Ig Genes - Roswell Park
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Ig Genes
Transcript of Ig Genes - Roswell Park
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Ig Genes
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Kidney B cell
Figure 5-2
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Antibody Diversity
• Junctional Diversity – Imprecise DNA rearrangement – P-nucleotide Addition – N-region Diversification
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Antibody Diversity • Junctional Diversity
– Imprecise DNA rearrangement – P-nucleotide Addition – N-region Diversification
• Somatic Mutation – Occurs after initial exposure to Ag – Mediated by AID (activation induced
cytidine deaminase)
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Figure 5-19
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