Human Anatomy and Physiology Physiology of air breathing The lungs.
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Transcript of Human Anatomy and Physiology Physiology of air breathing The lungs.
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Human Anatomy and Physiology
Physiology of air breathing The lungs
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Respiration
Oxygen utilization varies with activity Rest: 200 ml/min. Exercise: 6,000 ml/min.
Importance Breathing increases due to metabolic
demands Regulated by pH of ECF
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Organization
Conducting zone Trachea, 1° - 3° bronchi
Respiratory zone Bronchioles, alveolar ducts
alveoli
Trachea1°
2°
3°
brochioles
Alveolor ducts
alveoli
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Functions of pathway
Conducting zone Warm, cleanse and humidify air Phonation (vocal cords) Regulation of air flow (dilation/constriction)
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Functions of pathway Respiratory zone
Gas exchange
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Functions of pathway Respiratory zone
Cell type I (gas exchange) Cell type II (surfactant)
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Gas Exchange Gases must penetrate 3 membranes
1.
2.
3.
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Diffusion distances Shorter is better
Animal Diffusion distance (µm)
Toad
Birds
pigeon
swallow
shrike
Mammals
rat
human
shrew
1.3 - 3.0
0.1 - 1.4
0.09
0.17
0.13 - 0.26
0.36 - 2.5
0.27
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Lung ventilation Closed compartment
Head, diaphragm, sternum, ribs and intercostal muscles
Pleura Parietal (chest) Visceral (lungs) Pleural fluid
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Ventilation steps
Exchange of air between atm. and alveoli Ventilation, bulk flow
Exchange of O2 and CO2 between alveoli and lung capillaries Diffusion
Transport of gases by blood Bulk flow
Exchange of gases between blood and tissues Diffusion
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Ventilation
Inspiration Expiration
Atmospheric Pressure760 mm Hg
Alveolar Pressure<760
Alveolar Pressure>760
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Ventilation
What pressure changes? Ans: alveolar pressure Bulk flow: F = K (∆P) How does pressure change?
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Ventilation Cavities
Pleural, pulmonary Intrapleural pressure. Why have it?
Tendency of lung recoil Surface tension of alveolar fluid Opposed by chest wall elasticity
Intrapulmonary pressure Balloon within a balloon
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Ventilation
ExpirationInspiration
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Ventilation
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Air flow
Flow (F) = ∆P/R ∆P: change in pressure between
atmosphere and alveoli R: resistance of airways
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Air flow
∆P: altered by contraction of inspiratory and expiratory muscles
Resistance Inversely proportional to 4th power of radius
€
R =1
r4 A B
€
R =1
1
€
R =1
81
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Air flow Lung compliance
V = change in volume P = change in pressure
V
P
Athletes have a high lung compliance
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Lung volumes Respirometer
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Lung volumes
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Dead space Anatomical dead space Alveolar dead space (inspired dead space)
Total dead space