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OBJECTIVE: An increased production of nitric oxide (NO) in liver cirrhosis has

been documented. NO could intervene in regulating gallbladder contraction, asuggested by clinical and experimental studies. Our aim was to investigate thinfluence of an NO donor on gallbladder motility in cirrhotic patients in relatioto the severity of liver cirrhosis.METHODS: The subjects were six controls an18 patients with liver cirrhosis (six in each Child class). Gallbladder emptyingwas monitored by ultrasound for 90 min after a mixed meal (14 g fat, 425kcal). Fasting gallbladder volume, minimal residual volume, ejection fraction,area under emptying curve, and half contraction time of the gallbladder wereassessed at 15-min intervals. The patients were evaluated on two consecutiv

Gallbladder hyporesponsiveness to anexogenous nitric oxide donor, glyceryltrinitrate, in patients with advanced livercirrhosis

Authors: Acalovschi, M.1; Spirchez, Z.; Hamoudi, W.T.Y.

Source:The American Journal of Gastroenterology, Volume

94, Number 10, 1 October 1999 , pp. 3005-3009(5)

Publisher: Blackwell Publishing

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days, with or without perlingual administration of 0.5 mg glyceryl trinitrate(GTN). Statistical analysis was performed by the two-tailed Student's t testand Pearson's correlation coefficient.RESULTS: GTN significantly reducedgallbladder motility in controls and compensated cirrhotics (p < 0.02), but hano effect upon gallbladder emptying in Child class B and C cirrhotics.CONCLUSIONS: Gallbladder hypocontractility in liver cirrhosis is related to thseverity of the disease. This study is the first to show that GTN has no effect

upon gallbladder motility in advanced liver cirrhosis when administered indoses that induce relaxation in controls and compensated cirrhosis.

Document Type: Research article

DOI: 10.1016/S0002-9270(99)00439-6

Affiliations:1: a3rd Medical Clinic, University of Medicine and Pharmacy, ClNapoca, Romania