Impaired Renal Outcome In Former ELBW Cases At Young...
Transcript of Impaired Renal Outcome In Former ELBW Cases At Young...
Erasmus MC Rotterdam, the Netherlands
KU Leuven, Belgium
[email protected] [email protected]
Impaired Renal Outcome In Former ELBW Cases At Young Adolescent Age Is Common, But Not Associated With Perinatal Steroids
Cystatin C and eGFR
Characteristic Cases Controls
P N Estimate N Estimate
Renal length (cm) 84 8.73 79 9.01 0.004
Parenchymal thickness (cm) 84 1.06 79 1.09 0.089
eGFR cystatin C (mL/min/1.73 m2) 59 97.2 59 108.7 <0.001
UVNa/average renal length (mmol/cm) 67 11.93 65 11.85 0.93
PRA (ng/mL/h) 56 1.21 71 1.75 0.001
Raaijmakers et al. Hypertension 2017
indicators of cardiovascular risk are much more common in former ELBW cases
(pre)hypertension, 30 and 20 %
eGFR, CKD stage 2, 25 % at 11 years
risk factor assessment in our cohort was negative
next steps ?
microvasculature/microcirculation (retina)
pooling of data with other ELBW cohorts in search of risk factors
pooling of data with other cohorts (healthy aging, NEVA-HT study)
pooled data in 157 ELBW cases and 123 term controls at 11 years risk factors in ELBW cases, eGFR and kidney size (ultrasound) gestational age birth weight disease severity pre- and postnatal steoids
Erasmus MC Rotterdam, the Netherlands
KU Leuven, Belgium
[email protected] [email protected]
impaired renal outcome in former ELBW cases at young adolescent age is common, but not associated with perinatal steroids