How is Asian/Chinese Skin different for photodamage?
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How is Asian/Chinese Skin different for photodamage?How is Asian/Chinese Skin different for photodamage?
Overview of Ultraviolet Effects:Acute DamageChronic Damage
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UV Pathways to Skin DamageUV Pathways to Skin DamageDamaging effects are effects are 80% UVB/20% UVA80% UVB/20% UVA
Direct DNA damage
UVB
ROS generation
UVA
Inflammatory Mediators
Inflammatory Mediators
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Inflammatory Mediators
Inflammatory Mediators
UV Pathways to Skin DamageUV Pathways to Skin DamageDamaging effects are effects are 80% UVB/20% UVA80% UVB/20% UVA
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Enzymes
Matrix-degradingenzymes (MMP, etc)
Matrix-degradingenzymes (MMP, etc)
Enzymes
UV Pathways to Skin DamageUV Pathways to Skin DamageDamaging effects are effects are 80% UVB/20% UVA80% UVB/20% UVA
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Enzymes
Matrix-degradingenzymes (MMP, etc)
Matrix-degradingenzymes (MMP, etc)
Enzymes
UV Pathways to Skin DamageUV Pathways to Skin DamageDamaging effects are effects are 80% UVB/20% UVA80% UVB/20% UVA
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Matrix-degradingenzymes (MMP,
etc)
Enzymes
UV Pathways to Skin DamageUV Pathways to Skin DamageDamaging effects are effects are 80% UVB/20% UVA80% UVB/20% UVA
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• Direct DNA damage– Immune suppression
– Mutations and skin cancer
• Reactive Oxygen Species
UVB UVA
Inflammation
PigmentationMetalloproteineasesCollagen and elastin degradationSagging, wrinkles
Both UVA and UVB both Both UVA and UVB both lead to chronic photodamagelead to chronic photodamage
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Chinese women 14 – 20 years old
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Chinese women 14 – 20 years old
Indian women 14 – 20 years old
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Chinese women 65 - 75 years old
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Indian women 65 - 75 years old
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• Skin aging parameters start later than Caucasian1,2 with different patterns
• Within Chinese population, skin aging parameters start earlier for higher UV exposure by approximately 10 years1
• Korean wrinkle formation is highly correlated with sun exposure3
• Pigment changes are different in Asian skin versus Caucasian with aging and photoaging1
• Photoaging differences are not all explained by differences in pigmentation
1. Zhao, P. Wang C. Solar ultraviolet Radiation and Skin Damage: An epidemiological study among a Chinese popoulation. Archives of Environmental Health, 53:6, 1998.
2. Chung, J.H. Photoaging in Asians. Photodermatology, Photoimmunology & Photomedicine. 19:109-121. 20033. Chung, J.H. Et al. Cutaneous Photodamage in Koreans. Archives of Dermatology 137:1043-1051.
How is Asian/Chinese Skin How is Asian/Chinese Skin different for photodamage?different for photodamage?
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Photograph courtesy of Robert & Margaret Weiss, MD
Photodamage is not just about Photodamage is not just about pigmentation and wrinklespigmentation and wrinkles
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Photograph courtesy of Robert & Margaret Weiss, MD
• UV exposure induces photodamage and photoaging through several mechanisms
• UVA can produce photoaging in the absence of UVB
• In order to reduce photodamage, sunscreens must protect against both UVB and UVA
Effects of UV on Photoaging:Effects of UV on Photoaging:ConclusionsConclusions