Impact of the « One Health »

approach in public health Example of the EJP on

Foodborne Zoonoses

Biorisk Meeting, Anses, Maisons-Alfort

22 May 2018

This meeting is part of the European Joint Programme One Health EJP. This project has received funding from the European Union’s Horizon 2020

research and innovation programme under Grant Agreement No 773830.

By

CORDEVANT Christophe

ANSES Strategy and Programme Department

Research and Reference Division

No single definition of One Heath; scope can be very large Broad sense:

• Eco-Health, • Global Health, • Planetary Health

In the narrow sense (FAO) ‘A collaborative, international, cross-sectoral, multidisciplinary mechanism to address threats and reduce risks of detrimental infectious diseases at the animal-human-ecosystem interface.’

Interface between human and animal

“Med – Vet approach”

The concept of “One health”

2

Source: OIE - http://www.oie.int/en/for-the-media/onehealth/

HORIZON 2020 - Work Programme

2016 - 2017

Area : “Food security, sustainable

agriculture and forestry, marine and maritime and inland water

research and the bioeconomy healthy and safe foods and diets for all”

Call SFS-36-2017: "One Health" (zoonoses – emerging threats)

Publication date: 14 October 2015 Deadline: 14 February 2017

Type of action: European Joint Programme - EJP

Duration : 5 years

Cofund: 90€M 3

One Health EJP – EU cofund initiative

Partnership: 41 partners /19 Members States

Selected in

October 2017

OH EJP Kick off meeting – Jan 2018

"One Health EJP“ started on January 2018

Launch meeting - 30 & 31 January at ANSES

40 partners from 19 Member States

140 participants: project partners, Ministries of Health, Agriculture, Research,

EFSA, ECDC, DG Agri & Health and REA

4

- Following a One Health approach

“Med-Vet” Partnership

- The EJP aims to create a sustainable European One Health framework

- By alignment and integration of medical, veterinary and food institutes strategies and expertise

- Through joint programming of national research agendas and by funding research projects

- Matching the needs of European and national policy makers and stakeholders 5

One Health EJP Concept

6

One Health EJP scope

6

Direct (Air, Contact)

Environment Food

Vector borne

“One Health”

Zoonoses Emerging threats

(ET)

Food Borne Zoonose

(FBZ)

Bacteria

Viruses

Prions

Parasites

Antimicrobial

Resistance

(AMR)

Transmission

by food

or not

Zoonotic potential

suspected

NFBZ

FBZ

(2/3) (1/3)

15%

85%

7

One Health EJP scope

A European network of public research institutes on food safety

8

FP6 Network of Excellence 7 Med + 7 Vet/Food = 14p Foodborne zoonoses

Association (Loi 1901) A self-sustained Network 20 Research institutes Foodborne zoonoses

EJP

2003 2008

2009 2017

A Pre-existing network looking for a long term sustainability plan

2018 2022

Cofund EJP H2020 Network 40 Research institutes Foodborne zoonoses

One Health EJP consortium

Austria Belgium Bulgaria Czech Republic Denmark Estonia France Germany Hungary Ireland Italy Netherlands Norway Poland Portugal Romania Spain Sweden United Kingdom

One Health EJP consortium

9

10

CountryProgramme manager

Med

Programme manager

Vet

AT

BE WIV-ISP CODA-CERVA

NCIPD NDVRI

Stefan Angeloff Ins (LTP)

CZ SZU/NIPH VRI

RKI BfR

FLI

DK SSI DTU

EE University of Tartu VFL

ISCIII INIA

UCM (VISAVET)

EU MVNA

ANSP (LTP) ANSES

Institut Pasteur de Paris INRA

PHE APHA

Surrey Univ

HU NCE IVMR

IE NUIG TEAGASC

ISS IZS AM Teramo

IZS LER Brescia

RIVM WR

NCOH (LTP)

NO FHI/NIPH NVI

PL NIZP-PZH/NIPH-NIH PIWET/NVRI

PT INSA INIAV

RO CNIR IISPV

PHAS NFA

SVA

19 countries +

1 association

ES

BG

AGES

43 Full Members + 3 LTP + MedVetNet Association

NL

IT

GB

FR

SE

DEThe criteria to select a partner MS have been established by the consortium and in agreement with the EC 1. Mandates of reference 2. Scientific production in

zoonoses 3. Networking activities in that

field

41 Partners

One Health EJP

consortium

0

1

2

3

4

5Portugal MED

Portugal VETCZECH…

CZECH…

GREECE MED1

GREECE MED2

GREECE VET

BULGARIA…

BULGARIA…

BULGARIA VETCROATIA MED

CROATIA VETSERBIA VET

ISRAEL VETAUSTRIA…

SWEDEN MED

ESTONIA MED

ESTONIA VET1

ESTONIA VET2

IRELAND VET

IRELAND VET2

IRELAND MEDROMANIA MED

ROMANIA VET

REFERENCE

SCIENCE

NETWORK

One Health EJP governance

11

EC REA

Scientific Steering Board (SSB)

