HLA Dictionary

Tissue Antigens ISSN 0001-2815

The HLA dictionary 2008: a summary of HLA-A, -B, -C, -DRB1/3/4/5, and -DQB1 alleles and their association with serologicallydefined HLA-A, -B, -C, -DR, and -DQ antigensR. Holdsworth1,8,9, C. K. Hurley2,8,10, S. G. E. Marsh3,4,8,10, M. Lau5,8, H. J. Noreen6, J. H. Kempenich7,

M. Setterholm7,10 & M. Maiers7,10

1 Victorian Transplantation and Immunogenetics Service, Australian Red Cross Blood Service, Melbourne, Australia

2 Department of Oncology, Georgetown University Medical Center, Washington, DC, USA

3 Anthony Nolan Research Institute, Hampstead, London, UK

4 UCL Cancer Institute, Royal Free Campus, Hampstead, London, UK

5 UCLA Immunogenetics Center, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, Los Angeles, CA, USA

6 Histocompatibility Laboratory, University of Minnesota Medical Center, Fairview, Minneapolis, MN, USA

7 National Marrow Donor Program, Minneapolis, MN, USA

8 WHO Nomenclature Committee for Factors of the HLA system

9 Australian Bone Marrow Donor Registry, NSW, Australia

10 Quality Assurance and IT Working Groups, World Marrow Donor Association, Leiden, The Netherlands

Key words

alleles; antigens; histocompatibility; HLA;

serological equivalents; serology

Correspondence

Rhonda Holdsworth, BSc

Victorian Transplantation and

Immunogenetics Service

Australian Red Cross Blood Service

PO Box 354

South Melbourne

Victoria 3205

Australia

Tel: 161 3 9694 0379

Fax: 161 3 9682 1630

e-mail: [email protected]

Received 27 October 2008; accepted 7

November 2008

doi: 10.1111/j.1399-0039.2008.01183.x

Abstract

The 2008 report of the human leukocyte antigen (HLA) data dictionary presents

serologic equivalents of HLA-A, -B, -C, -DRB1, -DRB3, -DRB4, -DRB5, and

-DQB1 alleles. The dictionary is an update of the one published in 2004. The data

summarize equivalents obtained by the World Health Organization Nomenclature

Committee for Factors of the HLA System, the International Cell Exchange,

UCLA, the National Marrow Donor Program, recent publications, and individual

laboratories. The 2008 edition includes information on 832 new alleles (685 class I

and 147 class II) and updated information on 766 previously listed alleles (577 class I

and 189 class II). The tables list the alleleswith remarks on the serologic patterns and

the equivalents. The serological equivalents are listed as expert assigned types, and

the data are useful for identifying potential stem cell donors who were typed by

either serology or DNA-based methods. The tables with HLA equivalents are

available as a searchable form on the IMGT/HLA database Web site (http://

www.ebi.ac.uk/imgt/hla/dictionary.html).

The 2008 edition of the human leukocyte antigen (HLA)

data dictionary is the fifth update; previous versions have

been published in 1997, 1999, 2001, and 2004 (1–4). The

HLA data dictionary is aimed at identifying the serological

types associated with each HLA-A, -B, -C, -DRB1, and

-DQB1 allelic product. The dictionary is a reference to help

with the identification of potential hematopoietic stem cell

(HSC) donors. The serologic equivalents of the DNA-

defined alleles can be used to identify potential donors listed

in unrelated donor registry databases and umbilical cord

banks who have been typed by serology. Although the

majority of laboratories useDNA-basedmethods for typing

today, there is a significant number of HLA assignments in

registries and banks that have been determined by serology-

based methods. For example, in the database of almost 7

million volunteers of the NationalMarrowDonor Program

ª 2009 John Wiley & Sons A/S � Tissue Antigens 73, 95–170 95

(NMDP) in the United States, the percent of serologic

assignments for volunteer donors is still significant, with

45% of the HLA-A and -B loci, 31% of the -C locus, 4% of

the -DRB1 locus, and 37% of the -DQB1 locus assignments

defined serologically. The availability of serologic equiv-

alents allows potentially matched volunteers typed by

serology to be matched to DNA-typed patients.

The number of newly identified HLA alleles grows each

year and since the 2004 publication, 832 new HLA alleles

have been added, including 235HLA-A, 310 -B, 140 -C, 116

-DRB1, 9 -DRB3/4/5, and 22 -DQB1 alleles. Information

has also been updated for 766 previously listed alleles

numbering 158 HLA-A, 303 -B, 116 -C, 133 -DRB1, 13 -

DRB3/4/5, and 43 -DQB1 alleles. This edition of the

dictionary includes all newly defined four-digit alleles

displayed in the IMGT/HLA database (5) to the end of

July 2007 in Tables 1–6.

Information for the 2008 edition of the dictionary has

been contributed from several sources. The World Health

Organization (WHO) serological assignment is taken from

the Nomenclature report 2004 (6) and from data submitted

to the WHO Nomenclature Committee for Factors of the

HLA System when a new allele is submitted for consider-

ation. The International Cell Exchange, UCLA program

provides a unique opportunity to obtain the serologic type

of rare and unusual alleles. Updated information for 335

alleles was provided by theCell Exchange for this dictionary

edition. Results are routinely submitted from laboratories

around the world. Half of the nearly 200 laboratories

actively participating in the Cell Exchange are outside the

United States, with laboratories in Canada, Europe, the

Middle East, Africa, Asia, Australia and New Zealand,

and South America. The serology typing data from this

program continue to enhance the dictionary information.

The NMDP data for 454 alleles have been updated with

serologic typing information. The 13 IHWS data have been

taken from the 2004 edition of the data dictionary. There

have been no further updates on these data. The artificial

neural network (NN) analysis (7) has been rerun to provide

valuable data on the most likely serological result for

a particular allele. The NN analysis now includes data for

alleles of the HLA-C and -DQB1 loci. In addition,

serological typing information has been submitted from

expert laboratories. The serology data from all sources have

been summarized by the authors in the second column of

Tables 1–6 as the expert assigned type.

WHO nomenclature: allele and serologicassignments

The 2008 edition of the dictionary contains all alleles from

the IMGT/HLA database in release 2.18.0 July 2007. Only

the four-digit numbering of alleles is listed in the tables

because the fifth and sixth digits (silent substitutions) are

not expected to alter the antigenic expression. Nonex-

pressed alleles with unique four-digit designations are in-

cluded for completeness. Nonexpressed alleles, which share

a four-digit designation with an expressed allele (e.g.

B*15010102N and B*15010101), have been excluded from

the tables.

The serologic assignment (third column of Tables 1–6) is

taken from the HLA Nomenclature report 2004 (6).

Serologic specificities of newly identified alleles are only

included when reported by the allele contributors as being

identical or very similar to the standard specificity

associated with the allele group (e.g. A1 associated with

A*01 alleles). Likewise, the contributor may report an allele

to be expressed as a serologically variant antigen. Such

information is included in the nomenclature report under

the heading ‘previous equivalents’ and is included here in

the ‘Comments’ column of Tables 1–6. In some cases, the

serological definition given in the WHO Nomenclature

Report and displayed in the third column has been derived

from the previous versions of the dictionary, as these data

were considered sufficiently compelling to be adopted as the

WHO value. Such instances of dictionary-derived WHO

values are indicated by a footnote in Tables 1–6.

International Cell Exchange, UCLA

The International Cell Exchange, UCLA provided data

showing serologic equivalents for 49 HLA-A, 128 -B, 35 -C,

88 -DRB1, 8 -DRB3, 3 -DRB4, 5 -DRB5, and 19 -DQB1

alleles. The latest HLA class I analysis has been updated

with the inclusion of data from 136 new samples, cells 1185–

1320, from healthy individuals, characterized between

February 2004 and November 2007. Each cell was typed

by an average number of 100 laboratories, ranging from

a low of 83 to a high of 118. The parallel typing for HLA-A,

-B, and -C alleles usingDNA-basedmethodswas performed

by an average of 46 laboratories, ranging from 43 to 51

reporting results for the monthly studies.

The HLA class II analysis was updated with the typing

information from 68 B lymphoblastoid cell lines (TER335-

402) from the same time period, February 2004 through

November 2007. Each cell was typed serologically by an

average number of 13 laboratories, ranging from a low of 8

to a high of 18. The parallel typing forHLA-DRB1, -DRB3,

-DRB4, -DRB5, and -DQB1alleles using DNA-based

methods was performed by an average of 80 laboratories,

ranging from a low of 66 to a high of 87.

HLA serologic equivalents have been analyzed in

heterozygous samples only if the other HLA allelic product

would not interfere with the serologic recognition. The

associated serologic specificities as reported by the partici-

pating laboratories are given with the lowest and highest

percentage recognition, shown in brackets in column 4 of

Tables 1–6.

HLA alleles and serologic types R. Holdsworth et al.

96 ª 2009 John Wiley & Sons A/S � Tissue Antigens 73, 95–170

Table

1HLA-A

allelesandtheirserologicdesignationsg

HLAallele

Expertassigned

WHO

assigned

InternationalC

ell

Exchange,UCLA

NMDP

IHW

S13data

NN

Assignedtype[%

]

Cells

tested

Assigned

type[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Comments

A*0101

A1

A1

A1[98–100]

34a

A1[99]

5612

A1

113

Theallele

wasused

fortrainingofthe

NN–A1

A*01010102N

Notexpressed

Null

––

––

––

NT

A*0102

A1

A1

––

A1[95]

129

––

Training–A1

A*0103

A1

A1b

A1[99]

2A1[94]c

33

A1

5Training–A1

A*0104N

Notexpressed

Null

––

cd

1–

–NT

A*0106

A1

––

–A1[100]c

3–

–A1

A*0107

A1

A1

––

––

––

A1

A*0108

A1

A1

––

––

––

A1

Norm

alA

1

A*0109

A1

––

––

––

–A1

A*0110

A1

––

––

––

–A1

A*0111N

Notexpressed

Null

––

––

––

NT

A*0112

Undefined

––

––

––

–Notassignede

NN:A1

A*0113

A1

––

––

––

–A1

A*0114

A1

––

––

––

–A1

A*0115N

Notexpressed

Null

––

––

––

NT

A*0116N

Notexpressed

Null

––

––

––

NT

A*0117

A1

––

––

––

–A1

A*0118N

Notexpressed

Null

––

––

––

NT

A*0119

A1

A1

––

––

––

Notassignede

NN:A1

A*0120

A1

––

––

––

–A1

A*0121

A1

––

––

––

–A1

A*0122N

Notexpressed

Null

––

––

––

NT

A*0123

A1

––

––

––

–A1

A*0124

A1

––

––

––

–A1

A*0125

A1

––

––

––

–A1

A*0126

A1

––

––

––

–A1

A*0127N

Notexpressed

Null

––

––

––

NT

A*0201

A2

A2

A2[99–100]

117a

A2[98]

6315

A2

230

Training–A2

A*02010102L

Low

A2

Low

A2

––

––

––

IdenticaltoA*0201

Significantlyreduced

orlow

cellsurface

expression

A*0202

A2

A2

A2[100]a

7A2[81]

859

A2

8Training–A2

ihw13:variant

serum

pattern

A*0203

A203/A2

A203

A2[99–100]a

10

A2[64]

472

A203

12

A2

ihw13:very

short

A2

A*0204

A2

A2

––

A2[77]

28

––

A2


R. Holdsworth et al. HLA alleles and serologic types

Table

1Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ell

Exchange,UCLA

NMDP

IHW

S13data

NN

Assignedtype[%

]

Cells

tested

Assigned

type[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Comments

A*0205

A2

A2

A2[100]

5A2[81]

462

A2

10

Training–A2

A*0206

A2

A2

A2[99–100]a

47

A2[68]

636

A2

24

Training–A2

A*0207

A2

A2

A2[100]a

15

A2[80]

135

A2

17

Training–A2

A*0208

A2

A2

––

A2[100]c

7–

–A2

A*0209

A2

A2

––

A2[100]c

10

––

A2

A*0210

A210/A2

A210

––

A2[100]c

10

––

A2

A*0211

A2

A2

A2[99]

1A2[74]

228

A2

17

A2

ihw13:shortA2

A*0212

A2

A2

––

A2[100]c

10

A2

1A2

A*0213

A2

A2

––

A2[100]c

17

––

A2

A*0214

A2

A2

––

A2[100]c

7–

–A2

A*0215N

Notexpressed

Null

––

c–

––

NT

A*0216

A2

A2

––

A2[81]c

16

––

A2

A*0217

A2

A2

––

A2[73]

51

A2

2A2

A*0218

A2

A2

––

A2[100]c

1–

–A2

A*0219

A2

––

–Blank[100]c

1–

–A2

A*0220

A2

A2

––

A2[100]c

26

––

A2

Norm

alA

2

A*0221

A2

A2

––

––

––

A2

A*0222

A2

A2

––

A2[100]c

21

––

A2

A*0224

A2

A2

––

A2[100]c

11

––

A2

A*0225

A2

A2

––

––

––

A2

A*0226

A2

––

–A2[100]c

3–

–A2

A*0227

A2

––

–A2[100]c

1–

–A2

A*0228

A2

––

–A2[100]c

1–

–A2

A*0229

A2

A2

––

A2[100]c

2–

–A2

A*0230

A2

––

–A2[100]c

7–

–A2

A*0231

A2

A2

––

––

––

A2

A*0232N

Notexpressed

Null

––

––

––

NT

A*0233

A2

––

–A2[100]c

3–

–A2

A*0234

A2

A2

––

––

––

A2

A*0235

A2

A2

––

A2[100]c

8A2

2A2

Norm

alA

2

A*0236

A2

––

–A2[100]c

1–

–A2

Norm

alA

2

A*0237

A2

––

––

––

–A2

A*0238

A2

––

–A2[67],blank[33]c

3–

–A2

Norm

alA

2

A*0239

A2

––

–A2[100]c

1–

–A2

A*0240

A2

––

––

––

–A2

A*0241

A2

A2

––

––

––

A2

A*0242

A2

A2

––

––

––

A2



Table

1Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ell

Exchange,UCLA

NMDP

IHW

S13data

NN

Assignedtype[%

]

Cells

tested

Assigned

type[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Comments

A*0243N

Notexpressed

Null

––

––

––

NT

A*0244

A2/blank

––

–Blank[100]c

6–

–A2

A*0245

A2

––

–A2[100]c

2–

–A2

A*0246

A2

A2

––

––

––

A2

A*0247

A2

––

––

––

–A2

A*0248

A2

––

––

––

–A2

A2x9,few

A231

24

sera

reactive

A*0249

A2

A2

––

––

A2

1A2

Norm

alA

2.TheHLA

clubce

llexch

ange:

ninelaboratories

perform

ingserology

A*0250

A2

A2

––

––

––

A2

A*0251

A2

––

––

––

–A2

A*0252

A2

––

––

––

–A2

A*0253N

Notexpressed

Null

––

––

––

NT

A*0254

A2

––

––

––

–A2

A*0255

A2/A28

––

––

––

–Notassignede

NN:A2,A28,A69

A*0256

A2

––

––

––

–A2

ShortA2

A*0257

A2

––

––

––

–A2

A*0258

A2

––

––

––

–A2

A*0259

A2

A2

––

––

––

A2

A*0260

A2

––

–A2[100]c

3–

–A2

A*0261

A2

––

––

––

–A2

A*0262

A2

––

––

––

–A2

A2variant;A2x69

variant

A*0263

A2

––

–A2[100]c

1–

–A2

A*0264

A2

––

–cd

1–

–A2

A*0265

A2/A19

A2/19

––

––

––

Notassignede

NN:A74

A*0266

A2

A2

––

A2[100]c

2–

–A2

A*0267

A2

A2

––

––

––

A2

A*0268

A2

A2

––

––

––

A2

A*0269

A2

––

––

––

–A2

A*0270

A2

A2

––

––

––

A2

A*0271

A2

A2

––

––

––

A2

A*0272

A2

A2

––

––

––

A2

A*0273

A2

A2

––

––

––

A2

A*0274

A2

A2

––

––

––

A2



Table

1Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ell

Exchange,UCLA

NMDP

IHW

S13data

NN

Assignedtype[%

]

