HO Kuliah 3 - Innate Immune System - Cellular

7/24/2019 HO Kuliah 3 - Innate Immune System - Cellular

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Dr. Ongko Susetia Totoprajogo MNs, Sp.GK

Jurusan D IV gizi

Poltekes Kemenkes

Malang

!"#

Innate immune s$stem

%&ellular '

(e)ture *


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The Purpose of this lectureStudents will understand :

1) The cellular immune system as a part of innate immune system.

2) Innate immune system consists of : Physico chemical barrier,

circulating molecule (complement) , cell (Macrophage, Natural

killer cell, monocyte, and granulocyte)and soluble mediators

(cytokines).

3) Phagocytosis proses inoling : Toll li!e receptor, opsonin, "ntigen

presenting cell ("P#) and cyto!ine production.

$) "ntigen presenting cell "P#) to T lymphocyte through the role of

ma%or histocompatibility comple& ('#) and #luster of

differentiation (#).

*) The role of natural !iller cells (+-cells).

) The relationship bet/een innate 0 adaptie immune system.


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Outline

1. Introduction.

2. Innate immune system

3. Innate to adaptie immune system

$. Phagocytosis

". Toll li!e receptor

. psoniation

#. #omplement 4 ne&t lecture

i. 'embrane attac! comple& ('"#) - ne&t lecture

ii. Pore formation - ne&t lecture

*. "ntigen presenting cell ("P#)

. 'a%or histocompatibility comple& ('#) 5 uman leucocyte

antigen (6")

7. +atural !iller cell (+ cell)

8. Innate to adaptie immune response.


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Immune system

Innate Adaptive

(Acquired)Physico chemicalbarrier

Skin

Mucous membrane

Lysozyme

Stomach acid

Commensal bacteria

Cutaneous & mucosalimmune system (!AL"#MAL"# ect)

Antibodies in mucosal

secretionsSecretory I$A%

#irculating molecules Complement Antibodies

#ells !ranulocytes

Monocytes macropha$e

'atural killer cells

Lymphocytes ( and ")

9oluble mediators Macropha$e derivedcytokines

Lymphocytes derivedcytokines

Gibney. M.J; 2003; Nutrition & metabolism; page: 285


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Adaptive(Specifc)

2line o deenseProtects/

re-exposure

HumoralComponents

Innate(onspecifc)

!line o deense

CellularComponents

CellularComponents

HumoralComponents

ImmuneS"stem


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&ellular immune s$stem + one marro-

origin

%Stem )ell origin'


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Immune cells description


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Innate immune system


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Skin

Mucose in GI tract

HCl in gaster

Complement

Leucocytes


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Mu)us + &iliate epit/elial )ells


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Pago!ytosis : "e pro!ess o# internali$ation antigen by Pago!yti! !ells

% Mononu!lear !ells: Mono!yte ma!ropage;

Polymorponu!lear: Granulo!ytes' intera!ting (it

!omplement & spe!i#i! immune system.

)psonisation : substrate tat #a!ilitate te pago!ytosis pro!ess.

%*omplement *+rea!ti,e protein- *P antibo/y'.

*ytoines : Pepti/e or Gly!oprotein me/iators ranging #rom 1.000 to 10.000

ilo/altons mole!ular (eigt tat a!t as inter!ellular signals.

Pro/u!e/ by " & ympo!ytes %ympoines'; by Mono!ytes

emopoeti! *4s inter#erons !onne!ti,e tissue gro(t #a!tors

%Monoines'.

efinitions


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Immune system

Innate Adaptive

(Acquired)Physico chemicalbarrier

Skin

Mucous membrane

Lysozyme

Stomach acid

Commensal bacteria

Cutaneous & mucosalimmune system (!AL"#MAL"# ect)

Antibodies in mucosalsecretions

Secretory I$A%

#irculating molecules Complement Antibodies

#ells !ranulocytesMonocytes macropha$e

'atural killer cells

Lymphocytes ( and ")

9oluble mediators Macropha$e derivedcytokines

Lymphocytes derivedcytokines

Gibney. M.J; 2003; Nutrition & metabolism; page: 285


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P/ago)$tosis


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Toll like re)eptor %T(0'


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O li


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Outline

1. Introduction.

2. Innate immune system

3. Phagocytosis

". Toll li!e receptor

. psoniation

#. #omplement 4 ne&t lecture

i. 'embrane attac! comple& ('"#) - ne&t lecture

ii. Pore formation - ne&t lecture

$. "ntigen presenting cell ("P#)

