Improving Chronic Disease Management with Pieces › sites › NIHKR › KR ›...

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Improving Chronic Disease Management with Pieces A Pragmatic Trial to Improve Care of Patients with Chronic Kidney Disease, Diabetes and Hypertension 1

Transcript of Improving Chronic Disease Management with Pieces › sites › NIHKR › KR ›...

Page 1: Improving Chronic Disease Management with Pieces › sites › NIHKR › KR › Slides...Identification of HF patients in Real-Time Using NLP Processing and Data Mining ID Risk List

Improving Chronic Disease Management with Pieces

A Pragmatic Trial to Improve Care of Patients with Chronic Kidney

Disease, Diabetes and Hypertension

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Page 2: Improving Chronic Disease Management with Pieces › sites › NIHKR › KR › Slides...Identification of HF patients in Real-Time Using NLP Processing and Data Mining ID Risk List

ICD - PiecesTM

Study Core

UT Southwestern / Biostatistics Center

Parkland Center Clinic Innovation (PCCI)

SUNY of Buffalo

Health Care Systems

Parkland Health and

Hospital System

Texas Health

Resources ProHealth VA North

Texas

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Triad of CKD, Diabetes & Hypertension

CKD

Diabetes HTN

CKD

DiabetesHTN

Public health implications Progression to ESRD

Excessive CV morbidity/mortality Vulnerable populations Gaps clinical practice

High Risk Excess Risk

(larger excess mortality than sum each risk)

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Multidisciplinary team Medical homes community

Identify patients using EHR Implement optimal care

Novel technology platform (PiecesTM)

Collaborative primary-subspecialty care

Experience with CKD at Parkland

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What is PiecesTM?

Parkland Intelligent e-Coordination and Evaluation System

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PiecesTM

Parkland Intelligent e-Coordination and Evaluation System ◦ Sits on top of EHR/EPIC ◦ Natural language processing to read EHR ◦ Near real-time risk stratification ◦ Automated protocol activation ◦ Patient-tailored interventions ◦ Electronic ascertainment of outcomes

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Pieces™ TCU CHF Readmission Reduction

Admission Discharge 30 Days 90 Days

ID Risk List Orders

Inpatient Intervention Outpatient Intervention

24 hours

7 days

1 2 3 4

5 5 6

1

2

3

4

5

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Pieces™ Identification of HF patients in Real-Time Using NLP Processing and Data Mining

System ranks HF Patients into Risk Categories for readmission

System provides list of targeted high risk patients to intervention coordination teams

Intervention teams orders inpatient and outpatient interventions in EHR

Intervention teams conduct inpatient and outpatient interventions

Monitoring and evaluation of Heart Failure patient outcomes

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Concentrated care management efforts on ¼ of the patients

26% relative reduction in odds of readmission

Absolute reduction of 5 readmissions per 100 index admissions

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34%

14%

9%

12% 11%

14%

11% 11%9%

10%

8% 9%

Texas Health Resources HEB Readmission Rates

40%

35%

30%

25%

20%

15%

10%

5%

Pre‐Intervention

20%

12%

20%

22% 20%

26%

21%

17%

31%

18%

12%

32%

0%

Post-Intervention

8/27/2014 Proprietary and Confidential © 2013 PCCI 9

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Detection of CKD in a Primary

Reference:

CKD in • Problem List • ICD-9 • Progress Note

or CKD clinic referral

Joint Primary Care – Nephrology Care

Care Clinic Community Oriented Primary Care Clinics

(Medical Homes)

New cases CKD

Notification Confirmation Enrollment

PiecesTM screens EHR

• eGFR < 60 ml/min/1.73m2 • Albuminuria • Proteinuria

Primary outcome: Number of patients newly detected with CKD 10

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Undercoding: Patients Newly Detected with CKD by PiecesTM

% Patients newly

detected with CKD n=105 n=188n=208

80

70 64% 62% 60

50 46%

40

30

20

10

0 East Dallas Family Primary Care

Clinic Medicine General Clinic Medicine

ClinicFrom July 1, 2011 to August 31, 2012 11

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Treatment of CKD and Associated Conditions by PiecesTM

CKD patients

Primary care clinic

PiecesTM screens EHR

Tracks variables real time

CKD patients

Primary care clinic

eGFR >20% change Hospital admissions BP <140/90 mmHg Use ACEI/ARBs Use statins

Updates electronic dashboard

Notification investigators/clinicians 12

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Achievement Goals CKD Pieces Study Screening

% at Goal

Last follow-up visit % at Goal

Clinical Measurement

n=107 n=107 P-value (McNemar’s test)

Follow-up duration, month median [range]

11.2 [0.2 - 21.5]

Systolic blood pressure 34.6% 43.0% 0.14

Diastolic blood pressure 57.9% 65.4% 0.17

ACEI/ARB 57.0% 86.9% <0.0001

Statin 43.9% 79.4% <0.0001

if positive test for proteinuria or albuminuria, then goal BP <130/80; Otherwise goal BP < 140/90).