Cells

tested

Assigned

type[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Comments

A*0275

A2

––

––

––

–A2

A*0276

A2

––

––

––

–A2

A*0277

A2

A2

––

––

––

A2

A*0278

Undefined

A2

––

––

––

Notassignede

NN:A69,A28

A*0279

A2

A2

––

––

––

A2

A*0280

A2

––

––

––

–A2

A*0281

A2

––

–A2[100]c

1–

–A2

A*0282N

Notexpressed

Null

––

––

––

NT

A*0283N

Notexpressed

Null

––

––

––

NT

A*0284

A2

––

––

––

–A2

A*0285

A2

––

–A2[100]c

1–

–A2

A*0286

A2

––

––

––

–A2

A*0287

A2

––

––

––

–A2

A*0288N

Notexpressed

Null

––

––

––

NT

A*0289

A2

A2

––

––

––

A2

A*0290

A2

A2

––

––

––

A2

A*0291

A2

––

––

––

–A2

A*0292

A2

––

––

––

–A2

A*0293

A2

––

––

––

–A2

A*0294N

Notexpressed

Null

––

––

––

NT

A*0295

A2

A2

––

––

––

A2

A*0296

A2

––

––

––

–A2

A*0297

A2

A2

––

––

––

A2

A*0299

A2

––

––

––

–A2

A*9201

A2

––

––

––

–A2

A*9202

A2

––

––

––

–A2

A*9203

A2

––

––

––

–A2

A*9204

A2

––

––

––

–A2

A*9205

A2

A2

––

––

––

A2

A*9206

A2

––

––

––

–A2

A*9207

A2

––

––

––

–A2

A*9208

A2

––

––

––

–A2

A*9209

A2

––

––

––

–A2

A*9210

A2

––

––

––

–A2

A*9211

A2

––

––

––

–A2

A*9212

A2

––

––

––

–A2

A*9213N

Notexpressed

Null

––

––

––

NT



Table

1Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ell

Exchange,UCLA

NMDP

IHW

S13data

NN

Assignedtype[%

]

Cells

tested

Assigned

type[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Comments

A*9214

A2

––

––

––

–A2

A*9215

A2

––

––

––

–A2

A*9216

A2

––

––

––

–A2

A*9217

A2

––

––

––

–A2

A*9218

A2

––

––

––

–A2

A*9219

A2

––

––

––

–A2

A*9220

A2

––

––

––

–A2

A*9221

A2

––

––

––

–A2

A*9222

A2

––

––

––

–A2

A*9223

A2

––

––

––

–A2

A*9224

A2

––

––

––

–A2

A*9225N

Notexpressed

Null

––

––

––

NT

A*9226

A2

––

––

––

–A2

A*0301

A3

A3

A3[98–100]a

44

A3[99]

3504

A3

106

Training–A3

A*03010102N

Notexpressed

Null

––

––

NT

A*0302

A3

A3

A3[99–100]

2A3[78]

342

A3

3Training–A3

A*0303N

Notexpressed

Null

––

––

––

NT

A*0304

A3

A3

––

cd

1–

–A3

A*0305

A3/blank

A3

––

Blank[100]c

5Blank

1A3

ihw13:onlyreactive

withsomeA31

11

andA31

191

34

sera;norm

alA

3

A*0306

A3/blank

––

––

–A3/blank

1A3

ihw13:very

shortA3

A*0307

A3

––

–A3[75]c

4–

–A3

A*0308

A3

––

–A3[100]c

4–

–A3

A*0309

A3

––

–cd

1A3

1A3

A*0310

A3/blank

––

––

––

–A3

A3sera

negative,only

A31

301

311

33

monoclonal

antibodie

positive

A*0311N

Notexpressed

Null

––

––

––

NT

A*0312

A3

––

––

––

–A3

A*0313

A3

––

––

––

–A3

A*0314

A3

––

––

––

–A3

A*0315

A3

––

––

––

–A3

A*0316

A3

––

––

––

–A3

A*0317

A3

––

––

––

–A3



Table

1Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ell

Exchange,UCLA

NMDP

IHW

S13data

NN

Assignedtype[%

]

Cells

tested

Assigned

type[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Comments

A*0318

Undefined

––

––

––

–A1

A*0319

A3

––

––

––

–A3

A*0320

A3

A3

––

––

––

A3

A*0321N

Notexpressed

Null

––

––

––

NT

A*0322

A3

––

––

––

–A3

A*0323

A3

––

––

––

–A3

A*0324

A3

A3

––

––

––

A3

A*0325

A3

––

––

––

–A3

A*0326

A3

––

––

––

–A3

A*0327

A3

––

––

––

–A3

A*0328

A3

––

––

––

–A3

A*0329

A3

––

––

––

–A3

A*0330

A3

––

––

––

–A3

A*1101

A11

A11

A11[99–100]a

77

A11[99]

2530

A11

118

Training–A11

A*1102

A11

A11

A11[99]

1A11[76]

42

A11

8A11

ihw13:shortA11

A*1103

A11

A11

––

A11[82]c

17

A11

1A11

A*1104

A11

A11

A11[63–69]

2A11[75],blank[25]c

8–

–A11

ShortA11;norm

al

A11

A*1105

A11

A11

––

A11[80]c

5–

–A11

ShortA11;3/31A11

sera

reactive

A*1106

A11

––

–A11[100]c

2–

–A11

A*1107

A11

A11

––

––

––

A11

Norm

alA

11

A*1108

A11

A11

––

––

––

A11

ShortA11

A*1109

A11

A11

––

A11[100]c

1–

–A11

A*1110

A11

A11

––

Blank[100]c

1–

–A10

A*1111

Undefined

––

––

––

–Notassignede

NN:A11

A*1112

A11

A11

––

A11[100]c

3–

–A11

Norm

alA

11

A*1113

A11

A11

––

––

––

A11

ShortA11

A*1114

A11

A11

––

––

––

A11

ShortA11,likeA11.2

A*1115

A11

A11

––

––

––

A11

A*1116

A11

––

––

––

–A11

A*1117

Undefined

––

––

––

–Notassignede

NN:A11

A*1118

Undefined

––

––

––

–Notassignede

NN:A11

A*1119

A11

A11

––

––

––

A11

A*1120

A11

––

––

––

–A11

A*1121N

Notexpressed

Null

––

––

––

NT

A*1122

A11

––

––

––

–A11



Table

1Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ell

Exchange,UCLA

NMDP

IHW

S13data

NN

Assignedtype[%

]

Cells

tested

Assigned

type[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Comments

A*1123

A11

––

––

––

–A11

A*1124

A11

––

––

––

–A11

A*1125

A11

A11

––

––

––

A11

A*1126

A11

––

––

––

–A11

A*1127

Undefined

––

––

––

–Notassignede

NN:A11,A1

A*1128

A11

––

–A11[100]c

1–

–A11

A*1129

A11

––

––

––

–A11

A*1130

A11

––

––

––

–A11

A*1131

A11

––

––

––

–A11

A*1132

A11

––

––

––

–A11

A*2301

A23

A23(9)

A23[95–100]a

29

A23[95],A24[1]

5119

A23

42

Training–A9,A23

A*2302

A23

––

–A23[100]c

5–

–A23

A*2303

A23

––

–A9[100]c

1–

–A23

A*2304

A23

A23(9)b

––

––

A23

1A23

ihw13:shortA23,

negativewithA91

80(1

1)sera

A*2305

A23

––

–A23[100]c

2–

–A23

A*2306

A23

––

––

––

–A23

A*2307N

Notexpressed

Null

––

––

––

NT

A*2308N

Notexpressed

Null

––

––

––

NT

A*2309

A23

––

––

––

–A23

A*2310

A23

––

––

––

–A23

A*2311N

Notexpressed

Null

––

––

––

NT

A*2312

A23

A23(9)

––

––

––

A23

A*2313

A23

––

––

––

–A23

A*2314

A23

––

––

––

–A23

A*2315

A23

––

––

––

–A23

A*2316

A23

––

––

––

–A23

A*2402

A24

A24(9)

A24[97–100]

99a

A24[97],A2403[1]

3098

A24

146

Training–A9,A24

A*24020102L

Low

A24

Low

A24(9)

A24[0–5]a

3–

–Blank

1IdenticaltoA*2402


orlow

cellsurface

expression

A*2403

A2403/A24

A2403

A24[66–68],A2403

[29–31]a

10

A24[55],blank[20],

A9[4],A2403[1]

282

A24

5A24

ihw13:shortA24,

negativewithA91

80(1

1)sera

A*2404

A24

A24(9)

––

A24[62],blank[25],

A2403[13]c

8–

–A9



Table

1Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ell

Exchange,UCLA

NMDP

IHW

S13data

NN

Assignedtype[%

]

Cells

tested

Assigned

type[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Comments

A*2405

A9

A9

A23[67–70],A24

[14–19]a

2A24[45],A23[50]c

20

––

A24

A*2406

A24

A24(9)

––

A24[67],blank[33]c

3A24

5A24

A*2407

A24

A24(9)

A24[99–100]a

21

A24[59]

320

A24

17

Training–A9,A24

A*2408

A24

A24(9)

––

A24[47],blank[26]

30

––

A24

ShortA24,sim

ilarto

A2403

A*2409N

Notexpressed

Null

––

Blank[100]c

2–

–NT

A*2410

A2403/A24

A2403

––

A24[42],A9[9],blank

[16],A2403[3]

32

A24

1A24

A2403;ihw13:short

A24

A*2411N

Notexpressed

Null

Blanka

1Blank[100]c

2–

–NT

A*2413

A24

A24(9)

––

cd

1–

–A24

A*2414

A24

A24(9)

––

A24[82]c

11

––

A24

A*2415

A24

––

–c

––

–A24

A*2417

A24

A24(9)b

––

A24[82]c

11

A24

3A24

ihw13:shortA24

A*2418

A24/A3

A24(9)/A3

––

––

––

A9f

A2403x3;shortA24

withmostA3and

A9reactive;NN:

A24

A*2419

A9

A9

––

––

––

A24

Very

shortA9

A*2420

A24

A24(9)b

––

A24[100]c

9A24

1A24

A*2421

A24/A9

A24(9)

––

––

––

A24

A9variant;A24sera

negative

A*2422

A24

A9

––

A24[83]c

6A24

1A24

ihw13:shortA24,

negativewithA91

80(1

1)sera;A

2403

like

A*2423

A24

A2403

––

A24[100]c

11

––

A24

A2403

A*2424

A9

––

––

––

–A9f

NN:A23

A*2425

A24

––

–A24[100]c

13

––

A24

A*2426

A24

––

–A24[100]b

2–

–A24

A*2427

A24

A24(9)b

––

––

A24

1A24

ihw13:shortA24

A*2428

A9

A24(9)

––

A24[50],A9[50]c

2–

–Notassignede

NN:A9,A24,A2

A*2429

A24

––

–A24[100]c

1–

–A24

A*2430

A24

––

––

––

–A24

A*2431

A24

––

––

––

–A24

A*2432

A24

––

–A24[100]c

4–

–A24

A*2433

A2403/A24

A2403

A24[99–100]a

4A24[100]c

4A24

1A24

A2403



Table

1Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ell

Exchange,UCLA

NMDP

IHW

S13data

NN

Assignedtype[%

]

Cells

tested

Assigned

type[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Comments

A*2434

A24

––

––

––

–A24

A*2435

A24

––

––

––

–A24

A*2436N

Notexpressed

Null

––

––

––

NT

A*2437

A24

A24

A24[94–97]a

4A24[100]c

1–

–A24

A*2438

A24

––

––

––

–A24

A*2439

A24

––

––

––

–A24

A*2440N

Notexpressed

Null

––

––

––

NT

A*2441

A24

––

––

––

–A24

A*2442

A24

––

––

––

–A24

A*2443

A24

A24(9)

––

––

––

A24

A*2444

A9

––

––

––

–A9f

NN:A24

A*2445N

Notexpressed

Null

––

––

––

NT

A*2446

A24

––

––

––

–A24

A*2447

A24

––

––

––

–A24

A*2448N

Notexpressed

Null

––

––

––

NT

A*2449

A24

––

––

––

–A24

A*2450

A24

––

––

––

–A24

A*2451

A24

––

––

––

–A24

A*2452

A24

––

––

––

–A24

A*2453

A24

––

––

––

–A24

A*2454

A24

––

––

––

–A24

A*2455

A24

––

––

––

–A24

A*2456

A24

––

––

––

–A24

A*2457

A24

––

––

––

–A24

A*2458

A24

A24(9)

––

––

––

A24

A*2459

A24

––

––

––

–A24

A*2460N

Notexpressed

Null

––

––

––

NT

A*2461

A24

––

––

––

–A24

A*2462

A24

––

––

––

–A24

A*2463

A24

––

––

––

–A24

A*2464

A24

––

––

––

–A24

A*2465

A24

––

––

––

–A24

A*2466

A24

––

––

––

–A24

A*2467

A24

––

––

––

–A24

A*2468

A24

––

––

––

–A24

A*2469

A24

––

––

––

–A24

A*2470

A24

––

––

––

–A24



Table

1Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ell

Exchange,UCLA

NMDP

IHW

S13data

NN

Assignedtype[%

]

Cells

tested

Assigned

type[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Comments

A*2471

A24

––

––

––

–A24

A*2472

A24

––

––

––

–A24

A*2473

A24

––

––

––

–A24

A*2474

A24

––

––

––

–A24

A*2475

A24

––

––

––

–A24

A*2476

A24

A24(9)

––

––

––

A24

A*2477

A24

––

––

––

–A24

A*2478

A24

A24(9)

––

––

––

A24

A*2479

A24

––

––

––

–A24

A*2501

A25

A25(10)

A25[94–99]

6a

A25[95],A10[2]

1375

A25

18

Training–A10,A25

A*2502

A25

A25(10)b

––

A25[88]c

8A25

1A25

Norm

alA

25

A*2503

A25

––

–A25[100]c

2–

–A25

A*2504

A25

––

––

––

–A25

A*2505

A25

––

–A2[100]c

1A25

A*2506

A25

––

––

–A25

A*2601

A26

A26(10)

A26[95–97]a

27

A26[97],A10[2]

1730

A26

47

Training–A10,A26

A*2602

A26

A26(10)

A26[91–97]a

3A26[81]

31

A26

2Training–A10,A26

A*2603

A26

A26(10)

A26[92–98]a

11

A26[68],A10[8]

38

A26

5Training–A10,A26

ihw13:shortA26

A*2604

A26

A26(10)

––

A10[50],blank[50]c

2–

–A26

A*2605

A26

A26(10)

––

A26[90],A25[10]c

10

––

A26

A*2606

A26

A26(10)

––

A26[100]c

1–

–A26

A*2607

A26

A26(10)

––

A26[100]c

1–

–Notasssignede

NN:A43,A10,A26

A*2608

A26

A26(10)

––

A26[95]

65

A26

3A26

ihw13:shortA26,

sim

ilarto

A*2603;

norm

alA

26

A*2609

A26

A26(10)b

––

A26[33],A10[33],

A34[33]c

3A26

2A26

ihw13:shortA26

A*2610

A10

A10

––

––

––

A26

ShortA26,A10

variant

A*2611N

Notexpressed

Null

––

––

––

NT

A*2612

A26

––

–A26[75],A34[25]c

4–

–A26

A*2613

A26

––

–A26[100]c

3–

–A26

NN:A66

A*2614

A26

––

––

––

–A26

A*2615

A10

A10b

––

––

A10

2A26

ihw13:onlyfew

A10

sera

reactive,may

betypedasblank;A

blank



Table

1Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ell

Exchange,UCLA

NMDP

IHW

S13data

NN

Assignedtype[%

]

Cells

tested

Assigned

type[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Comments

A*2616

A26

––

–A26[100]c

1–

–A26

A*2617

A26

––

––

––

–A26

A*2618

A10

––

–Blank[100]c

1–

–A10f

NN:A26

A*2619

Undefined

––

––

––

–Notassignede

NN:A43,A10

A*2620

A26

––

––

––

–A26

A*2621

A26

––

––

––

–A26

A*2622

A26

A26(10)

––

––

––

A26

A*2623

A26

A26(10)

