HUMAN HEART DEVELOPMENT - Columbia University · INTRODUCTION TO HUMAN HEART DEVELOPMENT Debbie...
Transcript of HUMAN HEART DEVELOPMENT - Columbia University · INTRODUCTION TO HUMAN HEART DEVELOPMENT Debbie...
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INTRODUCTION TO HUMAN
HEART DEVELOPMENT
Debbie Yelon
Developmental Genetics Program
Department of Cell Biology
Skirball Institute, NYU School of Medicine
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HUMAN HEART DEVELOPMENT
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POSTNATAL CIRCULATION
PULMONARY CIRCULATION
RIGHT CHAMBERS
SYSTEMIC CIRCULATION
LEFT CHAMBERS
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HUMAN HEART DEVELOPMENT
• HEART TUBE FORMATION
• CARDIAC LOOPING
• CHAMBER SEPTATION
• VALVE AND OUTFLOW FORMATION
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CONGENITAL HEART DISEASE
• RELATIVELY COMMON
• GENERALLY INITIATED BY EARLY
DEVELOPMENTAL ERRORS
• CAN BE CAUSED BY EXPOSURE TO
TERATOGENS
• CAN ORIGINATE WITH GENETIC
DEFECTS
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LONGITUDINAL FOLDING
POSITIONS CARDIAC CELLS
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LATERAL FOLDING
FACILITATES TUBE FORMATION
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TUBE FORMATION BEGINS
ROSTRALLY
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PRIMITIVE HEART TUBE
SINUS VENOSUS
BULBUS CORDIS
PRIMITIVE VENTRICLE
TRUNCUS ARTERIOSUS
PRIMITIVE ATRIUM
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CARDIAC LOOPING
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CARDIAC LOOPING
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DEXTROCARDIA AND
SITUS INVERSUS
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GENETIC BASIS FOR
HETEROTAXY
• NODAL FAMILY OF GROWTH FACTORS
REQUIRED FOR ESTABLISHMENT OF LEFT-
RIGHT AXIS
• CFC1 GENE ENCODES A COMPONENT OF THE
RECEPTOR FOR NODAL FACTORS
• MUTATIONS IN CFC1 CAUSE HETEROTAXY
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FROM FETAL TO
POSTNATAL CIRCULATION
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PARTITIONING THE HEART
• ATRIAL SEPTATION
• VENTRICULAR SEPTATION
• ATRIOVENTRICULAR VALVE FORMATION
• DIVISION OF THE OUTFLOW TRACT
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SAGITTAL
SECTIONS
CORONAL
SECTIONS
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ATRIAL SEPTATION I:
SEPTUM PRIMUM
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ATRIAL SEPTATION II:
FORAMEN SECUNDUM
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ATRIAL SEPTATION III:
SEPTUM SECUNDUM
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ATRIAL SEPTATION IV:
COMPLETION
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ATRIAL SEPTAL DEFECTS
NORMAL OSTIUM SECUNDUM
(HIGH) ASD
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GENETIC CAUSES OF ASD
HETEROZYGOSITY OF MUTATIONS IN
GENES LIKE:
– Nkx2-5, ENCODING A HOMEODOMAIN
TRANSCRIPTION FACTOR
– TBX5, ENCODING A T-BOX
TRANSCRIPTION FACTOR (HOLT-
ORAM SYNDROME)
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BEGINNING OF
VENTRICULAR SEPTATION
Plane of section D
Fused endocardial
cushions Fused endocardial cushions
Developing interventricular septumArrow passing through
right atrioventricular canal
Septum primum
Sinoatrial valve guarding
orifice of sinus venosus
Foramen primum
Left atrioventricular canal
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PROGRESSION OF
VENTRICULAR SEPTATION
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COMPLETION OF
VENTRICULAR SEPTATION
MUSCULAR SEPTUM
MEMBRANOUS SEPTUM
CONOTRUNCAL SEPTUM
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MEMBRANOUS VSD
NORMAL VSD
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ENDOCARDIAL CUSHION
FORMATION
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VALVE FORMATION
Cusps of mitral valve
Chordae tendineae
Papillary muscle
Cusps of
tricuspid valve
Developing
mitral valve
Membranous part of
interventricular septum
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OUTFLOW SEPTATION
Aorta
Pulmonary trunk
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OUTFLOW SEPTATION
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DEFECTS IN OUTFLOW SEPTATION
NORMAL
NO SEPTUM:
PERSISTENT
TRUNCUS
ARTERIOSUS
ASYMMETRIC
SEPTUM:
PULMONARY
STENOSIS;
TETRALOGY OF
FALLOT
STRAIGHT
SEPTUM:
TRANSPOSITION
OF GREAT
VESSELS
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NEURAL CREST AND
OUTFLOW TRACT SEPTATION
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GENETIC BASIS FOR
OUTFLOW DEFECTS
• TBX1 ENCODES A TRANSCRIPTION FACTOR
EXPRESSED NEAR MIGRATING NEURAL CREST
CELLS
• TBX1 MUTATION IN MICE CAUSES DEFECTS
RESEMBLING DIGEORGE SYNDROME
• DELETION OF TBX1 FOUND IN MANY DIGEORGE
SYNDROME PATIENTS
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HUMAN HEART
DEVELOPMENT
• HEART TUBE FORMATION
• CARDIAC LOOPING
• CHAMBER SEPTATION
• VALVE AND OUTFLOW FORMATION
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SINUS VENOSUS AND
RIGHT ATRIUM
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PULMONARY VEINS AND LAPulmonary veins
Primordial left atrium
Part of left atrium formed from
absorbed pulmonary vein tissue
Primordial pulmonary vein
Primordial left atrium
Primordial left atrium
Entrance of four pulmonary veins
Smooth-walled part of left atrium
Right and left pulmonary veins
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ATRIAL SEPTAL DEFECTS
• OSTIUM PRIMUM (LOW) ASD
• OSTIUM SECUNDUM (HIGH) ASD
• SINUS VENOSUS ASD
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End