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Infection Control Facts: How to Select an Ideal
Disinfectant
Lee Nesbitt, BMScLee Nesbitt, BMScManager, Professional & Technical ServicesManager, Professional & Technical ServicesVirox Technologies IncVirox Technologies IncPhone: 1-800-387-7578 x115Phone: 1-800-387-7578 x115Email: [email protected]: [email protected]
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2003: CDN Hospitals notified >900 patients that improper sterilization of equipment may have exposed them to HIV, Hepatitis and other diseases. $150M class action lawsuit filed alleging negligence in failing to meet adequate sterilization standards.
Government ordered a province-wide audit of hospital infection-control practices
Healthcare Quarterly Vol. 8, Special IssueOctober 2005
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Canadian law clearly establishes a positive duty on care providers to inform patients of errors that occur during their care
When care providers realize that patients may have been exposed to infection from equipment, other patients or healthcare workers, a legal obligation may arise to contact patients to warn them of the risk and provide advice regarding appropriate follow-up testing and care.
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The removal of adherent visible soil, blood, protein substances (tissue) and other debris from surfaces by mechanical or manual process
Generally accomplished with water and detergents
Removes or eliminates the reservoirs of potential pathogenic organisms
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Viruses (enveloped) Bacteria (Gram +ve & Gram -ve) Fungi Viruses (non-enveloped) Mycobacteria Protozoa Bacterial Spores
Most Susceptible
Least Susceptible
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Once the device has been defined determine the Disinfection Process
Choose the CORRECTProduct
Consider the Device Classification(According to Spaulding)
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Sterilization
High LevelDisinfection
Intermediate Level Disinfection
Low LevelDisinfection
Critical Devices*
Semi-Critical Devices
Non-Critical Devices
*Foot Care Instruments defined as critical according to CCDR Vol. 23S8 (Dec 1997) Infection Control Guidelines: Foot Care by Health Care Providers
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refers to the level of disinfection required when processing noncritical items or some environmental surfaces and kills most vegetative bacteria and some fungi as well as enveloped viruses but not mycobacteria or bacterial spores.
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refers to disinfectant that kills vegetative bacteria, most viruses and most fungi but not resistant bacterial spores.
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refers to a process which destroys vegetative bacteria, mycobacteria, fungi, enveloped and non-enveloped viruses, but not necessarily bacterial spores
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refers to the chemical disinfection process that destroys all forms of microbial life including bacteria, viruses, spores and fungi.
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LLD ILD HLD Chemical Sterilants
Enveloped Viruses
3 Log / 99.9%
3 Log / 99.9%
Vegetative Bacteria
6 Log / 99.9999%
6 Log / 99.9999%
Fungi 5 Log / 99.999%
5 Log / 99.999%
5 Log / 99.999%
5 Log / 99.999%
Non-Enveloped Viruses
3 Log / 99.9%
3 Log / 99.9%
Mycobacteria 4 Log / 99.99%
6 Log / 99.9999%
6 Log / 99.9999%
Spores 6 Log / 99.9999%
6 Log / 99.9999%
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What’s in your bottle?
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Disinfectants are the backbone of Environmental Infection Control
>8000 Products registered in the U.S. & Canada
50% of which are used for Healthcare Infection Control
There are 300 different active chemistries› 14 are in 95% of the disinfectant
products› 6 are the most common
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Detergency properties for cleaning Not Readily Neutralized in Organic or
Inorganic Matter Microorganism Resistance will not develop Broad-Spectrum & Fast Acting Germicidal
Activity
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Alcohols Chlorine Phenolics QUATs AHPMust have good cleaning ability to remove organic soil load on surface.
Alcohols are noteffective cleanersas they do notcontaindetergencyProperties
Chlorine can beinactivated by a soilload and do notcontain detergencyProperties
Phenolics are ineffective cleaners
Quaternary Ammonia Compounds are not effective cleaners
AHP contains acombination ofsuperior surfactantsthat are proven effective cleaners insynergy withH2O2
Is effective in a soil load.