––

––

––

A26

A*2624

A26

––

––

––

–A26

A*2625N

Notexpressed

Null

––

––

––

NT

A*2626

A26

A10

––

––

––

A26

A*2627

A26

––

––

––

–A26

A*2628

A26

––

––

––

–A26

A*2629

A26

A26(10)

––

––

––

A26

A*2630

A26

––

––

––

–A26

A*2631

A26

––

––

––

–A26

A*2632

A26

––

––

––

–A26

A*2633

A26

––

––

––

–A26

A*2634

A26

––

––

––

–A26

A*2635

A26

––

––

––

–A26

A*2901

A29

A29(19)

A29[98]a

1A29[96]

115

A29

10

Training–A29

A*29010102N

Notexpressed

Null

––

––

––

NT

A*2902

A29

A29(19)

A29[98–100]a

17

A29[99]

1488

A29

28

Training–A29

A*2903

A29

––

–A29[100]c

4–

–A29

A*2904

A29

––

–A29[100]c

1–

–A29

A*2905

A29

––

––

––

–A29

A*2906

A29

––

––

––

–A29

A*2907

A29

––

––

––

–A29

A*2908N

Notexpressed

Null

––

––

––

NT

A*2909

A29

––

––

––

–A29

A*2910

A29

A29(19)

––

A29[100]c

2–

–A29

A*2911

A29

––

––

––

–A29

A*2912

A29

––

––

––

–A29

A*2913

Undefined

––

––

––

–Notassignede

NN:A32,A29

A*2914

Undefined

––

––

––

–Notassignede

NN:A29,A30

A*2915

A29

––

––

––

–A29

A*2916

A29

A29(19)

––

––

––

A29



Table

1Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ell

Exchange,UCLA

NMDP

IHW

S13data

NN

Assignedtype[%

]

Cells

tested

Assigned

type[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Comments

A*3001

A30

A30(19)

A30[97–100]a

25

A30[89],A31[3],

blank[3],A19[1]

2895

A30

28

Training–A30

A*3002

A30

A30(19)

A30[96–100]a

17

A30[93],A31[2],

A19[1]

2124

A30

25

Training–A30

A*3003

A30

A30(19)

––

A30[83],blank[17]c

6–

–A30

A*3004

A30

A30(19)

A30[97–98]a

2A30[94]

85

A30

7Training–A30

A*3006

A30

––

–cd

1–

–A30

A*3007

A30

––

–A30[100]c

2–

–A30

A*3008

A30

––

––

––

–A30

A*3009

A30

––

–A30[100]c

3A30

1A30

ihw13:very

short

A30,onlybroad

A19sera

reactive

A*3010

A30

––

–A30[100]c

10

––

A30

A*3011

A30

A30(19)

––

––

––

A30

A*3012

A30

––

––

––

–A30

A*3013

A30

––

––

––

–A30

A*3014L

A30

Low

A30(19)

––

––

––

A30


orlow

cellsurface

expression

A*3015

A30

A30(19)

––

––

––

A30

A*3016

A30

––

––

––

–A30

A*3017

A30

A30(19)

––

––

––

A30

A*3018

A30

A30(19)

––

––

––

A30

A*3019

A30

––

––

––

–A30

A*3020

A30

––

––

––

–A30

A*3021

A30

––

––

––

–A30

A*3022

A30

––

––

––

–A30

A*3101

A31

A31(19)

A31[94–98]a

23

A31[90],A30[3],

A19[1]

3517

A31

58

Training–A31

A*3102

A31

A31(19)b

––

A31[100]c

17

––

A31

A*3103

A31

––

–A31[100]c

2–

–A31

A*3104

A31

A31(19)

––

––

––

A31

A*3105

A31

A31(19)

––

––

––

A31

A*3106

A31

––

––

––

–A31

A*3107

Undefined

––

––

––

–Notassignede

NN:A32,A23,A9



Table

1Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ell

Exchange,UCLA

NMDP

IHW

S13data

NN

Assignedtype[%

]

Cells

tested

Assigned

type[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Comments

A*3108

A31/A24

––

–A32[100]c

1–

–Notassignede

A31x24;previously

A*2416;NN:A23,

A9,A32

A*3109

A31

––

–A31[100]c

3–

–A31

Bw4motifpresent

A*3110

A31

A31(19)

––

––

––

Notassignede

NN:A32

A*3111

A31

––

––

––

–A31

A*3112

A31

A31(19)

––

––

––

A31

A*3113

A31

––

––

––

–A31

A*3114N

Notexpressed

Null

––

––

––

NT

A*3115

A31

––

––

––

–A31

A*3116

A31

––

––

––

–A31

A*3117

A31

––

––

––

–A31

A*3118

A31

––

––

––

–A31

A*3201

A32

A32(19)

A32[97–99]a

20

A32[94]

3441

A32

50

Training–A32

A*3202

A32

A32(19)

––

A32[100]c

3–

–Notassignede

NN:A32

A*3203

A32

––

–A32[67],blank[33]c

3–

–A32

A*3204

A32/A3

––

–A3[75],A19[13],

A32[13]c

8A‘3204’

1Notassignede

A3withmostA32

sera

reactive

(ihw13);NN:A32,

A3

A*3205

A32

––

––

––

–A32

A*3206

A32

––

––

––

–A32

A*3207

A32

––

–A32[100]c

1–

–A32

A*3208

A32

––

–A32[100]c

2–

–A32

A*3209

A32

––

––

––

–A32

A*3210

A32

––

––

––

–A32

A*3211Q

A32

––

––

––

–A32

Notexpectedto

be

expressed

A*3212

A32

––

––

––

–A32

A*3213

A32

––

–A32[100]c

1–

–A32

A*3214

A32

A32(19)

––

––

––

A32

A*3215

A32

––

––

––

–A32

A*3301

A33

A33(19)

A33[97–100]

10a

A33[87],A19[3],

blank[4]

687

A33

19

Training–A33

A*3303

A33

A33(19)

A33[95–100]a

36

A33[95],A34[1]

887

A33

27

Training–A33

A*3304

A33

––

–A33[50],blank[50]c

2–

–A33

A*3305

A33

A33(19)

––

A33[92]c

13

A33

1A33

ihw13:shortA33



Table

1Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ell

Exchange,UCLA

NMDP

IHW

S13data

NN

Assignedtype[%

]

Cells

tested

Assigned

type[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Comments

A*3306

A33

––

–cd

1–

–A33

A*3307

A33

––

––

––

–A33

A*3308

Undefined

A33(19)

––

––

––

Notassignede

NN:A31,A33

A*3309

Undefined

A19

––

––

––

Notassignede

NN:A31,A33

A*3310

A33

––

––

––

–A33

A*3311

A33

––

––

––

–A33

A*3312

A33

––

––

––

–A33

A*3313

Undefined

––

––

––

–Notassignede

NN:A33

A*3401

A34

A34(10)

A34[93–98]a

30

A34[67],A26[10],

A10[5],A66[4],

A33[2],blank[7]

269

A34

25

Training–A10,A34

ihw13:distinct

pattern

from

A*3402

A*3402

A34

A34(10)

A34[92–95]a

11

A34[89],A33[4],A26

[3],A10[2]

996

A34

11

Training–A10,A34

ihw13:distinct

pattern

from

A*3401

A*3403

A34

––

––

––

–A34

A*3404

A34

A34(10)

––

––

A34

2A34

ihw13:shortA34,

withsomeA11and

A19sera

reactive;

A34variantwith

someA10sera

reactive

A*3405

A34

––

––

––

–A34

A*3406

A10

––

––

–A10f

NN:A34

A*3407

A34

––

––

–A34

A*3408

A34

––

–A10[100]c

1A34

A*3601

A36

A36

A36[85–93],A1[5–8]a

5A36[68],A1[16],

blank[6]

807

A36

7Training–A36

A*3602

A36

––

––

––

–A36

A*3603

A36

A36

––

––

––

A36

A*3604

A36

A36b

––

––

A36

2A36

A*4301

A43

A43

––

A26[50],A10[13],

A34[13],A19[13],

blank[13]c

8–

–Training–A43



Table

1Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ell

Exchange,UCLA

NMDP

IHW

S13data

NN

Assignedtype[%

]

Cells

tested

Assigned

type[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Comments

A*6601

A66

A66(10)

A66[37–59],A‘6601’

[22–42],A26[15–

18],A10[2–7]a

14

A26[61],A66[20],

A34[8],A10[3],

A25[1]

799

A66

19

Training–A10,A66

ihw13:A‘6601’

pattern

–different

from

A‘6602’;

reactivewithA341

66sera

A*6602

A66

A66(10)

A‘6602’[35–65],

A66[15–42],A34

[7–18],A10[4]a

8A66[38],A34[27],

A10[10],A74[5],

A26[4]

205

A66

2A66

ihw13:A‘6602’,short

A66

A*6603

A10

A10

––

A66[32],A34[18],

A10[7],A26[7]

28

––

A10f

ShortA10;NN:A26

A*6604

A66

––

––

––

–A66

A*6605

A26

––

–A26[100]c

1–

–A26

A*6606

A66

A66(10)

––

––

––

A66

A*6801

A68

A68(28)

A68[53–68],A28

[31–45]a

34

A28[63],A68[27]

2736

A68

49

Training–A28,A68

A*6802

A68

A68(28)

A68[55–65],A28

[32–43]a

15

A28[72],A68[19],

A69[1]

2327

A68

18

Training–A28,A68

A*6803

A68

A68(28)b

A68[47–66],A28

[34–48]a

16

A28[63],A68[28]

202

A68

4A68

A*6804

A68

A68(28)

––

A28[75],A68[25]c

4–

–A68

A*6805

A68

A68(28)

––

A28[53],A68[29]

59

A28

1A68

ihw13:possiblyA68,

butcellalsoA2

positive

A*6806

A68

––

–A28[50],A68[50]c

2–

–A68

A*6807

A68

––

–Blank[100]c

1–

–A68

A*6808

A68

A68(28)

A68[38–45],A28[53]

2A28[100]c

2–

–A68

A*6809

A68

––

–A68[100]c

1–

–A68

A*6810

A68

A28b

––

Blank[50],A1[50]c

2A28

1A68

ihw13:possiblyA68,

butcellalsoA2

positive

A*6811N

Notexpressed

Null

––

––

––

NT

A*6812

A28

A28

––

A28[50],blank[50]c

6–

–A68

ShortA28

A*6813

A68

––

––

––

–A68

A*6814

A68

––

––

––

–A68

A*6815

A68

––

––

––

–A68

A*6816

A68

A68(28)

––

––

––

A68



Table

1Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ell

Exchange,UCLA

NMDP

IHW

S13data

NN

Assignedtype[%

]

Cells

tested

Assigned

type[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Comments

A*6817

A68

A28b

––

A28[100]c

1A28

1A68

ihw13:possiblyA68,

butcellalsoA2

positvie

A*6818N

Notexpressed

Null

––

––

––

NT

A*6819

A68

––

–A28[100]c

1–

–A68

A*6820

A68

––

––

––

–A68

A*6821

A68

––

––

––

–A68

A*6822

A68

––

––

––

–A68

A*6823

A68

––

–A68[100]c

1–

–A68

A*6824

A68

––

––

––

–A68

A*6825

A68

––

–A28[100]c

1–

–A68

A*6826

A68

A28

––

––

––

A68

A*6827

A68

––

––

––

–A68

A*6828

A68

––

––

––

–A68

A*6829

A68

––

––

––

–A68

A*6830

A68

––

––

––

–A68

A*6831

A68

––

––

––

–A68

A*6832

A68

––

––

––

–A68

A*6833

A68

A68(28)

––

––

––

A68

A*6834

A68

––

––

––

–A68

A*6835

A68

––

––

––

–A68

A*6836

A68

A68(28)

––

––

––

A28f

NN:A68

A*6837

A68

––

––

––

–A68

A*6838

A68

––

––

––

–A68

A*6839

A68

––

––

––

–A68

A*6840

A68

––

––

––

–A68

A*6901

A69

A69(28)

A69[40–70],A28

[33–49]a

3A28[56],A69[7],

A2[6],A68[3]

289

A69

6Training–A28,A69

A*7401

A74

A74(19)

A74[72–95]a

13

A74[40],A19[11],

blank[36]

115

A74

11

Training–A74

A*7402

A74

A74(19)

––

Blank[50],A74[17],

A33[17],A31[17]c

6–

–A74

A*7403

A74

A74(19)

A74[89–91]

5Blank[72],A74[17]

29

A74

4A74

A*7404

A74

––

–A74[100]c

1–

–A74

A*7405

A74

––

–Blank[100]c

1–

–A74

A*7406

A74

A74(19)

––

A74[100]c

1A74

1A74

A*7407

A74

A74(19)

––

––

––

A74

A*7408

A74

––

––

––

–A74



National Marrow Donor Program

Assignments made using the expectation

maximization algorithm

The 2008 data set includes only those typings from US

volunteer donors where both serologic and allele-level results

havebeen reported for theHLA-A, -B, -C, -DRB1, or -DQB1

loci. As in past versions of the dictionary, the expectation

maximization (EM) algorithm was used to obtain the cor-

relation between alleles and serologic assignments. Readers

are referred to previous versions of the dictionary that des-

cribe theuse of theEMalgorithmand thenuances of thedata.

In this version, data for alleles serologically typed in 20 or

more donors (cells tested) have not been updated and

remain the same as that shown in the 2004 dictionary (4).

For these alleles, we believe that adequate data have been

accumulated to define the serologic assignments.

A subset of theEMdata including the alleleswith counts of

less than 20 in the last dictionary version plus newly described

alleleswas analyzed.TheEMalgorithmprovides anunbiased

assignment of serologic specificities using information from

all cells carrying the allele in question. In addition, experts

reviewed the serologic assignments for all cells carrying an

allele in this category and assigned serologic specificities.

Uninformative cells were eliminated and known serologic

cross-reactivity was considered in the assignment. The

information from the EM algorithm and the results from

the review were compared and final serologic assignments

were made. The table shows the predicted serologic assign-

ments and the percent of informative individuals carrying

those assignments. The percentages listed in the table are

derived from the review of typings as described above; this

differs from previous years in which the percentages were

derived from the EM algorithm. This change will better

reflect the serologic assignment of these less frequent alleles.

In theEMalgorithm, percent assignments are skewed by cells

carrying a second more common allele with the same

serologic assignment. For example, cells carrying both

A*0201 and A*0208 frequently appear. The EM assignment

is influenced by the more common A*0201 allele resulting in

a lower percent assignment for A*0208 (78%). Expert review

eliminated these uninformative cells (i.e. carrying both

A*0201 and A*0208) resulting in an A2 assignment for

A*0208 of 100%.

The information for 454 alleles, including 122 HLA-A,

200 -B, 50 -C, 73 -DRB1, and 9 -DQB1, was reviewed and

updated. The reviewed and updated alleles are indicated by

a footnote in the tables. If an allele appears five times or less,

the serologic assignment(s) should be considered as only an

approximation of the serologic reactivity of the resultant

antigen. It should be noted that the number of individuals

carrying each allele shown in the tables might not be the

total number of volunteer donors carrying the allele in theTable

1Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ell

Exchange,UCLA

NMDP

IHW

S13data

NN

Assignedtype[%

]

Cells

tested

Assigned

type[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Comments

A*7409

A74

––

–A74[33],A33[33],

blank[33]c

3–

–A74

A*7410

Undefined

––

––

–Notassignede

NN:A74

A*7411

A74

––

–cd

1A74

A*7412N

Notexpressed

Null

––

––

NT

A*8001

A80

A80

A80[68–88],A36

[0–3]

11

Blank[77],A80[10],

A36[2],A1[1]

505

A80

9Training–A80

ihw13:d

ifficultto

type

nextto

A1orA24

NT,nottested;NN,neuraln

etw

ork;HLA,humanleukocyte

antigen;WHO,WorldHealthOrganization;NMDP,NationalM

arrow

DonorProgram.

aUpdatedInternationalC

ellExchange,UCLA.

bWHO

assignmentbasedondictionary

data.

cUpdatedNMDPdata.Insomecases,theinform

ationreportedinpreviousdictionarieshaschanged.C

ells

havebeenexcludedfrom

thisstudyinsomecasesbecausetheirHLAtypinghaschanged.

dTheallele

hasbeenidentifiedbutserologynotinform

ative.

eNotassigned;seecommentcolumnforpredictions>0.20.

fIfaprimary

specificityisprovidedbytheNN,otherspecificities>0.4

are

shownin

thecomments

column.

gRef13–28,61.



