Hybrid Fluorescence Molecular Tomography– X-ray Computed Tomography method and system

Administrative + Financial Aspects • Project Overview

• Reporting

• Deliverables & Milestones

Veronika Erben

HHybridybrid FFluorescenceluorescence MMolecularolecular TTomographyomography –– XX--rayray CComputedomputed TTomographyomography method and systemmethod and system

Acronym: FMT-XCT

Collaborative project: Small or medium-scale focused research project

Grant agreement No: 201792

Starting date: 1st March 08

Duration: 4 years

Funding: European Commission- FP7

Funding rate: € 4.5 Mio

Partners/Beneficiaries FMT-XCT

University College London

Commissariat a L’Energie Atomique

Fudacion para la Investigacion Biomedica del Hospital Gregorio Marañon

Verfahren und Apparate derMedizinischen Physik

Technische Universität München

Executive CommitteeExecutive CommitteeHMGU/TUM: Prof. Vasilis Ntziachristos (WP1,5,9)

CEA-Leti: Prof. Philippe Rizo (WP2)

Forth: Dr. Jorge Ripoll( WP3)

UCL: Prof. Simon Arridge (WP4)

CEA-Lime: Prof. Bertrand Tavitian (WP6)

UZH: Prof. Markus Rudin (WP7)

FIHGM: Dr. Juan Jose Vaquero (WP8)

Vamp: Dr. Holger Brünner

Executive CommitteeExecutive CommitteeHMGU/TUM: Prof. Vasilis Ntziachristos (WP1,5,9)

CEA-Leti: Prof. Philippe Rizo (WP2)

Forth: Dr. Jorge Ripoll( WP3)

UCL: Prof. Simon Arridge (WP4)

CEA-Lime: Prof. Bertrand Tavitian (WP6)

UZH: Prof. Markus Rudin (WP7)

FIHGM: Dr. Juan Jose Vaquero (WP8)

Vamp: Dr. Holger Brünner

ReasearchersReasearchersDr. Ralf Schulz, Dr. Marta Zientowska, Anelique Ale, Dr. Giannis Zacharakis, Dr. Veronique Rebuffel, Dr. Alejandro Sisniega, Dr. Manuel Desco, Marco Brambilla, Dr. T. Rudge, Dr. V.Soloviev, Dr. J.Elisee, Dr. Juan Aguirre, Dr. Judith Chamorro, Dr. Katerina Dikaiou, Dr. Sandra Bürki, Dr. Florian Stuker, Dr. Garafolakis Anikotos and others

ReasearchersReasearchersDr. Ralf Schulz, Dr. Marta Zientowska, Anelique Ale, Dr. Giannis Zacharakis, Dr. Veronique Rebuffel, Dr. Alejandro Sisniega, Dr. Manuel Desco, Marco Brambilla, Dr. T. Rudge, Dr. V.Soloviev, Dr. J.Elisee, Dr. Juan Aguirre, Dr. Judith Chamorro, Dr. Katerina Dikaiou, Dr. Sandra Bürki, Dr. Florian Stuker, Dr. Garafolakis Anikotos and others

Advisory CommitteeAdvisory Committee

Prof. Markus Schwaiger – TUM

Prof. Clemens Lowik – Leiden University

Prof. Chrit Moonen – University Victor Segalen Bordeaux

Advisory CommitteeAdvisory Committee

Prof. Markus Schwaiger – TUM

Prof. Clemens Lowik – Leiden University

Prof. Chrit Moonen – University Victor Segalen Bordeaux

Coordinator: HMGUCoordinator: HMGU Project leader: Prof. Vasilis Ntziachristos Project manager: Dr. Veronika Erben

Coordinator: HMGUCoordinator: HMGU Project leader: Prof. Vasilis Ntziachristos Project manager: Dr. Veronika Erben

= Consortium

European CommissionProject officer: Dr. Torbjoern Ingemannson

Management structure

Management Support Management Support TeamsTeams

Project management office

Financial departments

Legal departments

Communication /press

Management Support Management Support TeamsTeams

Project management office

Financial departments

Legal departments

Communication /press

Reporting ScheduleReporting Schedule4 Year Collaborative Project with 4 Reporting Periods4 Year Collaborative Project with 4 Reporting PeriodsWork packagesWork packages

