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Transcript of Human Diseases Introduction: Chapter 1. Definitions Disease Disorder or cessation of body functions,...
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Human Diseases
Introduction: Chapter 1
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DefinitionsDisease
Disorder or cessation of body functions, systems or organs having at least 2 of the following:
Recognized etiologyIdentifiable group of symptoms and signsConsistent anatomic alteration
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DefinitionsIllness
Condition of the patient experiencing the disease
SyndromeGroup of signs & symptoms associated with any disease that together constitute a picture of that disease
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DefinitionsSymptom
Complaints of the patientSubjectiveAbdominal pain, shortness of breath, etc.
SignPhysical findingsObjectiveLabored respirations, pallor, etc.
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Disease CategoriesAccording to etiology (cause)
Infectious, traumatic, hereditary, etc
According to body system involvedCardiac, respiratory, dermatologic, etc
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Disease CategoriesAcute vs. chronicMultiple system vs. single systemFocal vs. diffuseOrganic vs. psychologicalAge group (pediatric vs. geriatric)
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How a diagnosis is madeSOAP formatS = subjective = symptoms
Patient complaints and observations
O = objective = signsPhysical exam, tests by examiner
A = assessment (suspected diagnosis)
Differential diagnoses
P = plan (further tests & treatment)
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EtiologyThe cause of the diseaseMany diseases are multifactorial
More than one causal factorAdult onset diabetes, addictions
Predisposing factors:Condition making a person more susceptible to developing a diseaseHypertension, diabetes, colon polyps, etc
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Hereditary DiseasesDue to abnormalities of DNA or chromosomesNot the same as congenital disease
Recognizable at birth
May affect any or multiple organ systems, various severitiesMay not be apparent at birth
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Terminology: GeneticsChromosome
23 pairs, counting 2 sex chromosomes
HomozygousHeterozygousGenotypePhenotypeMutation
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Hereditary Diseases: Categories
Mendelian alterationsOne gene involved
Chromosomal alterationsPart or all of a chromosome involvedMultiple genes involved
Multifactorial errors
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Mendelian DisordersMutation in a single geneSubcategories:
RecessiveDominantSex-linkedAutosomal
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Mendelian DisordersAutosomal disorders
Two identical copies of a gene existRecessive disease
Will not manifest if there is at least one normal copy of the gene
Dominant diseaseWill manifest if there is even one abnormal copy of the gene
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Autosomal Disorders: Examples
Autosomal RecessiveCystic fibrosis, Tay-Sachs disease, PKU, cretinism, sickle cell anemia
Autosomal DominantDiabetes insipidus, retinoblastoma
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Other Mendelian DisordersSex-linked or X-linkedHemophiliaDuchenne’s Muscular Dystrophy
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Hereditary Diseases: Chromosomal
Abnormalities in chromosome number or chromosome structureMechanisms of these alterations:
AdditionsDeletionsTranslocations
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Chromosomal Diseases: Examples
Trisomy 21 (Down Syndrome)Klinefelter’s Syndrome (XXY)Turner’s Syndrome (missing X)
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Disease Category: Inflammatory
InflammationCascade of numerous chemical reactionsIncrease local WBC and edema
Acute or chronicResponse to many stimuli
Physical agents, toxins, infections, trauma, allergens, chemicals
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Inflammatory DiseasesSigns and Symptoms
EdemaErythemaPain/tendernessWarmthVariable loss of function
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Disease Category: Infectious
Infection:Invasion and multiplication of pathogenic organisms in the body
Bacteria, viruses, rickettsiae, fungi, protozoa, parasites
Vs. non-pathogenic organismsOvergrowth = pathological
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Infectious AgentsBacteria (bacterium)
Single celled organism capable of reproduction, DNA, RNA, & protein synthesis.Gram negative or gram positive in colorCocci, bacilli, or spiral in shapeMay be pathogenic or nonpathogenic
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Infectious AgentsRickettsiae (rickettsia)
A genus of bacteria (Rickettsiales)Obligate intracellular parasitesArthropod vectors usuallyTyphus, Rocky Mtn. Spotted Fever, etc
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Infectious AgentsProtozoa
Unicellular animal-like microorganismsPhylum ProtistaSaprophytes often
Live on dead tissue
Fecal-oral route, food or water contaminated with cysts/spores, insect biteMalaria, giardia, sleeping sickness
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Infectious AgentsVirus
Smallest microorganismsA nucleic acid inside a protein shellReproduces only after infecting host cellClassified by
DNA vs. RNAReproductive method (retrovirus)Mode of transmission (enterovirus)Etc.
