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CENTRAL COUNCIL FOR RESEARCH IN HOMOEOPATHY

SALIENT ACHIEVEMNTS OF RESEARCH STUDIES CONCLUDED

Sl.no

Name of the project andPlace of the study

Period Salient findings Remarks

1. Clinical evaluation ofhomoeopathic medicines insinusitis

Place(s) of study:

- Regional Research Institute(Hom.), Shimla- Clinical Research Unit(Hom.), Chennai.

1985 - 2003 Different clinical patterns were observed, viz.

acute/chronic, frontal, fronto-maxillary (mixed),sphenoidal and multiple sinusitis.

Though 83% of cases improved in varying degree withhomoeopathic therapy, 31% cases were cured withcomplete removal of subjective and objective symptomsand no relapse occurred for one year.

Belladonna, Kali bichromicum, Lachesis, Natrumsulphuricum, Pulsatilla), Rhus toxicodendron andSiliceaare most indicated and effective medicines.

2. Clinical evaluation ofhomoeopathic medicines in

the management ofwithdrawal symptoms of drugdependents.

Place(s) of study:

Clinical Research Unit (Hom.),Varanasi (U.P.).

1988 - 1994 Drug dependent cases were referred from Nav-Chetna

Drug De-addiction centre, Varanasi.

Out of 241 cases that followed up regularly; 83% casesshowed improvement in withdrawal symptoms. Rhus toxicodendron was found to be most effective

medicine. Other medicines found effective are Avenasativa, Nux vomica, Arsenic album, Bryonia alba andChamomilla.

Rhus toxicodendron, Arsenic album and Chamomillaare found to be effective in 10M potency while Bryoniaalbaand Nux vomicain 200C potency and Avena sativain mother-tincture.

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3. Clinical evaluation ofhomoeopathic medicines inbehavioural problems ofmentally retarded children

Place(s) of study:

Central Research Institute(Hom.), Kottayam (Kerala).

1991 - 2001 Common behavioural problems in mentally retardedchildren like aggressiveness, destructiveness,

disruptiveness etc. were studied.

Out of 835 cases that followed up regularly 63% casesshowed improvement.

Baryta carbonicumwas the most effective medicine inthe treatment of behavioural problems in mentallyretarded children.

Other medicines found effective are Antimoniumcrudum, Argentum nitricum, Arsenicum album, Baryta

carbonicum, Baryta muriaticum, Belladonna, Cannabisindica, Causticum, Chamomilla, Cina, Cuprummetallicum, Gelsemium, Hyoscyamus, Kali bromatum,Mercurius solubilis, Phosphorus, Pulsatilla,Stramonium, Sulphur, Tarentula hispanica, andTuberculinum.

In hyperactive children, Belladonna, Sulphur, Tarentulahispanicaand Tuberculinumare found more effective.

In aggressive children, Belladonna, Hyoscyamus andTarentula hispanicaare found more effective.

In dull, backward and shy children Baryta carb., Barytamur., Opium and Pulsatilla are found more effective.

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4. Clinical evaluation ofhomoeopathic medicines inthe management of sicklecell anaemia

Place(s) of study:

- Clinical Research Unit(Hom.) at Sambalpur(Orrisa).

1987 - 2004 Out of 406 cases followed up regularly, 51% casesshowed significant improvement while 32% cases

showed mild improvement.

Medicines found effective are Alumina, Arsenic album,Bryonia alba, Ceanothus americanus, Chelidoniummajus, Kalmegh, Lecithinum, Natrum muriaticum,Phosphorus, Pulsatilla nigricans, Rhus toxicodendronand Vanadium metallicum.

Bryonia albaemerged as the most commonly indicatedmedicine in controlling painful crisis attacks.

In 45% of cases, Hb % improved from 7-9% to 9-11%.

10% of the cases which were followed up for 6 yearsdid not develop acute crisis under homoeopathictreatment.

5. Clinical evaluation ofhomoeopathic medicines inchronic cervicitis and cervical

erosion

Place(s) of study:

- Clinical Research Units(Hom.) at Shimla, Imphal,Varanasi, (U.P.), Tirupathi- Regional Research Institute(Hom.), at New Delhi

1987 - 2004 Out of 3213 cases followed up, 73% cases showedsignificant improvement while 22% cases showed mildimprovement.

Medicines found effective are Alumina, Borax,Calcarea carbonicum, Caulophyllum, Hydrastis,Kreosotum, Lachesis, Mercurius solubilis, Natrummuriaticum, Pulsatillaand Sepia.

Sepia alone emerged as the most frequently indicatedmedicine for cervicitis and cervical erosion.

Cases that required repeated cauterization for theirerosion got relieved after homoeopathic treatment.

