Infection of parasite nematodes confounds vaccination efficacy (Urban et al. 2007)

Journal Club of Veterinary Medicine, 18 October 2007

If you want to be innovative? The get rid of the laid back

attitude!

It has to hurt a little to participate in an innovation project. If it is too fun and cozy, it does not move, concludes a

ph.d.-dissertation.

Ingeniøren, 13 October 2007

Immune System

Adaptive Immune System

T-cell development

Cytokines can prime of T helper cells development

INF

IL12

TNF

IL4

IL13

IL10

Th0

Th1 Th2

Intracellular Extracellular

“Infection of parasite nematodes confounds vaccination efficacy”

(Urban et al. 2007)

Veterinary Parasitology. 2007 August 19; 148(1): 14-20

+

Vaccination

Cytokines

Antibodies

(IgG1, IgG2)

Challenge (2nd vaccination)

General vaccination strategy

“Infection of parasite nematodes confounds vaccination efficacy”

(Urban et al. 2007)

Veterinary Parasitology. 2007 August 19; 148(1): 14-20

+

Vaccination Challenge (2nd vaccination)

+

Nematode

Heligomosomoides polygyrus

Plasmodium yoelii (malaria antigen,

mice)• IL3• IL4• IL5• IL9• IL13• IgG1 & IgE

INF

IL4IL13IL10TGF

Mouse model

“Infection of parasite nematodes confounds vaccination efficacy”

(Urban et al. 2007)

Veterinary Parasitology. 2007 August 19; 148(1): 14-20

+

Nematode Vaccination Challenge (2nd vaccination)

Ascaris suum Mycoplasma hyopneumonia

(commercial killed vaccine)

+

• Weak Th1 (lungs)• Th2 (intestine)

• 33% specific antibody response to M. Hyopnemonia.

• Serum conversion did not exceed 78 %.

• More lung pathology

Pig model

Parasitic infections as medicine

Chron’s Disease (regional interitis) An inflammatory bowel disease

Th1-dominated

Autoimmune disease

Th2

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