Ho t F l a she s • Nigh t Swe a t s • Ir r i t ab i l i t y

Information forHealth Care Professionals

Acteane® combines five homeopathic ingredients that have been prescribed and recommended for decades to relieve hot flashes and night sweats associated with perimenopause.

A randomized, double-blind and placebo-controlled multicentric clinical study shows that Acteane significantly improves the hot flashes score when compared to a placebo during a 12-week treatment period with a very good tolerance.1

Acteane is a new therapy to temporarily relieve hot flashes, night sweats, and irritability associated with menopause, especially in women who do not qualify for hormonal therapy or cannot take phytoestrogens.

Acteane offers the advantages of a homeopathic medicine – excellent tolerance, no known interactions with other medications, herbs, or supplements, and no risk of overdose.

Hot flashREL IEF

Hot flashREL IEF

Drug FactsActive ingredients PurposeArnica montana 4C HPUS.................................................................................Relieves blotchy face associated with hot flashes

Cimicifuga racemosa 4C HPUS.......................Relieves irritability and occasional sleeplessness associated with menopauseGlonoinum 4C HPUS........................Relieves sudden hot flashes with profuse sweating and throbbing headache associated

Lachesis mutus 5C HPUS

..................................Relieves irritability, hot flashes, and night sweats associated with menopause

Sanguinaria canadensis 4C HPUS........................................................Relieves flushing of the face associated with menopause

The letters HPUS indicate that this ingredient is officially included in the Homeopathic Pharmacopoeia of the United States.

Uses temporarily reduces the symptoms of menopause including the intensity and frequency of hot flashes, night sweats,and irritability.

WarningsStop use and ask a doctor if symptoms persist for more than 1 month or worsen. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children.

Other information Do not use if glued carton end flaps or perforation is open, or if the blister seal is broken.Based on four tablets per day, one box of Acteane, or 120 tablets, will provide a one-month supply.

Directions Adults: Allow one tablet to slowly dissolve in the mouth 2 to 4 times throughout the day or night, depending on the

intensity of the symptoms. Daily use for three months is recommended. Children: Not recommended.

Inactive ingredientslactose, magnesium stearate, sucrose.

Questions or comments?www.BoironUSA.com info@boiron.com1-800-BOIRON-1 (1-800-264-7661)Distributed by Boiron Inc.6 Campus Blvd.Newtown Square, PA 19073-3267

MO

NO

GRPH

.ACT

EAN

E.US

rev.1

1/17

Acteane®

HOT FLASH RELIEF

Acteane is availablein a box of 120 tablets.

BoironUSAhcp.comBoironUSAhcp.com

with menopause

World Leader in Homeopathic Medicines World Leader in Homeopathic Medicines

Pharmacology

BoironUSAhcp.com

References used to prepare this document:1. Colau JC et al. Efficacy of a non-hormonal treatment, BRN-01, on menopausal hot flashes: a multicenter, randomized, double-blind, placebo-controlled trial. Drugs R D. 2012 Sep 1;12(3):107-192. D. Demarque, MD, et al. Pharmacology and Homeopathic Materia Medica. Ed. CEDH. 3. Martindale 30th Edition. The Pharmaceutical Press. London, UK. 4. PDR for Herbal Medicines. 3rd edition.Thomson PDR. 5. Natural Standards databases. www.naturalstandard.com 6. Bordet M.F., Colas A., Marijnen P., et al. Treating hot flushes in menopausal women with homeopathic treatment: results of an observational study. Homeopathy. 2008;97:10–5. doi: 10.1016/j.homp.2007.11.005. 7. U.S. Food and Drug Administration. Sec. 400.400. Conditions Under Which Homeopathic Drugs May be Marketed (CPG 400.400). Available at www.fda.gov/ora/compliance_ref/cpg/cpgdrg/cpg400-400.html. 8. Guermonprez et al. Homeopathic Materia Medica.Ed Boiron 1997. 2nd Edition. (French) 9. Clarke J.H. A Dictionary of Practical Materia Medica. (Vol. 3). 1993 B. Jain Publishers. New Delhi.10. D. Zicari et al., “Arnica 5 CH Activity On Retinal Function,” Investigative ophthalmology & visual science, 38(4), 1997, pp. 3549-3549

No estrogenic or other hormonal effectsExcellent tolerance; no risk of overdoseTargets several symptoms associated with perimenopauseDosage can be easily adapted to each patient’s needsNo known interactions with other medications or biological testsCan be used with treatments for concomitant symptoms associated with perimenopause (mucosal dryness, calcium supplementation, etc.)Based on four tablets per day, one box of Acteane, or 120 tablets, will provide a one-month supply.

