Idiopathic Thrombocytopenic Purpura Clinical Features.

Idiopathic Thrombocytopenic Purpura

Clinical Features

• Onset of chronic ITP is insidious• Characterized by:

– mucocutaneous bleeding and a low, often very low, platelet count, with otherwise normal peripheral blood cells and smear

• Rarely, life-threatening bleeding, including in the central nervous system, (intracerebral or subarachnoid hemorrhages) can occur (<5,000 per mm3)

• The amount and severity of symptoms is related to the severity of the decrease in the platelet count Harrison’s Principle of Internal Medicine 17th ed.

Robbins Basic Pathology 8th ed.Wikipedia Encyclopedia

http://www.nhlbi.nih.gov/health/dci/Diseases/Itp/ITP_SignsAndSymptoms.htmlDivisions of Nursing and Hematology( James Cancer Hospital & Solove Research Institute, The Ohio State University Medical

Center)Mayoclinic

• Purpura - easy or excessive bruising • Mucocutaneous bleeding

– Petechiae (superficial bleeding into the skin that appears as a rash of pinpoint-sized reddish-purple spots, usually on lower legs

– Spontaneous bleeding from gums, oral mucosa, nose (epistaxis), GI tract

– Any of which may occur if the platelet count is below 20,000 per mm3

• Prolonged bleeding from cuts• Blood in urine or stools• Unusually heavy menstrual flows• Profuse bleeding during surgery

Harrison’s Principle of Internal Medicine 17th ed.Robbins Basic Pathology 8th ed.

Wikipedia Encyclopediahttp://www.nhlbi.nih.gov/health/dci/Diseases/Itp/ITP_SignsAndSymptoms.html

Divisions of Nursing and Hematology( James Cancer Hospital & Solove Research Institute, The Ohio State University Medical Center)

Mayoclinic

• A very low count (<10,000 per mm3) may result in the formation of hematomas (collection of clotted or partially clotted blood under the skin) in the mouth or on other mucous membranes




Mayoclinic

Two types of ITP

• Acute (temporary or short-term) ITP:– generally lasts less than 6 months– mainly occurs in children, both boys and girls, and is

the most common type of ITP– often occurs after an infection caused by a virus

• Chronic (long-lasting) ITP: – lasts 6 months or longer and mostly affects adults– some teenagers and children can get this type of ITP– affects women 2 to 3 times more often than men




Mayoclinic

• Any kind of bleeding that is hard to stop could be a sign of ITP

• A low number of platelets doesn't cause pain, fatigue (tiredness), problems concentrating, or any other symptoms




Mayoclinic

Idiopathic Thrombocytopenic Purpura Clinical Features.

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