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Infectious AgentsFungi (fungus)
Yeast, mold, or mushroomBelongs to the kingdom FungiCandidiasis, Valley Fever, aspergillosis
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Disease Category: Trauma
Physical, chemical, radiation injuryUsually physical mechanism
Effects of external force applied to the bodyCategories:
Blunt or penetratingAccording to body part affectedPhysical, chemical, radiation
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TraumaMay cause shockShock
Hypoperfusion stateClassical signs and symptoms
TachycardiaHypotensionPallorAltered mental status/consciousness
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Head TraumaSkull fractures
Often “protective”, less force transmitted to brainCategories: open, closed, basilar
Cerebral contusionsContusion of brain
ConcussionAlteration in function of brain without visible damage to brain
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Head TraumaIntracranial hemorrhages
Intracerebral- inoperableSubarachnoid-nuchal rigidityEpidural-lucid period Subdural-most common ICB
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Chest TraumaRib fractures
flail
Pneumothorax“collapsed lung”, abnormal air collection in between the pleura
HemothoraxInjury to heart, esophagus, lungs, major vessels
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Abdominopelvic TraumaBlunt
Liver and spleen most commonly injured
PenetratingSmall intestine most commonly injured
Major considerations:Hemorrhage and infection (spillage of GI contents and nonpathogenic bacteria)
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Spinal TraumaCervical spine trauma commonly associated with head traumaTypical signs and symptoms:
Paresis or paralysis below injury levelLoss/alteration in sensation below injury levelSome autonomic (ANS) loss also
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Extremity TraumaMay be fractures, dislocations, soft tissue or skin injuryMay be associated with major disability May be associated with nerve or blood vessel disruption
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Environmental DiseasesConditions caused by the effects of various components of the environment
Heat or coldRadiationChemicalsBariatric (atmospheric pressure)Electrical injuryChemicals Animals, insects, marine lifeSubmersion or drowning
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Environmental DiseasesHeat-related diseases
Prickly heat-rash, blockage of sweat poresHeat edemaHeat syncopeHeat crampsHeat tetanyHeat exhaustion-temp nl to 104Heat stroke- temp over 105, altered mental status
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Environmental DiseasesCold-related diseases
Hypothermia-temp less than 95 degreesChilblains-damp, nonfreezing exposureTrench foot-nonfreezing, water exposureFrostbite-freezing, ice crystals in tissuesFrostnip-superficial injury, no ice crystals
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Bariatric DiseasesLow Pressure
Altitude diseasesHypoxia, pulmonary HTN, Acute Mountain Sickness, HAPE, HACE
High PressureAir embolism, nitrogen narcosisDecompression sickness
Nitrogen bubbles in blood & tissuesThe “bends” = musculoskeletal form
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Electrical InjuriesElectric shockMay be due to natural (lightning strike) or man-made sourcesMajor effects:
Internal and external burnsCardiac dysrhythmiasLocal injuries/path of electrical current
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Toxicology/PoisoningPurposeful exposure
Suicide attemptsindustrial exposure
Accidental exposureChildhood ingestionsTheraputic medication errorsOccupational/industrial exposure
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ToxicologyBimodal peaks of overdoses according to age
Toddler age groupadolescence
Supportive care usually the key to treatment and survivalAntidotes are rare.
