Hypoxia
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Transcript of Hypoxia
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Hypoxia
The Department of Pathophysiology
Guo lirong
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Definition of hypoxia (What is hypoxia?)
Parameters of Blood Oxygen
HypoxiaMain points to study
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External respiration
BloodBlood CirculationCirculation
Tissue Tissue cellscells
OxygenOxygen SupplySupply
OxygenOxygenUtilizationUtilization
Hypoxia
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Definition
Hypoxia is the commonest pathological process , which is defined as that cells can not obtain enough oxygen or can not fully utilize oxygen , thus leading to changes in their metabolism , function , or structure.
Hypoxia
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1.Partial pressure of oxygen1.Partial pressure of oxygen (( POPO22
))2.Oxygen binding capacity2.Oxygen binding capacity (( COCO2 max2 max ))
3.Oxygen content3.Oxygen content (( COCO22 ))
4.Oxygen saturation4.Oxygen saturation ( ( SOSO22 ))
Parameters of Blood OxygenHypoxia
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Partial pressure of oxygen ( PO
2 )
1.Definition : the tension produced by oxygen molecules physically dissolved in plasma.
2.Normal value : PaO2=13.3kPa(100mmHg)
PvO2=5.33kPa(40mmHg)
Hypoxia
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Oxygen binding capacity ( CO2ma
x ) 1. Definition : It is the maximum amount of oxygen that can be combined to hemoglobin in 100 ml of blood.
2.Normal value : 20ml/dl
Hypoxia
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Oxygen content ( CO2 )
1.Definition : It is the actual content of oxygen in 100ml blood.
2.Normal value : CaO2=19ml/dl CvO2=14ml/dl
Hypoxia
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Arteriovenous oxygen content (Ca-vO2)
19ml/dl 14ml/dl
5ml/dl
O2O2 O2O2 O2O2 O2O2 O2O2A V
Definition: It is the difference of oxygen content between arterial blood and mixed venous blood.Normal value : 5ml/dl
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Definition: It is the percentage of hemogl
obin present as oxyhemoglobin.
Oxygen saturation (SO2)
Normal value : SaO2=95%; SvO2=70%
CO2-dissolved O2
CO2max100%
=SO2
Hypoxia
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P50
Definition: P50 is a parameter reflecting t
he affinity of Hb to oxygen; it is the O2 p
ressure required to sturate 50% of Hb.
Normal value : 26~28 mmHg
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Dissociation curve of oxyhemoglobinDissociation curve of oxyhemoglobin
20
40
60
80
100
20 40 60 80 100
Hb
Sat
ura
tion
(%
Hb
Sat
ura
tion
(%
))
PaOPaO22 (mmHg) (mmHg)
pH↓pH↓2,3-DPG↑2,3-DPG↑CO2 ↑↑Temperature↑↑
Leftward-shifteLeftward-shifted curve:d curve:
Rightward-shifteRightward-shifted curved curve
Hypoxia
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