Testing is done with no soil load.
Neutralized by soil.
Testing is done with a soil load
Testing is generally done without a soil load.
Testing is done with a soil load.
Will not lead to development of resistant organisms
Active ingredient evaporates
Active ingredient evaporates
Leaves active ingredient residual on surface
Leaves active ingredient residual on surface
Active ingredient hydrogen peroxide evaporates from surface
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Alcohols Chlorine Phenolics QUATs AHPVegetative Bacteria
YES3 min to 10 min
YES10 min
YES 5 min to 10 min
YES3min to 10 min
YES30 sec to 20 min
Enveloped Viruses
YES3 min to 10 min
YES10 min
YES3 min to 10 min
YES3 min to 10 min
YES1 min to 5 min
Fungi YES3 min to 10 min
YES10 min
YES3 min to 10 min
YES3 min to 10 min
YES3 min to 5 min
Non-Enveloped Viruses
NO YES10 min
YES / NOProduct Specific Review label3 min to 10 min
NO YES1 min to 5 min
Mycobacteria
YES3 min to 10 min
YES10 min
YES3 min to 10 min
ONLY WITH SOLVENT OR ALCOHOL3 min – 10 min
YES1 min to 5 min
Bacterial Spores
NO YES10 min
NO NO YES10 min
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OPA Gluteraldehyde AHP
Fungi YES10 min
YES20 min – 45 min
YES5 min – 20 min
Mycobacteria YES10 min
YES20 min – 45 min
YES5 min – 20 min
Bacterial Spores YES32 hours
YES8 – 12 hours
YES20 min – 6 hours
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Safe to Transport & Easy to Store• Improper storage of disinfectants may lead to
explosions or fires Long Shelf Life• Improper or prolonged storage of disinfectants
may lead to growth of bacteria in them Non-Corrosive & Material Compatible• Using the wrong type or level of disinfectant may
cause corrosion or other damage to expensive items such as flexible endoscopes
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Alcohols Chlorine Phenolics QUATs AHP
Does not have storage limitations
Flammable Highly reactive with other chemicals creating toxic by-products
Toxicity poses risk for water and food contamination. Cannot be used around children
Caution with products that contain solvents or alcohols
Non-flammable or combustible
Realistic Shelf life and stabilty
Readily evaporates decreasing concentration
Readily degrades once open, diluted product must be made fresh daily
Relatively stable in both concentration and Use Dilution
Relatively stable in both concentration and Use Dilution
Stable in concentrate and Use Dilution
Compatible with a wide variety of surfaces and materials
Concerns with plastics and glues
Concerns with stainless steel and fabric materials
Concerns with residue build up on vinyl
Concerns with residue build up or Quat burn on some flooring and vinyl
Concerns with prolonged exposure to copper and brass
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OPA Gluteraldehyde AHP
Does not have storage limitations
Non-flammable or combustible
Do not store at elevated temperatures and keep away from ignition sources.