TECHNICAL DEVELOPMENT IN-VIVO ALGORITHMIC TRAINING & PRE-CLINICAL IMAGING

Cancer imaging with focus on breast cancer imaging (Wp6)WP leader CEA-Lime

Imaging Cancer Therapy for enabling

intervention (Wp7)WP leader: UZH

MANAGEMENT (Wp1) WP leader: HMGU

Theory for 360 degree FMT (Wp3)WP leader: FORTH

FMT Inversion with priors (Wp4)

WP leader: UCL

FMT-XCT integration (Wp5)

WP leader: HMGU

TRAINING, DISSEMINATION &TECHNOLOGY TRANSFER (Wp9) WP leader: HMGU

XCT Development (Wp2)WP leader: CEA-Leti

FMT-XCT Imaging accurancy vs PET-XCT (Wp8)WP leader: FIHGM

Report

Reporting ScheduleReporting Schedule4 Year Collaborative Project with 4 Reporting Periods4 Year Collaborative Project with 4 Reporting Periods

12 months

Officia

l sta

rting

date:

Mar

ch 01

,2008

t

Febru

ary 2012

Febru

ary 2011

Reporting ScheduleReporting Schedule

Febru

ary 2009

Febru

ary 2010

• Periodic report (WP and Management report) + financial report

• 60 days after the end of each reporting period • No incomplete reports

12 months 12 months 12 months

+60

days

Report Report Report

ReportingPeriod

1

ReportingPeriod

2

ReportingPeriod

3

ReportingPeriod

4

Activity report:

1. Publishable summary

2. Project objectives for the reporting period

3. Work progress and achievements during the period:

For each work package -- except project management

4. Deliverables and Milestones tables

5. Project Management

6. Explanation of the use of the resources

Periodic reportPeriodic reportbased on Annex Ibased on Annex I

3. Work progress and achievements during the period/WP

• Summary and Progress towards objectives• Technical appendix (can also include deliverables)

4. Deliverables and Milestones tables• Deliverables that are of a nature other than written "reports", such as

"prototypes", "demonstrators" or "others", should also be accompanied by a short report, so that the European Commission has a record of their existence

6. Explanation of the use of the resources/Partner• More detailled as Form Cs

Reporting ScheduleReporting Schedule4 Year Collaborative Project with 4 Reporting Periods4 Year Collaborative Project with 4 Reporting Periods

Periodic reportPeriodic report based on Annex Ibased on Annex I

Financial reporting

Financial ReportFinancial ReportForm CsForm Cs

Form Cs: Excel table

FORCE WEB BASED EDITOR

OF FORMS C FOR FP-6 AND FP-7

FORCE WEB BASED EDITOR

OF FORMS C FOR FP-6 AND FP-7

Online reporting tool

FORCE WEB BASED

EDITOROF FORMS C FOR

FP-6 AND FP-7

FORCE WEB BASED

EDITOROF FORMS C FOR

FP-6 AND FP-7

Online reporting tool

• Coordinators can registering via SESAM

• Only the coordinator should have access and submit Forms C to the Commission

• Next version: individual access/Partner

Financial report Financial report FORCEFORCE

FORCEFORCEFORM C EDITOR FORM C EDITOR

register as a new user in SESAM/FORCE

FORCEFORCEFORM C EDITOR FORM C EDITOR

register as a new user in SESAM/FORCE

Financial reportFinancial reportFORCEFORCE

Description available how to register and use FORCE http://webgate.ec.europa.eu/sesam/index.do;jsessionid=V2XyJk0Ybcn8vLG803x1YPQJq1dPQSnhJLky6vWZ1dT3DG24MCLL!-1976463397!-1882849135

     

Total EC contributionTotal EC contributiondue to Annex1 [€]due to Annex1 [€]

August 08August 08[€][€]

April/MayApril/May[€][€]

July/AugustJuly/August[€][€]

1 HMGU 1.294.102 323.525 129.410 ?

2 CEA 1.212.389 303.097 121.239 91.026

3 FORTH 488.550 122.137 48.855 42.742

4 UCL 409.600 102.400 40.960 43.165

5 FIBHGM 478.400 119.600 47.840 138.900

6 UZH 365.600 91.400 36.560 36.260

7 VAMP 263.500 65.875 26.350 24.049

TOTAL 4.512.141 1.128.034 451.214

1st

prefinancing

2nd

prefinancing

spent in

year 1 (F

orm C)

Payment SchedulePayment Schedule

• Transfer between activities (RTD, Management, Other) possible; should be clarified EC

•A certificate on the financial statements (certificate of the accounting system) is only required when the amount of financial contribution is equal to or superior to EUR 375 000

• Money can be transfered to next year

Payment SchedulePayment Schedule

audit

• + 5 years after end of the project• time sheets

AuditAudit

• Next consortium meeting mo 24 = Feb.2010 (Where? When?)

