Hypertensive Disorders in Pregnancy · Incidence •Hypertensive disorders of pregnancy – 12-22%...
Transcript of Hypertensive Disorders in Pregnancy · Incidence •Hypertensive disorders of pregnancy – 12-22%...
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Hypertensive Disorders
in Pregnancy
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Incidence
• Hypertensive disorders of
pregnancy – 12-22%
• Gestational HTN
–6-17% nulliparous women
–2-4% multiparous women
• Preeclampsia – 5-8%
ACOG 2002
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Risk Factors
• 1st pregnancy
• Previous pregnancy with preeclampsia
• Age ≥ 35 yrs
• Multiple pregnancy
• African American race
• Chronic medical conditions
ACOG 2002
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Different Classifications
• Chronic hypertension
• Gestational hypertension
• Preeclampsia
• Superimposed Preeclampsia
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Chronic Hypertension (NHBPEP)
• Chronic Hypertension
–HTN prior to conception, or
diagnosed before 20th week of
gestation that does not resolve
postpartum
ACOG 2002, 2013
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Gestational HTN
• SBP ≥ 140 or DBP ≥ 90 on 2 occasions > 4 hours apart developing after 20 weeks gestation
• No changes in labs
• May be transient or chronic in nature
• Returns to normal postpartum
ACOG 2002, 2013
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Preeclampsia
• Preeclampsia
– Systemic disease with hypertension accompanied by proteinuria (≥ 300mg in 24 hr or Protein/Creatinine ratio of ≥ 0.3) or thrombocytopenia, impaired liver function, or new onset renal insufficiency without proteinuria
ACOG 2002, 2013
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Superimposed Preeclampsia
• Preeclampsia that develops in the presence of preexisting hypertension or renal disease
ACOG 2002, 2013
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Preeclampsia with Severe
Features • SBP ≥ 160 or DBP ≥ 110 on two
occasions
• Confirmation can occur quickly to help
facilitate antihypertensive therapy within 4
hours of diagnosis
• Lab changes
• Symptomatic
ACOG 2002, 2013
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Preeclampsia with Severe
Features • Labs:
– Proteinuria ≥ 5g in 24 hours or ≥ 3+ on
dipstick on 2 occasions ≥ 4hrs apart
– Oliguria <500cc in 24 hrs
– Elevated liver enzymes (twice normal)
– Thrombocytopenia (<100,000)
– Progressive renal insufficiency – Cr
1.1mg/dl ACOG 2002, 2013
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Preeclampsia with Severe
Features • Symptoms:
– Headache
– Visual disturbances
– Epigastric of RUQ pain unresponsive to
meds
– Pulmonary edema
ACOG 2002, 2013
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Preeclampsia with Severe
Features
• Additional Considerations:
–Fetal growth restriction may be
present
–HELLP
ACOG 2002, 2013
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Eclampsia
• Eclampsia – Convulsive stage, when seizures cannot
be attributed to other causes
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Normal Pregnancy Changes
• Markedly vasodilated state
–Peripheral resistance ↓ 25% due to ↑ in
prostacyclin (potent vasodilator) and
endothelium-derived relaxing factor
• 50% ↑ in total blood volume by end
2nd trimester
• CO ↑ in 1st trimester, peaking at 35%
to 50% above non-pregnant levels
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Normal Pregnancy Changes
• ↑ renal blood flow, ↑ GFR, activation
of renin-aldosterone system (results
in falling BP)
• DBP drops to an average of 10
mmHg below non-pregnant values by
mid-pregnancy, then slowly
approaches non-gravid levels in 3rd
trimester
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Pathophysiology of Pre-Eclampsia
• “Disease of theories” - no established cause
• 2 stages:
– Disruptions in placental perfusion
– Maternal syndrome
• Abnormal prostacyclin:thromboxane ratios
• Prostacyclin vasodilation and inhibits
platelet aggregation
• Thromboxane vasoconstriction and
platelet aggregation
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Disruptions in Placental Perfusion
• Normal pregnancy: cells from placenta
invade the maternal spiral arteries,
causing the vessels to change from
thick-walled vessels to flaccid sac-like
vessels
• Results in ↑ vessel diameter and
expansion to accommodate the 10-fold ↑
in uterine blood flow
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• In preeclampsia, the vessels remain thick-walled and a distinctive lesion (acute atherosis) noted
• These lesions, along with placental infarcts, lead to ↓ placental perfusion and hypoxia
• It is the placental hypoxia that is believed to be the initial cause of preeclampsia
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Maternal Syndrome
• Normal pregnancy:
–Systemic vasorelaxation occurs,
results in ↑ blood volume, HR, CO
• Preeclampsia
–Blood vessels become hyper-
sensitive to vasoactive hormones and
vasoconstriction occurs
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Widespread Vasospasm
• Arterial vasospasm
• Disrupts arterial & venous circulation due to alternating segments of constriction & dilatation, resulting in endothelial damage
• Vascular wall damage activates platelet aggregation, intravascular volume, results in tissue ischemia from impaired blood flow to organs
• BP rises as result of narrowed lumens (vasoconstriction) and high resistance state