Table

2HLA-B


HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*0702

B7

B7

B7[98–100]a

32

B7[98]

10,841

B7

83

Training–B7

B*0703

B703/B7

B703

––

B7[94]b

17

B703,B7,blank

1B7

ShortB7,B71

42

sera

reactive,B71

22sera

negative

B*0704

B7

B7

––

B7[89]

44

B7

2Training–B7

B*0705

B7

B7

B7[91–97]a

4B7[95]

42

B7

6Training–B7

B*0706

B7

B7

B7[94–95]

4B7[96]

23

––

B7

B*0707

B7

B7

––

B7[93]b

15

––

B7

B*0708

B7

B7c

––

––

B7

1B7

ShortB7,negative

withB71

22sera,

sim

ilarto

B703

B*0709

B7

B7

B7[97–98]

2B7[100]b

8B7

2B7

B*0710

B7

B7c

––

B7[92]b

12

B7

2B7

B*0711

B7

B7

––

––

––

B7

B*0712

B7

B7c

––

B7[100]b

5–

–B7

B*0713

B7/blank

––

–Blank[100]b

3–

–B7

B*0714

B7

B7c

––

B7[100]b

10

B7

1B7

B*0715

B7

B7

––

B7[100]b

1–

–B7

B7variant,someBw6

sera

negative

B*0716

B7

B7

––

B7[50],B60[50]b

2–

–B7

ShortB7,few

B7sera

reactive,sim

ilarto

B703

B*0717

B7

B7

––

––

––

B7

B*0718

B7

––

––

––

–B7

B*0719

B7/42

––

–B42[100]b

1–

–B42

ShortB7

B*0720

B7/blank

––

––

––

–B7

ShortB7,B7sera

negative,B71

42

sera

reactive

B*0721

B7

––

–B7[100]b

1–

–B7

B*0722

B7

––

––

––

–B7

B*0723

B7

––

–bd

1–

–B7

B*0724

B7

B7

––

––

––

B7

B7weaklyexpressed,

reactivewithB71

27(1

40)sera

B*0725

B7

––

––

––

–B7

B*0726

B7

B7

––

B7[100]b

1–

–B7

Norm

alB

7

B*0727

Undefined

––

––

––

–Notassignede

NN:B7

B*0728

B7

––

––

––

–B7



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*0729

B7

––

––

––

–B7

B*0730

B7

B7

––

––

––

B7

B7variant

B*0731

B7/B42

B7/B42

––

––

––

B7

B7x42,shortB7

B*0732

B7/blank

––

––

––

–B7

Bblank

B*0733

B7

––

–B7[100]b

1–

–B7

B*0734

B7

––

––

––

–B7

B*0735

B7

––

––

––

–B7

B*0736

B7

––

–B7[100]b

1–

–B7

Bw4positive

B*0737

B7

––

––

––

–B7

B*0738

Undefined

––

––

––

–Notassignede

B*0739

B7

––

––

––

–B7

B*0740

B7

B7

––

––

––

B7

B*0741

B7

––

––

––

–B7

B*0742

B7

––

––

––

–B7

B*0743

B7

––

––

––

–B7

B*0744

B7

––

––

––

–B7

B*0745

B7

––

––

––

–B7

B*0746

B7

B7

––

––

––

B7

B*0747

B7

––

––

––

–B7

B*0748

B7

––

––

––

–B7

B*0749N

Notexpressed

Null

––

––

––

NT

B*0750

Undefined

––

––

––

–NT

NN:B7

B*0751

B7

––

––

––

–B7

B*0752

B7

––

––

––

–B7

B*0753

B7

––

––

––

–B7

B*0754

B7

––

––

––

–B7

B*0755

B7

––

––

––

–B7

B*0756

B7

––

––

––

–B7

B*0757

B7

B7

––

––

––

B7

B*0758

B7

B7

––

––

––

B7

B*0801

B8

B8

B8[100]a

9B8[99]

6518

B8

61

Training–B8

B*0802

B8

B8

––

bd

2B‘0802’

1Notassignede

B8Bw4;ihw13:B8

Bw4withextra

reactions;NN:B8

B*0803

B8

B8

––

B8[100]b

1–

–Notassignede

B8Bw4

B*0804

B8/blank

–B8[51–71],B59[6–7]

3B8[80],blank[20]b

5B8

1B8

BlankBw6;ihw13:

shortB8

B*0805

B8

––

–bd

1–

–B8



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*0806

B8

B8

––

B8[100]b

1–

–B8

B*0807

B8

B8

––

B8[100]b

1–

–B8

B*0808N

Notexpressed

Null

––

––

––

NT

B*0809

B8

B8

––

B8[100]b

11

B8

2B8

B*0810

B8

B8

––

––

––

B8

ShortB8

B*0811

B8

––

–B8[100]b

3–

–B8

B*0812

B8

––

–bd

1–

–B8

B*0813

B8

––

–B8[100]b

1–

–B8

B*0814

B8

––

––

––

–B8

B*0815

B8

B8

––

––

B8

1B8

B*0816

B8

B8

––

––

––

B8

B*0817

Undefined

––

––

––

–Notassignede

Bblank;NN:B8

B*0818

B8

B8

––

––

––

B8

B*0819N

Notexpressed

Null

––

––

––

NT

B*0820

B8

––

––

––

–B8

B*0821

B8

––

––

––

–B8

B*0822

B8

––

––

––

–B8

B*0823

B8

––

––

––

–B8

B*0824

B8

––

––

––

–B8

B*0825

B8

––

––

––

–B8

B*0826

B8

––

––

––

–B8

B*0827

B8

––

––

––

–B8

B*0828

B8

––

––

––

–B8

B*0829

B8

B8

––

––

––

B8

B*0830N

Notexpressed

Null

––

––

––

NT

B*0831

B8

––

––

––

–B8

B*0832

B8

––

––

––

–B8

B*0833

B8

––

––

––

–B8

B*1301

B13

B13

B13[95–99]a

4B13[97]

238

B13

9Training–B13

B*1302

B13

B13

B13[98–100]a

9B13[99]

1307

B13

17

Training–B13

B*1303

B49/B15

––

–B13[100]b

1–

–B13

B15x21–Bw4;B21

variantwithsome

B15sera

reactive

B*1304

B49/B15

B15/B21

B21[22–38],B49[15],

B15[7–17],B15x21

[0–15],B50[5–11],

B63[0–8],B77[4–7]

2–

–B‘1304’

1B13

B15x21–Bw4,sim

ilar

toB*1303;ihw13:

new

pattern,also

B49,B63andB77

reactivity



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*1306

B13

––

––

––

–B13

B*1307N

Notexpressed

Null

––

––

––

NT

B*1308

B13

––

––

––

–B13

B*1309

Undefined

––

––

––

–Notassignede

Bw6pos;NN:B13

B*1310

B13

––

–B13[100]b

2–

–Notassignede

NN:B13B15

B*1311

B13

––

–B13[100]b

1–

–B13

B*1312

B13

––

––

––

–B13

B*1313

B13

B13

––

––

B13

B*1314

B13

––

––

––

–B13

B*1315

B13

––

––

––

–B13

B*1316

B13

––

––

––

–B13

B*1317

B13

––

––

––

–B13

B*1318

B13

––

––

––

–B13

B*1319

B13

––

––

––

–B13

B*1320

B13

––

––

––

–B13

B*1401

B64

B64(14)

B14[49–58],B64

[32–43],B65

[2–10]a

8B14[72],B64[10],

B65[10]

1003

B64

11

Training–B14

B*1402

B65

B65(14)

B65[50–54],B14

[45–47],B64[1–3]a

9B14[71],B65[25],

B64[2]

2244

B65

22

Training–B14

B*1403

B14

B14c

––

B14[50],B65[35]

40

––

B14

B*1404

B14

––

–B14[67],B64[33]b

3–

–B14

B*1405

B14

––

–B14[40],blank[60]b

5B65

1B14

B*1406

B14

B14

––

B14[100]b

8–

–B14

B65

B*1407N

Notexpressed

Null

––

––

NT

B*1501

B62

B62(15)

B62[93–98]a

30

B62[96],B15[2]

1906

B62

64

Training–B15B62

B*15010102N

Notexpressed

Null

––

––

––

NT

B*1502

B75

B75(15)

B75[79–86],B15

[8–11],B62[5–12]

16

B75[62],B62[22],

B15[7]

1035

B75

18

Training–B15B75

B*1503

B72

B72(70)

B70[47–61],B72

[31–45]a

17

B70[61],B72[10],

B35[2],B62[1],

blank[11]

2569

B72

25

Training–B70B72

B*1504

B62

B62(15)

B62[90],B15[5],

B75[4]a

1B62[69],B15[10]

29

B62

1B62

B*1505

B62

B62(15)

B62[88]

1B62[64],B15[18]

22

B62

3B62

B*1506

B62

B62(15)

––

B62[81]b

13

––

B62

B*1507

B62

B62(15)

B62[93]

2B62[79]

101

B62

2Training–B15B62



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*1508

B75/B62

B75(15)

B75[30–48],B15

[19–35],B62

[6–19],B‘1508’

[11–14]

2B62[20],B15[18],

B75[18]

45

B75

3B15

B*1509

B70

B70

––

B70[53],blank[33]

65

B71

2Training–B70B71

B*1510

B71

B71(70)

B70[41–49],B71

[41–47]a

15

B70[49],B35[4],B72

[2],B71[2],B75[1],

B15[1],blank[13]

1204

B71

7Training–B70B71

B*1511

B75

B75(15)

B75[31–51],B15

[21–38],B46

[6–12],B‘1511’

[0–19]

3B62[27],B75[21],

B46[15],B15[15]

68

B75

4B15

B*1512

B76

B76(15)

B76[76–88],B45

[3–6]

5B76[29],B62[18],

B75[6],B15[29]b

17

B76

2Training–B15B76

B*1513

B77

B77(15)

B77[46–53],B63

[0–16]

2B77[21],B63[19],

B15[15],B75[12],

blank[13],B62[8],

B53[6]

116

B77

7Training–B15B77

B*1514

B76

B76(15)

B76[23],B45[20],

B15[20],B70[6],

B63[5]

1B45[80],B44[20]b

5B76

1B62

B*1515

B75/62

B62(15)

B75[43–57],B62

[31–42],B15

[8–15]a

10

B62[49],B75[28],

B15[13]

138

B75

1B15

ihw13:shortB75

B*1516

B63

B63(15)

B63[96–97]a

8B63[80],B57[3],

B15[3]

816

B63

3Training–B15B63

B*1517

B63

B63(15)

B63[92–96]

5B63[88],B15[3],

B57[1]

797

B63

11

Training–B15B63

B*1518

B71

B71(70)

B70[52–64],B71

[28–34]a

11

B70[51],blank[34],

B71[3]

552

B71

8Training–B70B71

B*1519

B76

B76(15)

B76[29],B15[19],

B45[11],B62[8],

B75[7]

1B70[50],B76[50]b

2–

–B76

B*1520

B62

B62(15)

B62[73],B15[18],

B75[5]

1B62[100]b

10

B62

1B62

ihw13:shortB62

B*1521

B75

B75(15)

B75[80–88],B15

[6–9],B62[3–10]

21

B75[55],B62[12],

B15[7]

132

B75

9Training–B15B75



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*1523

B70/B5/blank

–B‘1523’[17],B5

[14–15],B77

[7–11],B70[7–9],

B15[5–8]

2Blank[50],B70[17],

B51[17],B53[8]b

12

B‘1523’

2Notassignede

B5x70–Bw4,B5/53/

77variant;NM5;

ihw13:new

pattern,shortB71-

Bw4;NN:B70B71

B*1524

B62

B62(15)

B62[45–48],B‘1524’

[23–24],B15

[21–22],B77[4–6],

B63[2–3]

4B62[44],blank[22]

54

B62

8B15

B62Bw4

B*1525

B62

B62(15)

B62[86–94],B75

[2–10]a

10

B62[74],B75[8],

B15[7]

116

B62

1Training–B15B62

ihw13:shortB62,

shortB75

B*1526N

Notexpressed

Null

––

––

––

NT

B*1527

B62

B62(15)

B62[97]a

1B62[76],B15[7]

76

B62

2Training–B15B62

ihw13:shortB62,

shortB75

B*1528

B62

B62(15)c

––

B62[80],B15[20]b

5–

–B62

B*1529

B70

B15

B70[54–58],B15

[11–12],B71[7–10]

2Blank[71],B70[19]

21

B71

2B71

B*1530

B62

B62(15)c

B62[63–86],B75

[4–13],B15[12–19]

3B62[64],B15[17]

98

B62

3Training–B15B62

ihw13:shortB62,

shortB75

B*1531

B75

B75(15)

––

B75[38],B62[38]b

13

B75

1B75

ihw13:shortB75

B*1532

B62

B62(15)

––

B62[100]b

5–

–B62

B*1533

B62

B15

––

––

––

B62

B62

B*1534

B62

B62(15)c

––

B62[100]b

8–

–B62

Norm

alB

62

B*1535

B62

B62(15)c

B62[86–93],B75

[5–7]a

14

B62[79]

34

B62

5Training–B15B62

B*1536

Undefined

––

–B13[100]b

3–

–B15

Bw4positive,NN:

B77

B*1537

B70

B70c

B70[46],B71[11],

B78[9]

2Blank[54],B70[30]

24

––

B71

B*1538

B62

––

–B62[100]b

3–

–B62

B62variant,also

reactivewithB52

sera

B*1539

B62

B62(15)c

B62[92–98]

2B62[84],B15[13]b

38

B62

3B62

B*1540

B62/blank

––

–Blank[61],B70[10],

B62[8]

26

––

B62

ShortB62

B*1542

B15

––

––

––

–B62

ShortB15;reactive

withsomeB22sera



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*1543

B15

––

––

––

–B15f

Bw4positive,NN:

B62

B*1544

B75

––

––

––

–B75

B*1545

B62

B62(15)

––

B62[92]b

13

––

B62

B*1546

Undefined

B72(70)

––

B50[50],B72[25]b

4–

–Notassignede

NN:B15B62

B*1547

B70/blank

––

–Blank[57],B35[14]b

14

––

B72

B48,allB15sera

negative

B*1548

B62

B62(15)

––

B62[100]b

3–

–B62

B*1549

B72

––

––

––

–B72

B*1550

B62

––

––

––

–B62

B*1551

B70

B70

––

B35[100]b

1–

–B71

B*1552

Undefined

B15

––

Blank[67]b

3–

–B71

B15

B*1553

Undefined

––

––

––

–Notassignede

B*1554

B72

––

–B70[50],B72[50]b

2–

–B72

B*1555

B15

B15

––

––

––

B15f

B15Bw6;NN:B75

B*1556

B62

––

––

––

–B62

B*1557

B62

––

––

––

–B62

B*1558

B62

B62(15)

––

B62[100]b

3–

–B62

B15orB62

B*1560

B62

––

––

––

–B62

B*1561

B72

––

––

––

–B72

B*1562

Undefined

––

–B62[67]b

3–

–Notassignede

NN:B70B72

B*1563

B62

––

–B62[100]b

2–

–B62

B*1564

B71

––

––

––

–B71

B*1565

B62

––

–B62[100]b

2–

–B62

B*1566

B62

––

–B62[100]b

1–

–B62

B*1567

B63

––

––

––

–B63

Bw4positive

B*1568

Undefined

B35

––

––

––

Notassignede

NN:B70B72

B*1569

B72

––

––

––

–B72

B*1570

B62

B62(15)

––

––

B62

1B62

ihw13:shortB62,

shortB75

B*1571

B62

B62(15)

––

B62[83],B75[17]b

6–

–B62

B*1572

B71

––

––

––

–B71

B*1573

B62

B62(15)