AdvantagesAs a convenient and reliable first choice for relieving hot flashes, irritability and night sweats, Acteane has many advantages:

Flavonoids and polysaccharides: Action on capillary tissue and ecchymoses.

Black cohosh(Ranunculaceae)Actaea racemosa

Arnica montana 4C

Formononetin: Isoflavone withestrogenic properties.

Cimicifuga racemosa 4C

Relieves blotchy face associated with hot flashes.

Leopard’s bane (Asteraceae)

Arnica montana

Relieves irritability and occasional sleeplessnessassociated with menopause.

Antidepressants(Escitalopram,fluoxetine, orvenlafaxine)

Clonidine

Increased serotonin levelscould contribute to moreregulated body heat andthe improvement of irritability.

No hormonal side effects. Nausea, dizziness, weight gain,dry mouth, sexual dysfunction.

May reduce the action ofincreased level of noradrenalineassociated with hot �ashes.

No hormonal side effects;decreases blood pressure.

Drowsiness, dizziness,dry mouth, constipation.

MEDICINES 2-5

Phytoestrogens(Soy, hop, red clover,flaxseed, kudzu, etc.)

Foods rich in phytoestrogensare thought to reduce theincidence of hot �ashes.

Possible estrogenic effects.

Traditionally used forgynecological symptoms,including menopausal.

Likely safe when consumedin amounts commonly foundin foods.

Alternative to hormonaltreatment in menopausalsyndrome.

Alternative to hormonaltreatment in menopausalsyndrome.

Possible allergies, high dosesare possibly unsafe.

Possible allergy to concentratedherbal extract of black cohoshor salicylates; possibly unsafein women with hormone-sensitiveconditions.

Potentially carcinogenic effects;high doses are possibly unsafe.

Black cohosh extracts(Actaea racemosa)

Dong quai (Angelica sinensis)

HOW IT WORKS ADVANTAGESSIDE EFFECTS/DISADVANTAGESHot flashes

Acteane® Homeopathic symptom-speci�caction on hot �ashes, irritability,and night sweats associatedwith perimenopause.

Hormone-free; soy-free;no known interactions withother medications, herbs, or supplements;over-the-counter medicine.

None knownNone known.

Hormonal therapy Most effective treatmentagainst hot �ashes.

Contraindicated for patientspresenting risks for cancer andcardiovascular complications.

Replaces the decreasingamount of estrogens.

Along with other effects, the venom causesvasodilation and increased capillary permeability,alternation between brain excitation anddepression, and vasomotor disturbances.

Bloodroot(Papaveraceae)

Sanguinaria canadensis

Lachesis mutus 5C

Bloodroot causes many toxic effects (nausea,vomiting, burning sensations, etc.) and producesa flushed face with red cheeks.

Sanguinaria canadensis 4C

Relieves irritability, hot flashes, and night sweatsassociated with menopause.

Bushmaster Snake’s Venom(Viperidae)

Lachesis muta muta

Relieves flushing of the face associatedwith menopause.

Herbs

Supplements

BoironUSAhcp.com

Homeopathy has shown positive effects on relieving symptoms associated with menopause such as hot �ashes:

An open, multinational, noncomparative observational study conducted among 99 physicians in eight countries with 438 patients showed that hot �ashes and the quality of life in menopausal women was improved with homeopathic treatment. The study revealed a 56 percent reduction (p<0.001) in the frequency and intensity of hot �ashes by day and night, as well as a signi�cant reduction in the daily discomfort the hot �ashes caused.6

Acteane® combines �ve homeopathic medicines manufactured according to the Homeopathic Pharmacopoeia of the United States.7 A multicentric, placebo controlled, double-blind randomized clinical study showed Acteane signi�cantly improved the hot �ashes scorewhen compared to a placebo during a 12-week treatment period with a very good tolerance.1

Indications for homeopathic medicines have been illustrated by years of empirical use by thousands of physicians. As our knowledge of biochemistry and pharmacology progresses, more and more of these indications �nally make sense. This table shows the relationships between the toxico-pharmacological properties of the strain (in red) and the general indications of its homeopathic dilutions (in blue).2-5, 8-10

Relieves sudden hot flashes with profusesweating and throbbing headache associatedwith menopause.

NitroglycerineC3H5(NO3)3

Vasodilating properties.

Glonoinum 4C

It is important to clearly distinguish the difference between herbal extracts of

Black cohosh (Actaea racemosa), whichare concentrated and can cause allergic

reactions and side effects, and the homeopathicpreparation Cimicifuga racemosa 4C HPUS,

which is highly diluted in Acteane’s formula,has slightly different indications, and

no known side effects.