*. 'a%or histocompatibility comple& ('#) 5 uman leucocyte

antigen (6")

. +atural !iller cell (+ cell)

7. Innate to adaptie immune response.


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P/ago)$tosis

6ire!t

In+6ire!t

7ntibo/y

4ur#a!e re!eptor

4ur#a!e antigen

Killi i t/ / P/ t i


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Killing mi)roes t/roug/ P/ago)$tosis pro)ess

1


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P/ago)$tes 1 )$tokines prou)tion

uring in2lammation


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Complement

3ill e is)use on t/e ne4t le)ture

5 ti ti ll 5P&


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5ntigen presenting )ell 6 5P&

P/ t i l 5 ti ti


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P/ago)$tosis + l$sosome + 5ntigen presenting


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Major /isto7)ompatiilit$ )omple4 6 M8&


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M8& 6 8(5

3/at is &D


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3/at is &D

In molecular biology,

C!(cluster of differentiation$)

is a glycoproteinfound on the surface of

immune cells such as :

1. T helper cells,

2. monocytes,

3. macrophages, and$. dendriticcells.

#$ is a co-receptorthat assists the T cell receptor(T#)

in communicating /ith an antigen-presenting cell.

Pat/-a$ to antigen presentation
http://en.wikipedia.org/wiki/Molecular_biologyhttp://en.wikipedia.org/wiki/Cluster_of_differentiationhttp://en.wikipedia.org/wiki/Glycoproteinhttp://en.wikipedia.org/wiki/T_helper_cellhttp://en.wikipedia.org/wiki/Monocyteshttp://en.wikipedia.org/wiki/Macrophageshttp://en.wikipedia.org/wiki/Dendritic_cellshttp://en.wikipedia.org/wiki/Dendritic_cellshttp://en.wikipedia.org/wiki/Co-receptorhttp://en.wikipedia.org/wiki/T_cell_receptorhttp://en.wikipedia.org/wiki/Antigen-presenting_cellhttp://en.wikipedia.org/wiki/Antigen-presenting_cellhttp://en.wikipedia.org/wiki/T_cell_receptorhttp://en.wikipedia.org/wiki/Co-receptorhttp://en.wikipedia.org/wiki/Dendritic_cellshttp://en.wikipedia.org/wiki/Dendritic_cellshttp://en.wikipedia.org/wiki/Macrophageshttp://en.wikipedia.org/wiki/Monocyteshttp://en.wikipedia.org/wiki/T_helper_cellhttp://en.wikipedia.org/wiki/Glycoproteinhttp://en.wikipedia.org/wiki/Cluster_of_differentiationhttp://en.wikipedia.org/wiki/Molecular_biology


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Pat/-a$ to antigen presentation

M8& 6 8(5 )lass " 1 )lass


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M8& 6 8(5 )lass " 1 )lass

&D 9 1 &D#

MHC " C$ C ll killi


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MHC " # C$ # Cell killing

Ma)rop/age 7 5P& + M8& II -it/ &D # T + l$mp/o)$te


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Ma)rop/age 7 5P& + M8& II -it/ &D # T + l$mp/o)$te.

Macrophage T lymphocyte


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Natural killer )ell

Target cell


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%atural killer cell%& cell

&iller cellTarget cell

'infected with a (irus

Target orientedgranules

eath of )othinfected cell * (irus

Surface contact


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Innate to adaptie immune system.

2


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(eu)o)$te mo:ement 2rom loo :essel

Intra (ascular

Innate to aapti:e immune s$stem


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Innate to aapti:e immune s$stem

"P#

Complement system

Mem)rane attackcomple+ 'M,C-

Cell lysis

Innate

5apti:e

T/e kineti)s o2 t/e innate 1 aapti:e immune response


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p p

(ater response T l$mp/o)$te

a)ti:ation

Initial response

&ellular

P/$si)o7)/emi)al

arrier

&ir)ulating

mole)ule

&ir)ulating

mole)ule

&ellular

Immune system

0esume;


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y

Innate Immune system "daptie immune system

#ellular#irculating molecule(Next lecture)

'acrophage

"P#

endrit cell

cell

T lymphocyte 4 Th;

Th 2Th 1

cell

MHC I -II

CD4 -8

0esume;

HO Kuliah 3 - Innate Immune System - Cellular

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