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Effects on Systems/Organs
• C = Cardiovascular
• H = Hematologic
• H = Hepatic
• U = Uteroplacental
• R = Renal
• N = Neurologic
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Cardiovascular
• Hypertension – arterial vasospasm SVR, HTN, edema
– organ perfusion
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R/O White Coat HTN
• ~ 15 to 30% of the general
population exhibits “white coat”
HTN, but a higher incidence is
noted among the elderly and
among pregnant women
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Hematologic
• Vasospasm vascular damage
• hct – inadequate plasma volume expansion
– blood viscosity, maternal organ perfusion
• Thrombocytopenia – schistocytes, burr cells
– bili
– hemolysis compromises tissue O2 delivery
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Normal RBC’s
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Shistocytes
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Burr Cells
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Hematologic
• Change in plasma proteins
– Colloid oncotic pressure -- “pulling
pressure of proteins”
• Hydrostatic (water) pressure
– pushing pressure of intravascular fluid
against the vessel walls
– balance of these 2 maintains fluid levels
in capillaries
– If COP < hydrostatic pressure, fluid
moves rapidly out of capillaries
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Hematologic
• Hemoconcentration
– due to capillary permeability, plasma volume
– tissue perfusion, reduced blood flow
– norm is hemodilution & physiologic anemia
• DIC
– rare, may occur if severe preeclampsia
• HELLP
– clotting studies, liver function tests
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HELLP Syndrome
• A variant of severe pre-eclampsia
• H = Hemolysis
• EL = Elevated Liver enzymes
–2x normal
• LP = Low Platelets
–< 100,000
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Assessment
• Look for s/s bleeding
• Monitor labs - watch for platelet
count, lab value changes
• Observe for s/s of anemia
• Observe for adequate oxygenation
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Hepatic
• Vasospasm & fibrin deposits may
obstruct blood flow & cause ischemic
changes in liver
• Ischemia, necrosis, and intrahepatic
hemorrhage can lead to hepatic rupture
• liver enzymes due to poorly perfused
liver
• Glucose metabolism, excretion of
drugs may be affected
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Assessments
• Assess for RUQ epigastric pain,
substernal pain, tenderness to
palpation
• N/V, malaise, viral-like syndrome
• Monitor labs for liver function
–AST, ALT, LDH, bilirubin
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Uteroplacental System
• Physiology:
• Vasospasm
causes in
uteroplacental
perfusion
• in O2 and
nutrients to fetus
• risk placental
abruption
• Assessment:
• Evaluate FHR
pattern, watch for
signs of
perfusion & O2
• Assess UC
activity/pattern
• Fetal surveillance
for activity,growth,
AFV
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Renal System • Vasospasm & damage results in flow
through kidneys, GFR, creatinine
clearance, and urinary output
– normal pregnancy, renal plasma volume
& GFR 30-50%
• Kidneys unable to excrete waste
products (urea, creatinine, uric acid)
• Proteinuria due to kidney damage, larger
molecules leak out
• Important to remember when giving
meds excreted by kidneys, ie, MgSO4
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Renal (con’t)
• Proteinuria - classic sign
• Decreased urine output
• Edema
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Renal Assessment/Care
• Weight gain
• Edema
• Breath sounds
• Pulse ox
• Strict I&O
• Infusion pumps
• Hourly output,
call if < 30 cc/hr
• Watch Mg levels
closely
• Monitor urine protein
• Monitor lab values:
– H&H
– BUN
– creatinine
– uric acid
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Neurologic System
• ↓ cerebral perfusion due to HTN
• Vessel damage & vasospasm can cause intracranial pressure, cerebral edema, ischemia, hemorrhage
• S/S: drowsiness, tinnitus, visual disturbances (blurred vision, photophobia), persistent HAs, N/V
• Hyperreflexia & clonus
• Seizure
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Neurologic Assessment
• Assess for HA, visual disturbances,
drowsiness, N/V, altered LOC,
hypersensitive to noise/light
• Assess DTR’s/clonus
• Monitor Mg level
• Assess for s/s of seizure, protective
environment, seizure tray at bedside
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DTR’s
• 0 No response, hypoactive, abnormal
• +1 Somewhat diminished, not abnormal
• 2+ Average response
• 3+ Brisker than average, not abnormal
• 4+ Hyperactive, very brisk, abnormal
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Clonus
• Repetitive, rhythmic contractions of a muscle when attempting to hold it in a stretched state
• A strong, deep tendon reflex that occurs when the CNS fails to inhibit it
• Often tested for in the ankle, wrist, and kneecap
• Normal = no beats
• Video
http://www.mult-sclerosis.org/clonus.html
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Neurologic Assessments
• Pupil size (equal, size, reactive)
• Hand grasp
• Level of consciousness
• Response to painful
stimuli
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Other Nsg Assessments
• Emotional health assessment
–communicate w/patient/family
– referrals as necessary
