Experimenting with Experimental Brain Science Dr. Michael Raucci.
Human Anatomy & Physiology Dr. Michael Raucci. Types of Anatomical Study Gross anatomy – the study...
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Transcript of Human Anatomy & Physiology Dr. Michael Raucci. Types of Anatomical Study Gross anatomy – the study...
Human
Anatomy &
Physiology
Dr. Michael Raucci
Types of Anatomical Study
Gross anatomy – the study of structures visible to the naked eye.
Histology – the study of tissues (Gr. histos – “tissue”) with the aid of a microscope
Cytology – the study of cellular structure and function (Greek kytos – “container”).
Embryology – the study of the origin, structure, and development of the embryo (the initial 8 week stage of human development).
Pathology – the study and diagnosis of disease (Gr. pathos – “suffering”).
Anatomical Location
Body Organization
• Tissue – a group of similar cells working together
• Organ – 2 or more tissues working together
• Organ System – …
• Homeostasis – the maintenance of a stable internal environment
Tissue Types1) Epithelial Tissue
– covers and protects underlying tissues
- Skin and lining of organs
2) Nervous Tissue – Sends electrical signals- Nerves and sensory organs
3) Muscle Tissue – made of cells that can contract and
relax to produce movement- muscles and hollow organs
4) Connective Tissue – joins, supports, protects,
insulates, nourishes and cushions organs. It keeps organs from falling apart.
- fat, bone, ligaments
The Human Body
• Contains 100 trillion cells (200 different types)
• All cells require energy
• DNA
• Body Organization
Homeostasis• The maintenance of a stable and
optimal internal environment for cells, tissues, organs, organ systems, and organisms.
• A stimulus leads to a response which is controlled through negative or positive feedback.
• Requires the measurement & regulation of homeostatic variables including temperature, pH, pressure, volume, concentration, etc.
Negative Feedback
• By far the more common method of regulation
• Stimulus leads to a response which then causes suppression of the response
Organ Systems• Integumentary System –external covering of the body; skin, hair & nails.
• Skeletal System –body’s internal framework; the bones.
• Muscular System –body’s means of movement and manipulation.
• Nervous System –body’s control center; the brain, spinal cord, and nerves.
• Endocrine System –glands that secrete hormones (chemical messages) into the blood
• Cardiovascular System –body’s major transport system; heart, blood vessels, and blood.
• Lymphatic/Immune System – returns fluid to the blood stream; detects and repels pathogens; lymphatic vessels, spleen, lymph nodes, tonsils, thymus, and more.
• Respiratory System – delivers O2 to the blood and removes CO2; nasal cavity, pharynx, larynx, trachea, bronchi, and lungs.
• Digestive System – transports, breaks down, and absorbs food; eliminates indigestible remains; oral cavity, pharynx, esophagus, stomach, small and large intestines, salivary glands, pancreas, liver, and gallbladder.
• Excretory System – eliminates nitrogenous wastes from the blood; regulates blood volume, pressure, pH, and electrolytes; kidneys, ureters, urinary bladder and urethra.
• Male Reproductive System – produces sperm and testosterone; testes, penis, vas deferens, prostate gland, seminal vesicles.
• Female Reproductive System – produces oocytes, estrogens, and progesterone; receives, retains, and expels the embryo/fetus/infant; ovaries, fallopian tubes, uterus, and vagina.
Integumentary System
• Skin, hair, and nails– Protects underlying tissues
Skin
Water-proof – keeps water in or out and foreign particles out
Has nerve endings for senses
Regulates body temperature with sweat glands(evaporation causes cooling). Sweat also removes some wastes
Synthesizes Vitamin D
Skin layers• Epidermis –
epithelial tissue– Mostly dead cells
filled with the protein keratin
– outer portion of skin
• Dermis – mostly connective tissue-lies below the epidermis with a lot of the protein collagen
• Hypodermis – fat & other connective tissues
Skin Color
• Genetically determined
• Melanin – skin pigment– Absorbs harmful radiation reducing DNA
damage
Hair and Nails
• Hair - Can protect skin from UV radiation– Melanin gives it its color– In most mammals it can assist in body
temperature regulation by standing the hair up and creating a blanket effect
• Nails – protect toes and fingertips– Grow from a nail bed
• Fingernails grow approximately 2 to 3 millimeters, or about 1/8 inch, per month.
• Toenails grow slower than fingernails, at a rate of about 1 mm per month.
• Hair, on the other hand, grows at a much faster rate: roughly ¼ to ½ inch per month, or 6 inches per year.
