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Transcript of IHP March 2015
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WWW.IHPMAGAZINE.COM MARCH 2014
Nothing’s Hotter Than Hemp
Looking Back – Looking Forward: InsideOut Health Solutions
the Halifax Naturopathic Health Centre
MANAGING THE BRAIN/HEARTCONNECTION
001.IHP_Cover.indd 4 2015-03-11 3:18 PM
contents
DEPARTMENTS
FEATURES
MARCH 2015 • IHPMAGAZINE.COM 6
9 Publisher’s Letter
12 Bits and Bites Industry and Research News
24 Gallery In-Cam Symposium
26 Product Profiles
54 Exit Strategy Three powerful Natural Health Supplements
22 US Declares War on Global Tuberculosis Epidemic
30 Clinic Profile Updates Revisiting InsideOut Health Solutions and the Halifax Naturopathic Health Centre
36 The Brain Heart Arteries Connections
40 Nucleotide related therapy as a novel approach Uses in Alzheimer’s Disease and Hepatitis C
44 Nothing’s Hotter Than Hemp
50 The Healing Power of Fat Tissue
find us on 4030
36
IHP Contents.indd 6 2015-03-11 3:19 PM
MARCH 2015 • IHPMAGAZINE.COM 9
publisher’s letter
W elcome to the redesigned Integrated Healthcare
Practitioners. You will probably notice many
changes inside – and there are many more excit-
ing changes to come.
We have built a dedicated readership over the past seven
years, and intend to keep serving that core audience with
plenty of articles focusing on research and contributing to
the knowledge and evolution of integrative healthcare. We
will keep running research papers – but shorter, simplified
versions – with the full, referenced versions available on
your tablet and our website. This makes all the articles more
accessible and meaningful while still serving as a “journal.”
We also aim to expand that readership – by providing
interesting, lively discussion and engaging information for
alternative healthcare practitioners in a wide range of
specialties.
As always, your participation is welcome. Call us, talk
to us, check out our social media pages and keep reading
Canada’s best resource for Integrated Healthcare
Practitioners.
Founder, Publisher & Editor-in-Chief Olivier Felicio
Managing Editor Dale Sproule
Art Director Scott Jordan
Junior Designer Kaitlin Yep
Contributors Adina Currie, Rochelle Fernandes, Irina Lytchak, Leonard Taylor
President Olivier Felicio
General Manager Melanie Seth
General Customer Care Manager Lucy Holden
Subscription RatesCanada $80 (gst included) for six issues International $120
Canada Post Canadian Publication Mail Agreement Number 4067800 The publisher does not assume any responsibility for the contents of any advertisement and any and all repre-sentations or warranties made in such advertising are those of the advertiser and not of the publisher. The publisher is not liable to any advertiser for any misprints in advertising not the fault of the publisher and in such an event the limit of the publisher’s liability shall not exceed the amount of the publisher’s charge for such advertising. No portion of this publi-cation may be reproduced, in all or part, without the express written permission of the pub-lisher. ihp magazine is pleased to review unsolicited submissions for editorial consideration under the following conditions: all material submitted for editorial consideration (photo-graphs, illustrations, written text in electronic or hard copy format) may be used by ihr Media Inc. and their affiliates for editorial purposes in any media (whether printed, elec-tronic, internet, disc, etc.) without the consent of, or the payment of compensation to, the party providing such material. Please direct submissions to the Editor, ihp magazine.
Published by IHP Magazine
CirculationRive Gauche Media1235 Bay St., suite 400; Toronto, Ontario, M5R 3K4Email: [email protected]
Advertising Olivier Felicio(416) 203-7900 x [email protected]
Toronto ParisTheRGMGroup.
MARCH 2015 • Volume 8 Issue 1
Olivier Felicio
Publisher/Editor-in-Chief
The Evolution of IHP
IHP PubLetter.indd 9 2015-03-12 11:43 AM
MARCH 2015 • IHPMAGAZINE.COM 36
cover story
The BrainHeartArteries Connectionsby Leonard Taylor
IHP HeartBrain.indd 36 15-03-11 2:16 PM
MARCH 2015 • IHPMAGAZINE.COM 37
After the leaves had turned their million autumnal
shades of red and yellow, but before the first
snows had fallen, a study appeared in the pages
of the journal Public Library of Science (PLOS) One.
It contained details on research being conducted by
scientists at the Ottawa Heart Institute and the University
of Maryland School of Medicine (UM SOM) – disclosing
that they had uncovered a new pathway by which the
brain uses an unusual steroid to control blood pressure.
The study, which also suggests new approaches for
treating high blood pressure and heart failure, could
eventually lead to new treatments for hypertension and
heart failure.
“This research gives us an entirely new way of under-
standing how the brain and the cardiovascular system
work together,” said Dr. John Hamlyn, professor of phys-
iology at the University of Maryland School of Medicine,
one of the principal authors. “It opens a new and exciting
way for us to work on innovative treatment approaches
that could one day help patients.”
IHP HeartBrain.indd 37 15-03-11 2:16 PM
MARCH 2015 • IHPMAGAZINE.COM 38
cover story
For decades, researchers have known
that the brain controls the activity of the
heart and the diameter of the peripheral
arteries via the nervous system. Electrical
impulses from the brain travel to the heart
and the arteries via a network of nerves
known as the sympathetic nervous system.