• Provide education
–disease process
–procedures, pertinent policies
–explain equipment to family
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When to Deliver
• At diagnosis after 37 weeks for any
preeclampsia or Gestational HTN
• At diagnosis after 34 weeks if severe
features
• Prior to 34 weeks – give corticosteroids
(Betamethasone) and seek expert care
(MFM) for individualized plan of care
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Goals
• Prevent preeclampsia
• Appropriately timed delivery
• Control of blood pressure
–Goal is 140-159/90-109
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Common Medications
• Magnesium sulfate
• Hydralazine
• Nifedipine
• Labetalol
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MgSO4
• Drug of choice for seizure precautions - CNS
depressant
– Not necessary in the absence of severe features
• Loading dose: 4-6 grams over 20-40 minutes
• Maintenance dose: 1-3 grams/hr
• Therapeutic range 5-8 mg/dl
• Antidote - calcium gluconate
ACOG (2015) & Core Curriculum for Maternal Newborn Nursing (2016)
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Mg Levels & Toxicity
Sign or Symptom Mg Level (mg/dl)
Loss of patellar reflexes 8-12
Feeling of warmth/flushing 9-12
Somnolence 10-12
Slurred speech 10-12
Muscular paralysis 15-17
Respiratory depression 15-17
Cardiotoxicity 30-35
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Hydralazine/Apresoline
• Antihypertensive, vasodilator
• Dosing: 5-10 mg IV
–Administer over 2 min
–Can repeat every 20 min
–Max of 30mg
ACOG (2015) & Core Curriculum for Maternal Newborn Nursing (2016)
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Labetalol
• Beta blocker - reduce arterial vasospasm,
BP, prevent vascular injury
• Dosing: Initial dose 20mg IV
–Recheck in 10 min: Give 40mg if
needed
–Recheck in 10 min: Give 80mg if
needed
–Maximum of 300mg
ACOG (2015) & Core Curriculum for Maternal Newborn Nursing (2016)
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Procardia/Nifedipine
• Calcium channel blocker - intravascular
resistance and C.O.
• Dosing: 10mg orally
• May repeat in 30 min if needed (can do
20mg)
• Max 50mg
ACOG (2015) & Core Curriculum for Maternal Newborn Nursing (2016)
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Treatment of Eclampsia
• Goal is to protect the patient
• Avoid insertion of airways and
padded tongue blades - can cause
upper airway trauma and hemorrhage
• IV access
• Suction, O2
• MgSO4 2gm IV over 5 minutes
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Alternative Anticonvulsants
• Lorazepam (Ativan) 2-4mg IV x1, may repeat x1
after 10-15 minutes
• Diazepam (Valium) 5-10 mg IV every 5-10 min to
max of 30mg
• Phenytoin(Dilantin) 15-20mg/kg IV, may repeat
10mg/kg IV after 20 minutes if no response; avoid
with hypotension, may cause cardiac arrhythmias
• Keppra 500mg IV or orally, may repeat in 12
hours, dose adjustment needed if renal
impairment
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Post Seizure Care
• Assess maternal labs
• Assess fetal well-being, inutero
resuscitation
• Plan for delivery, induction okay if
cervical readiness
• No need for immediate C/S
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Other Complications
• Pulmonary edema
– Fluid overload & COP
–Occurs more often after delivery
– Lasix 10-20mg IV
• Oliguria
–Goal at least 30cc/hr
–Small fluid boluses (250-500cc)
–PP diuresis common
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Other Complications
• Persistent hypertension
–BP may remain for several days
– by definition, preeclampsia resolves
by 6 weeks
• DIC
– rarely occurs without abruption
– low platelets is not DIC
– requires blood products & delivery
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Postpartum Course
• Cardiogenic
–Rapid improvement ? Hemorrhage
–Blood loss not tolerated well
–Use of methergine contraindicated
–Watch for uterine hypotonus w/MgSO4
– in BP and U.O. may indicate
hemorrhage and shock
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Postpartum
• Hematologic
–Thrombocytopenia resolves ~ 3 days
• Hepatic
– Improvement in liver function studies
• Uteroplacental
–Monitor vag flow closely, weigh pads
–Watch uterine tone
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Postpartum
• Renal
– Improvement in urine output
–Large diuresis sign of recovery
– Improvement in BUN, creatinine,
uric acid
• Neurologic
–Regression of HA
–Reflexes return to normal
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Postpartum
• Subjective improvement
–Treat until signs of improvement
– If mom isn’t feeling well, she isn’t
well
–Keep MgSO4 running until signs
the disease is regressing and mom
feels better
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Case Studies
• Examples of clinical errors when
administering Magnesium
Sulfate and the outcomes…
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A woman in PTL was receiving IV MgSO4. Despite treatment,
precipitous labor & birth occurred. Oxytocin was ordered after
delivery of placenta. Instead of oxytocin, the MgSO4 was
infused at a rapid rate. (The MgSO4 infusion had been DC’d
and the IV line removed from the pump, but remained
connected to the patient at the Y port.) Pt. returned to her LDR
room and VS assessed. Approximately 30 min. later, pt. found
unresponsive and not breathing. Code initiated, resuscitation
difficult, defibrillation x 3 and 9 minutes to restore HR.
