Hypertension in Pregnancy
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Pregnancy Induced Hypertension
Jun Ma
Dept. of Obstetrics & Gynecology
The First Hospital of Xi’an Jiaotong Univ
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Introduction
Incidence: China: 9.4%, worldwide: 7-12%
The most common and yet serious conditions seen in obstetrics
cause substantial morbidity and mortality in the mother and fetus
Death due to cerebral hemorrhage, aspiration pneumonia, hypoxic encephalophathy, thromboembolism, hepatic rupture, renal failure
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Hypertension in pregnancy
Definition Diastolic BP ≥90 mmHg
Systolic BP ≥140 mmHg
Or as an increase in the diastolic BP of ≥ 15 mmHg or in the systolic blood pressure of 30 mmHg, as compared to previous pressure
The increased blood pressures be present on at least two separate occasions, > 6h apart
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Classification
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• Pregnancy-induced hypertension
Preeclampsia
Mild
Severe
Eclampsia
• Chronic hypertension preceding pregnancy
• Chronic hypertension with superimposed PIH
Superimposed preeclampsia
Superimposed eclampsia
• Gestational hypertension
Classification of Hypertensive Disorders in Pregnancy (ACOG)
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Classification (1)1. Pregnancy-induced hypertension:
Hypertension associated with proteinuria and edema, occurring primarily in nulliparas after the 20th week or near term.
Preeclampsia
【 mild 】 BP ≥ 140/90mmHg Onset after 20 weeks’ gestation Proteinuria (>300mg/24-hr urine collection) or + Epigastric discomfort Thrombocytopenia
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Classification (2)【 severe 】 BP ≥ 160/110 mmHg Marked proteinuria (>1-2 g/24-hr urine collection or 2+ or
more), oliguria Cerabral or visual disturbances such as headache and
scotomata Pulmonary edema or cyanosis Epigastric or right upper quadrant pain (probably caused by
subcapsular hepatic hemorrhage) Evidence of hepatic dysfunction, or thrombocytopenia
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Classification (3)
Eclampsia
Meets the criteria of preeclampsia
Presence of convulsions, not attributable
to other neurological disease,
Occurrence: 0.5 -4 %, with 25%
occurring in the 1st 72 hs postpartum
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Classification (4)
2. Chronic hypertension proceeding pregnancy (essential or secondary to renal disease, endocrine disease, or other causes)
BP ≥ 140/90 mmHg
Presents before 20 wk gestation
Persists beyond 12 wk postpartum
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Classification (5)
3. Chronic hypertension with superimposed preeclampsia or eclamptia
Coexistence of preeclampsia or eclampsia with preexisting chronic hypertension
Cause greatest risk
When diagnosis is obscure, it is always wise to assume that the findings represent preeclampsia and treat accordingly.
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Classification (6)
4. Gestational hypertension: not mentioned in the
ACOG
Finding of hypertension in late pregnancy in the
absence of other findings suggestive or
preeclampsia
Transient hypertension of pregnancy
May develop into chronic hypertension if elevated
BP persists beyond 12 weeks postpartum
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High risk factors
Nulliparous <18ys or >40 ys, multiple pregnancy Has previous gestational hypertensive disorders Chronic nephritis Diabetic Malnutrition Low social status Hydatidiform mole
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Etiology: UNCLEAR Immune mechanism (rejection phenomenon, insufficient
blocking Ab)
Injury of vascular endothelium----disruption of the equilibrium between vasoconstriction and vasodilatation, imbalance between PGI and TXA
Compromised placenta profusion
Genetic factor
Dietary factors: nutrition deficiency
Insulin resistance
Increase CNS irritability
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Pathophysiology
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Central nervous system
Raised BP disrupt autoregulation
Increased permeability due to vasospasm---thrombosis of arterioles, microinfarcts, and petechial hemorrhage
Cerebral edema: increased intracranial pressure
CT scan (1/3-1/2 positive): focal hypodensity
Cerebral angiography: diffuse arterial vasoconstriction
EEG: nonspecific abnormality (75% in eclamptic patient)
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Eyes
Serous retinal detachment Cortical blindness
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Pulmonary system
Pulmonary edema Cardiogenic or noncardiogenic Excessive fluid retention, decreased hepatic
synthesis of albumin, decreased plasma colloid oncotic pressure,
Often occurs postpartum Aspiration of gastric contents: the most
dreaded complications of eclamptic seizures
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Kidneys
