Inflammation and Course Themes Nancy Long Sieber, Ph.D. Sept. 14, 2009.

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Transcript of Inflammation and Course Themes Nancy Long Sieber, Ph.D. Sept. 14, 2009.

  • Inflammation and Course Themes

    Nancy Long Sieber, Ph.D.Sept. 14, 2009

  • http://www.usc.edu/hsc/dental/PTHL312abc/312a/02/Graphics/figure01.gifChallenges and Adaptation

  • http://www.siumed.edu/~dking2/crr/images/CR007b.jpg

  • What is the significance of injury and toxicity?Tissues differ in their capacity for repairEpithelial cells are continuously replacedNerve cells, in general, do not divide

    Organs also differ in their safety factorsAll organs have some amount of excess capacityWith aging and injury, the excess capacity is lost, and this may lead to loss of function

  • http://www.wirednewyork.com/hotels/marriott_marquis/images/marriott_marquis_elevators.jpg

  • http://www.gkivdo.com/gkii/wire_3.jpgElevator cable for passenger elevators has a safety factor of about 11

  • Necrosis and Apoptosishttp://pubs.niaaa.nih.gov/publications/arh25-3/image01.gif

  • Developing human hand before web apoptosishttp://www.i-am-pregnant.com/img/day48-hand.gif

  • Developing hand after web apoptosishttp://www.grg.org/breakingnews2001.htm

  • Modified from: http://www.chrononhotonthologos.com/inactive/strokedr/hbothera.htm

    . . Area of dead tissue (Ischemic core) Ischemic penumbra where cells are irreversibly damaged.Cells in this region often undergo apoptosis in the hours after the stroke.

  • http://www.uic.edu/classes/bios/bios100/lecturesf04am/inflammation01a.jpgInflammation

  • InflammationPro-inflammatory cytokines IL-1 IL-6 TNFLIVERPositive acute phase reactants: FibrinogenSerum amyloid AC-reactive ProteinC3Haptoglobin

  • http://www.easterncarolinaent.com/Allergy-Triggers-copy.jpgCommon Allergens

  • http://www.euromeds.co.uk/allergy-treatment-information.htmAllergen binds to IgE, which links to mast cells, triggering release of histamine.

  • Autoimmune Diseasehttp://www.mctd.eu/images/AutoimmuneDisorder.jpg

  • http://www.wellesley.edu/Chemistry/chem227/nucleicfunction/cancer/cancer.htmlCancer

  • http://www.wellesley.edu/Chemistry/chem227/nucleicfunction/cancer/cancer.html

  • Stress Responses

  • Obesity Trends* Among U.S. AdultsBRFSS, 1985(*BMI 30, or ~ 30 lbs overweight for 5 4 person)No Data
  • http://www.cancer.gov/cancertopics/factsheet/Risk/obesity

  • Obesity Trends* Among U.S. AdultsBRFSS, 1986(*BMI 30, or ~ 30 lbs overweight for 5 4 person)No Data
  • Obesity Trends* Among U.S. AdultsBRFSS, 1987(*BMI 30, or ~ 30 lbs overweight for 5 4 person)No Data
  • Obesity Trends* Among U.S. AdultsBRFSS, 1988(*BMI 30, or ~ 30 lbs overweight for 5 4 person)No Data
  • Obesity Trends* Among U.S. AdultsBRFSS, 1989(*BMI 30, or ~ 30 lbs overweight for 5 4 person)No Data
  • Obesity Trends* Among U.S. AdultsBRFSS, 1990(*BMI 30, or ~ 30 lbs overweight for 5 4 person)No Data
  • Obesity Trends* Among U.S. AdultsBRFSS, 1991(*BMI 30, or ~ 30 lbs overweight for 5 4 person)No Data
  • Obesity Trends* Among U.S. AdultsBRFSS, 1992(*BMI 30, or ~ 30 lbs overweight for 5 4 person)No Data
  • Obesity Trends* Among U.S. AdultsBRFSS, 1993(*BMI 30, or ~ 30 lbs overweight for 5 4 person)No Data
  • Obesity Trends* Among U.S. AdultsBRFSS, 1994(*BMI 30, or ~ 30 lbs overweight for 5 4 person)No Data
  • Obesity Trends* Among U.S. AdultsBRFSS, 1995(*BMI 30, or ~ 30 lbs overweight for 5 4 person)No Data
  • Obesity Trends* Among U.S. AdultsBRFSS, 1996(*BMI 30, or ~ 30 lbs overweight for 5 4 person)No Data
  • Obesity Trends* Among U.S. AdultsBRFSS, 1997(*BMI 30, or ~ 30 lbs overweight for 5 4 person)No Data
  • Obesity Trends* Among U.S. AdultsBRFSS, 1998(*BMI 30, or ~ 30 lbs overweight for 5 4 person)No Data
  • Obesity Trends* Among U.S. AdultsBRFSS, 1999(*BMI 30, or ~ 30 lbs overweight for 5 4 person)No Data
  • Obesity Trends* Among U.S. AdultsBRFSS, 2000(*BMI 30, or ~ 30 lbs overweight for 5 4 person)No Data
  • Obesity Trends* Among U.S. AdultsBRFSS, 2001(*BMI 30, or ~ 30 lbs overweight for 5 4 person)No Data
  • (*BMI 30, or ~ 30 lbs overweight for 5 4 person)Obesity Trends* Among U.S. Adults BRFSS, 2002No Data
  • Obesity Trends* Among U.S. AdultsBRFSS, 2003(*BMI 30, or ~ 30 lbs overweight for 5 4 person)No Data
  • Obesity Trends* Among U.S. AdultsBRFSS, 2004(*BMI 30, or ~ 30 lbs overweight for 5 4 person)No Data
  • Obesity Trends* Among U.S. AdultsBRFSS, 2005(*BMI 30, or ~ 30 lbs overweight for 5 4 person) No Data
  • http://www.lipidsonline.org/slides/slide01.cfm?q=abdominal+fat&pg=1

  • http://mednews.wustl.edu/tips/page/normal/8947.html

    In this abdominal MRI scan, it is possible to see subcutaneous fat around the abdomen, surrounding abdominal muscles. Visceral fat is deeper inside the abdomen, surrounding internal organs.It is the visceral fat that secretes IL-6, strongly suggesting a mechanistic link to systemic inflammation.

  • The women in this study did not gain weight, but they did have an increase in abdominal fathttp://www.lipidsonline.org/slides/slide01.cfm?q=abdominal+fat&dpg=10

  • *We have never had an epidemic like this that we have been able to track so thoroughly and see. As I told you, this is conservative.About 60 million adults, or 30 percent of the adult population, are now obese, which represents a doubling of the rate since 1980.

    *We have never had an epidemic like this that we have been able to track so thoroughly and see. As I told you, this is conservative.About 60 million adults, or 30 percent of the adult population, are now obese, which represents a doubling of the rate since 1980.