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6. Clinical Evaluationof HomoeopathicMedicines inOsteoarthritis

Place(s) of study:

- Clinical Research Institute(Hom.), Kottayam, (Kerela)

- Regional Research Institute(Hom.), Gudivada, (AndhraPradesh)

- Clinical Research Unit(Hom.), Patiala, (Punjab).

1984 - 2005

Although improvement was observed in 76% of thetreatment group, this was significantly seen in 47% of

the cases.

A group of homoeopathic drugs has been identified andfound effective in relieving the symptoms and signs ofosteoarthritis when prescribed as per their indications.

Most effective medicines are Arnica, Arsenicum album,Bryonia alba, Calcarea carbonica, Calcarea fluoricum,Causticum, Graphites, Lycopodium clavatum,Medorrhinum, Natrum mur., Pulsatilla, Rhustoxicodendronand Sulphur.

7. Clinical evaluation ofHomoeopathic medicines inUpper Respiratory TractInfections

Place(s) of study:

Clinical Research CumEpidemic Cell (Hom.), Bhopal.

2000 - 2005

Significant improvement has been observed in 90% ofthe cases of acute rhinitis. Mild improvement was alsoseen in 4% of the cases also.

A group of fourteen medicines has been identified andfound effective in relieving the signs and symptoms ofacute rhinitis.

Most frequently indicated and effective medicines areArsenicum album, Justicea adhatoda, Lemna minorandSilicea.

8. Clinical evaluation ofHomoeopathic Medicines infilariasis

Place(s) of study:

- Regional Research Institute(Hom.), Puri, (Orissa)- Regional Research Institute(Hom.), Gudivada, (AndhraPradesh)- Clinical Research Unit(Hom.), Tirupathi, (AndhraPradesh).

1980 - 2003

79% of the cases improved in varying degrees andsignificant improvement was achieved in 55% of thecases.

These 55% cases had complete absence of clinicalevents for a period ranging from 2 to 3 years.

A group of homoeopathic drugs has been identified andfound effective in relieving the symptoms and signs offilariasis when prescribed as per their indications.

Most indicated and effective medicines observed areRhus toxicodendron, Bryonia alba, Sulphur, Apis mel.,Natrum muriaticum, Pulsatilla and Rhododendron.

Homoeopathic medicines could disappear or reduce thegrade I and grade II lymphoedema in 79% of the cases.

High potencies have been found useful in acute clinicalevents.

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9. Clinical evaluation ofhomoeopathic medicines inthe management of Allergicdermatitis.

Place(s) of study:

- Clinical Research Units(Hom.) Gurgaon andPatiala

1980-2003 The outcome of the study shows that homoeopathicmedicines have effective role in managing Allergic

dermatitis.

Seventy five percent of the cases were significantlyimproved, though mild improvement was also seen inother 21% of the cases.

The most indicated and efficacious medicines observedare Apis mellifica, Bovista, Dulcamara, Graphites,Natrum muriaticum, Petroleum, Rhus toxicodendron,Sepia, Sulphur and Urtica urens.

The study verified the reliability of symptoms of theprescribed medicines in allergic dermatitis.

Further study with improvedparameters for diagnosis,

follow up and outcomeassessment will furtherstrengthen theeffectiveness ofhomoeopathic medicines.

10. Clinical evaluation ofhomoeopathic medicines inthe management of bronchialasthma.

Place(s) of study:

- Regional Research Institutes(H) at New Delhi, Gudivada(Andhra Pradesh) and Shimla(Himachal Pradesh)- Clinical Research Units (H)at Udupi (Karnataka)and Patiala (Punjab)

1978-2003 The homoeopathic medicines have been found to haveeffective role in managing acute attacks as well as incontrolling recurrent attacks of bronchial asthma.

Sixty four percent of the cases had shown significantimprovement though mild improvement was also seenin other 24% of cases.

Arsenicum album has been found to be the mostindicated and effective medicine in the treatment ofasthma.

Other most indicated and effective medicines found areHepar sulphuris, Kali carbonicum, Lycopodiumclavatum, Natrum sulphuricum, Phosphorus andPulsatilla nigricans.

Viburnum opulus Q has been found effective duringacute attacks of asthma.

Further study withimproved parameters foroutcome assessment(spirometery, etc.) willfurther strengthen the role

of homoeopathic medicinesin the management ofbronchial ashma.

11. Drug Proving Homoeopathicpathogenetic Trials of newand old drugs

Since inception(1974 onwards)

The council has completed proving of 76 drugs. 07 new drugs proved by the Council:i. Cassia fistulaii. Cassia sopheraiii. Curcuma longaiv. Cuscuta reflexav. Glycyrrhiza glabra

35 drugs are underClinical Verificationprogramme to verifythe data obtainedduring drug proving.