––

B62[100]b

1–

–B62

B*1574

B72

––

––

––

–B72

B*1575

B62

––

–B62[100]b

1–

–B62

B*1576

Undefined

––

––

––

–Notassignede

NN:B15

B*1577

B62

––

––

––

–B62

B*1578

B62

B15

––

––

––

B62



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*1579N

Notexpressed

Null

––

––

––

NT

B*1580

B70

B70

––

––

––

B71

B70

B*1581

B62

––

––

––

–B62

B*1582

B62

B62(15)

––

––

––

B62

B621

A30/31

B*1583

B62

––

––

––

–B62

NN:B15

B*1584

B62

B62(15)

––

––

––

B62

B*1585

B62

––

––

––

–B62

B*1586

Undefined

––

––

––

–Notassignede

NN:B15,B62

B*1587

B15

––

––

––

–B15

B*1588

B75

––

––

––

–B75

B*1589

B77

––

––

––

–B77

B*1590

B71

––

––

––

–B71

B*1591

Undefined

––

––

––

–Notassignede

NN:B70,B72,B12

B*1592

B62

––

––

––

–B62

B*1593

B71

B71(70)

––

––

––

B71

B*1594N

Notexpressed

Null

––

––

––

NT

B*1595

B63

––

––

––

–B63

B*1596

B62

B62(15)

––

––

––

B62

B*1597

B62

––

––

––

–B62

B*1598

B72

––

––

––

–B72

B*1599

B71

––

––

––

–B71

B*9501

Undefined

––

––

––

–Notassignede

NN:B15,B46

B*9502

B62

B62(15)

––

––

––

B62

B*9503

B70

B70

––

––

––

B72

B*9504

B62

––

––

––

–B62

B*9505

B62

––

––

––

–B62

B*9506

Undefined

––

––

––

–Notassignede

NN:B15,B62

B*9507

B62

B62(15)

––

––

––

B62

B*9508

B71

B71(70)

––

––

––

B71

B*9509

B62

––

––

––

–B62

B*9510

B62

––

––

––

–B62

B*9511N

Notexpressed

Null

––

––

––

NT

B*9512

B75

B15

––

––

––

B75

B*9513

B62

––

––

––

–B62

B*9514

B70

B70

––

––

––

B71

B*9515

B70

––

––

––

–B70

B*9516

B62

––

––

––

–B62

B*9517

B62

––

––

––

–B62



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*9518

B62

––

––

––

–B62

B*9519

B71

––

––

––

–B71

B*9520

B62

––

––

––

–B62

B*9521

B75

––

––

––

–B75

B*9522

B62

––

––

––

–B62

B*9523

B72

––

––

––

–B72

B*9524

B71

––

––

––

–B71

B*9525

B62

––

––

––

–B62

B*9526

B62

––

––

––

–B62

B*9527

B72

––

––

––

–B72

B*9528

B62

––

––

––

–B62

B*9529

B62

––

––

––

–B62

B*9530

B62

––

––

––

–B62

B*9532

B72

––

––

––

–B72

B*1801

B18

B18

B18[97–100]a

12

B18[96]

1641

B18

53

Training–B18

B*1802

B18

B18

––

B18[90]

31

B18

3Training–B18

B*1803

B18

B18

––

B18[83],blank[17]

29

B18

1B18

B*1804

B18

B18c

––

B18[84],blank[11]b

19

B18

1Notassignede

NN:B18

B*1805

B18

B18

––

B18[83]b

6B18

1B18

ihw13:shortB18,

blank

B*1806

B18

B18

––

––

––

B18

B18variant,negative

withBw4andBw6

sera

B*1807

B18/blank

––

–Blank[100]b

1B18

1B18

ihw13:shortB18,

blank,B18spec

sera

negative

B*1808

B18

––

–B18[100]b

1–

–B18

B*1809

B18

B18

––

––

––

Notassignede

B18,Bw4;NN:B18,

B38

B*1810

B18

––

––

––

–B18

B*1811

B18

––

––

––

–B18

B*1812

B18

––

–B18[50],blank[50]b

2–

–B18

B*1813

B18

––

–B18[100]b

2–

–B18

B*1814

B18

––

–B18[100]b

2–

–B18

B*1815

B18

––

–B18[100]b

1–

–B18

B*1817N

Notexpressed

Null

––

––

––

NT

B*1818

B18

––

–B18[100]b

4–

–B18

B*1819

B18

––

––

––

–B18



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*1820

B18

––

––

––

–B18

B*1821

Undefined

––

––

––

–Notassignede

NN:B18

B*1822

B18

––

––

––

–B18

B*1823N

Notexpressed

Null

––

––

––

NT

B*1824

B18

––

––

––

–B18

B*1825

B18

––

––

––

–B18

B*1826

B18

––

––

––

–B18

B*2701

B27

B27

––

B27[100]b

12

––

B27

B*2702

B27

B27

B27[97]

1B27[87]

417

B27

9Training–B27

ihw13:shortB27

B*2703

B27

B27

B27[97]

1B27[88]

26

B27

5Training–B27

B*2704

B27

B27

B27[98]a

1B27[97]

31

B27

7B27

B*2705

B27

B27

B27[99–100]

6B27[99]

1194

B27

22

Training–B27

B*2706

B27

B27

B27[97–99]a

10

B27[97]

29

B27

6B27

Previouslyalso

namedB*2722

B*2707

B27

B27

––

B27[100]b

49

B27

5B27

B*2708

B2708/B27/B7

B2708

B2708[36–58],

B7[19–41],B27

[11–19]

3B27[31],B7[34],

blank[16],B2708

[9]b

32

B2708

1B27

B7variant,mostB27

sera

negative;

ihw13:alsoB73B7

blank

B*2709

B27

B27

B27[100]

1B27[100]b

15

––

B27

B*2710

B27

B27

––

B27[100]b

5–

–B27

B*2711

B27

B27

––

B27[100]b

2–

–Notassignede

B27variant,extra

reactivitywithB40

sera;NN:B27

B*2712

Undefined

B27

––

Blank[78],B60[9],

B27[4],B61[4]b

23

Blank

1Notassignede

BlankBw6;B27sera

negative,B71

27

(140)sera

positive;

ihw13:blank,B61

B27–Bw6;NN:B27

B*2713

B27

B27

––

––

––

B27

B*2714

B27

B27c

––

B27[100]b

14

––

B27

B*2715

B27

––

––

––

–B27

BlankBw4

B*2716

B27

––

––

––

–B27

ShortB27,someB40

sera

reactive

B*2717

B27

B27

––

––

––

B27

Norm

alB

27

B*2718

Undefined

––

–Blank[100]b

2–

–Notassignede

Bw6positive

B*2719

B27

B27

––

––

––

B27

Norm

alB

27

B*2720

B27

B27

––

––

––

B27



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*2721

B27

––

––

––

–B27

B*2723

Undefined

––

––

––

–Notassignede

BlankBw6,Bw4

negative/w

eak,

onlyreactivewith

few

B441

27sera

B*2724

B27

––

––

––

–B27

B*2725

B27

––

––

––

–B27

B*2726

B27

––

––

––

–B27

B*2727

B27

––

––

––

–B27

B*2728

B27

––

––

––

–B27

B*2729

B27

B27

––

––

––

Notassignede

NN:B27

B*2730

B27

B27

––

––

––

B27

B*2731

B27

––

––

––

–B27

B*2732

B27

––

––

––

–B27

B*2733

Undefined

––

––

––

–Notassignede

NN:B27,B40,B61

B*2734

B27

––

––

––

–B27

NN:B27

B*2735

B27

––

––

––

–B27

B*2736

B27

––

––

––

–B27

B*2737

B27

––

––

––

–B27

B*2738

B27

B27

––

––

––

B27

B*3501

B35

B35

B35[97–100]a

27

B35[98]

2023

B35

58

Training–B35

B*3502

B35

B35

B35[94–99]

3B35[72]

1013

B35

9Training–B35

B*3503

B35

B35

B35[95–100]

3B35[94]

1226

B35

22

Training–B35

B*3504

B35

B35

––

B35[100]

26

––

B35

B*3505

B35

B35

B35[98–99]

9B35[94]

231

B35

7Training–B35

B*3506

B35

B35

––

B35[100]b

13

––

B35

B*3507

B35

B35

––

––

––

B35

B*3508

B35

B35

B35[95–98]a

6B35[91]

345

B35

5Training–B35

B*3509

B35

B35

––

B35[100]b

3–

–B35

B*3510

B35

B35c

––

B35[77],B70[15]b

13

B35

1B35

ihw13:shortB35

B*3511

B35

B35

––

B35[88]b

16

––

B35

B*3512

B35

B35

B35[98–100]a

12

B35[78]

422

B35

2B35

B*3513

B35

B35

––

–b

––

B35

B*3514

B35

B35

B35[98]a

1B35[79]

29

––

B35

B*3515

B35

B35

––

Blank[50],B35[33]b

6–

–B35

ShortB35,B75CREG

sera

reactive

B*3516

B35

B35c

B35[63],B70[20]

2B35[33],blank[34]

41

B35

1B35

ihw13:shortB35

B*3517

B35

B35

B35[97–100]

9B35[93]

261

B35

2Training–B35



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*3518

B35

B35

––

B35[100]b

1–

–B35

B*3519

B35/blank

B35

––

B35[40],B70[20],

B77[20]b

5Blank

2B35

ihw13:new

pattern,

blank,very

short

B35

B*3520

B35

B35

––

B35[42],blank[13]

23

B35

5B35

B*3521

B35/B78

––

–B35[42],B78[33],

blank[25]b

12

B78

1B35

ihw13:B35/78variant

B*3522

B35

––

–B35[100]b

2–

–B35

B*3523

B35

B35c

B35[84–88]

4B35[92]b

13

B35

1B35

B*3524

B35

––

–B35[75],B78[25]b

8–

–B35

B*3525

B35

B35c

––

B35[33],blank[67]b

3B35

1B35

ihw13:shortB35

B*3526

B35

––

––

––

–B35

B*3527

B35

B35

––

B35[100]b

2–

–B35

B*3528

B35

––

–B35[50],blank[43]b

14

––

B35

B*3529

B35

B35

––

B35[100]b

2–

–B35

B*3530

B35

B35

––

B35[100]b

7–

–B35

Norm

alB

35

B*3531

B35

––

–Blank[67],B61[17],

B48[17]b

6B35

1B35

ihw13:shortB35;

reactivewithfew

B40andB35sera,

Korean

B*3532

B35

B35

––

B35[100]b

2–

–B35

B*3533

B35

––

––

––

–B35

B*3534

B35

––

–B35[100]b

1–

–B35

B*3535

B35

B35

––

––

––

B35

B*3536

B35

––

–B35[100]b

1–

–B35

B*3537

B35

––

–B35[100]b

1–

–B35

B*3538

B35

––

–bd

1–

–B35

B*3539

B35

––

––

––

–B35

B*3540N

Notexpressed

Null

––

––

––

NT

B*3541

B35

B35

––

B35[100]b

3–

–B35

B*3542

B35

B35

––

––

––

B35

Norm

alB

35

B*3543

B35

B35

B35[95–97]a

3B35[63],B70[12]

379

B35

2Notassignede

PreviouslyB*1522;

NN:B35

B*3544

Undefined

B35

––

––

––

Notassignede

PreviouslyB*1559

B*3545

B35

––

––

––

–B35

B*3546

B35

B35

––

––

––

B35

B*3547

B35

––

–B35[100]b

1–

–B35

B*3548

B35

––

––

––

–B35



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*3549

B35

––

–B35[100]b

1–

–B35

B*3550

B35

B35

––

––

––

B35

B*3551

B35

B35

––

––

––

B35

B*3552

B35

B35

––

––

––

B35

B*3553N

Notexpressed

Null

––

––

––

NT

B*3554

B35

––

––

––

–B35

B*3555

B35

B35

––

––

––

B35

B*3556

B35

––

––

––

–B35

B*3557

B35

B35

––

––

––

B35

B*3558

B35

––

––

––

–B35

B*3559

B35

––

––

––

–B35

B*3560

B35

B35

––

––

––

Notassignede

NN:B35

B*3561

B35

B35

––

––

––

B35

B*3562

B35

––

––

––

–B35

B*3563

Undefined

––

––

––

–Notassignede

NN:B40

B*3564

B35

––

––

––

–B35

B*3565Q

B35

––

––

––

–B35

Notexpectedto

be

expressed

B*3566

B35

––

–Blank[100]b

1–

–B35

B*3567

Undefined

––

––

––

–Notassignede

NN:B35

B*3568

B35

––

––

––

–B35

B*3569

B35

––

––

––

–B35

B*3570

B35

B35

––

––

––

B35

B*3571

B35

––

––

––

–B35

B*3572

B35

––

––

––

–B35

B*3573

B35

––

––

––

–B35

B*3574

B35

––

––

––

–B35

B*3575

B35

––

––

––

–B35

B*3576

B35/22

B35/22

––

––

––

B22f

NN:B56

B*3577

B35

––

––

––

–B35

B*3701

B37

B37

B37[98–100]a

6B37[93]

1721

B37

27

Training–B37

B*3702

B37/B27

––

–B27[33],blank[33],

B37[17],B47[17]b

6–

–Notassignede

B37x27orblank;few

B37andfew

B27

sera

reactive;NN:

B37

B*3703N

Notexpressed

Null

––

––

––

NT



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*3704

B37

B37c

––

B37[50],blank[50]b

2B37

1B37

B37variant,reactive

withfew

B37and

B18sera

B*3705

Blank

––

––

––

–Notassignede

BlankBw6,B37,and

Bw4sera

negative,

Korean;NN:B37

B*3706

B37

––

––

––

–B37

B*3707

Undefined

––

––

––

–Notassignede

B*3708

B37

B37

––

––

––

B37

B*3709

B37

B37

––

––

––

Notassignede

NN:B37

B*3710

B37

B37

––

––

––

B37

B*3711

Undefined

––

––

––

–Notassignede

NN:B37

B*3712

B37

––

––

––

–B37

B*3713

B37

––

––

––

–B37

B*3801

B38

B38(16)

B38[96–100]a

14

B38[94],B16[1],

B39[1]

2317

B38

43

Training–B16B38

B*3802

B38

B38(16)

B38[91–99]a

15

B38[87],B39[2],

B16[2]

788

B38

15

Training–B16B38

ihw13:differentfrom

B*3801

B*3803

B38

B16

––

Blank[100]b

1–

–Notassignede

B16Bw4,B38,and

B39sera

negative;

NN:B16B38

B*3804

B38

––

––

––

–B38

B*3805

B38

B38(16)

––

––

––

B38

Norm

alB

38

B*3806

B38

––

––

––

–B38

B*3807

B38

––

––

––

–B38

B*3808

B38

––

––

––

–B38

B*3809

B38

B16c

––

––

––

B38

B16–Bw4,oncell

VOATer299

B*3810

B38

––

––

––

–B38

B*3811

B38

––

––

––

–B38

B*3812

B38

B38(16)

––

––

––

B38

B*3813

B38

––

––

––

–B38

B*3814

B38

––

––

––

–B38

B*3815

B38

B38(16)

––

––

––

B38

B*3816

B38

––

––

––

–B38

B*3901

B3901/B39

B3901

B39[96–99]a

7B39[95]

476

B39

21

Training–B16B39

B*39010102L

Low

B39

Low

B39

––

––

IdenticaltoB*3901



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*3902

B3902/B39

B3902

B39[97–99]a

7B39[87]

96

B39

5Notassignede

ihw13:shortB39;N

N:

B16B39

B*3903

B39

B39(16)

––

B39[89]

19

B39

1B39

B*3904

B39

B39(16)

––

–b

––

B39

B*3905

B39

B39c

B39[89–92],B16

[4–7],B38[1–5]a

17

B39[82]

245

B39

4B39

B39variant,ST-16;

ihw13:B39and

B38sera

positive

B*3906

B39

B39(16)

B39[96–99]

6B39[94]

508

B39

8Training–B16B39

B*3907

B16

––

–Blank[100]b

1–

–B16

B*3908

B39

B39(16)

B39[86–91],B16

[3–5]

4B39[48],blank[41]

57

B39

1Notassignede

ihw13:B39andB38

sera

positive;NN:

B16

B*3909

B39

B39(16)

B39[96–99]

6B39[100]b

29

B39

2B39

B*3910

B39

B39(16)

B39[98]a

4B39[82],blank[16]

