IION Agri-Food and Health Conference: Edmund Lui

7/27/2019 IION Agri-Food and Health Conference: Edmund Lui

1/22

Associate Professor, Physiology& Pharmacology,Schulich School of Medicine, Western University

SD Ontario Ginseng Innovation & ResearchConsortium

Founder of Western Phytoceutica Ltd

Can head delegate ISO TC249, WG-1 & 2

Editor-in-Chief, J Complementary & Integrativemedicine

President, CICMR


2/22

e oppor un y

Increase demand for high quality NHPs

But funding for NHPS through traditional channelsvery limited.

Opportunity :

2007 ORF funding program Round 2. Ministry ofResearch and Innovation

Open competition

Why ginseng?

Max $10 million (5 yrs):


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Ginseng as a traditional medicine:

Wild Ginseng Cultivated Ginseng

Grows naturally inhardwood forest.

endangered species

Grown on farms under shadesOntario # 1 producer in the world > $100million per yearWorld Ginseng Exports 2011-

$355,000,000Significance: ISO standards

Two major species:o Panax (Asian) ginseng

- 4,000 yearso N American ginseng- 400 years


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Ontario Ginseng Innovation and Research Centre

Partners and Resources: Value-chain model

Agricultural sector:

Grower- OGGA

Analytical facility -A&L

Canada Labs Ltd.

Botanical Extract producer/

Ingredient supplier:

Naturex

NHPs Manufacturer,

distributor:

Jamieson Lab Ltd

Multiple disciplines:

Medicine

AgriculturePlant Biotechnology

Sciences

Biochemical Engineering

Ivey School of Business

Kings University College

Academia: UWO, U Guelph, U Ottawa,

McMaster U, Northern Ontario Medical College

Government: MRI, AAFC

Basic R&D:


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New technologies for ginseng agricultureand product development

2008 2013 (2014 extension)Overall Objectives of the OGIRC:

1. Evaluate product quality:

Potency and consistency

2. Improve quality by agriculture and plant biotechnology

3. Develop value-added products

By advanced processing technology


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Quality issues Measurement of quality?

Shape, size, taste and aroma

Phytochemical methodology:LC-MS, NMR metabolomics product

differentiation, branding, traceability

Pharmacological parametersWide range of medicinal property health claim forcommercialization

Significant variability exists in current products


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Agriculture

Breeding program Clonal lines for ginseng cultivar

Production of disease resistance and specific medicinalproperty ginseng. Reduce variability in quality.


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Advanced processing New value-added products

Novel extracts

Formulations Delivery system for specific health benefits

Removal of contaminants

Green Peace:

Chinese herbs: Elixir of health or pesticidecocktails


9/22

New initiative: Consortium for natural

products and integrative medicine in Ontario

Multi-sector, value-chain based Innovation &commercialism in natural products for health

promotion Translation of new knowledge to end users and gate-

keeper of health care services health care providers


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Objectives: R&D, innovation and

commercialization of Natural products in Ontario

CONSORTIUM-ONTARIO

Academia

Government

Privatesector

Value-chainpartners

National andinternationalpartners

Role: Mobilize expertise and resourcesCoordinate and synergizeKey services: method development (non-animal model for screening),metabolomics centre, pilot processing, marketingKnowledge translation, training HQP


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To benefit Ontario Bioeconomy

Sustainable use of natural resources

International reputation to elevate capacity of Ontario toinnovate and commercialize traditional medicines and

NHPs that are competitive in the global market Networking infrastructure and mechanism for maximizing

R&D and innovation in NHPs

HQP with interdisciplinary training and experience needed

for the emerging market Provide comprehensive, patient-centred and evidence-

based health care through Integration of NHPs andrespecting cultural diversity


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Action Plan 1. Identify and provide networking of resources

or activities from different sectors and value-chain partners to maximize R&D output and

provide environment for innovation andcommercialization.

Recognize the potential for dynamic growthduring the proposed funding period.

Involve the Private sector from the start todevelop strategic plan for innovation andcommercialization.


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2. Form partnership with private sector and

different levels of government to advanceR&D for innovation and resolve technicaldifficulties identified by the industry.

Working closely with national and regionalorganizations, such as NRC/IRAP, MITACS,

SCOR EDC to maximize existing assistanceand incentive programs.


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Partners:I. Private-sector: Broadly based sharing common needs

and interest.

1. Agriculture:* A&L environmental monitoring, contaminants, soilmicrobials;*Growers associations: OGGA, Ontario Lavender

Association, Ontario Hop Growers Association, HaskapsCanada Association ...Others: individual growers of seabuckthorn, goji,

medicinal herbs (e.g. goldenseal, black cohosh, Echinacea,numerous other herbs). Medicinal and edible mushrooms.Vegetable growers association.

* Other non-plant based products, e.g. chicken egg

products for health benefits


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2. Manufacturing, distribution, marketing: Naturex,Jamieson, Western Phytoceutica Ltd., Agrimix (producer offeeds for live stocks)

3. Advanced processing: WPC, Suntrition? Bioniche LifeScience?

4. Analytical, metabolomics, genomics:

AB Sciex: committed partner. LC-MS/MS; Can Lab forAcademia Platform

Bruker Biospin: Committed partner. NMR,

Agilent Technologies,Viscotek: chromatography, GPC

5. Knowledge translation, regulatory affairs, clinical:

Nutrasource Ltd, Let Talk Science


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II. Government agency

Ontario Federal MRI Agriculture Agri-food CanadaGuelph (antioxidants, nutrition)London, Winnipeg (Plant biology

and cardiovascular health) OMAF and MRA Can Food Inspection Agency

(seed quality testing)

OM Health LTC ? NHP Directorate, Health

Canada?

OCE?

South Central Ontario Region EDC


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III. Academia and research network

Western U, OGIRC Ottawa U Guelph: U WaterlooU WindsorNorthern Ontario School of Medicine

Network for Cancer Therapeutics Researchand Services

Innovation Initiatives Ontario North

(IION)


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McMaster U Algoma U: bioprospecting, phytochemistry Brock U: agriculture, plant biotechnology U Toronto Erie Commercialization and Innovation:

knowledge translation, networking

Colleges: Fanshawe College: biotech program

Loyalist College: extraction technology


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Priority products Consider products with different levels of risk for

commercalization

Herbal products

Unique vegetables

Non-plant based products

Products for non-human use


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pec c arge researc :Establish service-based core facilities to:

i) Develop non-animal models for evaluation ofefficacy and safety of natural products

an evidence based holistic approach

ii) conduct metabolomics analysis to ascertainquality of natural products and to provide system

biology approach for evaluating their healthbenefits

iii) provide pilot plant for scale-up production ofnatural products


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Knowledge translation and integrative medicine

1) Education programs:

- collaboration with Fanshawe college, Biotech

program, co-op opportunity - new curriculum developments in natural products

in academia

Youth outreach

Consumers Industry Stakeholders

Government regulators and policy makers


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2) Gate-keeper of health care services

Physcians, family medicine, medical

curriculumNaturopathic medicine: practice and

curriculum

Traditional Chinese medicine: practice andcurriculum

IION Agri-Food and Health Conference: Edmund Lui

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