Proving data of 06drugs is under

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vi. Phyllanthus nirurivii. Bacopa monniere

36 drugs are indigenous:1. Abroma augusta folia2. Acalypha indica3. Acorus calamus4. Aegle folia5. Aegle marmelos6. Andrographis paniculata7. Argemone mexicana8. Atista indica

9. Azadirachta indica10. Boerhaavia diffusa11. Calotropis gigantea12. Carica papaya13. Cassia fistula14. Cassia sophera15. Cephalandra indica16. Clerodendron infortunatum17. Coleus aromaticus

18. Curcuma longa19. Cuscuta reflexa20. Cynodon dectylon21. Embelia ribes22. Ficus religiosa23. Glycyrrhiza glabra24. Holarrhena antidysenterica25. Hydrocotyle asiatica26. Mangifera indica27. Nyctanthes arbortristis28. Ocimum sanctum29. Rauwolfia serpentina30. Ricinus communis31. Saraca indica32. Terminalia arjuna33. Terminalia chebula34. Tinospora cordifolia35. Tribulus terrestris36. Tylophora indica

compilation.

The data so farobtained has beensent to all theHomoeopathic MedicalColleges in India fortheir use.

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1. The data of 62 drugs has been published for the

use of professionals.2. Data of 08 drugs will be published shortly.

Council completed clinical verification of 52 drugs sinceinception of the project

Focus was on fragmentarily proved drugs mainly ofindigenous origin.,

Council has published data of 28 drugs, out of which 17are indigenous. Main clinical conditions of these drugsare mentioned below.

1. Abroma augusta folia arthritis, diabetis mellitus.2. Achyranthes aspera coryza, stomatitis, diarrhoea, boils3. Aegle folia dyspepsia, diarrhoea, dysentery

4. Aegle marmelos coryza, stye, vertigo, dysentery5. Amygdalus persica nausea, vomiting. morning sickness,6. Anthrakokali acute & chronic skin disorders

7. Atista indica - dysentery8. Bacillinum ringworm, lymph adenitis

9. Baryta iodata tonsillitis, induration of glands

10. Berberis vulgaris renal calculi,11. Boerhaavia diffusa hypertension, urinary troubles,dropsical swelling

12. Cassia sophera upper & lower respiratory tractinfections, arthritis.13. Carica papaya conjunctivitis, anorexia, constipation,

jaundice

14. Caesalpaenia bonducella - fever15. Damiana impotency, spermatorrhoea

16. Embelia ribes intestinal worms, diarrhoea, flatulence17. Hydrocotyle asiatica stomatitis, constipation,leucorrhoea, various skin diseases18. Hygrophilla spinosa renal calculi, UTI, leucorrhoea,urticaria, fever

19. Jaborandi falling of hair, graying of hair, acne,headache

12. Clinical Verification ofPartially proved and lesserknown drugs from thefollowing literature Sources :1. Clarkes Materia Medica2. Hering Guiding Symptoms3. Allens Encyclopedia

4. Boerickes Materia Medica5. Drugs of Hindoostan6. Provings conducted byCCRH

1979 - 2004

20. Justicea adhatoda respiratory tract infections

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21. Kali muriaticum stomatitis, headache, otorrhoa,otalgia, tonsillitis, coryza, constipation.

22. Lac caninum rheumatic arthritis23. Nyctanthes arbortristis various kind of fevers,constipation24. Saraca indica leucorrhoea, menstrual irregularities,amenorrhoa, backache, constipation,bleeding piles.

25. Sarsaparilla constipation, UTI26. Terminalia chebula constipation, bleeding piles,dyspepsia,27. Tarentula hispanica dyspepsia, constipation

28. Viscum album hypotension, otorrhoea, palpitation,arthritis

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Central Council for Research in Homoeopathy

S.No

.Name of the Project Salient findings Re

ma

rksName of Drug Name of the

Profile Studied

Findings

Pharmacognosy

Part used: Fruit.

Endocarp strongly lignified made up of pitted, thick-

walled fibers arranged in various planes. Seed coat

compressed, consists of disorganized, pigmented cells.Endosperm massive and composed of polygonal cells

with thin-walls containing aleurone grains, oil droplets

and acicular crystals.

Physico-chemical TLC studies: A) Toluene: ethyl acetate

: diethylamine (7:2:1 v/v) as mobile phase. (i) Under

U.V.light(366nm) one spot appears at Rf 0.83 (blue),(ii)

On spraying withAnisaldehyde sulphuric acid three spots

appear at 0.31(blue), 0.50(blue) and 0.72(grey).

1. Drug Standardization Cocculus

indicus

Hindi Jermae,kakmari

English Fish-

berry, crow killer,

levant- berry,

poison-berry.

