Immunoglobulin Isotypes Definition - Antigenic determinants that characterize the classes and...
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Immunoglobulin IsotypesDefinition - Antigenic determinants that
characterize the classes and subclasses of heavy chains and types and subtypes of light chains
![Page 3: Immunoglobulin Isotypes Definition - Antigenic determinants that characterize the classes and subclasses of heavy chains and types and subtypes of light.](https://reader036.fdocuments.in/reader036/viewer/2022062322/5697bf831a28abf838c861c7/html5/thumbnails/3.jpg)
Immunoglobulin Isotypes
OccurrenceImportance
Ig levels
• Definition
• Location
IgM (kappa)IgG1 (kappa)
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• Definition - Antigenic determinants specified by allelic forms of the Ig genes
• Location
• Occurrence
– Source of anti-allotypic Abs
IgG1 (kappa)
Person 2
IgG1 (kappa)
Person 1
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• Nomenclature– G1m(3)– Km(1)
Chain Domain Allotype Amino Acid
Position
CH1 G1m(f) = (3) Arg 214
CH1 G1m(z) = (17) Lys 214
IgG1
CH3 G1m(a) = (1) Arg, Asp,Glu, Leu
355-358
CL Km(1) Val, Leu 153, 191lightchain CL Km(3) Ala, Val 153, 191
- G2m(23)
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• IgG – 25 Allotypes• IgA2 – 2 Allotypes• k (L) – 3 Allotypes
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Immunoglobulin IdiotypesDefinition - Unique antigenic determinants
present on individual antibody molecules or on molecules of identical specificity
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Immunoglobulin IdiotypesDefinitionLocation
IgG1 (kappa)
Person 1
anti-B
IgG1 (kappa)
Person 1
anti-A
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Immunoglobulin IdiotypesDefinitionLocation Importance
V region markerRegulation of immune responses
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Immunoglobulin IdiotypesDefinitionLocation Importance
V region markerRegulation of immune responsesVaccines
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Ag Id anti-Id
+
-
Anti-Idiotype Vaccines
Ag Id anti-Id
+
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Anti-Idiotype Vaccines
Ag + Ab Ag / Ab
+Ab = Ag Anti-Id-Ab Vaccine