1. # Introducing the iminoforce honey

2. # Backed by Science PhytoQuest owns science that dives deeper into the molecular biology of natural products to find ingredients that will be beneficial for the food, beverage, herbal medicine, and cosmetics industries. 3. About PhytoQuest PhytoQuest was founded by Professor Robert Nash in 1999 as a spin-off of the UK's Institute of Grassland and Environmental Research (IGER). He is a global leader in the field of phytochemistry, spending a decade researching anti-viral agents with the Medical Research Council AIDS-Directed Programme at King's College London and the Royal Botanic Gardens, Kew before moving to the IGER. Prof. Nash has published over 200 scientific publications and patents. He was awarded the 1st Pierre-Fabre Award of the Phytochemical Society of Europe in 2001 and gives many international conference presentations and media interviews. 4. Proprietary Knowledge Our company has invested in a solid IP base and maintains other proprietary knowledge assets. We have partnered with major global brands. Our clients benefit from our pipeline and our unique insights and approaches to the commercialisation of plant- derived compounds. Imnoforce honey is protected by the following patent PCT/GB2003/000906 (WO03/074147), EP03706757.6 IS is a registerd Trademark 5. # iminosugars 6. What are Iminosugars? Although iminosugars are more or less ubiquitous in plants, only a few researchers have mastered the techniques required to isolate and fully investigate them. 1 At PhytoQuest, our ability to identify, isolate and analyse ingredients and compounds is unique and unmatched. We use our proven PhytoQuest Fingerprint technology, used in hundreds of real-world analytical processes, to discover active components and isolate novel structures. Once isolated, we further clarify their properties and quickly develop appropriate methods for confirming beneficial applications. This new level of knowledge yields both intellectual property (IP) and marketing benefits. 1. Watson AA, et al. Phytochemistry 2001;56:26595 & Kato A, et al. J. Nat. Prod: 2007;70:9937. 7. D-glucose Equivalent iminosugar What are Iminosugars? The crucial difference between regular sugars and iminosugars is that an oxygen atom is substituted with a nitrogen atom, preventing normal metabolism. 8. What are Iminosugars? Carbohydrates a new place to search for novel therapies: 9. What Can Iminosugars Achieve? Plants and microorganisms benefit from the broad activity of iminosugars to protect them against insect attack, disease and digestion. Due to the great importance of carbohydrates to mammalian physiology and disease progression, these properties have the potential to treat a wide rage of ailments and diseases. These include: Skin irritation Inflammation Blood sugar regulation Blood Lipids 10. Why Now? There are several reasons why iminosugar development has been slow up until now. For example, iminosugars lack chromophore making them difficult to identify. They are also highly water-soluble making working with them extremely technically challenging. In addition, they occupy the aqueous fraction of natural product extracts that contain the protein component and may have been overlooked. With literally billions of natural targets to investigate, finding those with real therapeutic potential is extremely challenging, a challenge we are meeting head on with our imino_series portfolio. 11. # iminoforce honey 12. iminoforce honey iminoforce honey is a IS rich honey for daily consumption PQ has tested several varieties of tropical honey and selected a special variety derived only from Syzygium Guineense. iminoforce honey is rich in a specific IS, casuarine and the product for everyday use is standardized at a casuarine factor of 10 13. iminoforce honey: science inside iminoseries force is a IS-casuarine rich honey Honey consumption is traditionally associated will well-being and almost all the civilizations have used honey or its derivatives in a wide varieties of ailments. Honeys and bees products have a long tradition of immuno- stimulation and improvement of the immune system. IS Honey is obtained from a African plant Syzygium Cumini, and is controlled, via PQ patented process so that it has a content of Casuarine. Casuarine is a potent IS that has shown,in various clinical trials, tone capacity to act as ahuman immune stimulant, re- enforcing the capacity to overcome infections 14. iminoforce honey : the product iminoforce honey is a IS rich organic tropical honey iminoforce honey is available in 340 grams jars/multipack of 6 jars, for convenient, daily use. 15. # 16. imino_series Overview The imino_series contains our portfolio of iminosugars, a widespread group of relatively unexplored, naturally occurring plant and microbial sugar analogues. They are attracting interest as therapeutic agents due to their excellent drug-like qualities and ability to interact with human glycosidases, other proteins and sugar receptors. 2 2. Nash RJ, et al. Future Med. Chem. 2011;3(12):151321. 17. imino_series Portfolio 18. Find Out More For more information on this innovative, ground- breaking research and what value it can bring to your product portfolio, contact us on: info@iminoseries.com or visit our dedicated websites: www.iminoseries.com www.crownhealth.eu