127

B39

5B39

B*3911

B39

B39(16)c

––

B39[79],blank[14]b

29

––

B39

B*3912

B39

B39(16)

––

B39[100]b

1B39

1B39

B*3913

B39

B39(16)

––

B39[40],blank[40]b

5–

–Notassignede

NN:B16,B39

B*3914

B39

––

–B39[100]b

4–

–B39

B*3915

B39

B39(16)c

––

B39[100]b

6B39

1B39

B*3916

B39

––

––

––

–B39

B*3917

B39

––

–B39[100]b

1–

–Notassignede

NN:B39,B16

B*3918

B39

––

––

––

–B39

B*3919

B39

B39(16)c

––

Blank[100]b

1B39

1B39

B*3920

B39

–B39[73],B16[16]a

1Blank[67],B38[33]b

3–

–B16f

NN:B38

B*3922

B39

––

–bd

1–

–B39

B*3923

B39

B39(16)

––

––

––

Notassignede

NN:B16,B39

B*3924

B39

B39(16)

––

B39[97]b

30

B39

1B39

Norm

alB

39

B*3925N

Notexpressed

Null

––

––

––

NT

B*3926

B39

––

––

––

–B39

B*3927

B39

B39(16)

––

––

––

B39

Norm

alB

39

B*3928

B39

––

––

––

–B39

B*3929

B39

––

––

––

–B39

B*3930

B39

––

––

––

–B39

B*3931

B39

––

–B39[100]b

2–

–B39

B*3932

B16

––

––

––

–B16f

NN:B39

B*3933

B39

––

––

––

–B39

B*3934

B39

B39(16)

––

––

––

B39

B*3935

B39

––

–B39[100]b

1–

–B39



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*3936

Undefined

––

––

––

–Notassignede

NN:B39,B16,B14

B*3937

B39

––

––

––

–B39

B*3938Q

B39

––

––

––

–B39

Notexpectedto

be

expressed

B*3939

B39

––

––

––

–B39

B*3940N

Notexpressed

Null

––

––

––

NT

B*3941

B39

B39(16)

––

––

––

B39

B*3942

B39

––

––

––

–B39

B*4001

B60

B60(40)

B60[96–98]a

37

B60[93],B40[4],

B61[2]

3854

B60

48

Training–B40B60

B*4002

B61

B61(40)

B61[75–95],B40

[3–19],B60[2–21]a

24

B61[80],B60[8],

B40[6]

1460

B61

33

Training–B40B61

B*4003

B61

B61(40)c

––

B61[62],B60[23]

31

B61

1B61

B*4004

B61

B61(40)c

––

B61[47],B60[12]

57

B61

3B61

B*4005

B4005/B50

B4005

B4005[41–57],B50

[28–36],B21[5–9]

3B50[34],B4005[12],

blank[23],B61[7],

B70[4],B21[4],

B60[4]

293

––

B61

BN21,B21variant

B*4006

B61

B61(40)

B61[87–90],B40[4],

B60[4–8]a

6B61[75],B60[5],

B40[5]

585

B61

17

Training–B40B61

B*4007

B60

B60(40)c

––

B60[100]b

12

––

B60

B‘Fu’

B*4008

B61/blank

–B61[20–27],B40

[20–30],B‘4008’

[9–10],B48[2–14]

3Blank[71],B61[12],

B40[9]

138

B61

2B61

B40x48variant,only

reactivewithsome

B401

48(1

7)

CREGsera

B*4009

B61

B61(40)

––

B61[60],B40[20]b

5B61

1B61

B*4010

B60

B60(40)

B60[75–93],B40

[14–15],B61[3–8],

B48[2–3]a

10

B60[43],B61[25],

B40[14],blank

[11]b

28

B60

2B60

ShortB60,B48like

B*4011

B61

B61(40)c

––

B61[71],B60[26]b

38

B61

2B61

B*4012

B60/B48

–B48[28–34],B70[7–

20],B40[11],B72

[10],B‘4012’[8],

B61[5]

3B48[37],B60[26],

blank[21],B40

[16]b

19

––

Notassignede

B48x70,some

reactivitywithB40

148andB151

70

CREGsera;NN:

B48

B*4013

Undefined

––

–Blank[100]b

1–

–Notassignede

B40Bw4;NN:B61

B40

B*4014

B60

B60(40)

––

B60[100]b

3–

–B40f

NN:B60



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*4015

Undefined

––

––

––

–Notassignede

NN:B41

B*4016

B61

B61(40)

––

B61[58],B60[25],

B40[17]b

12

––

Notassignede

NN:B40,B41

B*4018

B61

––

–B61[100]b

1–

–B61

B*4019

B61

––

––

–B‘4019’

1Notassignede

B40Bw4,B*4002

withBw4epitope;

ihw13:new

pattern

shortB61Bw4

positive;NN:B61,

B40

B*4020

B61

B61(40)c

––

B61[77],B60[8],

B40[8]b

13

B61

1B61

B*4021

B40/B15

––

––

––

–Notassignede

B40x15,reactivewith

B401

48,B

151

57

sera,notwithB40

113sera;N

N:B

15,

B48

B*4022N

Notexpressed

Null

––

––

––

NT

B*4023

B40

––

––

––

–B40f

NN:B60

B*4024

B61

––

––

––

–B61

B*4025

B40

––

––

––

–B60

ShortB40,few

B40

sera

reactive

B*4026

B21

B21

––

––

––

B40f

NN:B61

B*4027

B61

B61(40)

––

B61[68],B60[26]b

19

––

B61

Norm

alB

61

B*4028

Undefined

––

––

––

–Notassignede

NN:B40,B61

B*4029

B61

B61(40)

––

––

B61

1B61

B*4030

B60

––

––

–B60

1B60

ihw13:B61withfew

B60sera

pos

B*4031

B60

B60(40)

––

bd

1–

–B60

Norm

alB

60

B*4032

B40

––

–B60[50],B61[50]b

2–

–Notassignede

NN:B40,B41

B*4033

B60

––

––

––

–B60

B*4034

B60

B60(40)

––

––

––

B60

B*4035

B61

B61(40)

––

––

––

B61

ShortB40,B60sera

negative

B*4036

B60

––

––

––

–B60

B*4037

B61

––

–B61[100]b

1–

–B61

B*4038

B60

––

––

––

–B60

B*4039

B61/B41

B41

––

––

––

B61



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*4040

B61

––

–B61[100]b

1–

–B61

B*4042

B60

––

––

––

–B60

B*4043

B60

––

––

––

–B60

B*4044

B61

––

––

––

–B61

B*4045

B60

––

––

––

–B60

B*4046

B60

––

––

––

–B60

B*4047

B40

B40

––

––

––

Notassignede

B40Bw4;shortB60,

Bw4pos:NN:B40,

B60

B*4048

B60

B60(40)

––

––

––

B60

B*4049

B60

––

––

––

–B60

B*4050

B61

B61(40)

––

––

––

B61

B*4051

Undefined

––

––

––

–Notassignede

NN:B40

B*4052

B60

B60(40)

––

––

––

B60

B*4053

B61

B61(40)

––

––

––

B61

B*4054

B60

B60(40)

––

––

––

B60

B*4055

B60

––

––

––

–B60

B*4056

B61

B61(40)

––

––

––

B61

B*4057

B61

––

––

––

–B61

B*4058

B40

––

––

––

–B40

B*4059

B40

––

––

––

–B40f

NN:B60

B*4060

Undefined

––

––

––

–Notassignede

NN:B60,B40

B*4061

B60

––

––

––

–B60

B*4062

B60

––

––

––

–B60

B*4063

B60

––

––

––

–B60

B*4064

B61

B40

––

––

––

B61

B*4065

B60

––

––

––

–B60

B*4066

B60

––

––

––

–B60

B*4067

B60

––

––

––

–B60

B*4068

Undefined

––

––

––

–Notassignede

NN:B40,B61

B*4069

B60

––

––

––

–B60

B*4070

B61

B61(40)

––

––

––

B61

B*4071

B61

––

––

––

–B61

B*4072

B60

––

––

––

–B60

B*4073

B60

––

––

––

–B60

B*4074

B60

––

––

––

–B60

B*4075

B61

––

––

––

–B61

B*4076

B60

––

––

––

–B60



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*4077

B60

––

––

––

–B60

B*4101

B41

B41

B41[91–95]a

7B41[87]

543

B41

14

Training–B41

B*4102

B41

B41

B41[91–95]

9B41[87]

478

B41

16

Training–B41

B*4103

B41

B41

––

B41[92]b

13

––

B41

B*4104

B41

––

––

––

–B41

B*4105

B41

––

––

––

–B41

ShortB41,Bw6sera

negative

B*4106

B41

––

––

––

–B41

B*4107

B41

––

––

––

–B41

B*4108

B41

––

––

––

–B41

B*4201

B42

B42

B42[89–97]a

12

B42[93],B55[1],B7

[1]

1015

B42

9Training–B42

B*4202

B42

B42

B42[87–96],B67

[0–12]

6B42[95]

80

B42

2Training–B42

B*4204

B42

––

––

––

–B42

B*4205

B42

––

–Blank[100]b

1–

–B42

B*4206

B42

––

––

––

–B42

B*4207

Undefined

––

––

––

–Notassignede

NN:B42,B8

B*4208

B42

––

––

––

–B42

B*4209

B42

––

––

––

–B42

B*4402

B44

B44(12)

B44[99–100]

–B44[98]

6959

B44

55

Training–B12B44

B*44020102S

Seecomment

Soluble

––

––

––

IdenticaltoB*4402

Secretedmolecule

only(reference:62)

B*4403

B44

B44(12)

B44[97–100]a

30

B44[94]

2854

B44

65

Training–B12B44

B*4404

B44

B44(12)

––

B44[65]

42

B44

7B44

ihw13:shortB44

B*4405

B44

B44(12)

––

B44[92]

130

B44

1B44

B*4406

B44

B44(12)

––

B44[46],blank[31]b

13

B44

7Notassignede

ShortB44orblank;

ihw13:blank,short

B44;NN:B44,B12

B*4407

B44

B44(12)

––

B44[100]b

3–

–B44

B*4408

B44

B44(12)

––

B44[100]b

3B44

3B44

ShortB44;also

reactivewithB621

631

57sera,in

Welsh,butvery

rare;ihw13:new

pattern



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*4409

B45

B45(12)c

––

B45[92]b

12

B45

1B12

B44Bw6,willbe

typedasB45or

B12;m

ostB44-and

B45-specificsera

negative

B*4410

B44

B44(12)c

––

B44[70]

37

––

B12f

NN:B44

B*4411

B44

––

–B44[100]b

2–

–B44

B*4412

B44

B44(12)

––

––

––

B44

B*4413

B44

B44(12)

––

––

––

B44

B*4414

B44

B44(12)

––

––

––

B44

ShortB44

B*4415

B12

B12

––

––

––

B45

B45Bw4,willbe

typedasB44orB12

B*4416

B47/B44

B47

B47[52],B44[12]

1–

––

–B44

B44x47,reactivewith

mostB47andfew

B44/12sera

B*4417

B44

B44(12)

––

B44[100]b

1–

–B44

B*4418

B44

––

–B44[100]b

1–

–B12f

NN:B49

B*4419N

Notexpressed

Null

––

––

––

NT

B*4420

B44

––

–B44[100]b

1–

–B44

B*4421

B44

––

–B44[100]b

1B44

2B44

ihw13:blankorvery

shortB44

B*4422

B44

––

–B44[100]b

1–

–B44

B*4423N

Notexpressed

Null

––

––

Blank

1NT

B*4424

B44

––

––

––

–B44

B*4425

B44

––

–B44[100]b

1–

–B44

B*4426

B44

––

––

––

–B44

B*4427

B44

B44(12)

––

B44[100]b

30

––

B44

ShortB44

B*4428

B44

––

––

––

–B44

B*4429

B44

B44(12)c

––

B44[100]b

2–

–B44

Norm

alB

44

B*4430

B44

––

––

––

–B44

B*4431

B44

B44(12)

––

––

––

Notassignede

Alm

ostnorm

alB

44;

NN:B60,B40,B12

B*4432

B44

B44(12)

––

––

––

B44

ShortB44

B*4433

B44

––

––

––

–B44

B*4434

B44

––

––

––

–B44

B*4435

B44

––

––

––

–B44

Norm

alB

44

B*4436

B44

––

––

––

–B44

B*4437

B44

––

–bd

2–

–B44



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*4438

B44

––

––

––

–B44

B*4439

B44

––

––

––

–B44

B*4440

B44

B44(12)

––

––

––

B44

B*4441

B44

––

––

––

–B44

B*4442

Undefined

B21

––

––

––

B44

B*4443

B44

B44(12)

––

––

––

B44

B*4444

B44

––

––

––

–B44

B*4445

B44

––

––

––

–B44

B*4446

B12

––

––

––

–B12

B*4447

B44

––

––

––

–B44

B*4448

B44

––

––

––

–B44

B*4449

B44

––

––

––

–B44

B*4450

B44

––

––

––

–B44

B*4451

B44

––

––

––

–B44

B*4452N

Notexpressed

Null

––

––

––

NT

B*4453

B44

B44(12)

––

––

––

B44

B*4454

B44

B44(12)

––

––

––

B44

B*4501

B45

B45(12)

B45[96–99]

7B45[93],B12[1],

B44[1],B50[1]

2307

B45

16

Training–B12B45

B*4502

B45

––

–B45[100]b

3–

–B45

B*4503

B45

––

––

––

–B45

B*4504

B21

––

––

––

–B21f

NN:B50

B*4505

B45

––

––

––

–B45

B*4506

B45

––

–B45[100]b

1–

–B12f

NN:B45

B*4507

B45

––

––

–B45

B*4601

B46

B46

B46[91–97]a

17

B46[58],blank[27],

B62[1],B35[1]

1487

B46

30

Training–B46

B*4602

B46

B46

––

––

––

B46

B46variant,negative

withB461

75sera

B*4603

B46

B46

––

––

––

B46

B*4604

B46

B46

––

––

––

B46

B*4605

B46

B46

––

––

––

B46

B*4606

Undefined

––

––

––

–Notassignede

NN:B46,B81

B*4607N

Notexpressed

Null

––

––

––

NT

B*4608

B46

––

––

––

–B46

B*4609

B46

––

––

––

–B46

B*4610

B46

––

––

––

–B46

B*4611

B22

––

––

––

–B22



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*4701

B47

B47

B47[90–96]

3B47[50],B27[5],

blank[32]

311

B47

12

Training–B47

B*4702

B47

B47

––

B47[40],blank[40],

B60[20]b

5B61

1Notassignede

B47Bw6,B

471

131

27sera

negative,

B401

131

47sera

positive;NN:B47

B*4703

B47

B47

B47[70–77],B60

[4–9],B61[7–8],

B40[6–7]

2Blank[33],B47[17],

B13[17],B40[17],

B61[17]b

6B47

1B47

B47Bw4,B471

13

sera

negative,B40

113sera

positive

B*4704

Undefined

––

––

––

–Notassignede

NN:B47

B*4705

B17

––

––

––

–B47

B*4801

B48

B48

B48[90–100]a

26

B48[78],B60[6],

B61[2],B40[2]

610

B48

11

Training–B48

B*4802

B48/B70

B48

––

Blank[44],B35[16],

B70[13],B48[3]

39

B71

2Notassignede

B71like;ihw13:

pattern

identicalto

B*1510;NN:B35

B*4803

B48

B48c

B48[97]a

1B48[66],B60[13]

32

B48

1B48

B*4804

B48

B48

––

B48[50],B40[25]b

4–

–B48

Norm

alB

48

B*4805

B48

B48

––

––

––

Notassignede

NN:B48,B7

B*4806

Undefined

––

––

––

–Notassignede

NN:B48

B*4807

B48

B48

––

B60[42],B48[33],

B61[8]b

12

B48

2B48

B*4808

Undefined

––

––

––

–Notassignede

NN:B7,B48

B*4809

B48

B48

––

––

––

B48

B*4810

B48

B48

––

––

––

B48

B*4811

B48

––

––

––

–B48

B*4812

B48

––

––

––

–B48

B*4813

Undefined

––

––

––

–Notassignede

NN:B48,B61

B*4814

B48

––

––

––

–B48

B*4815

B48

––

––

––

–B48

B*4816

B48

––

––

––

–B48

B*4817

Undefined

B48/40

––

––

––

Notassignede

NN:B48

B*4818

B48

––

––

––

–B48

B*4901

B49

B49(21)

