Improve Engagement in HIV Care Lessons from …...üHealth education packages üNon-cash financial...
Transcript of Improve Engagement in HIV Care Lessons from …...üHealth education packages üNon-cash financial...
![Page 1: Improve Engagement in HIV Care Lessons from …...üHealth education packages üNon-cash financial incentives ØStandard of Care (SOC) Primary outcome: 1 mo LTC + 12 mo RiC McNairy](https://reader034.fdocuments.in/reader034/viewer/2022050118/5f4f1a86a4d923261f785dd4/html5/thumbnails/1.jpg)
Optimization: Cross-Cutting Optimization: Cross-Cutting Lessons from Interventions to Lessons from Interventions to Improve Engagement in HIV CareImprove Engagement in HIV Care
Michael J. Mugavero, MD, MHScDepartment of Medicine, Division of Infectious DiseasesUniversity of Alabama at Birmingham (UAB)Co-Director, UAB Center for AIDS Research (CFAR)
![Page 2: Improve Engagement in HIV Care Lessons from …...üHealth education packages üNon-cash financial incentives ØStandard of Care (SOC) Primary outcome: 1 mo LTC + 12 mo RiC McNairy](https://reader034.fdocuments.in/reader034/viewer/2022050118/5f4f1a86a4d923261f785dd4/html5/thumbnails/2.jpg)
https://www.nastad.org/domestic/hiv-prevention-health-equityStatus neutral continuum slide courtesy of Hyman Scott
Status Neutral Continuum of HIV Status Neutral Continuum of HIV Prevention and CarePrevention and Care
![Page 3: Improve Engagement in HIV Care Lessons from …...üHealth education packages üNon-cash financial incentives ØStandard of Care (SOC) Primary outcome: 1 mo LTC + 12 mo RiC McNairy](https://reader034.fdocuments.in/reader034/viewer/2022050118/5f4f1a86a4d923261f785dd4/html5/thumbnails/3.jpg)
Ulett et al. AIDS Pt Care STDS 2009;23:41-49Mugavero et al. Clin Infect Dis 2011;52(S2)
Blueprint for HIV Treatment Success: Blueprint for HIV Treatment Success: ‘Dynamic’ Engagement in HIV Care‘Dynamic’ Engagement in HIV Care
1 2
3
![Page 4: Improve Engagement in HIV Care Lessons from …...üHealth education packages üNon-cash financial incentives ØStandard of Care (SOC) Primary outcome: 1 mo LTC + 12 mo RiC McNairy](https://reader034.fdocuments.in/reader034/viewer/2022050118/5f4f1a86a4d923261f785dd4/html5/thumbnails/4.jpg)
‘Fast Track,’ Rapid ‘Fast Track,’ Rapid Start ProgramsStart Programs
![Page 5: Improve Engagement in HIV Care Lessons from …...üHealth education packages üNon-cash financial incentives ØStandard of Care (SOC) Primary outcome: 1 mo LTC + 12 mo RiC McNairy](https://reader034.fdocuments.in/reader034/viewer/2022050118/5f4f1a86a4d923261f785dd4/html5/thumbnails/5.jpg)
Early Steps on the Care Continuum: Early Steps on the Care Continuum: Historical Impact on ART Start & VSHistorical Impact on ART Start & VS
Giordano. Ryan White HIV/AIDS Program Clinical Conference. August 21-23, 2017
![Page 6: Improve Engagement in HIV Care Lessons from …...üHealth education packages üNon-cash financial incentives ØStandard of Care (SOC) Primary outcome: 1 mo LTC + 12 mo RiC McNairy](https://reader034.fdocuments.in/reader034/viewer/2022050118/5f4f1a86a4d923261f785dd4/html5/thumbnails/6.jpg)
Public Health Approach: SF RAPIDPublic Health Approach: SF RAPID
Pilcher et al. JAIDS 2017;74
Time (days): HIV Dx to: RAPID (n=39) SOC (n=47)ART 1 (0-7) 22 (14-48)Clinic referral 6 (2-11) 11 (3-4)VL<200 c/mL 65 (52-119) 170 (79-363)
![Page 7: Improve Engagement in HIV Care Lessons from …...üHealth education packages üNon-cash financial incentives ØStandard of Care (SOC) Primary outcome: 1 mo LTC + 12 mo RiC McNairy](https://reader034.fdocuments.in/reader034/viewer/2022050118/5f4f1a86a4d923261f785dd4/html5/thumbnails/7.jpg)