Pharmacology The fruit and seed mother tincture were safe up to dose

level of 0.1 ml /100 g. b.w. in mice and 0.15 ml /100 g

.b.w. in rats, respectively. The drug does not show anti-

inflammatory action, fall in blood pressure & analgesic

activities but shows antipyretic effect.

2. Cochleariaarmoracia

English Horse

radish

Pharmacognosy

Part used: Root.

Phellogen indistinct and phelloderm, thin-walled

followed by a wide zone of cortex of tangentially

elongated, oval or isodiametric parenchyma cells

containing numerous starch grains; sclereids solitary or in

groups. Idioblasts contain brown contents present in

phelloderm, cortex and xylem parenchyma.

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Physico-chemical

TLC studies:

(A) chloroform:methanol (9:1 v/v) as mobile phase.

(i) Under U.V.lighttwo spots appear at Rf0.54(greenish)

and 0.97(blue). (ii) On spraying with antimony trichloride in chloroform reagent four spots appear at Rf0.39( pink), 0.51( violet), 0.67(violet),and 0.91(pink).

(B) n-butanol:acetic acid:n propanol:water(3:1:!:1 v/v) as

mobile phase.(i) On spraying with ferric cyanide

(potassium) ferric chloride reagent five blue spots appear

at Rf0.50, 0.65, 0.76, 0.85 and 0.91.Pharmacology The present study demonstrates that Cochlearia

armoracia Q is safe up to dose level of 0.15 ml/100g.b.w.

in mice and has no atrophic/ degenerative changes in anyendocrine glands. The drug does not show any

antiinflammatory, anti-pyretic, anti-convulsant, C.N.S.

activity and fall in blood pressure but shows analgesic

effect.

Pharmacognosy Part used: Dried bark.Stone cells arranged in concentric tangential bands,

associated with crystal sheath containing prisms of

calcium oxalate. Laticiferous ducts containing brownish

contents present in phloem. Rosettes or prisms of

calcium oxalate and starch present throughout

parenchymatous tissue.

Physico-chemical TLC studies:-

using chloroform: methanol (9:1v/v) as mobile phase and

on spraying the plate withDragendorffs reagent sixorange spots appear at Rf0.20, 0.30, 0.65, 0.70, 0.80 and

0.90.

3.

Holarrhena

antidysentrica

Hindi Kurchi,karchi

English Kurchi,

conessi or

tellichery bark

Pharmacology Q was safe up to dose level of 0.4 ml/ kg b.w. in rabbit.

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Pharmacognosy Part used: Leaf

Lamina: stomata paracytic occasionally anomocytic, only

on lower surface; trichomes numerous, multicellular,

uniseriate, meristele shows crescent shaped, conjoint,bicollateral vascular bundle embedded in parenchymatous

ground tissue. Rosette aggregates of calcium oxalate

scattered throughout leaf. Stomatal index: 7-13, palisade

ratio: 4.25-8. Petiole shows horse-shoe shaped outline

Physico-chemical TLC studies :

A) Under U.V.lightfive spots appear at Rf 0.28(red),

0.47(red),0.57(blue), 0.89(red) and 0.94(red).

B) On exposure to iodine vapours six spots appear at Rf.

0.28, 0.47, 0.52, 0.76, 0.89 and 0. 94.

4. . Gymnema

sylvestre

Hindi Gurmar,

merasingi

EnglishPeriploca

of woods, small

Indian ipecacuanha

Pharmacology Q was safe up to dose level of 0.1 ml/100g. b.w. in mice

and 0.1 ml /100 g .b.w. in rats. G. sylvestre Q possess

mild hypoglycemic activity.

Pharmacognosy Part used: Leaf.

Trichomes uniseriate, multicellular with longitudinal

striations; stomata paracytic, only on lower surface.Starch grain, laticifers and numerous rosette aggregates of

calcium-oxalate in parenchyma tissue. Palisade ratio 7-

8.3, Stomatal index 8.8-12.7.

5. Tylophora

indica

Hindi Jangli-

pikvam, antamul

English Emetic

swallowwort,India

n or Physico-chemical TLC studies :(A)Under U.V.light (366nm) five spots appear at Rf0.69(blue), 0.75(greenish), 0.80(blue), 0.86(blue) and

0.90(red).

(B) On spraying with Anisaldehyde sulphuric acidreagent three spots appear at Rf0.45(pink),0.70(blue) and

0.81(violet) .

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Pharmacology Q (diluted) was safe up to dose level of 1.0 ml / 100g.b.w. in mice but did not possess C.N.S. activity,

behavioural effect, respiratory and heart rate at the dose

level of 1.0 ml/100 g.b.w. in mice and also did notpossess any anti-fertility effect.