Informatics for the Neuroimaging Research Enterprise Dan Marcus Washington University NITRC...
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![Page 1: Informatics for the Neuroimaging Research Enterprise Dan Marcus Washington University NITRC Enhancement Grantee Meeting Monday, June 30, 2008.](https://reader036.fdocuments.in/reader036/viewer/2022070400/56649ebd5503460f94bc73cd/html5/thumbnails/1.jpg)
Informatics for the Neuroimaging Research
EnterpriseDan Marcus
Washington UniversityNITRC Enhancement Grantee Meeting
Monday, June 30, 2008
![Page 2: Informatics for the Neuroimaging Research Enterprise Dan Marcus Washington University NITRC Enhancement Grantee Meeting Monday, June 30, 2008.](https://reader036.fdocuments.in/reader036/viewer/2022070400/56649ebd5503460f94bc73cd/html5/thumbnails/2.jpg)
The Central Neuroimaging Data Archive
• Supporting Wash U investigators since 2003• Currently holds 25000 MR, PET and CT scans
from over 5000 individual studies• ~100 active users from two dozen labs• Supports all of the Univ.’s imaging facilities
and many of its research centers.
![Page 3: Informatics for the Neuroimaging Research Enterprise Dan Marcus Washington University NITRC Enhancement Grantee Meeting Monday, June 30, 2008.](https://reader036.fdocuments.in/reader036/viewer/2022070400/56649ebd5503460f94bc73cd/html5/thumbnails/3.jpg)
Defining the enterprise
Lab
Stakeholders: Principal investigator, students, postdocs, research techs.
![Page 4: Informatics for the Neuroimaging Research Enterprise Dan Marcus Washington University NITRC Enhancement Grantee Meeting Monday, June 30, 2008.](https://reader036.fdocuments.in/reader036/viewer/2022070400/56649ebd5503460f94bc73cd/html5/thumbnails/4.jpg)
Defining the enterprise
Center
LabLab Lab
Stakeholders: Director, scanner facility, IT department, human studies
![Page 5: Informatics for the Neuroimaging Research Enterprise Dan Marcus Washington University NITRC Enhancement Grantee Meeting Monday, June 30, 2008.](https://reader036.fdocuments.in/reader036/viewer/2022070400/56649ebd5503460f94bc73cd/html5/thumbnails/5.jpg)
Defining the enterprise
Center
LabLab Lab
Center
LabLab Lab
Center
LabLab Lab
Multisite collaborationMultisite collaboration
Stakeholders: study PI, individual PIs, research cores, coordinating center
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Defining the enterprise
• Labs: Focused on data & analysis• Centers: Focused on operations & oversight• Multisite studies: Focused on technical &
scientific coordination and logistics
![Page 7: Informatics for the Neuroimaging Research Enterprise Dan Marcus Washington University NITRC Enhancement Grantee Meeting Monday, June 30, 2008.](https://reader036.fdocuments.in/reader036/viewer/2022070400/56649ebd5503460f94bc73cd/html5/thumbnails/7.jpg)
Defining informatics: Data Capture
NEUROIMAGING
GENETICS
OTHER SOURCES
Integrity: Do I have the data?Quality Control: Are the data any good?
![Page 8: Informatics for the Neuroimaging Research Enterprise Dan Marcus Washington University NITRC Enhancement Grantee Meeting Monday, June 30, 2008.](https://reader036.fdocuments.in/reader036/viewer/2022070400/56649ebd5503460f94bc73cd/html5/thumbnails/8.jpg)
Defining informatics: Local Use
NEUROIMAGING
GENETICS
OTHER SOURCES
Application: Can I do things with the data?Automation: Am I optimizing throughput?
![Page 9: Informatics for the Neuroimaging Research Enterprise Dan Marcus Washington University NITRC Enhancement Grantee Meeting Monday, June 30, 2008.](https://reader036.fdocuments.in/reader036/viewer/2022070400/56649ebd5503460f94bc73cd/html5/thumbnails/9.jpg)
Defining informatics: Collaboration
NEUROIMAGING
GENETICS
OTHER SOURCES
Access: Are colleagues getting the data they need?Security: Are colleagues getting data they shouldn’t?
![Page 10: Informatics for the Neuroimaging Research Enterprise Dan Marcus Washington University NITRC Enhancement Grantee Meeting Monday, June 30, 2008.](https://reader036.fdocuments.in/reader036/viewer/2022070400/56649ebd5503460f94bc73cd/html5/thumbnails/10.jpg)
Defining informatics: Public access
NEUROIMAGING
GENETICS
OTHER SOURCES
Privacy: Am I respecting the rights of the study participants?Convenience: How usable are the data?
![Page 11: Informatics for the Neuroimaging Research Enterprise Dan Marcus Washington University NITRC Enhancement Grantee Meeting Monday, June 30, 2008.](https://reader036.fdocuments.in/reader036/viewer/2022070400/56649ebd5503460f94bc73cd/html5/thumbnails/11.jpg)
QUARANTINE LOCAL USE COLLABORATION PUBLIC ACCESSCAPTURE
NEUROIMAGING
GENETICS
OTHER SOURCES
The XNAT workflow
• Quality control• Data archiving• Data access• Security
• Visualization• Automation• Integration• Data sharing
![Page 12: Informatics for the Neuroimaging Research Enterprise Dan Marcus Washington University NITRC Enhancement Grantee Meeting Monday, June 30, 2008.](https://reader036.fdocuments.in/reader036/viewer/2022070400/56649ebd5503460f94bc73cd/html5/thumbnails/12.jpg)
Lessons learned: stakeholders
• Identify the stakeholders and their personalities– The Micromanager– The Empire builder– The Outsourcer– The Benefactor
• N investigators ≠N databases
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Lessons learned: budgets
• Hardware costs will be over budgeted.• Personnel costs will be under budgeted.
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Lessons learned: personnel
• Hire software engineers.• Good Java programmers are rare.• Good Java programmers who will work for
what you want to pay them? Forget about it.• There are no rules.• Except: your software engineering team is
your most important asset.
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Lessons learned: software engineering
• Use the least possible technology.• Half the features. Twice the usability.• Compliance issues (HIPAA, IRBs, IT security)
becomes increasingly burdensome• Open source is your friend.
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Lessons learned: data
• Remain agnostic to formats• Except DICOM. Drink the Kool-Aid.