World Leader in Homeopathic Medicines World Leader in Homeopathic Medicines

Pharmacology

BoironUSAhcp.com

References used to prepare this document:1. Colau JC et al. Efficacy of a non-hormonal treatment, BRN-01, on menopausal hot flashes: a multicenter, randomized, double-blind, placebo-controlled trial. Drugs R D. 2012 Sep 1;12(3):107-192. D. Demarque, MD, et al. Pharmacology and Homeopathic Materia Medica. Ed. CEDH. 3. Martindale 30th Edition. The Pharmaceutical Press. London, UK. 4. PDR for Herbal Medicines. 3rd edition.Thomson PDR. 5. Natural Standards databases. www.naturalstandard.com 6. Bordet M.F., Colas A., Marijnen P., et al. Treating hot flushes in menopausal women with homeopathic treatment: results of an observational study. Homeopathy. 2008;97:10–5. doi: 10.1016/j.homp.2007.11.005. 7. U.S. Food and Drug Administration. Sec. 400.400. Conditions Under Which Homeopathic Drugs May be Marketed (CPG 400.400). Available at www.fda.gov/ora/compliance_ref/cpg/cpgdrg/cpg400-400.html. 8. Guermonprez et al. Homeopathic Materia Medica.Ed Boiron 1997. 2nd Edition. (French) 9. Clarke J.H. A Dictionary of Practical Materia Medica. (Vol. 3). 1993 B. Jain Publishers. New Delhi.10. D. Zicari et al., “Arnica 5 CH Activity On Retinal Function,” Investigative ophthalmology & visual science, 38(4), 1997, pp. 3549-3549

No estrogenic or other hormonal effectsExcellent tolerance; no risk of overdoseTargets several symptoms associated with perimenopauseDosage can be easily adapted to each patient’s needsNo known interactions with other medications or biological testsCan be used with treatments for concomitant symptoms associated with perimenopause (mucosal dryness, calcium supplementation, etc.)Based on four tablets per day, one box of Acteane, or 120 tablets, will provide a one-month supply.

AdvantagesAs a convenient and reliable first choice for relieving hot flashes, irritability and night sweats, Acteane has many advantages:

Flavonoids and polysaccharides: Action on capillary tissue and ecchymoses.

Black cohosh(Ranunculaceae)Actaea racemosa

Arnica montana 4C

Formononetin: Isoflavone withestrogenic properties.

Cimicifuga racemosa 4C

Relieves blotchy face associated with hot flashes.

Leopard’s bane (Asteraceae)

Arnica montana

Relieves irritability and occasional sleeplessnessassociated with menopause.

Antidepressants(Escitalopram,fluoxetine, orvenlafaxine)

Clonidine

Increased serotonin levelscould contribute to moreregulated body heat andthe improvement of irritability.

No hormonal side effects. Nausea, dizziness, weight gain,dry mouth, sexual dysfunction.

May reduce the action ofincreased level of noradrenalineassociated with hot �ashes.

No hormonal side effects;decreases blood pressure.

Drowsiness, dizziness,dry mouth, constipation.

MEDICINES 2-5

Phytoestrogens(Soy, hop, red clover,flaxseed, kudzu, etc.)

Foods rich in phytoestrogensare thought to reduce theincidence of hot �ashes.

Possible estrogenic effects.

Traditionally used forgynecological symptoms,including menopausal.

Likely safe when consumedin amounts commonly foundin foods.

Alternative to hormonaltreatment in menopausalsyndrome.

Alternative to hormonaltreatment in menopausalsyndrome.

Possible allergies, high dosesare possibly unsafe.

Possible allergy to concentratedherbal extract of black cohoshor salicylates; possibly unsafein women with hormone-sensitiveconditions.

Potentially carcinogenic effects;high doses are possibly unsafe.

Black cohosh extracts(Actaea racemosa)

Dong quai (Angelica sinensis)

HOW IT WORKS ADVANTAGESSIDE EFFECTS/DISADVANTAGESHot flashes

Acteane® Homeopathic symptom-speci�caction on hot �ashes, irritability,and night sweats associatedwith perimenopause.

Hormone-free; soy-free;no known interactions withother medications, herbs, or supplements;over-the-counter medicine.

None knownNone known.

Hormonal therapy Most effective treatmentagainst hot �ashes.

Contraindicated for patientspresenting risks for cancer andcardiovascular complications.

Replaces the decreasingamount of estrogens.

Along with other effects, the venom causesvasodilation and increased capillary permeability,alternation between brain excitation anddepression, and vasomotor disturbances.

Bloodroot(Papaveraceae)

Sanguinaria canadensis

Lachesis mutus 5C

Bloodroot causes many toxic effects (nausea,vomiting, burning sensations, etc.) and producesa flushed face with red cheeks.