B49[94–98]a

6B49[94],B50[1],

B21[1]

3002

B49

22

Training–B21B49

B*4902

B49

B49(21)

––

B49[100]b

6–

–B49

Norm

alB

49

B*4903

B49

––

––

–B49

1Notassignede

ShortB49;NN:

B49,B21



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*4904

B49

––

––

––

–B49

B*4905

B49

B49(21)

––

––

––

B49

B*5001

B50

B50(21)

B50[92–97]a

12

B50[85],B21[3],

B49[2],B45[1]

1700

B50

20

Training–B21B50

B*5002

B45

B45(12)

B45[87–91],B50[7],

B44[5]a

2B45[96]

79

B45

3TrainingB12B45

B*5004

B50

B50(21)

––

B50[67]b

3–

–B50

B*5101

B51

B51(5)

B51[96–99]

40

B51[96],B5[2],

B52[1]

1899

B51

88

Training–B5B51

B*5102

B5102/B51

B5102

B51[38–57],B5102

[21–33],B53

[8–16],B5[4–7],

B52[3–7]

11

B51[73],B53[11],

B52[6],B5102[3],

B5[3]

218

B5102

5B51

ihw13:shortB51with

someB351

53

sera

reactive

B*5103

B5103/B51

B5103

––

B51[100]b

3–

–B51

B*5104

B51

B51(5)c

––

B51[75],B52[12],

B5[12]b

8B51

1B51

B*5105

B51

B51(5)

B51[45],B53[33],

B5[3],B52[3]

1B51[48],B53[24],

B52[16]

25

B51

3B51

ihw13:B5102,short

B51withsomeB35

153sera

reactive

B*5106

B51

B51(5)

B51[82–88],B53

[1–4],B52[0–4],

B5102[0–3]a

5B51[64],B53[12],

B52[7]

42

B51

5B51

B5,mostB51sera

negative;ihw13:

shortB51,distinct

pattern

B*5107

B51

B51(5)

––

B51[78],B52[9]

68

B51

3Training–B5B51

ihw13:shortB51,

distinctpattern

B*5108

B51

B51(5)

B51[96–99]a

3B51[77],B53[4]

154

B51

4Training–B5B51

B*5109

B51

B51(5)

––

B51[86]

43

––

Training–B5B51

B*5110

B51

––

–Blank[100]b

2B51

1B51

ihw13:B5102,short

B51withsomeB35

153sera

reactive

B*5111N

Notexpressed

Null

––

––

––

NT

B*5112

B51/blank

––

––

––

–B51

B‘blank’,possiblynot

expressed

B*5113

B51

–B51[95–98]a

2B51[100]b

7–

–B51

B*5114

B51

B51(5)c

––

B51[88],B5[12]b

17

B51

1B51

B*5115

Undefined

––

––

––

–Notassignede

NN:B59

B*5116

B51

B5

––

B51[100]b

1–

–B51

B*5117

B51

B51(5)

––

––

––

B51



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*5118

B51

B51(5)

––

––

––

B51

B*5119

B51

––

––

––

–B51

B*5120

B51

––

––

––

–B51

B*5121

B51

––

–B51[100]b

1–

–B51

B*5122

B51

––

–B51[100]b

2–

–B51

B*5123

B51

––

–d

2–

–B51

B*5124

B51

B51(5)

––

––

B51

1B51

B*5126

B51

––

––

––

–B51

B*5127N

Notexpressed

Null

––

––

––

NT

B*5128

B51

B51(5)

––

––

B51

1B51

B*5129

B51

B51(5)

––

B51[100]b

1–

–B51

B*5130

B51

––

––

––

–B51

B*5131

B51

B51(5)

––

d1

––

B51

B*5132

B51

––

––

––

–B51

B*5133

B51

––

––

––

–B51

B*5134

B51

––

––

––

–B51

B*5135

B51

B51(5)

––

––

––

B51

B*5136

B51

––

––

––

–B51

B*5137

B51

––

––

––

–B51

B*5138

B51

––

––

––

–B51

B*5139

B51

––

––

––

–B51

B*5140

B51

––

––

––

–B51

B*5141N

Notexpressed

Null

––

––

––

NT

B*5142

Undefined

B44(12)

––

––

––

Notassignede

NN:B44,B12,B53

B*5143

B51

B51(5)

––

––

––

B51

B*5144N

Notexpressed

Null

––

––

––

NT

B*5145

Undefined

––

––

––

–Notassignede

NN:B5,B51

B*5146

B51

B51(5)

––

––

––

B51

B*5147

B51

––

––

––

–B51

B*5148

B51

––

––

––

–B51

B*5149

B51

––

––

––

–B51

B*5201

B52

B52(5)

B52[93–95]

13

B52[82],B51[7],

B5[2],B53[1]

2823

B52

32

Training–B5B52

B*5202

B52

––

–B52[100]b

2–

–B52B15

B*5203

B52

––

–B52[100]b

1–

–B52

B*5204

B52

B52(5)

B52[76],B5[11]

1–

––

–B52

Norm

alB

52

B*5205

B52

––

––

––

–B52

B*5206

B52

––

––

––

–B52



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*5207

B52

B52(5)

––

––

––

B52

B*5208

B52

B52(5)

––

––

––

B52

B*5209

B52

––

––

––

–B52

B*5210

B52

––

––

––

–B52

B*5211

B52

––

––

––

–B52

B*5301

B53

B53

B53[91–94]a

25

B53[86],B35[5],

B51[1]

3054

B53

20

Training–B53

B*5302

B53

––

–B53[83]b

6–

–B53

B*5303

B53/B35

––

–B35[100]b

2–

–Notassignede

NN:B35,B53

B*5304

B53

––

–B53[100]b

2–

–B53

LongB53,someB5

sera

reactive

B*5305

B53

––

–B53[100]b

3–

–B53

B*5306

B53/B51

––

––

–B51

1B53

B53x51,longB53,

extrareactivitywith

someB51sera

B*5307

B53

B53

––

––

––

Notassignede

B53x37,reactivewith

someB37CREG

sera;NN:B51,B5

B*5308

B53

––

––

––

–B53

B*5309

B53

––

––

––

–B53

B*5310

B53

––

–B53[100]b

1–

–B53

B*5311

B53

B53

––

––

––

B53

B*5312

B53

––

––

––

–B53

B*5313

B53

––

––

––

–B53

B*5401

B54

B54(22)

B54[88–94]a

8B54[67],B55[10],

B22[3],B56[2],

blank[9]

631

B54

20

Training–B22B54

B*5402

B54

B54(22)

––

––

––

B54

B*5403

B22

––

––

––

–B54B56

B*5404

B54

––

––

––

–B54

B*5405N

Notexpressed

Null

––

––

––

NT

B*5406

Undefined

––

––

––

–Notassignede

NN:B22

B*5407

B54

––

––

––

–B54

B*5408N

Notexpressed

Null

––

––

––

NT

B*5409

Undefined

––

––

––

–Notassignede

NN:B54,B22

B*5410

B54

––

––

––

–B54

B*5411

B54

B54(22)

––

––

––

B54

B*5412

Undefined

––

––

––

–Notassignede

NN:B54,B22



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*5413

B54

––

––

––

–B54

B*5501

B55

B55(22)

B55[89–97]

4B55[92],B22[5]

453

B55

21

Training–B22B55

B*5502

B55

B55(22)

B55[89–96]a

6B55[84],B54[3],

B22[2]

309

B55

11

Training–B22B55

B*5503

B55

B55(22)c

––

B55[100]b

1–

–B55

B55x67,someBw6

sera

negative

B*5504

B55

B55(22)

––

B55[80],B56[7],

B22[7]b

15

––

B22

B*5505

B55

B22

––

B22[100]b

1–

–B55

B*5507

B54

B54(22)

––

B55[25],B54[25],

B56[25],blank

[25]b

4–

–B22f

NN:B54

B*5508

B56

B56(22)

––

––

B56

2B56

B*5509

B22

B22

––

––

––

B55

ShortB22,B7CREG

sera

positive,

negativewithB55

andB56sera

B*5510

B55

B55(22)

––

B55[100]b

1–

–B22

B*5511

B55

––

––

––

–B55

B*5512

B55

B22

––

––

––

B55

B*5513

B55

––

–B55[100]b

1–

–B55

B55v

B*5514

Undefined

––

––

––

–Notassignede

NN:B22,B55

B*5515

B55

B55(22)

––

––

––

B55

B*5516

B55

B22

––

––

––

B55

B*5517

B55

––

––

––

–B55

B*5518

Undefined

––

––

––

–Notassignede

B*5519

B55

––

––

––

–B55

B*5520

B22

––

––

––

–B22f

NN:B55

B*5521

B55

––

––

––

–B55

B*5522

B22

B55(22)

––

––

––

B22f

NN:B56

B*5523

B55

––

–B55[100]b

1–

–B55

B*5524

B55

––

––

––

–B55

B*5525

B55

––

––

––

–B55

B*5526

B55

––

––

––

–B55

B*5527

B55

––

––

––

–B55

B*5601

B56

B56(22)

B56[94–96]

5B56[72],B22[5],B55

[3],blank[8]

671

B56

23

Training–B22B56



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*5602

B56

B56(22)

––

B56[63],B55[12],

blank[25]b

8B56

6Training–B22B56

B*5603

B22/15

B22

––

B56[65],B22[6],

blank[12]b

17

B56

1Notassignede

B22variant,B55,B56

sera

negative,B15

1461

70sera

reactive;in

Asians

B*5604

B56

B56(22)

B56[88–93],B22

[1–5]a

4B56[82],B54[4],B22

[4],blank[11]b

28

B56

1B56

ShortB56s,some

B56andB22sera

negative

B*5605

B56

B56(22)

––

Blank[100]b

1B56

4B22

ShortB56

B*5606

B78

B78

––

––

––

B22

B78variant,some

B35andB15CREG

sera

positive,all

B22sera

negative

B*5607

B56

B56(22)

––

––

B56

1Notassignede

B56Bw4,someB7

sera

positive;

ihw13:B56Bw4;

NN:B56,B22

B*5608

B56

––

––

––

–B56

B*5609

B56

––

––

––

–B56

B*5610

B55

B55(22)

––

––

––

B55

ShortB22,reactive

withB541

55sera,

negativewithB55

17sera

B*5611

B56

B56(22)

––

––

––

B56

ShortB56

B*5612

B22

B55(22)

––

––

––

B22

B*5613

B56

B56(22)

––

––

––

B56

B*5614

B56

––

––

––

–B56

B*5615

B56

B56(22)

––

––

––

B56

B*5616

B56

––

––

––

–B56

B*5617

B56

––

–Blank[100]b

1–

–B56

B*5618

Undefined

––

––

––

–Notassignede

NN:B22

B*5619N

Notexpressed

Null

––

––

––

NT

B*5620

B56

B56(22)

––

––

––

B56

B*5701

B57

B57(17)

B57[87–98],B58

[1–7],B17[1–6]a

12

B57[92],B17[5],

B58[2]

3670

B57

28

Training–B17B57

B*5702

B57

B57(17)

B57[95–96]a

8B57[78],B17[8]

65

B57

4Training–B17B57

ihw13:shortB57



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*5703

B57

B57(17)

B57[96–98]a

5B57[85],B17[6],

B58[6]

412

B57

7Training–B17B57

B*5704

B57

B57(17)

––

B57[67],B17[7]

32

B57

1B57

ihw13:shortB57

B*5705

B57

––

–B57[100]b

3–

–B57

B*5706

B57

––

––

––

–B57

B*5707

B57

––

––

––

–B57

B*5708

B57

B57(17)

––

––

––

B57

Bw4sera

negative,

onlystrongly

reactivewithB151

57sera

B*5709

B57

––

––

––

–B57

B*5710

B57

––

––

––

–B57

B*5711

B57

––

––

––

–B57

B*5712

B57

––

–B57[100]b

1–

–B57

B*5713

B57

––

––

––

–B57

B*5801

B58

B58(17)

B58[90–100]a

25

B58[79],B57[8],

B17[4]

2096

B58

28

Training–B17B58

B*5802

B58

B58(17)

B58[82–93]a

2B58[72],B57[12],

B17[3]

837

B58

10

Training–B17B58

B*5804

B58

––

–B58[100]b

1–

–B58

B*5805

B58

––

––

––

–B58

B*5806

B58

––

–B58[100]b

1–

–B58

B*5807

B58

––

––

––

–B58

B*5808

B17/B5

B17

––

––

––

B5

B17andsomeB5

sera

reactive;NN:

B17

B*5809

B17

––

––

––

–B58

B57

B*5810N

Notexpressed

Null

––

––

––

NT

B*5811

B58

––

––

––

–B58

B*5812

B58

––

––

––

–B58

B*5813

B58

––

––

––

–B58

B*5814

B58

––

––

––

–B58

B*5815

B58

––

––

––

–B58

B*5901

B59

B59

B59[92–95]a

9B59[45],blank[41]

123

B59

6Training–B59

B*5902

B59

B59

––

––

––

B59

B*6701

B67

B67

B67[86–90],B39

[5–11]a

6B39[43],B67[32],

B55[8],blank[11]

81

B67

5Training–B67

ihw13:pattern

includedin

B22

B*6702

Undefined

––

–B39[100]b

1–

–Notassignede

NN:B67



Table

2Continued

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

IHWS13data

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

B*7301

B73

B73

B73[81–87]

4Blank[69],B73[22]

106

B73

3Training–B73

ihw13:pattern

sim

ilar

toB2708

B*7801

B78

B78

B78[83–90],B35

[1–9],B51[1–6]

5B78[41],B35[15],

B51[10],B70[4],

blank[19]

210

B78

1Training–B78

B*7802

B78

B78

––

B78[25],B35[25],

B51[25]b

4–

–B78

B*7803

B78

––

––

––

–B78

B*7804

B35

––

–B35[100]b

5–

–Notassignede

NNB35

B*7805

Undefined

––

––

––

–Notassignede

NNB52

B*8101

B81

B81

B81[81–90],B7

[10–18],B48[0–3]a

12

B7[76],B81[8]

657

B81

7Training–B81

B*8102

B81

B81

B81[89–90],B7[10],

B48[0–3],B60

[2–3]a

2–

––

–B81

B*8201

B82

B82

B‘8201’[28],B22[9]

1Blank[68],B45[4],

B70[4],B‘82’[3],

B65[3]

146

B‘82’

4B56

B22x45,reactivewith

someB45andB22

sera;ihw13:

pattern

alm

ost

includedin

B55

B*8202

B82

–B82[23],B81[19],

B‘8201’[11],B56

[5],B22[3],B42[3]a

1B45[33],blank[67]b

3B‘82’

1B56

B*8301

Undefined

––

–B45[100]b

1–

–Notassignede


etw



arrow

DonorProgram.


ellExchange,UCLA.

bUpdatedNMDPdata.Insomecasestheinform


ells



cWHO


data.

dTheallele


ative.

eNotassigned;seecommentcolumnforpredictions>0.20.

fIfaprimary


are

shownin

thecomments

column.

gRef13–16,29–57,62.