Non-flammable or combustible
Realistic Shelf life and stability
Shelf life decreases to 75 days once bottle is opened
Once activated shelf life rapidly decreases
Shelf life does not decrease once opened
Compatible with a wide variety of surfaces and materials
Concerns with plastics and glues
Concerns with residue build up on vinyl
Concerns with prolonged exposure to copper and brass
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Non-Toxic to humans & animals Non-Allergenic & non-sensitizing Non-Hormone disruption
• Certain microbicidal chemicals or their breakdown products can disrupt hormone function in humans & animals
Safe for the User and Patient• Exposure to cleaner & disinfectant vapours
may cause respiratory sensitization• Improperly rinsed endoscopes or other devices
may release residues of disinfectants into body cavity
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Alcohols Chlorine Phenolics QUATs AHP
Indoor Air Quality (VOCs)
Contains high levels of VOCs which contribute to poor indoor air quality
Creates high levels of VOCs through reactions with surface and soil load
Contain VOCs; Toxicity poses risk for water and food contamination
Contain VOCs; Contains no VOCs
Does not contain hormone disrupting or carcinogenic chemicals
Does not contain APEs / NPEs
Highly reactive creating toxic / carcinogenic by-products
Phenolic Compounds have been found to be carcinogenic
Many formulations contain APEs / NPEs
Does not contain APEs/NPEs ; is not carcinogenic
Will not lead to development of resistant organisms
Active ingredient evaporates
Active ingredient evaporates
Leaves active ingredient residual on surface
Leaves active ingredient residual on surface
Active ingredient hydrogen peroxide evaporates from surface
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OPA Gluteraldehyde AHP
Indoor Air Quality (VOCs)
Contains high levels of VOCs which contribute to poor indoor air quality
Contain VOCs; Requires special ventilation
Contains no VOCs
Adverse Reactions to Residues left on surfaces after reprocessing
Residues have lead to anaphylactic reactions
Anaphylactic reactions to both vapours and residues
No Active Residue left on surface
Will not lead to development of resistant organisms
Leaves active ingredient residual on surface
Leaves active ingredient residual on surface
Active ingredient hydrogen peroxide evaporates from surface
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Environmentally sound (Biodegradable) • Environmentally-stable sanitizers &
disinfectants can contaminate food or water (groundwater & surface water)
No Active Residual Chemistry Good Air Quality
• Free of any pungent smell • No Volatile Organic Compounds (VOCs)• Use of gaseous or volatile products may
negatively affect indoor air quality• Fragrance Free
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Alcohols Chlorine Phenolics QUATs AHP
Positive environmental profile including indoor air quality.
Contains high levels of VOCs which contribute to poor indoor air quality
Creates high levels of VOCs through reactions with surface and soil load
Contain VOCs; Toxicity poses risk for water and food contamination
Contain VOCs; often contain hormone disruptors
Contains no VOCs and no hormone disruptors
Will not lead to development of resistant organisms
Active ingredient evaporates
Active ingredient evaporates
Leaves active ingredient residual on surface
Leaves active ingredient residual on surface
Active ingredient hydrogen peroxide evaporates from surface
Carries EcoLogo or Green Seal Certification
Does not meet certification criteria
Does not meet certification criteria
Does not meet certification criteria
Only1 product meets Canada’s EcoLogo criteria
Received certifications by EcoLogo and Green Seal
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OPA Gluteraldehyde
AHP
Positive environmental profile including indoor air quality.
Contains high levels of VOCs which contribute to poor indoor air quality
Contain VOCs; requires special ventilation
Contains no VOCs; does not require special ventilation
Restrictions to Disposal
Restrictions in disposal
Restrictions in disposal
Can be disposed into municipal waste water
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Clearly outlines the requirements of what must be included on a label• Name of Product & Manufacturer• DIN must be on the main panel• Active Ingredients• Intended Use• Net contents• Lot Number & Expiry Date• Precautionary symbols and cautionary
statements
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Label requirements continued:• Claims• Area or Site of Use• Directions for Use
• Specific directions for preparing in-use dilution including ratios or metric units
• Reference to level of hardness of product diluent at time of testing
• Pre-cleaning or cleaning requirements• Contact Times• Temperature• Stability of diluted or in-use product
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Label requirements continued:• Rinse procedures• Directions for Use for intended use against
bloodborne pathogens• Reference to PPE• Directions for disposal of infectious waste
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Remember: Match Product with
Protocol› Surfaces vs
Instruments Cleaning = 1st step Disinfection = 2nd step Contact Time is
MANDATORY!
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Guidelines for Environmental Infection Control in Healthcare Facilities, CDC. MMWR June 2003, Vol 52, No RR-10
Best Practices for Cleaning, Disinfection and Sterilization in All Health Care Settings, PIDAC, May 2006
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Block S. Disinfection. Sterilization, and Preservation, 5th Ed. 2001
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Degussa, Hydrogen Peroxide: Properties, Handling and Application
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