Sanguinaria canadensis 4C

Relieves irritability, hot flashes, and night sweatsassociated with menopause.

Bushmaster Snake’s Venom(Viperidae)

Lachesis muta muta

Relieves flushing of the face associatedwith menopause.

Herbs

Supplements

BoironUSAhcp.com

Homeopathy has shown positive effects on relieving symptoms associated with menopause such as hot �ashes:

An open, multinational, noncomparative observational study conducted among 99 physicians in eight countries with 438 patients showed that hot �ashes and the quality of life in menopausal women was improved with homeopathic treatment. The study revealed a 56 percent reduction (p<0.001) in the frequency and intensity of hot �ashes by day and night, as well as a signi�cant reduction in the daily discomfort the hot �ashes caused.6

Acteane® combines �ve homeopathic medicines manufactured according to the Homeopathic Pharmacopoeia of the United States.7 A multicentric, placebo controlled, double-blind randomized clinical study showed Acteane signi�cantly improved the hot �ashes scorewhen compared to a placebo during a 12-week treatment period with a very good tolerance.1

Indications for homeopathic medicines have been illustrated by years of empirical use by thousands of physicians. As our knowledge of biochemistry and pharmacology progresses, more and more of these indications �nally make sense. This table shows the relationships between the toxico-pharmacological properties of the strain (in red) and the general indications of its homeopathic dilutions (in blue).2-5, 8-10

Relieves sudden hot flashes with profusesweating and throbbing headache associatedwith menopause.

NitroglycerineC3H5(NO3)3

Vasodilating properties.

Glonoinum 4C

It is important to clearly distinguish the difference between herbal extracts of

Black cohosh (Actaea racemosa), whichare concentrated and can cause allergic

reactions and side effects, and the homeopathicpreparation Cimicifuga racemosa 4C HPUS,

which is highly diluted in Acteane’s formula,has slightly different indications, and

no known side effects.

World Leader in Homeopathic Medicines World Leader in Homeopathic Medicines

Ho t F l a she s • Nigh t Swe a t s • Ir r i t ab i l i t y

Information forHealth Care Professionals

Acteane® combines five homeopathic ingredients that have been prescribed and recommended for decades to relieve hot flashes and night sweats associated with perimenopause.

A randomized, double-blind and placebo-controlled multicentric clinical study shows that Acteane significantly improves the hot flashes score when compared to a placebo during a 12-week treatment period with a very good tolerance.1

Acteane is a new therapy to temporarily relieve hot flashes, night sweats, and irritability associated with menopause, especially in women who do not qualify for hormonal therapy or cannot take phytoestrogens.

Acteane offers the advantages of a homeopathic medicine – excellent tolerance, no known interactions with other medications, herbs, or supplements, and no risk of overdose.

Hot flashREL IEF

Hot flashREL IEF

Drug FactsActive ingredients PurposeArnica montana 4C HPUS.................................................................................Relieves blotchy face associated with hot flashes

Cimicifuga racemosa 4C HPUS.......................Relieves irritability and occasional sleeplessness associated with menopauseGlonoinum 4C HPUS........................Relieves sudden hot flashes with profuse sweating and throbbing headache associated

Lachesis mutus 5C HPUS

..................................Relieves irritability, hot flashes, and night sweats associated with menopause

Sanguinaria canadensis 4C HPUS........................................................Relieves flushing of the face associated with menopause

The letters HPUS indicate that this ingredient is officially included in the Homeopathic Pharmacopoeia of the United States.

Uses temporarily reduces the symptoms of menopause including the intensity and frequency of hot flashes, night sweats,and irritability.

WarningsStop use and ask a doctor if symptoms persist for more than 1 month or worsen. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children.

Other information Do not use if glued carton end flaps or perforation is open, or if the blister seal is broken.Based on four tablets per day, one box of Acteane, or 120 tablets, will provide a one-month supply.

Directions Adults: Allow one tablet to slowly dissolve in the mouth 2 to 4 times throughout the day or night, depending on the

intensity of the symptoms. Daily use for three months is recommended. Children: Not recommended.

Inactive ingredientslactose, magnesium stearate, sucrose.

Questions or comments?www.BoironUSA.com info@boiron.com1-800-BOIRON-1 (1-800-264-7661)Distributed by Boiron Inc.6 Campus Blvd.Newtown Square, PA 19073-3267

MO

NO

GRPH

.ACT

EAN

E.US

rev.1

1/17

Acteane®

HOT FLASH RELIEF

Acteane is availablein a box of 120 tablets.

BoironUSAhcp.comBoironUSAhcp.com

with menopause

World Leader in Homeopathic Medicines World Leader in Homeopathic Medicines