Scientific Directors / Head of Dpts

Project Management Team

(PMT) Coordinator + WP leaders

Programme Managers Committee (PMC)

Directors/CEO

Support Team (ST)

External Scientific

Advisory Board

(ESAB)

Programme Owners Committee

( POC ) (Ministry of authority)

Stakeholders Committee

National Mirror Groups (NMG)

Ethics Advisors

EJP Kick off meeting participants

12

EC REA

Scientific Steering Board (SSB)

Scientific Directors / Head of Dpts

Project Management Team

(PMT) Coordinator + WP leaders

Programme Managers Committee (PMC)

Directors/CEO

Support Team (ST)

External Scientific

Advisory Board

(ESAB)

Committee

( POC ) (Ministry of authority)

Stakeholders Committee

National Mirror Groups (NMG)

Ethics

Advisors

14/41

38/41

15/44

13/13

13

One Health EJP structure

Andre Jestin

Roberto La Ragione Hein Imberechts Ann Lindberg

Arjen van de Giessen

Annemarie Kaesbohrer

Luca Busani

14

One Health EJP dynamics

WP2 – Integrative SRA Strategic Research Agenda (SRA) and the priority topics in the three domains identified: foodborne zoonoses, antimicrobial resistance and emerging threats

analytical Isabel Cuesta ISCIII Jean-Yves Madec ^ ANSES Dan Horton Surrey 6 MED

methods Stefano Morabito > ISS Dik Mevius CVI Steven van Borm CODA-CERVA 6 VET

Nadine Botteldoorn WIV-ISP Ana Alastruey ISCIII Ralitsa Popova-Ilinkina NDRVMI

Jeffrey Hoorfar DTU Henrik Hasman SSI Barry Rockx RIVM

host-microbe Karen Krogfelt ^ SSI Bruno González-Zorn > VISAVET-UCM Zoltán Zádori VMRI 4 MED

interaction Karsten Nöckler BfR Didier Mazel IPP Miguel Angel Jiménez INIA 8 VET

Artur Rzezutka PIWet Ákos Tóth NCE Philippe Velge INRA

Cecilia Jernberg PHA Lynda Gun UCD Heinrich Neubauer FLI

epidemiology Henriette de Valk InVS Dariusz Wasyl > Piwet Joke van der Giessen ^ RIVM 8 MED

Paolo Calistri IZSAM Akke Vellinga NUI Simon Cauchemez IPP 4 VET

Klaus Stark RKI Annalisa Pantosti ISS Jenny Frössling SVA

Solveig Jore FHI Alex Cook Surrey Line Vold FHI

risk assessment Renata Karpíšková VRI Aleksander Masny NIZP-PZH Sarah Welby CODA-CERVA 6 MED

Maarten Nauta > DTU Neil Woodford PHE Barbora Macková NIPH 6 VET

Stayanka Stoitsova SAIM-BAS Bernd-Alois Tenhagen BfR Dilys Morgan PHE

Jakob Ottoson NFA Dearbhaile Morris NUI Pascal Hendrikx ANSES

intervention Merete Hofshagen NVI Klemens Fuchs AGES Enikő Bán NCE 5 MED

Rob Davies APHA Mardjan Arvand RKI Marianne Elvander > SVA 7 VET

Christian Kornschober AGES Chris Teale APHA Giorgio Varisco IZSLER

Iva Christova NCIPD Giovanni Alborali IZSLER Katarzyna Pancer NIZP-PZH

11 MED - 9 VET 10 MED - 10 VET 8 MED - 12 VET

Foodborne zoonoses Antimicrobial resistance Emerging threats

15

60 scientific experts gathered over 2 days to produce the research topics Priority setting of research topics using Multi-Criteria Decision Analysis (MCDA)

EJP preparation - SRA & 1st Internal Call

Experts meeting Anses, May 3&4 2016

Domain-theme-area secretaries

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MRESI grant funding Experts consultation

EJP preparation - SRA & 1st Internal Call

DOMAINES

THEMES Food Borne Zoonoses (FBZ)

AntiMicrobial resistance

(AMR)

Emerging threats

(ET)

Analytical methods

Host-microbe interaction

Epidemiology

Risk assessment

Intervention

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Selected priority topics first call

NGS based

methods Phenotypic

methods Non-NGS

based methods

Imp.surveillance Epi - AMR

RA - AMR

Biosecurity

Source Attribution

Joint integrative priority topics: Interpretation of surveillance data Common reporting and signalling procedures

Call 1: Selection of projects

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9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 1 2 3 4 5 6 7 8

Task 1. Define guidelines for identification of candidate coordinators and selection of activities to be funded

Define procedures (Task HI)

Task 2. Collect Letters of Intent, perform eligibility check and send them to EJP Coordinator

Launch invitation to propose research activities (Task AJ): 9 June 9

Preparation of Letters of Intent

Deadline submission Letters of Intent: 8 July 8

Collect Letters of Intent (Task AJ)