This system is essential for daily life, but is
often chronically over active in patients with
high blood pressure or heart failure. In fact,
many drugs that help with hypertension and
heart failure work by decreasing the activity
of the sympathetic nervous system. However,
these drugs often have serious side effects,
such as fatigue, dizziness, depression and
erectile dysfunction.
“A lot of the medications we used in the
past to block the sympathetic nervous
system interfere with the acute regulation,”
says Dr. Frans Leenen, Director of
Hypertension at the Ottawa Heart Institute,
and a principal author of the study. “These
drawbacks have led to the search for novel
ways to inhibit sympathetic nerve action
while causing fewer problems for patients.”
Working with an animal model of hyper-
tension, Dr. Leenen in collaboration with Dr.
Hamlyn and Dr. Mordecai Blaustein, professor
of physiology and medicine at the UM SOM,
found a new link between the brain and
increased blood pressure, namely, a lit-
tle-known steroid called ouabain (pro-
nounced WAH-bane).
This new study is the first to identify a
particular pathway by which the brain reg-
ulates the diameter of the arteries via
ouabain in the bloodstream, and causes an
increase in contractile proteins in the arter-
ies. This new humoral “chronic” pathway
acts together with the more “acute” sympa-
thetic nervous system pathway to control
the function of arteries and thereby contrib-
utes to high blood pressure.
“Now that we understand the role of
ouabain (EO), we can begin working on how
to modify this new pathway to help people
with cardiovascular problems,” said Dr.
Blaustein. “The potential for this is big.” Dr.
Blaustein, who has been doing research on
the substance since 1977, said medications
that block ouabain’s effects might improve
the lives of people with hypertension and
heart failure.
Dr. Leenen explains that there are new
drugs being tested in clinical studies that
can specifically block the Angiotensin II/EO
effect in the brain. He says these newer drugs
are just starting phase two trails. They
HEART FAILURE“Digoxin is in the same chemi-
cal class as ouabain – but the
body makes its own ouabain,
whereas digoxin is a derivative
of foxglove that has been used
for I don’t know how many
centuries. It’s used in heart
failure to increase the activity
of the heart – and get the
blood pumping. It’s not much
used anymore because it’s not
that effective. We have better
drugs now that regulate longer
as well. That is a different situ-
ation though – high blood
pressure than heart failure.
Even if some of the mecha-
nisms may be similar.”
– Dr. Frans Leenen
“Now that we understand the role of ouabain, we can begin working on how to modify this new pathway to help people with cardiovascular problems.”
IHP HeartBrain.indd 38 15-03-11 2:16 PM
MARCH 2015 • IHPMAGAZINE.COM 39
basically prevent “that resetting in the brain of the sympa-
thetic nervous system to a higher level, leaving the acute
regulation intact. Once these drugs have been tried in healthy
volunteers – the phase one trials are done and the drugs
are determined safe, with no major side effects, one moves
to what’s called phase two A studies – small scale studies in
this case of people with high blood pressure. This develop-
ment may not have come directly out of our study, but they
are building on each other and that’s the way to look at it.
I am actually collaborating with one of the discoverers of
this new drug class,” says Leenen.
The research was funded by the Canadian Institutes of
Health Research, the National Institutes of Health, and the
University of Maryland School of Medicine. The paper,
“Neuroendocrine Humoral and Vascular Components in the
Pressor Pathway for Brain Angiotensin II: A New Axis in Long
Term Blood Pressure Control,” is available on the The
University of Ottawa Heart Institute (UOHI) website
(www.ottawaheart.ca), as is a video of Dr. Frans Leenen
explaining the meaning of these recent findings.
The University of Ottawa Heart Institute is Canada’s
largest and foremost heart health centre dedicated to
understanding, treating and preventing heart disease. UOHI
delivers high-tech care with a personal touch, shapes the
way cardiovascular medicine is practised and revolutionizes
cardiac treatment and understanding. It builds knowledge
through research and translates discoveries into advanced
care. UOHI serves the local, national and international com-
munity and is pioneering a new era in heart health.
CHRONIC HIGH BLOOD PRESSURE“In the past, high blood pressure was a common cause
of heart failure. Now this is much less common,” say Dr.
Leenen. “Now heart failure is more due to heart attacks
which destroy the heart muscle and that’s quite a different
kind of thing. I rarely see anybody anymore with high
blood pressure induced heart failure. In North America
anyway – of course you can’t extrapolate that throughout
the world.
“We have to come up with better strategies to prevent
the blood pressure from going up in the first place. So this
is separate from heart failure issues, because chronic high
blood pressure results in a much broader consequence –
and for that you really have to understand what the mecha-
nisms are. And so in the past we would say whatever
happens in the brain would be all about the sympathetic
nervous system and the sympathetic nervous system is
crucial for acute second-to-second regulation of your blood
pressure in the biospheres of the brain that control the
acute regulation of EO that’s crucial for survival or living.
You have people who don’t have an effective sympathetic
nervous system anymore and they can barely stand because
the blood pressure would drop into their boots. When you
stand up there’s a potent reflex that prevents the blood
pressure from going down. So when you stand up you have
to think about gravity impacting on your body and if
nothing happened, all the blood would pool in your legs.”
IHP HeartBrain.indd 39 15-03-11 2:16 PM
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