

logistics information

Phase 3: 1st pre-series model NewCompliance 30

Main improvements in:

better overview of the orbs-system

automatic admission of patients

possibility to design own algorithms

Phase 3: 1st pre-series model Philips 31

Scenario:

Operating a

telemedicine center,

leasing tele-ICU functionality

to other hospitals,

average of € 4,500 per ICU bed

Profit grows beyond year two

and eventually reaches €

700,000 by year six

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32 Promising market analysis by tenderers

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33 Demonstration of pre-series models

DIVI 2016 in Germany

Presentation of THALEA pre-series models at the

biggest intensive care medicine congress in

Germany

5,800 participants in 2016

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34 Demonstration of pre-series models

Düsseldorf Rheinterrassen

Exhibition of successful R&D projects

Opening by Svenja Schulze, Minister of Innovation,

Science and Research of North Rhine-Westphalia

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35 Demonstration of pre-series models

Upcoming presentations of THALEA:

02.-03.03.2017 Düsseldorf R&I event

Opening Session by Svenja Schulze, Minister of

Innovation, Science and Research of North Rhine-

Westphalia

PCP

PCP as funding instrument requires innovative thinking

PCP leads to high innovation potential

PCP strengthens cooperation between science and industry

Thalea

Very successful PCP-project

Development of innovative products, which were non-existent before

Developed pre-series models open PDMS market to manufacturer independent solutions

Conclusion 36

The Thalea consortium

builds the foundation for the

first PCP-Project in whole

Europe which evolved into a

PPI

This is a tremendous

success!

First PCP evolving in a PPI 37

38 thalea@ukaachen.de www.thalea-pcp.eu