• After bone marrow, hair is the fastest growing tissue in the body.
• Hair and nails grow faster in the summer months than at any other time of the year.
Abnormalities• Wounds – heal via clotting, immune system
and new regeneration or scar tissue
• Cancer – damaged genetic material results in abnormal growth of cells and tissues.
Keratosis (mole) Squamous cellCarcinoma
Melanoma Basal CellCarcinoma
[
Neurofibromatosis keloid
Skin tag
quiz and atlas
Brief Atlas of Dermatologic Lesions
Muscular System
– Move bones – by contracting and relaxing– Maintain posture – continuously active– Squeeze and pump – assist the circulatory system
3 types of muscles
• Smooth – digestive system – moves food and waste through the system via peristalsis. Uses predominantly involuntary muscles.
• found within the "walls” of hollow organs; such as blood vessels, bladders, uteri. gastrointestinal tracts
• Cardiac – found only in the heart – self excitatory• Skeletal – attached to the bones for movement
How would you characterize this muscle? The nuclei are centrally located, there are no striations, and the muscle fibers do not branch.
Another good clue that this is smooth muscle is that when smooth muscle contracts, the nuclei take on a corkscrew appearance.
•
How would you characterize this muscle? The nuclei are centrally located, striations are present, and there is
branching of the muscle fibers. Several intercalated discs are indicated by the white arrow heads.
How would you characterize this muscle? The nuclei are peripheral, striations are present, and there is no branching
of the muscle fibers. Even when you cannot visualize striations, the peripherally placed nuclei allow you to
differentiate skeletal muscle from both cardiac and smooth muscle.
Muscle Definitions• Voluntary – under conscious control• Involuntary – work irregardless of
thought• Tendons – strands of connective
tissue located at the ends of muscle. Attach the muscle to the bone
• Flexor – bend a part of the body• Extensor – straighten a part of the
body• Muscle tone – a baseline
contraction that a muscle maintains even during relaxation
* Many muscles work in pairs
(contraction & relaxation)
Exercise
• Resistance (weights, bands, gravity, etc.) – increase the size and strength of a muscle– Isometric – contraction without movement– Isotonic – contraction creates movement of a
unchanging weight (barbell)– Isokinetic – contraction creates movement of a
changing weight (nautilus machine)
• Aerobic (running, swimming, cycling, etc) – improves the stamina of a muscle particularly the heart.– Defined as a sustained raising of the heart rate
Growth
• Muscles grow in length in response to a stretch.
• Muscles grow in bulk in response to a need.
Injury
• Muscle strain• Ruptured tendon
•Overstretching or overuse
•Overuse can be a singular event or a repetitive activity
•Inflammation
Treatment
• Ice or heat?
• Immobilization or mobilization?
R – restI – IceC – CompressionE - Elevation
What’s wrong with thesePictures?
Steroids• Anabolic Steroids – powerful chemicals that resemble
the male hormone testosterone.
Damages: heart, liver, kidneys, testes in men, labido, hirsuitism in women, emotional instability.
• It also happens to be cheating
Skeletal System
• Bones, cartilage and ligaments
• The bones in your skeleton are alive
What’s in a bone?
• Compact bone• Spongy bone – not really
“spongy” – actually provides most of the strength of the bone via trabeculation
• Compact bone – the hard, solid outer surface
• Marrow – inside the bone – stores fat and makes new red blood cells
• Cartilage lines the surface of a joint and is the flexible material found in the ears and tip of the nose
• Joint– Sliding-vertebra– Ball and socket-shoulder, hip– Hinge- elbow, knee, jaw
• Ligaments – connect bones to bones
• Growth plates – cartilage surfaces which allow bones to grow in length. These close by age 15 in girls and 18 in boys
Levers and lifting
• How do levers work?
• How do you increase the effectiveness of a lever
• What is the safest way to lift?
Cardiovascular system teaching aides
• Why do we need blood? Why do we need oxygen?• Discuss women’s increased need for iron d/t menses• WBC demo – 2 volunteers – 1 is a pathogen and 1 is a macrophage. I am
the WBC and I bump into cells of my own and recognize them but when I bump into a pathogen I make antibodies (Piece of blue tape) which attaches to pathogen and all its clones. Macrophage (24 hour buffet) only eats things that are marked with antibodies.
• Use same demo to explain why can’t get chicken pox twice. Also explain how modifying a virus allows us to create a vaccine. And how an antibiotic works.