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DrowningHypoxemia caused by obstruction of airway by laryngospasm and fluid while patient is submerged.
Fresh vs. salt vs. chlorinated water
Often associated with hypothermia.Other complications, e.g. aspiration pneumonia
Higher survival rates in children.Association with diving accidents.
Spinal trauma and other injuries
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Bites and StingsMost commonly fatal sting in US:
Hymenoptera (bee sting)Allergic etiology
Black Widow SpiderLocal muscle cramping generalizesAbdominal findings, severe painHTN in 10-30%, some with coma, shock, & respiratory failure
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Bites and StingsBrown Recluse Spider
Local effects: erythema, blisters, spreading necrosisVaries with amount of envenomation
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AsphyxiationCessation of oxygenationAlso carbon dioxide accumulationVariable etiologies
DrowningAirway obstructionHypoventilationToxic inhalational injuries
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BurnsCategorized by depthPercentage of TBA (total body surface area)
Rule of Nines (modified for pediatrics)
PrognosisVaries with depth and TBSA involved
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Immune-Related DiseasesBasic categories of immune diseases
Immune deficiencyDeficient protection against invading organismsMay be iatrogenic
Allergy/anaphylaxisActivation of inflammatory/histamine reactions
AutoimmunityImmune system reacts against the patient as if he/she is an invading organism
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Immune System ConceptsReview
Congenital or acquiredHumoral
Immunoglobulins (Ig’s)Circulating proteins, rapid response
CellularT-cells, B cells & othersTissue response mostlyOften delayed (takes days)
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Immune System ReviewVocabulary
PhagocytosisAntibodyAntigenMacrophagesanaphylaxis
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Allergic SymptomsSkin
Urticaria, whealsErythema, pruritis
RespiratoryAirway edema, obstruction, stridorWheezing, asthma, dyspnea
Life-threateningAnaphylactic shock
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Autoimmune DiseasesCan affect any body systemOften affect multiple systemsOften unpredictable course
Exacerbating and remitting
Examples:Ulcerative colitis, primary biliary cirrhosis, hemolytic anemia, ITP, Hashimoto’s thyroiditis, etc
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Immunodeficiency Diseases
Involve impaired resistance to infectionOften have recurrent or opportunistic infectionsExamples:
AIDS, Hodgkin’s lymphoma
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Nutritional DiseasesDeficiencies of some elements of diet
Vitamins, protein, minerals, etc
Excesses of some elements of dietSame as above
MalnutritionObesity
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MalnutritionCondition in which body is not getting enough nutrientsVaries from mild to life-threateningVariety of etiologies:
Improper quality & quantity of foodMalabsorption, anorexia, loss of taste or smell senses, drug-food interactionsIncreased metabolism or need for fuel (certain disease states e.g. trauma, burns, cancers)
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Types of MalnutritionKwashiorkor
Protein-calorie malnutrition, poor protein intake compared to calories, S/S: protuberant abdomen
MarasmusSevere malnutrition in children, mostly calorie deficiency, first year of life, disease or parasitic infestation = usual cause
StarvationLack of all/most nutrients needed to preserve life
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Vitamin DeficiencyScurvy = vitamin C deficiency
Fatigue, weakness, aches, gum bleeding
Rickets = Vitamin D deficiencyBone pain & weakening, deformities
Beriberi = thiamin (B1) deficiencyDiets with polished riceNerve & cardiac damage, lassitude, anorexia
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ObesityAccumulation of excess fat rather than excess weight aloneBMI (body mass index) over 30
Measure of weight relative to height
Over 50% adults and 20% children in US are overweight, 33% are obese2nd leading cause of preventable death in US (tobacco is #1)
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Other categories:Idiopathic
Of unknown etiology
IatrogenicCaused by medical treatment
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Vitamin DeficiencyPellegra = niacin (vit B3) deficiency
Also protein deficiency (tryptophan is an essential AA)Diet often relies on cornThe Four D’s
DiarrheaDermatitisDementiadeath