Humoral & cellural immunity done
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Transcript of Humoral & cellural immunity done
CELLS OF THE IMMUNE SYSTEM
Differentiation of Stem cells into B cells and T cells
Bursa of Fabricius
CELLS OF THE IMMUNE SYSTEM
Cells of the Immune System
Immune System
Myeloid Cells Lymphoid Cells
Granulocytic Monocytic T cells B cells
NeutrophilsBasophils
Eosinophils
MacrophagesKupffer cells
Dendritic cells
Helper cellsSuppressor cellsCytotoxic cells
Plasma cells
NK cells
Characteristics of B cells, T cells and Macrophages
CD4 (TH ) : MASTER REGULATOR• INFLUENCE functions of all cells of
immune system FUNCTIONALY TH1 TH2• IL 2, IF gamma IL4, 5,6,1O• Cytotoxic, Inflamm B cell
proliferation• Intracellular pathogens Ab production
viruses extracellular pathog
• Cell mediated imm Humoral immunity• Facilitate type lV hypersensitivity
MACROPHAGES
•HUMORAL IMMUNITY
B CELL PROLIFERATION
MARKERS: B LYMPHOCYTES
• B- LYMPHOCYTES• MATURE : Ig on surface– IgM, IgD Fc portion of IgG, C3, EB virus• IMMATURE CELLS Pre-B cells– u chains in
cytoplasm
CLONAL SELECTION The four basic principles of the clonal selection hypothesis
Each lymphocyte bears a single type of receptor of a unique specificity
Interaction between a foreign molecule and a lymphocyte receptor capable of binding that molecule with high affinity leads to lymphocyte activation
The differentiated effector cells derived from an activated lymphocyte will bear receptors of an identical specificity to those of the parental cell from which
that lymphocyte was derived
Lymphocytes bearing receptors specific for self molecules are deleted at an early stage in lymphoid cell development and are therefore absent from the repertoire of
mature lymphocytes
CLONAL SELECTION
UNIQUE SPECIFICITY
LYMPHOCYTE
ACTIVATION
DIFFERENTIATED
EFFECTOR CELL
Summary of Humoral Immunity
HUMORAL IMMUNE RESPONSE (Cooperation of cells)
B-CELL AS ANTIGEN PROCESSING CELL
•CELL MEDIATED IMMUNITY
MARKERS:T LYMPHOCYTES
• T- LYMPHOCYTES: MATURE CELLS• Surface antigens detected by Specific
monoclonal antibodies--- CLUSTER DIFFERENCIATION : CD T- helper cells: TH– CD4+
T- delayed type :TD – CD4- T- suppressor cells: TS– CD8-
T – cytotoxic type: TC– CD8+ MHC CLASS 1= CD8 MHC CLASS II=CD4• T - IMMATURE CELLS Prothrombocytes – Tdt – terminal
deoxynucleotidyl Immature thrombocytes -- Tdt
transferase
• CD4 (TH ) : MASTER REGULATOR • INFLUENCE functions of all cells of immune
system FUNCTIONALLY TH1
IL 2, IF gamma
Cytotoxic, Inflammatory
Intracellular pathogens
Cell mediated immunity Facilitate
type lV hypersensitivity
Macrophages activation
Synthesis of IgG2 Antibodies
TH2
IL4, 5, 6,10
B cell proliferation
Extracellular pathogensHumoral immunitySynthesis of other IgIncluding IgE.
T- CELL RECEPTOR (TCR)
CMI -- CLONAL EXPANSION
Cell Mediated Immunity
Summary of cell mediated immunity
ACTIVATION OF HELPER T CELL
ACTIVATION OF CYTOTOXIC T CELL
CYTOTOXIC T CELLS
COMPARISON OF HUMORAL :CELL MEDIATED IMMUNE
RESPONSE
THANKS
CLONAL PROLIFERATION OF T CELLS