• Platelets – discuss hemophilia• Heart - have demo heart available. Squeezing it makes no noise. Noise
is created when the vavles slap shut. Like slapping hands together.• Fill balloon with water and put in hand to simulate heart pumping blood
CardiovascularSystem
• AKA Circulatory System
• Heart pumps blood through all the blood vessels supplying nutrients and removing wastes
• Heart, arteries, veins, capillaries
Blood
• An adult human body contains approximately 5 liters of blood
• Plasma – the liquid part of the blood (water, minerals, nutrients, sugars, proteins, etc.)
• Solids – RBCs, WBCs, Platelets
Red Blood Cells
• Red blood cells (RBCs) – transport oxygen and carbon dioxide– Hemoglobin – the protein in blood that carries the
oxygen
– Hemoglobin contains iron (FE++)
– RBCs are made in the bone marrow
– RBCs lose all their organelles including their nucleus before entering the bloodstream thus they cannot divide and they can live only about 4 months
White Blood Cells
• Fight pathogens (foreign invaders in the body)
• WBCs release antibodies – mark pathogens for elimination
• Macrophage – engulfs foreign objects via endocytosis
• Made in bone marrow
Platelets
• Fragments of cells
• Live 5-10 days
• Form plugs when there is a cut and release chemicals that react with proteins in the blood to form a net of clotting fibers (Scab)
Heart
• Muscular organ• Located in the center of your chest behind the lungs• Size of your fist• Pumps blood through the body• Human heart has 4 chambers (left and right atria
[upper level chambers] and left and right ventricles [lower level chambers])
• Valves – close after the expulsion of blood to prevent back flow– Lub-dub is the valves closing
http://www.med.ucla.edu/wilkes/intro.html
Blood flow in the heart
• Deoxygenated blood is brought to the right atrium via the Vena Cava.
• This is then pumped into the right ventricle• From the right ventricle the deoxygenated blood is
pumped into the blood vessels of the lungs where oxygen perfuses into the blood
• The now oxygenated blood reenters the heart going into the left atrium.
• It is then pumped into the left ventricle.• Finally it is pumped out of the left ventricle into the
body via the aorta
Circulation
Circulation• From the body into the Vena Cava• From the Vena Cava in the heart’s right atrium• Right ventricle• Pulmonary artery• To the lung• From the lung into the pulmonary vein• Into the left atrium• Left ventricle• Pumped into the aorta and out to the body• http://www.mydr.com.au/default.asp?Article=3178http://library.med.utah.edu/kw/pharm/hyper_heart1.html
Blood Vessels
• 3 types– Arteries – carry blood away from the heart. Arteries
have thick muscular walls
– Capillaries – the smallest blood vessels. Usually only one cell thick. Allow nutrients, oxygen and other substances to diffuse through
– Veins – the veins transport the blood from the capillaries back to the heart. Veins have valves. The contraction of skeletal muscles helps to move the blood through the veins
What is Blood Pressure?
• Definition – the force exerted by blood on the walls of a blood vessel.
• 120/80 systolic/diastolic• Systolic is the pressure
when the ventricles contract• Diastolic is the pressure when the ventricles relax.• What’s the problem with high or low blood
pressure?Hypertension is a dangerous condition that may lead to heart attack,
stroke or kidney failure
Exercise and Blood Flow
• Exercise means increased need for energy hence increased need for oxygen thus the heart must beat faster (and you must breathe faster)
• Also blood is shunted away from internal organs towards the large muscles.
How does exercise help the heart?
Blood Type• Type A – has A antigens, and B antibodies
• Type B – has B antigens, A antibodies
• Type AB – has A and B antigens, have no antibodies to A or B
• Type O – has no antigens, have both A and B antibodies
Who is the universal donor?Who is the universal recipient?
Cardiovascular Diseases
• Effect heart, blood vessels and/or the blood.
• Atherosclerosis - #1 cause of death in the USA-blood vessels become narrower due to fatty (cholesterol)
buildup until they are blocked.
-If the blood vessels that supply oxygen to the heart mussel are blocked the effected area of heart muscle will die (AKA Heart Attack)
• Hypertension (high blood pressure) – blood vessels become weak and heart is overworked
• Stroke – when a blood vessel in the brain fails, bursts or becomes clogged (dissection, aneurysm, and embolism)
• DVT- deep vein thrombosis
Coronary Artery Disease
Thrombus with recanalizationatherosclerosis
90% closed Total closure
Lymphatic System
• Returns leaked fluids to blood vessels.
• Also involved in immunity
• Involved in reducing swelling
• Lymph (the fluid) is moved by
the squeezing of skeletal muscles.