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Improving Chronic Disease Management with PiecesTM:

A Collaboration of Multiple and Diverse Healthcare Systems

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Specific Aim UH2

Establish a Health Care Systems Collaboratory to conduct a pragmatic trial to improve care of patients with three chronic coexistent medical conditions: CKD, diabetes and hypertension.

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Diverse Participatory Healthcare Systems and EHRs

HCS Description Location EHR

Parkland Safety-net public Dallas County EPIC

Texas Health Resources Private non-profit North Texas EPIC/All Scripts

ProHealth Private non-profit Connecticut All Scripts

VA North Texas Federal North Texas CPRS

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Organization ICD - PiecesTM

Biostatistics Core (Dr. Chul Ahn and Dr. Song Zhang) Diabetes Core (Dr. Perry Bickel) SUNY (Dr. Chet Fox and Dr. Linda Khan)

Miguel Vazquez, MD, PI Robert Toto, MD, Co-PI Ruben Amarasingham, MD Adeola Jaiyeola, MD

PCCI (Drs. Amarasingham, Jaiyeola, Oliver)

Steering Committee

Dr. Susan Hedayati Dr. Ruben Amarasingham

Mr. John Lynch Dr. Ferdinand Velasco

ProHealthVATHRPHHS

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Specific Aim 1 UH3

Conduct a randomized pragmatic clinical trial of management of patients with CKD, diabetes and hypertension with a clinician support model enhanced by technology support (Pieces) compared with standard of care.

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Specific Aim 2 UH3

Develop and validate predictive models for risks of hospitalizations, cardiovascular events and deaths for all patients with coexistent CKD, diabetes and hypertension and to predict risk of 30 day readmissions for patients who are hospitalized.

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PiecesTM Identifies Patients with CKD and Diabetes and Hypertension

HCS Parkland

HHSn=2,002

PCPs=32 Patients=373

Texas Health

Resourcesn=6,931

PCPs=30

ProHealthn=6,813

Patients=1,271

VA North Texas

n=5,478

PCPs=30 Patients=1,293 PCPs=12 Patients=1,022Clusters

Patients to enroll CKD + Hypertension + Diabetes n=3,959

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Secure Database

Pieces™

Pieces TM Connects with Implementation Sites

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Detection CKD, Diabetes and Hypertension

PiecesTM

screens EHR

Texas Health

Resources ProHealth VA North

Texas Parkland

Diabetes Type 2

Hypertension

CKD

• BP > 140/90 mm/Hg • Use of antihypertensive medications • Diagnostic code / Problem list

• eGFR < 60 ml/min • Albuminuria • Proteinuria • Diagnostic code / Problem list

• Fasting glucose > 126 mg/dl, HblAlc > 6.5% • Random glucose > 200 mg/dl • Use of hypoglycemic agents • Diagnostic code / Problem list

Eligible patients CKD + Diabetes + Hypertension

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CKD, Diabetes and Hypertension Enhanced by PiecesTM

Primary care provider notified

Patient consented and

enrolled

Therapy plan activated

Primary care practitioner

Implementation facilitator

BP control

ACEI/ARBs

Statins

Glucose control

Avoidance NSAIDs/ nephrotoxic drugs

PiecesTM monitors 24

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Predictive Risk Model Parkland Health Texas Health ProHealth VA North

Care System Resources Physicians Texas

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CKD, Diabetes, HTN

Hospitalizations, Readmissions, CV Events, Deaths

Health care utilization factors

Behavioral factors

Demographic factors

Clinical factors

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Improving Chronic Disease Management with Pieces

Important public health problem Collaboration 4 large health care systems ◦ Socieconomic and ethnic diversity ◦ Diverse geographic distribution ◦ Different EHR

Novel technology platform Prior experience with chronic conditions Potential for application to other diseases

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