Characteristic lesion of preeclampsia: glomeruloendotheliosis
Swelling of the glomerular capillary endothelium
Decreased GFR
Fibrin split products deposit on basement membrane
Proteinuria
Increase of plasma uric acid, creatinine,
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Liver
The spectrum of liver disease in preeclampsia is broad
Subclinical involvement
Rupture of the liver or hepatic infarction
HELLP syndrome: hemolysis, elevated liver enzymes and low platelets
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Cardiovascular system
Generalized vasoconstriction, low-output, high-resistance state
Untreated preeclamptic women are significantly volume-depleted
Capillary leak
Cardiac ischemia, hemorrhage, infarction, heart failure
Increased sensitivity to vasoconstrictor effects of angiotensin
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Blood (1)
Volume: reduced plasma volume Normal physiologic volume expansion
does not occur Generalized vasoconstriction and capillary
leak Hematocrit
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Blood (2): coagulation Isolated thrombocytopenia: <150,000/l Microangiopathic hemolytic anemia DIC (5%) HELLP syndrome: in severe preeclampsia
1. schistocytes on the peripheral blood smear
2. lactic dehydrogenase > 600 u/L
3. total bilirubin > 1.2 mg/dl
4. aspartate aminotransferase >70 U/L
5. platelet count <100,000/mm3
Misdiagnosis: hepatitis, gallbladder disease, ITP
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Endocrine system
Vascular sensitivity to catecholamines and other endogenous vasopressors such as antidiuretic hormone and angiotensin II is increased in preeclampsia
Disequilibrium of prostacyclin/ thromboxane A2
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Placenta perfusion
500 m vs 200 m
Acute atherosis of spiral arteries: fibrinoid necrosis of the arterial wall, the presence of lipid and lipophages and a mononuclear cell infiltrate around the damaged vessel----vessel obliteration---- placental infarction
Fetus is subjected to poor intervillous blood flow
IUGR or stillbirth
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Clinical findings (1)Symptoms and signs
1. Hypertension
Diastolic pressure ≥ 90 mmHg or
Systolic pressure ≥ 140 mmHg or
Increase of 30/15 mmHg
2. Proteinuria
>300 mg/24-hr urine collection or
+ or more on dipstick of a random urine
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Clinical findings (2)
3. Edema
Weight gain: 1-2 lb/wk or 5 lb/wk is considered worrisome
Degree of edema
Preeclampsia may occur in women with no edema
Most recent reports omit it from the definition
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Clinical findings (3)
4. Differing clinical picture in preeclampsia-eclampsia crises: patient may present with
Eclamptic seizures
Liver dysfunction and IUGR
Pulmonary edema
Abruptio placenta
Renal failure
Ascites and anasarca
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Clinical findings (4)
Laboratory findings (1)
Blood test: elevated Hb or Hct, in severe cases, anemia secondary to hemolysis, thrombocytopenia, FDP increase, decreased coagulation factors
Urine analysis: proteinuria and hyaline cast, specific gravity > 1.020
Liver function: ALT and AST increase, alkaline phosphatase increase, LDH increase, serum albumin
Renal function: uric acid: 6 mg/dl, serum creatinine may be elevated
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Clinical findings (5)
Laboratory findings (2)
Retinal check:
Other tests: ECG, placenta function, fetal maturity, cerebral angiography, etc
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Differential diagnosis
Pregnancy complicated with chronic nephritis
Eclampsia should be distinguished from epilepsy, encephalitis, brain tumor, anomalies and rupture of cerebral vessel, hypoglycemia shock, diabetic hyperosmatic coma
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Complications
Preterm delivery
Fetal risks: acute and chronic uteroplacental insufficiency
Intrapartum fetal distress or stillbirth
IUGR
Oligohydramnios
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Predictive evaluation (1)
1. Mean arterial pressure, MAP= (sys. Bp + 2 x Dia. Bp) /3
MAP> 85 mmHg: suggestive of eclampsia
MAP > 140 mmHg: high likelihood of seizure and maternal mortality and morbidity
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Predictive evaluation (2)
2. Roll over test: ROT
Preeclamptic patients are more sensitive to angiotensin II
Difference between Bp obtained at left recumbent position and supine position (at a 5 min interval)
Positive: > 20 mmHg
3. Urine calcium/ creatinine < 0.04
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Prevention
Calcium supplementation: not effective in low risk women bur show effect in high risk group
Aspirin (antithrombotic): uncertain
Good prenatal care and regular visits
Baseline test for high-risk women
Eclampsia cannot always be prevented, it may occur suddenly and without warning.