• Question: Why must a paraplegic
(legs are paralyzed) have someone
move their legs for them occasionally?
• Question: Why might it be bad for a person
who has varicose veins to sit for a long period of time?
What is the
Lymphatic System?
The Lymphatic or "lymph" system is commonly known as "the garbage disposal system" of the body. It is often referred to as the "second circulatory system" and flows throughout the entire body. It is through the Lymphatic System that toxic substances move out of the body through the bloodstream.
Why is it important for your health to maintain your Lymphatic System?
When your Lymphatic System is blocked or clogged, this creates a condition of stagnation which promotes fatigue and ill health. Some of the common symptoms include lumps, bumps, pain and swelling.
How does the Lymphatic System become clogged or blocked?
Unlike the blood circulatory system, the Lymphatic System has no pump to keep fluid flowing. Some causes of a blocked lymph system are due in part to stress, lack of exercise, improper diet and repressed communication.
What are lymph nodes?
All the small and medium-sized lymph vessels open into lymph nodes which are situated in strategic positions throughout the body. The lymph drains through a number of nodes, usually 8 to 10, before returning to the blood. These nodes vary considerably in size: some as small as a pin head and the largest are about the size of an almond.
Lymph nodes are found throughout the body. in inflammation and malignant disease. As a result, palpation (feeling) of the neck, armpits and the groin area is an important part of clinical investigation. Lymph from the head and neck passes through deep and superficial cervical nodes.
Lymph Organs
• Lymph Nodes – bean sized and shaped organs which remove dead cells and pathogens (bacteria) from the blood
• Thymus – Makes WBCs but becomes completely or nearly completely inactive by teens.
• Spleen – filters blood and also releases WBCs. Older more fragile RBCs are broken down and the parts are recycled here.
• Tonsils – defend against infection entering from the oral and nasal cavities.. Can become infected themselves.
Respiratory System
• Absorb oxygen and release carbon dioxide
• Breathing and respiration are not the same thing. Breathing is part of respiration.
• Respiration is a 2 part process– 1) breathing – 2) cellular respiration – the
chemical reactions that release energy from food
• Nose
• Pharynx – connects nose to back of mouth
• Larynx – includes the vocal cords
• Trachea – surrounded by cartilage
• Bronchi – 2 main tubes split into thousands of bronchioles
• Lungs – gas and water exchange
Nasal cavity
Oral cavity
tongue
pharynx
larynx
epiglottis
trachea
esophagus
Lungs
• Air is expelled when the diaphragm relaxes causing the chest cavity to shrink, hence pushing air out.
•Air is brought in when the diaphragm contracts, enlarging the chest cavity and creating a negative pressure which makes air rush in.
Alveoli
• Alveoli – the tiny sacs at the end of bronchiole branches. They are surrounded by capillaries.
• At the alveoli carbon dioxide and water is forced in to the sac and oxygen is is forced out of the sac into he capillary.
• http://www.med.ucla.edu/wilkes/intro.html
http://www.smm.org/heart/lungs/breathing.htm
Respiratory Diseases
• Asthma – bronchioles constrict and release mucous. Often triggered by an irritant.
• Pneumonia – the lungs fill with fluids (primarily caused by an infection)
• Emphysema – The alveoli increase in size and decrease in number
• Lung Cancer - #1 cause is smoking
• http://www.med.ucla.edu/wilkes/lungintro.htm
•
Digestive System
• Breaks down food into absorbable nutrients
• Begins in the mouth and ultimately involves teeth, tongue, salivary glands, esophagus, stomach, pancreas, liver, gallbladder, small intestines and large intestines
The mouth• Teeth• Salivary glands – secrete
saliva which has enzymes to begin digestion.
• Esophagus – a muscular potential tube. Moves food down via peristalsis (rhythmic contractions which propel food in one direction)
The stomach• A muscular baglike organ• Attached to the esophagus on the
superior end and to the small intestines on the inferior end
• Produces acids and enzymes which break food into nutrients
• Grinds and mixes food with contractions
• After hours of grinding and acid mixing a sludge called chyme is released into the small intestines
Liver, Gallbladder, and Pancreas
• Liver – release bile which is stored in the gallbladder and which is then released into the small intestines (bile helps to digest fats)– The liver also stores nutrients– Cleanses the blood– Makes most of the cholesterol in your
body (needed for cell membranes)• Pancreas – produces digestive enzymes
- Also produces insulin for the absorption of sugar from the blood into other tissues
The Small Intestines
• A small muscular tube• Covered with villi – inside the
villi there are nutrient absorbing cells. Villi greatly increase the absorptive surface area.