Clinic-Based Approach: CCSIClinic-Based Approach: CCSI
Halperin et al. AIDS Patient Care STDs 2018;32Slide content courtesy of Jason Halperin
§ Crescent Care Start Initiative (CCSI): FQHC, NOLA, LAØ LTC & ART w/in 72 hrsØ 24-hr LTC coordinatorsØ Primary provider visit• Labs & DTG+TAF/FTC • 1st ART dose in clinic
Ø HIV specialist w/in 4 wks
§ CCSI ResultsØ 92% LTC & ART in 72 hrs (n=71/77)Ø All 71 CCSI patients achieved VS• Median time = 30 days
![Page 8: Improve Engagement in HIV Care Lessons from …...üHealth education packages üNon-cash financial incentives ØStandard of Care (SOC) Primary outcome: 1 mo LTC + 12 mo RiC McNairy](https://reader034.fdocuments.in/reader034/viewer/2022050118/5f4f1a86a4d923261f785dd4/html5/thumbnails/8.jpg)
Combination Combination Intervention Intervention
Strategies (CIS)Strategies (CIS)
![Page 9: Improve Engagement in HIV Care Lessons from …...üHealth education packages üNon-cash financial incentives ØStandard of Care (SOC) Primary outcome: 1 mo LTC + 12 mo RiC McNairy](https://reader034.fdocuments.in/reader034/viewer/2022050118/5f4f1a86a4d923261f785dd4/html5/thumbnails/9.jpg)
Link4Health for Linkage &Link4Health for Linkage &Retention in Adult HIV CareRetention in Adult HIV Care
§ Cluster RCT (10 clusters) in Swaziland, n=2197§ 2 study arms (1:1)
Ø Combination Intervention Strategy (CIS)ü Point-of-care CD4 testingü Accelerated ARTü Mobile phone appt remindersü Health education packagesü Non-cash financial incentives
Ø Standard of Care (SOC)§ Primary outcome: 1 mo LTC + 12 mo RiC
McNairy M et al. PLoS Med 2017;14(11):e1002420
![Page 10: Improve Engagement in HIV Care Lessons from …...üHealth education packages üNon-cash financial incentives ØStandard of Care (SOC) Primary outcome: 1 mo LTC + 12 mo RiC McNairy](https://reader034.fdocuments.in/reader034/viewer/2022050118/5f4f1a86a4d923261f785dd4/html5/thumbnails/10.jpg)
A CIS Strategy for Linkage &A CIS Strategy for Linkage &Retention in MozambiqueRetention in Mozambique
§ Cluster RCT (10 facilities) in Mozambique, n=2004§ 2 study arms (1:1)
Ø Combination Intervention Strategy (CIS)ü Point-of-care CD4 testingü Accelerated ARTü SMS health messages & appt remindersü Conditional non-cash financial incentives (CIS+)
Ø Standard of Care (SOC)§ Primary outcome: 1 mo LTC + 12 mo RiC
Elul B et al. PLoS Med 2017;14(11):e1002433
![Page 11: Improve Engagement in HIV Care Lessons from …...üHealth education packages üNon-cash financial incentives ØStandard of Care (SOC) Primary outcome: 1 mo LTC + 12 mo RiC McNairy](https://reader034.fdocuments.in/reader034/viewer/2022050118/5f4f1a86a4d923261f785dd4/html5/thumbnails/11.jpg)
Retention Retention ((RiC) RiC) & & Re-engagement in Re-engagement in Care InterventionsCare Interventions
![Page 12: Improve Engagement in HIV Care Lessons from …...üHealth education packages üNon-cash financial incentives ØStandard of Care (SOC) Primary outcome: 1 mo LTC + 12 mo RiC McNairy](https://reader034.fdocuments.in/reader034/viewer/2022050118/5f4f1a86a4d923261f785dd4/html5/thumbnails/12.jpg)
Retention via Enhanced Personal Retention via Enhanced Personal Contact (REPC): Clinic-Based Contact (REPC): Clinic-Based
ApproachApproach§ RCT at 6 U.S. HIV clinics, n=1838§ 3 study arms (1:1:1)
Ø Enhanced Personal Contact (EPC)Ø EPC + skills (EPC+)Ø Standard of Care (SOC)
§ Outcomes @ 12-months:Ø Visit adherenceØ 4-month visit constancy
Gardner LI et al. Clin Infect Dis 2014;59 Shrestha RK et al. JAIDS 2015;68
