Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

65
Human s in 2020 Ramez Naam @ramez

description

Ramez Naam Humanity 2020: The Next 10 Years of Human Development The decade between 2010 and 2020 will be a small but significant step in the development of human enhancement technology, with tremendous numbers of new discoveries in genetics fueled by the continuing exponential drop in gene sequencing cost, commercial availability of a new generation of cognitive enhancers and the first plausible aging inhibitors, likely advances in genetic reprogramming of embryos and of mature humans, and continued progress in prosthetics, imaging, sports enhancement, and numerous other areas. Science and technology will have made significant strides in empowering individuals to be smarter, stronger, faster, and longer lived than ever before. Computer scientist Ramez Naam, author of More Than Human: Embracing the Promise of Human Enhancement, and winner of the 2005 H.G. Wells Award for Contributions to Transhumanism will give a guided tour of the 10 year horizons across the board of human enhancement.

Transcript of Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Page 1: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Humansin

2020Ramez Naam

@ramez

Page 2: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Three Ingredients

Motive Opportunity Means

Page 3: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

•Why Would We Transform Humans?

•Why Even Invest in the R&D?

Motive•Wh

at’s Possible to Change?

Opportunity

•How Do We Actually Change a Human?

Means

Page 4: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Motivation is Medical

Page 5: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Human Baseline

Acceptable

Page 6: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Human Baseline

Questionable!

?

Page 7: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Page 8: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

External != Internal

Page 9: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Human Baseline

?

?

Page 10: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

The Power to Heal=

The Power to Enhance

Page 11: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Our Population is Aging

Page 12: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

A Worldwide Phenomenon

Page 13: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Page 14: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Disability as a Function of Age

Page 15: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Lost With Age

Mental

Memory

Speed

Problem Solving

Learning Rate

Physical

Strength

Cardio Fitness

Recovery

Metabolism

Appearance

Fertility

Sensory

Eyesight

Hearing

Touch

Taste

Balance

Page 16: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

A Very Large Motivator

Page 17: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Order: Trillions of $’s

Page 18: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Ten Thousand Dollars

Page 19: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

One Million Dollars

Page 20: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

One Billion Dollars

Page 21: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

One Trillion Dollars

You Are Here

Page 22: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Page 23: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

So What?

Page 24: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Opportunity?

Page 25: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Knowledge

Page 26: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Understanding

Page 27: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Human Construction

Page 28: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Page 29: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Page 30: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Page 31: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Page 32: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Goal: 100,000 Genomes by 2020

Page 33: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

2020: $100 Genome

Page 34: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Millions of Genomes Sequenced

Page 35: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Millions of Individual Humans

Page 36: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Every Mammalian Species

Page 37: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Lots of Data to Mine

Page 38: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Page 39: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

What Will We Find?Trait Genetic Component in USA

Height 87%

Skin, Eye, Hair Color 90+%

Weight, Body Fat, Obesity 50%

Muscular Strength 35-55%

Longevity 25-30%

IQ 52%

Extroversion/Introversion 53%

Openness to Experience 61%

Conscientiousness 41%

Page 40: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Page 41: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Knowing is Half the Battle

Page 42: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

The Other Half is Doing

Page 43: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

If the Genome is Digital

Page 44: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Can We Edit It?

Page 45: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Sometimes

Page 46: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Page 47: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Page 48: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Page 49: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Page 50: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Some Challenges

Page 51: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Immune Response

Page 52: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Cancer (from retroviral vectors)

Page 53: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Number of Cells Changed

Page 54: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Progress

Page 55: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Page 56: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Page 57: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Page 58: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Strength & Endurance: IGF-1, Myostatin, PPAR-Delta

Page 59: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Oxygen Capacity: EPO

Page 60: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

“About half the emails I get now are from athletes” - Gene Therapy Researcher Lee Sweeney

Page 61: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

More Provocative Changes are Likely Possible

Page 62: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

In Summary

Page 63: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

We Are Approaching the Day of the Editable Genome

Page 64: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

•Huge Medical Needs and Market in an Aging Population

Motive

•Will Become Evident from the Digitization of Biology

Opportunities

•Printing Genes, and Editing Through Gene Therapy (The Hard Part)

Means

Page 65: Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

Humansin

2020Ramez Naam

@ramez