• This is where the majority of absorption (into the bloodstream) takes place.
• Movement of chyme occurs through peristalsis
The Large Intestines
• Stores, compacts and eliminates undigested material – re-absorption of water creates a solid material (feces or stool).
• Rectum – the last section of the large intestines
• Anus – the opening to the outside
Problems in the Digestive System
• Heartburn – backflow of chyme from the stomach into the esophagus (ineffective sphincter – a ringed muscle at the junction between the esophagus and the stomach)
• Constipation – body does not get enough fiber, water, exercise or peristalsis is stopped or slowed and the contents of the rectum are very dry
• Diarrhea – too little water is removed from the large intestine. Can cause dangerous dehydration.
• Colon Cancer – • Gastric Ulcer – an open sore in the stomach
Ulcer
Diverticulosis
• http://www.nature.com/gimo/contents/pt1/fig_tab/gimo13_V1.html
• http://health.howstuffworks.com/adam-200088.htm
• http://www.mayoclinic.com/health/colonoscopy/MM00010
• Removes wastes from the blood and regulates body fluids and salts.
• Excretion – the process of removing wastes and excess products from the body by passing through a memebrane (skin, lungs, urinary system)
Excretory (Urinary) System
Kidneys• A paired organ • Filter 2000L of blood each day • Functional part is the nephron• Nephrons – remove urea,
water and excess salts from the kidney
• From the kidneys urine travels down the ureters to the centrally located bladder and is ultimately expelled through the urethra
• Why do we sweat?
• Why do we get thirsty?
• What is a diuretic?
Kidney Problems
• Infections
• Kidney Stones
• Kidney Disease– dialysis
Nervous System• Receives and sends electrical
messages throughout the body• Everything you hear, see, feel,
think, taste, smell etc. is perceived in the nervous system.
• How would you explain what sound is to someone who has been totally deaf since birth or what a color is to someone who has been totally blind since birth?
Definitions• Neuron – the impulse
transmitting and conducting cells of the body.
• Body
• Dendrite – receiving structures (many of these)
• Axon – transmitting structures
• Nerve – axons bundled together with blood vessels and connective tissue
NEURONS
The Peripheral Nervous System
• The peripheral nervous system is all the nerve structures located outside of the spinal cord
• Sensory System– neurons gather information from the environment through receptors (specialized dendrites)
• Motor System – neurons send information from the brain to other parts of the body which results in muscular contractions.– 1) Voluntary System– 2) Autonomic (or involuntary) System
The Central Nervous System
• The Brain, brainstem, and the spinal cord
Brain
• Cerebrum – right and left hemispheres– Thinking, memory,
voluntary movements, personality, sight, hearing, etc.
• Cerebellum – inferior to the posterior of the brain– Responsible for balance,
coordination of muscular movements, and proprioception (awareness of respective position of body parts)
Sagital View
Lateral view
Brainstem
• Midbrain • Medulla • Pons• The brainstem is often referred to as just medulla
though this is not correct• Controls important involuntary activities like
breathing, heart rate, blood pressure, etc.
Spinal Cord• Contained within the vertebra
which when stacked upon each other form a canal known as the spinal canal.
• The connection between the brain and the rest of the body
• Why does someone who suffers a spinal injury in their lower back only paralyzed in their legs?
• Why would a spinal cord injury at or above the middle of the neck be incompatible with life?
What is a reflex?
The Senses
• Sight
• Hearing
• Touch
• Taste
• Smell
Eyes
Ears
•
Nose and Tongue
•
Touch
Endocrine System
• Glands regulate body functions by sending out chemical messengers.
• Pituitary gland• Thyroid gland• Parathyroid gland• Thymus• Adrenal glands• Pancreas• Ovaries• Testes
Hormonal Feedback Mechanisms
Hormonal Imbalances
Immune System
• Fights disease and foreign invaders to the body. Eliminates dysfunctional cells.
Male Reproductive System
• Produces and delivers sperm
Female Reproductive System
• Produces eggs and nourishes and shelters the unborn baby
Irregularities
Irregularities and Disorders
• Multiple Births- One pair of identical twins is born for every how many births?
One in 250 births!
Oh No!
• Humans can have triplets, quadruplets, quintuplets, and more.
• The chance of quadruplets is one in 705,000 births.
Infertility
• Unable to have children
• In the U.S. 15% of married couples have difficulty producing offspring.
STD
• Sexually Transmitted Disease
• AIDS