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Treatment
A. Mild preeclampsia: bed rest & delivery Hospitalization or home regimen Bed rest (position and why) and daily weighing Daily urine dipstick measurements of proteinuria Blood pressure monitoring Fetal heart rate testing Periodic 24-h urine collection Ultrasound Liver function, renal function, coagulation
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A. Mild preeclampsia: bed rest & delivery
Observe for danger signals: severe headache, epigastric pain, visual disturbances
Sedatives: debatable
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B. Severe preeclampsia:
Prevention of convulsion: magnesium sulfate or diazepam and phenytoin
Control of maternal blood pressure: antihypertensive therapy
Initiation of delivery: the definitive mode of therapy if severe preeclampsia develops at or > 36 wk or if there is evidence of fetal lung maturity or fetal jeopardy.
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Magnesium sulfate
1. Decreases the amount of acetylcholine released at the neuromuscular junction
2. Blocks calcium entry into neurons
3. Vasodilates the smaller-diameter intracranial vessels
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Magnesium sulfate
1. Prevent convulsion
2. Virtually ineffective on blood pressure
3. i.v. or i.m. 5g loading dose 5-10 min, i.v. 1-2g/hr constant infusion Total dose: 20-30 g/d
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Toxicity: Diminished or loss of patellar reflex Diminished respiration Muscle paralysis Blurred speech Cardiac arrest
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How to prevent toxicity?
Frequent evaluation of patellar reflex and respirations
Maintenance of urine output at >25 ml/hr or 600 ml/d
Reversal of toxicity:
1. Slow i.v . 10% calcium gloconate
2. Oxygen supplementation
3. Cardiorespiratory support
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Antihypertensive therapy: reduce the Dia. pressure to 90-110 mmHg
Indication Bp> 160/110 mmHg
Dia. Bp > 110 mmHg
MAP > 140 mmHg
Chronic hypertension with previous antihypertensive drugs usage
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Antihypertensive therapy
Medications: Hydrolazine: initial choice
Labetolol
Nifedipine
Nimoldipine
Methyldoe
Sodium nitroprusside
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Medication Mechanism of action
Effects
hydralazineDirect peripheral vasodilation
CO, RBF maternal flushing, headache, tachycardia
labetalol adrenergic blocker
CO, RBF maternal flushing,headache, neonatal depressed respirations
nifedipineCalcium channel blocker
CO, RBF maternal orthostatic hypotensionHeadache, no neonatal effects
methyldopaDirect peripheral arteriolar vasodilation
CO, RBF maternal flushing,headache, tachycardia
sodium nitroprusside Direct peripheral vasodilation
Metabolite (cyanide) toxic to fetus
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Plasma expander Diuretics
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Delivery
Indication of termination of pregnancy
1. Preeclampsia close to term
2. <34 wk with decreased placental function
3. 2 hs after control of seizure
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Delivery
Induction of labor
1. First stage: close monitor, rest and sedation
2. Second stage: shorten as much as possible
3. Third stage: postpartum hemorrhage
Cesarean section
1. Induction of labor unsuccessful
2. Induction of labor not possible
3. Maternal or fetal status is worsening
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Eclampsia
No aura preceding seizure
Multiple tonic-clonic seizures
Unconsciousness
Hyperventilation after seizure
Tongue biting, broken bones, head trauma and aspiration, pulmonary edema and retinal detachment
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Management
Control of seizure Control of hypertension Delivery Proper nursing care