Information Management The old fashioned way! Gary R. Skuse, Ph.D. Director of Bioinformatics...
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Transcript of Information Management The old fashioned way! Gary R. Skuse, Ph.D. Director of Bioinformatics...
![Page 1: Information Management The old fashioned way! Gary R. Skuse, Ph.D. Director of Bioinformatics grssbi@rit.edu.](https://reader036.fdocuments.in/reader036/viewer/2022062515/56649cba5503460f949820f1/html5/thumbnails/1.jpg)
Information Management
The old fashioned way!
Gary R. Skuse, Ph.D.Director of Bioinformatics
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Essential Cell Biology : An Introduction to the
Molecular Biology of the Cell
by Bruce Alberts, Dennis Bray, Alexander Johnson, Julian Lewis, Peter Walter, Keith Roberts, Martin Raff
Garland Pub; ISBN: 0815320450
All Illustrations taken from:
![Page 3: Information Management The old fashioned way! Gary R. Skuse, Ph.D. Director of Bioinformatics grssbi@rit.edu.](https://reader036.fdocuments.in/reader036/viewer/2022062515/56649cba5503460f949820f1/html5/thumbnails/3.jpg)
Molecular Biology is about Information
Alice
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Information Flow within Cells
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Spatial Flow of Information
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DNA is Organized into Chromosomes
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Painted Chromosomes
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Electron Micrographs of Chromosomes
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Chromosomes are Comprised of DNA
Packaged with Proteins
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Chromosomes Contain Large Quantities of DNA
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DNA can Replicate Itself
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DNA Replication is Uncommonly Accurate
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Information in DNA is Transcribed into RNA
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There are Different Types of RNA
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Gene Organization in Prokaryotes
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Translation of Prokaryotic and Eukaryotic RNA
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DNA Serves as a Template for Transcription
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Eukaryotic Genes are Not Contiguous
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RNA Splicing is Sequence Directed
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Alternative Splicing Leads to Multiple Proteins from One Gene
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RNA Processing, Like All Things Biological, is
Complex
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Gene Expression is Regulated Differently for Different Genes
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RNA is Translated into Protein
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The Code Must be Parsed Accurately
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Linear Strings of Amino Acids Interact
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Proteins Fold to Form 3-D Structures
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We can Depict Protein Structures in
Many Ways
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We can Depict Protein Structures in
Many Ways
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We can Depict Protein Structures in
Many Ways
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We can Depict Protein Structures in
Many Ways
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Protein Shape Leads to Function
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Protein Shape Leads to Function
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Proteins may Change Shape as they Function
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Genes are Somewhat Modular
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Protein Structure Reflects that Modularity
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Preparation of DNA for Cloning
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Cloning of DNA
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The PCR