1 Human chromosomes: 50->250 million base pairs. Average gene: 3000 base pairs.
Humans have 23 pairs of chromosomes (total of 46 .
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Transcript of Humans have 23 pairs of chromosomes (total of 46 .
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• Humans have 23 pairs of chromosomes (total of 46.
• One pair of
chromosomes is related to the sex of an individual , these chromosomes are called sex chromosomes
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• Other 22 pairs of chromosomes are called autosomes (1-22)
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Blood Types-what’s the difference?
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Blood Donation ChartType O can’t receive any other blood type, but can be given to any other blood type.
Universal Donor is a type of blood that can be given to any other type because it has no antigens on its surface .
Type AB can receive all other blood types because it has A and B antigens.
Universal Receptor
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Codominant: A condition in which both alleles are expressed
phenotypically• Blood Typing:• A, B are codominant• O is recessive to A or B• IAIA, IBIB are pure breed/homozygous• ii is 0• IAIB is the codominant heterozygous• IAi or IBiare the heterozygous pattern.
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Codominant/Recessive Blood Typing
IA
i
IB i
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• In humans, the sex of kid depends on the presence or absence of the Y chromosome
XX = female
XY = male
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• Genes that are located on the X or Y chromosome are called sex-linked genes. There are many more traits on the X
• Traits determined by sex-linked genes are called sex-linked traits
(c = colorblind, C = normal)
Ex. Color blindnessfemale Xc Xc
male Xc Y
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Are you colorblind?
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• Most sex linked traits are recessive, this means both x chromosomes must have the gene in order for the trait to be expressed.
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Inheritance of X-linked recessive traits
• Hemophiliac female: Xh Xh
– must inherit recessive alleles from both parents
– Rare: 1 in 100,000,000• Hemophiliac male: XhY
– only inherit from mom (dad donates Y chromosome)
– Much more common: 1 in 10,000
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A hemophilia carrier x a normal male
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• If only one x chromosome is present (in males)and has the sex linked gene, then the trait will be expressed
• Sex-influenced traits are traits that have a different expression in males and females.
• Examples of Sex-linked:• Color blindness, hemophila, muscular dystrophy• Examples of sex-influenced:• Male pattern baldness
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• A carrier is a person that has the trait on only one chromosome and does not express the trait.
• Only females can be carriers of sex linked traits.
(C= normal, c= colorblind)
Ex. Color blind carrier XC Xc
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• A colorblind male marries a normal female. What are the offspring genotypes and phenotypes? (C = normal, c = colorblind)
Xc YXC
XC
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• A colorblind male marries a normal female. What are the offspring genotypes and phenotypes?
(C = normal, c = colorblind)
Xc Y XC XC Xc XC Y XC XC Xc XC Y
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• A normal male (not colorblind) marries a carrier. What are the offspring genotypes and phenotypes?
XC Y XC
Xc
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• A normal male (not colorblind) marries a carrier. What are the offspring genotypes and phenotypes?
XC Y XC XC XC XC Y
Xc Xc Xc Xc Y
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• A normal male (not colorblind) marries a colorblind female. What are the offspring genotypes and phenotypes?
XC Y Xc
Xc
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• A normal male (not colorblind) marries a colorblind female. What are the offspring genotypes and phenotypes?
XC Y Xc XC Xc Xc Y
Xc XC Xc Xc Y
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Comparison to autosomal traits
• Recessive autosomal traits require that all individuals (males and females) inherit two recessive copies in order to exhibit the recessive phenotype.
• Inherit one recessive allele from mom and one from dad
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Example: Cystic Fibrosis• A recessive trait whose gene is
located on an autosome (a chromosome that is not a sex chromosome).
• CFTR gene is responsible for making a protein that controls movement of salt and water into and out of cells– C: makes normal-functioning
protein– c: makes disfunctional protein
• Leads to thick, sticky mucus that damages lungs
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• Hemophilia is characterized by uncontrolled bleeding
• It is a sex linked disorder caused by errors in the DNA that codes for the proteins involved in clotting