WP1 ManagementWP1 Management

Deliverable No

Name Month

1.1 Consortium Agreement March `08

1.2 Minutes of the kick off meeting March `08

1.3 Project website and updates Feb. `09, Feb. `10, Feb. `11

1.4 Program of the consortium meetings Feb. `09, Feb. `10, Feb. `11

1.5 Half time report Feb. `10

WP2 XCT DevelopmentWP2 XCT Development

--LETILETI

• Milestone No 5 (mo 18= August 09): XCT dual energy vs. contrast enhancement

Deliverable No Name Month

2.1 XCT design March ` 08 Nov ` 08

2.2 Dual energy protototype May `09 Dec`09

2.3 Dual energy processing software May `09 Aug. `09

2.4 Preliminary technical specifications Aug.`09

2.5 Scattered energy measurements Nov. `09

2.6 Comparison of contrast enhancing strategies Feb. `10

2.7 Final technical specification for XCT system Feb. `10

WP3: Theory for 360 degree FMTWP3: Theory for 360 degree FMT

• Milestone No. 4 (month 15 = May 09): Direct vs Conventional FMT performance

* New Deliverable „Ultra- fast Inversion for FMT“ month 24=Feb. 10

Deliverable No Name Month

3.1 Direct inversion algorithm for fluorescence implementing boundary removal principles

Nov`09

3.2 Experimental training set measurements to serve as a training set for algorithmic optimization

Feb. `09

3.3 Quantitative evaluation of direct inversion performance vs established FMT inversion methods

Aug. `09

3.4 Multi-spectral algorithm Nov. `09

3.5 User friendly software environment Feb.`10

WP4: FMT inversion with image priorsWP4: FMT inversion with image priors

• Milestone No 6 (month 21 = Nov 09): Optimal FMT inversion with priors

Deliverable No Name Month

4.1 Inversion algorithms for improving recontruction Nov. `09, May `10

4.2 Quantification of algorithmic performance with simulated data Nov.`09

4.3 Inversion algorithms to determine the optical attenuation of different organs/tissues

Feb.`10

4.4 An automatic feature extraction algorithm Feb.`10

WP5: FMT –XCT integrationWP5: FMT –XCT integration

• Milestone No 8 (mo 24 = Feb. `10) : FMT-XCT Shielding

Deliverable No Name Month

5.1 360 degree FMT prototype Feb. `09

5.2 Optimal settings May `09

5.3 Gantry delopment Feb. `10

WP6: Cancer imaging with focus on breast cancerWP6: Cancer imaging with focus on breast cancer

Deliverable No Name Month

6.1 LIME To develop and characterize molecular probes Nov.`09, Aug. `10

6.2 LIME/HMGU?

Prepare mammary tumor animal models (lung and brain cancer)

Aug. `10

6.3 LIME Breed and make available PyMT animal models Feb. `10

Lime

WP7: Imaging cancer therapy for enabling interventionWP7: Imaging cancer therapy for enabling intervention

Deliverable No Name Month

7.1 Preparation of HIF transfected cancer cells Nov. 08

7.2

FMT of HIF induction of breast tumors May 09

WP8: FMT-XCT imaging accuracy vs. WP8: FMT-XCT imaging accuracy vs. PET-XCTPET-XCT

Deliverable No Name Month

8.1 Construct imaging phantoms Feb. `09

8.2 Phantom characterization with PET, FMT and XCT and appropriate probes

Feb.`10

, WP9: Training & DisseminationWP9: Training & Dissemination

Deliverable No Name Month

9.2 Training curriculum and implementation document

Feb.`09

• CEA-LETI will house a training session on XCT on mo.12 Veronique Rebuffel: May/June 09

• Crete will house a training session jointly with UCL on free-space FMT on mo. 24 (=Feb. 10)

Thank you for your attention!