Subsequently learned she had ~ 550 ml of the IV MgSO4 (22g).
Despite aggressive Rx, calcium chloride, and ICU care, she did
not regain consciousness and remains in a persistent vegetative
state.
MCN, May/June 2004
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A woman with preeclampsia being transferred to a
tertiary care center was receiving IV MgSO4 at 2g/hr.
Because the maternal transport team was not available,
a critical care nurse was selected to accompany the
patient. Illegibly written orders to continue the mag
sulfate at 2 g/hr were interpreted by the nurse to be 7
g/hr, and the dosage was adjusted accordingly. The
patient appeared stable , was noted to be sleeping
during the last portion of the trip, and found to have
respirations of 10/min. on arrival. The error in order
interpretation and dosage was discovered by nurses at
the accepting institution. Calcium gluconate was
administered and respiratory status improved quickly.
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A woman w/PTL had orders for 6g load of MgSO4 to be
followed by 3g/hr. Mainline IV fluids of LR were TRA 300ml/
hr. RN mixed 40 gm of MgSO4 in 1L LR and labeled the bag.
The RN gave the 6g loading dose without an infusion device and
then used a pump to give the MgSO4 and mainline fluids. Over
next 3 hrs, woman reported feeling flushed/nauseated. DTRs
not assessed. RR < to 10. RN assured woman/family these
symptoms were expected. Woman eventually appeared to be
sleeping deeply, RN assumed she needed rest after the stress of
being admitted w/PTL. Pt’s family left for dinner, upon return
found the woman not breathing. RN called to room and could
not palpate a pulse. Code initiated but was unsuccessful. Mg
toxicity suspected, IV fluids sent for analysis. Discovered the
bags had been mislabeled, received 12g/hr x 3 hours.
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Woman 4 days PP presented to ED in small rural hospital with
c/o severe HA, blurred vision, epigastric pain. BP 168/110 and 4+
pitting edema in legs. ER MD ordered MgSO4 to be given (2 g
load followed with 1 g/hr). A premixed bag of 40g/1000ml fluid
sent to ED. Together, the ED MD and RN calculated the infusion
rate for the pump to deliver 1g/hr. Jointly decided that 250 ml
was the correct infusion rate. Two hrs after the infusion started,
woman transferred to PP unit. Report abbreviated because ED
was busy. The admitting nurse noted the 250 ml rate and
assumed the MgSO4 must have been discontinued and that this
rate was the mainline bag, because she knew 250 ml/hr was too
high for MgSO4. Did not confirm rate and contents of each line.
Approx. 30 min. later, pt’s husband called to say his wife was
feeling weak & unable to move. Error noted when pt. reassessed.
Pt. had received 25g MgSO4 over 2.5 hrs. Calcium gluconate
given, pt. rapidly improved.
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References
• ACOG Committee Opinion number 623. (2015). Emergent Therapy for Acute-Onset, Severe
Hypertension During Pregnancy and the Post Partum Period.
• California Maternal Quality Care Collaborative. (2013, December 20). CMQCC Preeclampsia Toolkit.
California.
• The American Congress of Obstetricians and Gynecologist. (2013). Maternal Safety Bundle for
Severe Hypertension in Pregnancy.
• Mattson, S. & Smith, J.E. (2016). Core Curriculum for Maternal-Newborn Nursing. 5th ed. St. Louis,
MO: Elsevier.