Overall Black/AA Female Medicare Medicaid50%
60%
70%
80%
67%66% 65% 65%
66%
72%70% 70%
74%
71%
SOCIntervention
![Page 13: Improve Engagement in HIV Care Lessons from …...üHealth education packages üNon-cash financial incentives ØStandard of Care (SOC) Primary outcome: 1 mo LTC + 12 mo RiC McNairy](https://reader034.fdocuments.in/reader034/viewer/2022050118/5f4f1a86a4d923261f785dd4/html5/thumbnails/13.jpg)
Project HOPE (CTN049): Patient Project HOPE (CTN049): Patient Navigation +/- Financial IncentivesNavigation +/- Financial Incentives§ RCT in 11 U.S. Hospitals, n=801§ Sample: Hospitalized PLWH with substance use§ 3 study arms (1:1:1)
Ø Patient Navigationü Up to 11 sessions
Ø Patient Navigation + Financial Incentivesü Up to $1160 conditional for targeted behaviors
Ø Treatment as Usual (TAU)§ Primary outcome: 12-month viral suppression
Metsch et al. JAMA 2016;316(2)
![Page 14: Improve Engagement in HIV Care Lessons from …...üHealth education packages üNon-cash financial incentives ØStandard of Care (SOC) Primary outcome: 1 mo LTC + 12 mo RiC McNairy](https://reader034.fdocuments.in/reader034/viewer/2022050118/5f4f1a86a4d923261f785dd4/html5/thumbnails/14.jpg)
Lessons learned…Lessons learned…§ Effective engagement in care interventions are
incredibly time & resource intensive§ ‘Fast track’ programs show promise…will long-
term engagement & VS be sustained?§ Combination intervention strategies work…but
which components? Need all of them??§ Mixed findings for conditional incentives§ Effect sizes of engagement interventions are
relatively modest…no “silver bullet”§ Even when improve engagement outcomes…
challenging to improve VS
![Page 15: Improve Engagement in HIV Care Lessons from …...üHealth education packages üNon-cash financial incentives ØStandard of Care (SOC) Primary outcome: 1 mo LTC + 12 mo RiC McNairy](https://reader034.fdocuments.in/reader034/viewer/2022050118/5f4f1a86a4d923261f785dd4/html5/thumbnails/15.jpg)
U=U: Undetectable=UntransmittableU=U: Undetectable=Untransmittable
https://www.preventionaccess.org/about, https://www.health.ny.gov/diseases/aids/ending_the_epidemic/, https://www.cityofchicago.org/city/en/depts/cdph/provdrs/health_services/news/2017/september/city-of-chicago-and-community-leaders-join-u-u-campaign-as-part-.html
![Page 16: Improve Engagement in HIV Care Lessons from …...üHealth education packages üNon-cash financial incentives ØStandard of Care (SOC) Primary outcome: 1 mo LTC + 12 mo RiC McNairy](https://reader034.fdocuments.in/reader034/viewer/2022050118/5f4f1a86a4d923261f785dd4/html5/thumbnails/16.jpg)
HIV VS Trends Over Time: HIV VS Trends Over Time: CNICS Clinical Cohort, 1997-2015CNICS Clinical Cohort, 1997-2015
Nance R et al. Ann Intern Med 2018;169
![Page 17: Improve Engagement in HIV Care Lessons from …...üHealth education packages üNon-cash financial incentives ØStandard of Care (SOC) Primary outcome: 1 mo LTC + 12 mo RiC McNairy](https://reader034.fdocuments.in/reader034/viewer/2022050118/5f4f1a86a4d923261f785dd4/html5/thumbnails/17.jpg)
Engagement Engagement in HIV Care:in HIV Care:A Dynamic Behavior & Indicator(s)A Dynamic Behavior & Indicator(s)
Powers et al. JAIDS 2017; 74(S2)
![Page 18: Improve Engagement in HIV Care Lessons from …...üHealth education packages üNon-cash financial incentives ØStandard of Care (SOC) Primary outcome: 1 mo LTC + 12 mo RiC McNairy](https://reader034.fdocuments.in/reader034/viewer/2022050118/5f4f1a86a4d923261f785dd4/html5/thumbnails/18.jpg)
Going forward…Going forward…