Immune Escape Mechanisms in Leishmaniasis
-
Upload
emmanuel-manning -
Category
Documents
-
view
87 -
download
9
description
Transcript of Immune Escape Mechanisms in Leishmaniasis
![Page 1: Immune Escape Mechanisms in Leishmaniasis](https://reader035.fdocuments.in/reader035/viewer/2022062721/56813655550346895d9ddf32/html5/thumbnails/1.jpg)
Immune Escape Mechanisms Immune Escape Mechanisms in Leishmaniasisin Leishmaniasis
Nancy Noben-Trauth, Ph.D.Nancy Noben-Trauth, Ph.D.Assistant ProfessorAssistant Professor
Department of Microbiology, Immunology & Tropical Medicine
The George Washington University Medical Center
[email protected], 994-0531
![Page 2: Immune Escape Mechanisms in Leishmaniasis](https://reader035.fdocuments.in/reader035/viewer/2022062721/56813655550346895d9ddf32/html5/thumbnails/2.jpg)
Visceral Visceral LeishmaniasisLeishmaniasis
Cutaneous Cutaneous LeishmaniasisLeishmaniasis
Self-healing ulcer
“Leishmanization” with live leishmania
![Page 3: Immune Escape Mechanisms in Leishmaniasis](https://reader035.fdocuments.in/reader035/viewer/2022062721/56813655550346895d9ddf32/html5/thumbnails/3.jpg)
The Th1/Th2 Paradigm in Immunology The Th1/Th2 Paradigm in Immunology
Susceptible ResistantIL-4 IL-13 IL-10 IFN TNF IL-2
Th2 Th1AutoimmunityInflammation
AllergyInfections
Th2 Th1IL-4IL-13
IFN
Th2=BAD(Infection)
Th1=GOOD(Cure)
LeishmaniaLeishmania
![Page 4: Immune Escape Mechanisms in Leishmaniasis](https://reader035.fdocuments.in/reader035/viewer/2022062721/56813655550346895d9ddf32/html5/thumbnails/4.jpg)
Susceptible ResistantIL-4 IL-13 IL-10 IFN TNF IL-2
Th2 Th1
Th2 IL-10A New Immune EscapeMechanism
The The NEWNEW Paradigm in Paradigm in LeishmaniaLeishmania
IL-4R KO mice are defective in Th2 responses, but remain susceptible to Leishmania major infection
![Page 5: Immune Escape Mechanisms in Leishmaniasis](https://reader035.fdocuments.in/reader035/viewer/2022062721/56813655550346895d9ddf32/html5/thumbnails/5.jpg)
Susceptible ResistantIL-4 IL-13 IL-10 IFN TNF IL-2
Th2 Th1
Th2
Possible GWU CollaborationsPossible GWU Collaborations
IL-4R KO mice to studyModels of InflammationIL-10 gene analysis
Macrophages from IL-4RKO mice produce IL-10