Immunology Ontology Rho Meeting October 10, 2013.
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Transcript of Immunology Ontology Rho Meeting October 10, 2013.
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Immunology Ontology
Rho MeetingOctober 10, 2013
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Infectious Disease Ontology
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Infectious Disease Ontology• Coverage of the entire infectious disease domain
• domain-specific entities (e.g. infection)• generally relevant entities (e.g. lung)• basic biological as well as clinical entities (e.g.
genes and clinical tests)• spanning:
• diseases, hosts, pathogens• biological scale (molecule, cell, organism, population)• entities in the chain of infection (host, pathogen, vector,
reservoir)• Interoperability with other disease/health domains• Support for computation• Application independence
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Characterization of an infectious disease
disease signs and symptoms
diagnostic criteria
disease course stages
host organism type
relevant polymorphisms host niches endemic areas
pathogen organism type
pathogen classification virulence traits drug
susceptibilities
host-pathogen interaction
infection process host response
epidemiological
characteristicsroutes of
transmissionvector
organism types reservoirs prevention measures
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Development strategy• Developed within the OBO Foundry (http://www.obofoundry.org)
• common set of non-overlapping, interoperable ontologies for the biomedical domain
• import terms from existing ontologies where available
• Core-Extension Approach
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obo foundry• Single ontology for each portion of the domain
• Collaboratively developed• Common organization
• Basic Formal Ontology• Common set of formally defined relations
• Relation Ontology• Principled definitions for types• Availability in a computable format
• e.g. OWL or OBO
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ontologies used by idoClinical Entities Biological Entities Investigational
EntitiesOntology of General
Medical Science NCBI Taxonomy Ontology of Biomedical Investigation
Vital Signs Ontology Common Anatomy Reference Ontology
Symptom Ontology Cell Ontology
Disease Ontology Gene Ontology Cellular Component Ontology
Protein OntologyChemical Entities of Biological Interest
Phenotype and Trait Ontology
Environment OntologyGene Ontology
Biological Process Ontology
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IDO Core-extension approach
IIDO-Core
IDO-Bac
IDO-Virus
IDO-Sa
IDO-Flu IDO-Mal
IDO-Par
IDO-Fun
IDO-Flav
IDO-Mtb
IDO-Sch
IDO-Asp
IDO-Cry
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IDO and OBO Foundry ontologies
OGMS
OBIGO BP
CL
IIDO-Core
IDO-Bac
IDO-Virus
IDO-Sa
IDO-FluIDO-Mal
IDO-Par
IDO-Fun
IDO-Flav
IDO-TB
IDO-Sch
IDO-Asp
IDO-Cry
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purpose of ido-core• Provide terms relevant to infectious diseases generally(e.g. infection, host, pathogen, vector)
• reducing duplication of effort• Ensure interoperability between IDO extensions
• terminological consistency (term names and meanings)
• definition templates• consistent approach to classification• consistent approach to asserting relations
• Allows parallel development by domain experts• prevent common mistakes• ensure utility for computational applications
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users• Staphylococcus aureus
• Vance Fowler - Duke University Medical Center• Brucellosis
• Oliver He - University of Michigan• Salmonella
• Ina Hulsegge - Animal Breeding and Genomics Centre • Influenza
• Richard Scheuermann, Burke Squires - UT Southwestern Medical Center• Melanie Courtot - BC Cancer Research Center• Lynn Schriml - University of Maryland• Joanne Luciano - Rensselaer Polytechnic Institute
• Vector Survellance and Management• Lars Eison, Saul Lozano-Fuentes - Colorado State University
• Vector-borne diseases (Malaria)• Kitsos Louis, Pantelis Topalis - IMBB
• Eukaryotic pathogens• Chris Stoeckert - University of Pennsylvania
• Sepsis Use Case in Vital Signs Ontology• Albert Goldfain - Blue Highway
• APOLLO SV• Bill Hogan - University of Arkansas
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Immunology Ontology
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Domain EntitiesMolecules
CellsAnatomical entitiesBiological processes
Assays
Pathological entitiesPathological processes
DiseasesSigns and Symptoms
Diganostic Tests
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Domain EntitiesMolecules (PRO)
Cells (CL)Anatomical entities (FMA)
Biological processes (GOBP)Assays (OBI)
Pathological entitiesPathological processes
DiseasesSigns and Symptoms
Diganostic Tests
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Multiple Sclerosis• Clinically Isolated Syndrome• CSF• B cell• Brain lesion• MRI• Flow cytometry