Invitation to submit full proposal (Task AJ): 15 July 15

Task 3. Collect Full Proposals, perform eligibility check and organize evaluation by external experts

Identify and contact External Experts (Tasks HI + Task leader)

Propose uniform evaluation form with criteria (Task HI)

Preparation of Full Proposals

Deadline submission Full Proposals: 18 September 18

Collect Full Proposals (Tasks HI, AL, RL)

Send full proposals to External Experts (Task HI, AL, RL)

Evaluation of Full Proposals

Deadline evaluation: 6 November 6

Rank proposals and send them to Mgt Team (Task HI, AL, RL)

Task 4. Propose research activities to be funded; final validation by SSB

Send proposals to SSB and PMC for validation (Task AJ/HI): 10 November 10

Validation by SSB in meeting: 24 November 24

Invitation to prepare institutional letter (agreement for funding) (Task AJ): 6 November 6

Preparation of Letter of Commitment

Deadline Institutional letter 18 December 18

Inform research activity coordinators about the outcome: before Xmas (Task AJ or Adm Board)

Include the outcome in the 1Y and 5Y work plan (Task AJ): start 1 December

Submission of DoW Med-Vet EJP: 14 February 2017 (Task AJ) 14

Task 5. Follow up of JRP, JIP & PhD during the 5 year duration of the Med-Vet EJP

Define KPI for follow up of research activities (Task HI + Task leader)

Letter of Intent

April May June July August September

2016 2017

March JanuaryNovember December February

Document of Work

October

Full Proposal

Evaluation

Let. of Commitment

DOMAINES

THEMES Food Borne Zoonoses (FBZ)

AntiMicrobial resistance

(AMR)

Emerging threats

(ET)

Analytical methods

Host-microbe interaction

Epidemiology

Risk assessment

Intervention

19

OH EJP project proposals

METASTAVA

IMPART

MAD-VIR

NOVA ARDIG

RaDAR

AIR-SAMPLE

LISTADAPT

Joint integrative projects: • COHESIVE • ORION

TOX-Detect

MoMIR-PPC

MedVetKlebs

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Topic

ref

coord

MS

coord

Org

Projects

Acronyme

Projects

Title

IA-1 DE BfR ORION One health surRveillance Initiative on harmOnization of data collection and interpretation

IA-2 NL RIVM COHESIVE One Health Structure In Europe

AMR-1 NL CVI IMPART IMproving Phenotypic Antimicrobial Resistance Testing

AMR-2 GB APHA ARDIG Antibiotic Resistance Dynamics: the influence of geographic origin and management systems on

resistance gene flows within humans, animals and the environment

AMR-3 NL RIVM RADAR Risk and Disease burden of Antimicrobial Resistance

ET-1 FR Anses TOXdetect Development and harmonization of innovative methods for comprehensive analysis of food-borne

toxigenic bacteria, ie. Staphylococci, Bacillus cereus and Clostridium perfringens

ET-1 DK SSI MAD-VIR Metagenomic Array Detection of emerging Virus in EU

FBZ-1 SE SVA NOVA Novel approaches for design and evaluation of cost-effective surveillance across the food chain

FBZ-2 FR Anses LISTADAPT Adaptive traits of Listeria monocytogenes to its diverse ecological niches

FBZ-2 BE CODA-

CERVA METASTAVA

Standardisation and validation of metagenomics methods for the detection of foodborne zoonoses,

antimicrobial resistance and emerging threats.

FBZ-3 DK DTU AIR-SAMPLE A Low-Cost Screening Tool in Biosecured Broiler Production

FBZ-3 FR INRA MoMIR-PPC Monitoring the gut microbiota and immune response to predict, prevent and control zoonoses in

humans and livestock in order to minimize the use of antimicrobials

FBZ-4 FR IP MedVetKlebs Klebsiella pneumoniae: from ecology to source attribution and transmission control

Joint Research & Integrative Projects

13 projects selected and associated with WP3 & WP4

Two rounds of calls

2016 2017

Submission & selection

2018 – 2019 2020 - 2021 - 2022

Start of first round of Research &

Integrative Projects

Start of second round of

Research & Integrative Projects

WP2: Strategic Research

Agenda (1) Identification of

teams

11 Research Projects

2 Integrative Projects

WP2: Strategy

Research Agenda (2) Identification of

teams

10 Research Projects

3 Integrative Projects

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Budget

• Total budget = 90€M

• EC (50%) = 45€M

• Institutional = 45€M

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• Allocation of the resources = 90€M

• Overarching = 09€M

• Joint Research Projects = 50€M

• Joint Integrative Projects = 27€M

• Training Education = 04€M

A pilot experience

A cofund exercice

Ministry of authority providing Mandates

A consortium with majority of full partners

One Health , restriction to « Med-Vet »

Narrow scope « FOOD »

Internal calls, in kind

Policy-driven 23

Conclusion

Thank for your attention

André JESTIN - EJP Coordinator ANSES

Strategy and Programme Department

Research and Reference Division

Email : andre.jestin@anses.fr

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