Table

3HLA-C


HLAallele

Expert

assigned

WHO

assigned

InternationalCellExchange,U

CLA

NMDP

IHW

S13data

NN

Comments

Assignedtype[%

]

Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Cw*0102

Cw1

Cw1

Cw1[55–75]a

76

Cw1[92]

260

Cw1

104

Training–Cw1

Cw*0103

Cw1

Cw1

––

Cw1[100]b

1–

–Cw1

Cw*0104

Cw1

––

––

––

–Cw1

Cw*0105

Cw1

––

––

––

–Cw1

Cw*0106

Cw1

––

––

––

–Cw1

Cw*0107

Cw1/blank

––

–Cw1[100]b

1–

–Cw1

Cw

blank,theHLA

clubcell

exchange:nine

laboratories

perform

ing

serology

Cw*0108

Cw1

––

––

––

–Cw1

Cw*0109

Cw1

Cw1

––

––

––

Cw1

ShortCw1

Cw*0110

Cw1

––

––

––

–Cw1

Cw*0111

Cw1

––

––

––

–Cw1

Cw*0112

Cw1

––

––

––

–Cw1

Cw*0113

Cw1

––

––

––

–Cw1

Cw*0114

Cw1

––

––

––

–Cw1

Cw*0115

Cw1

––

––

––

–Cw1

Cw*0116

Cw1

––

––

––

–Cw1

Cw*0117

Cw1

––

––

––

–Cw1

Cw*0118

Cw1

––

––

––

–Cw1

Cw*0119

Cw1

––

––

––

–Cw1

Cw*0202

Cw2

Cw2

Cw2[62–76]a

27

Cw2[91]

382

Cw2

67

Training–Cw2

Cw*0203

Cw2

––

–Cw2[100]b

1–

–Cw2

Cw*0204

Cw2

––

––

––

–Cw2

Cw*0205

Cw2

––

––

––

–Cw2

Cw*0206

Cw2

––

––

––

–Cw2

Cw*0207

Cw2

––

––

––

–Cw2

Cw*0208

Cw2

Cw2

––

––

––

Cw2

Cw*0209

Cw2

––

––

––

–Cw2

Cw*0210

Cw2

Cw2

––

Cw2[75]b

4Cw2

Cw*0211

Cw2

––

––

––

–Cw2

Cw*0212

Cw2

––

––

––

–Cw2

Cw*0213

Cw2

––

––

––

–Cw2

Cw*0214

Cw2

––

––

––

–Cw2

Cw*0215

Cw2

––

––

––

–Cw2

Cw*0216

Cw2

––

––

––

–Cw2

Cw*0217

Cw2

––

––

––

–Cw2



Table

3Continued

HLAallele

Expert

assigned

WHO

assigned


CLA

NMDP

IHW

S13data

NN

Comments

Assignedtype[%

]

Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Cw*0218

Cw2

––

––

––

–Cw2

Cw*0302

Cw10

Cw10(w

3)

Cw3[45–67],Cw10

[6–13]a

13

Cw3[69],Cw10[5]

41

Cw10

11

Cw10

Cw*0303

Cw9

Cw9(w

3)

Cw3[55–68],Cw9

[8–15]a

38

Cw3[80],Cw9[6]

446

Cw9

75

Training–Cw3Cw9

Cw*0304

Cw10

Cw10(w

3)

Cw3[52–69],Cw9

[0–11],Cw10

[3–12]a

62

Cw3[92],Cw10[3],

Cw9[1]

603

Cw10

51

Training–Cw3Cw10

Cw*0305

Cw3

–Cw3[48],Cw10[7]a

1Cw3[83],blank[17]b

12

––

Cw10

Cw*0306

Cw10

Cw10(w

3)c

Cw3[52],Cw10[6]

1Cw3[75],blank[25]b

16

Cw10

1Cw10

ihw13:shortpattern

Cw*0307

Cw3

Cw3

––

Cw3[100]b

1–

–Cw10

Cw*0308

Cw10

––

––

––

–Cw10

Cw*0309

Cw10

Cw3c

Cw3[44–59],Cw10

[3–6]

3Cw3[100]b

1–

–Cw10

Cw*0310

Cw3

Cw3

––

Cw3[100]b

1–

–Cw10

Cw*0311

Cw9

Cw3

––

––

––

Cw9

Cw*0312

Cw9

––

––

––

–Cw9

Cw*0313

Cw9

––

––

––

–Cw9

Cw*0314

Cw10

––

––

––

–Cw10

Cw*0315

Undefined

––

––

––

–Notassignedd

NN:Cw3,Cw10

Cw*0316

Blank

––

––

––

–Cw3

Cw3,w9,w10sera

negative;NN:

Cw10

Cw*0317

Cw10

––

––

Cw10

Cw*0318

Cw9

––

–Cw3[100]b

1Cw9

Cw*0319

Cw3

Cw3

––

––

––

Cw10

Cw*0320N

Notexpressed

Null

––

––

––

NT

Cw*0321

Cw9

––

––

––

–Cw9

Cw*0322Q

Undefined

––

––

––

–Cw9

Notexpectedto

be

expressed

Cw*0323

Cw10

––

––

––

–Cw10

Cw*0324

Cw10

Cw3

––

––

––

Cw10

Cw*0325

Cw10

––

––

––

–Cw10

Cw*0326

Cw10

Cw10(w

3)

––

––

––

Cw10

Cw*0327

Cw10

––

––

––

–Cw10

Cw*0328

Cw10

Cw10(w

3)

––

––

––

Cw10

Cw*0329

Cw10

––

––

––

–Cw10

Cw*0330

Cw9

––

––

––

–Cw9



Table

3Continued

HLAallele

Expert

assigned

WHO

assigned


CLA

NMDP

IHW

S13data

NN

Comments

Assignedtype[%

]

Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Cw*0331

Cw9

––

––

––

–Cw9

Cw*0332

Cw10

––

––

––

–Cw10

Cw*0333

Cw10

––

––

––

–Cw10

Cw*0334

Cw10

––

––

––

–Cw10

Cw*0335

Cw10

––

––

––

–Cw10

Cw*0336

Cw10

––

––

––

–Cw10

Cw*0337

Cw10

––

––

––

–Cw10

Cw*0338

Cw10

––

––

––

–Cw10

Cw*0339

Cw9

Cw3

––

––

––

Cw9

Cw*0340

Cw10

Cw3

––

––

––

Cw10

Cw*0341

Cw10

––

––

––

–Cw10

Cw*0401

Cw4

Cw4

Cw4[54–76]a

107

Cw4[98]

736

Cw4

114

Training–Cw4

Cw*0403

Cw4/Cw6

–Cw4[16–33],Cw6

[7–26],C‘403’

[3–8]a

35

Blank[100]b

7Cw4

11

Notassignedd

NN:Cw4;Cw4/6

variant;ihw13:C

w6

orblank,onlyCw4

16sera

reactive

Cw*0404

Cw4

––

–Cw4[75],blank[25]b

4Blank

1Cw4

Cw*0405

Cw4

––

–Cw4[100]b

2–

–Cw4

Cw*0406

Cw4/Cw6

–Cw6[27–33],Cw4

[20–25],C‘403’

[2–3]a

4–

––

–Notassignedd

NN:Cw4

Cw*0407

Cw4

Cw4c

––

Cw4[100]b

1Cw4

1Cw4

Cw*0408

Cw4

––

–be

1–

–Cw4

Cw*0409N

Notexpressed

Null

–1

Blank[100]b

2–

–NT

Cw*0410

Cw4

Cw4

––

Cw4[100]b

1–

–Cw4

Norm

alC

w4

Cw*0411

Undefined

––

––

––

–Notassignedd

NN:Cw4

Cw*0412

Cw4

––

––

––

–Cw4

Cw*0413

Cw4

––

––

––

–Cw4

Cw*0414

Cw4

––

––

––

–Cw4

Cw*0415

Cw4

––

––

––

–Cw4

Cw*0416

Cw4

––

––

––

–Cw4

Cw*0417

Cw4

––

––

––

–Cw4

Cw*0418

Cw4

––

––

––

–Cw4

Cw*0419

Cw4

––

––

––

–Cw4

Cw*0420

Cw4

Cw4

––

––

––

Cw4

Cw*0421

Cw4

––

––

––

–Cw4

Cw*0423

Cw4

––

––

––

–Cw4

Cw*0424

Cw4

––

––

––

–Cw4

Cw*0425

Cw4

––

––

––

–Cw4



Table

3Continued

HLAallele

Expert

assigned

WHO

assigned


CLA

NMDP

IHW

S13data

NN

Comments

Assignedtype[%

]

Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Cw*0426

Cw4

––

––

––

–Cw4

Cw*0427

Cw4

––

––

––

–Cw4

Cw*0501

Cw5

Cw5

Cw5[50–63]a

13

Cw5[83],blank[15]

579

Cw5

69

Training–Cw5

Cw*0502

Cw5

Cw5

––

Cw5[100]b

2–

–Cw5

Cw*0503

Cw5

––

––

––

–Cw5

Cw*0504

Cw5

––

––

––

–Cw5

Cw*0505

Cw5

––

–Blank[100]b

1–

–Cw5

Cw*0506

Cw5

––

––

––

–Cw5

Cw*0507N

Notexpressed

Null

––

––

––

NT

Cw*0508

Cw5

––

––

––

–Cw5

Cw*0509

Cw5

––

–Cw5[100]b

1–

–Cw5

Cw*0510

Cw5

––

––

––

–Cw5

Cw*0511

Cw5

––

––

––

–Cw5

Cw*0512

Cw5

––

––

––

–Cw5

Cw*0513

Cw5

––

––

––

–Cw5

Cw*0514

Cw5

––

––

––

–Cw5

Cw*0515

Cw5

––

––

––

–Cw5

Cw*0516

Cw5

––

––

––

–Cw5

Cw*0517

Cw5

––

––

––

–Cw5

Cw*0602

Cw6

Cw6

Cw6[51–71]a

44

Cw6[74],Cw4[1],

blank[12]

665

Cw6

104

Training–Cw6

Cw*0603

Cw6

––

–Cw6[100]b

1–

–Cw6

Cw*0604

Cw6

––

–Cw6[100]b

2–

–Cw6

Cw*0605

Cw6

Cw6

––

––

––

Cw6

Cw*0606

Cw6

––

––

––

–Cw6

Cw*0607

Cw6

––

–Blank[100]b

1–

–Cw6

Cw*0608

Cw6

––

––

––

–Cw6

Cw*0609

Cw6

––

––

––

–Cw6

Cw*0610

Cw6

––

––

––

–Cw6

Cw*0611

Undefined

––

––

––

–Notassignedd

NN:Cw6

Cw*0612

Cw6

––

––

––

–Cw6

Cw*0613

Cw6

––

––

––

–Cw6

Cw*0614

Cw6

––

––

––

–Cw6

Cw*0615

Cw6

––

––

––

–Cw6

Cw*0616N

Notexpressed

Null

––

––

––

NT

Cw*0701

Cw7

Cw7

Cw7[52–73]a

36

Cw7[74],blank[20]

304

Cw7

129

Training–Cw7

Cw*0702

Cw7

Cw7

Cw7[51–73]a

110

Cw7[68],blank[14]

976

Cw7

144

Training–Cw7

Cw*0703

Cw7

––

–b

––

–Cw7



Table

3Continued

HLAallele

Expert

assigned

WHO

assigned


CLA

NMDP

IHW

S13data

NN

Comments

Assignedtype[%

]

Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Cw*0704

Cw7

Cw7

Cw7[59–72]

14

Cw7[64],blank[24]

54

Cw7

30

Cw7

Cw*0705

Cw7

Cw7c

––

––

Cw7

2Cw7

Cw*0706

Cw7

Cw7

Cw7[62–76]

4Cw7[67],blank[33]b

3–

–Cw7

Cw*0707

Cw7

––

–Blank[100]b

1–

–Cw7

Cw*0708

Cw7

––

–Cw7[100]b

1–

–Cw7

Cw*0709

Cw7

––

–Cw7[100]b

1–

–Cw7

Cw*0710

Cw7

––

–Cw7[100]b

1–

–Cw7

Cw*0711

Cw7

––

––

––

–Cw7

Cw*0712

Cw7

Cw7

––

––

––

Cw7

Cw*0713

Cw7

––

––

––

–Cw7

Cw*0714

Cw7

Cw7

––

––

––

Cw7

Cw*0715

Cw7

––

––

––

–Cw7

Cw*0716

Cw7

Cw7

––

Blank[100]b

1–

–Cw7

Cw*0717

Cw7

–Cw7[61%

]allele

typedoutside

primary

cellrange

1–

––

–Cw7

Cw*0718

Cw7

–Cw7[73]a

1Cw7[67],blank[33]b

3–

–Cw7

Cw*0719

Cw7

––

––

––

–Cw7

Cw*0720

Cw7

––

––

––

–Cw7

Cw*0721

Cw7

––

––

––

–Cw7

Cw*0722

Cw7

––

––

––

–Cw7

Cw*0723

Cw7

––

––

––

–Cw7

Cw*0724

Cw7

––

––

––

–Cw7

Cw*0725

Cw7

––

––

––

–Cw7

Cw*0726

Cw7

––

––

––

–Cw7

Cw*0727

Cw7

––

–be

1–

–Cw7

Cw*0728

Cw7

––

––

––

–Cw7

Cw*0729

Cw7

––

––

––

–Cw7

Cw*0730

Cw7

Cw7

––

––

––

Cw7

Cw*0731

Cw7

––

––

––

–Cw7

Cw*0732N

Notexpressed

Null

––

––

––

NT

Cw*0733N

Notexpressed

Null

––

––

––

NT

Cw*0734

Cw7

––

––

––

–Cw7

Cw*0735

Cw7

––

––

––

–Cw7

Cw*0736

Cw7

Cw7

––

––

––

Cw7

Cw*0737

Cw7

Cw7

––

––

––

Cw7

Cw*0738

Cw7

Cw7

––

––

––

Cw7

Cw*0739

Cw7

––

––

––

–Cw7



Table

3Continued

HLAallele

Expert

assigned

WHO

assigned


CLA

NMDP

IHW

S13data

NN

Comments

Assignedtype[%

]

Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Cw*0740

Cw7

Cw7

––

––

––

Cw7

Cw*0741

Undefined

––

––

––

–Cw8

Cw*0742

Cw7

––

––

––

–Cw7

Cw*0743

Cw7

––

––

––

–Cw7

Cw*0744

Cw7

Cw7

––

––

––

Cw7

Cw*0745

Cw7

Cw7

––

––

––

Cw7

Cw*0746

Cw7

––

––

––

–Cw7

Cw*0747

Cw7

––

––

––

–Cw7

Cw*0748

Cw7

––

––

––

–Cw7

Cw*0749

Cw7

Cw7

––

––

––

Cw7

Cw*0801

Cw8

Cw8

Cw8[40–66]a

62

Cw8[41],blank[34]

31

Cw8

40

Cw8

ihw13:pattern

differentfrom

Cw*0802

Cw*0802

Cw8

Cw8

Cw8[55–66]a

21

Cw8[67],blank[29]

234

Cw8

30

Training–Cw8

Cw*0803

Cw8

Cw8

Cw8[8–16]a

4Blank[100]b

3Blank

2Cw8

Cw*0804

Cw8

Cw8c

Cw8[43–57]a

4Cw8[100]b

2–

–Cw8

Cw*0805

Cw8

––

––

––

–Cw8

Cw*0806

Cw8

––

––

––

–Cw8

Cw*0807

Cw8

––

––

––

–Cw8

Cw*0808

Cw8

––

––

––

–Cw8

Cw*0809

Cw8

––

––

––

–Notassignedd

NN:Cw8,Cw7

Cw*0810

Undefined

––

––

––

–Cw5

Cw*0811

Undefined

––

––

––

–Notassignedd

NN:Cw8,Cw7

Cw*0812

Cw8

––

––

––

–Cw8

Cw*0813

Cw8

––

––

––

–Cw8

Cw*0814

Cw8

––

––

––

–Cw8

Cw*1202

Undefined

–Blank,noCw

antigen

reportedbymore

than5%

ofthe

laboratories

11a

Blank[94]

85

Blank

27

Notassignedd

ihw13:reactivewith

broadCw

reagents

Cw*1203

Undefined

–Blank

30a

Blank[59],Cw7[4]

238

Blank

75

Notassignedd

ihw13:reactivewith

broadCw

reagents

Cw*1204

Blank

–Blank

4a

Blank[100]b

3–

–Cw6

Cw*1205

Undefined

––

––

––

–Notassignedd

NN:Cw2,Cw6

Cw*1206

Undefined

––

––

––

–Notassignedd

Cw*1207

Undefined

––

––

––

–Notassignedd

NN:Cw6

Cw*1208

Undefined

––

––

––

–Notassignedd

Cw*1209

Undefined

––

––

––

–Notassignedd

NN:Cw2,Cw6



Table

3Continued

HLAallele

Expert

assigned

WHO

assigned


CLA

NMDP

IHW

S13data

NN

Comments

Assignedtype[%

]

Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Cw*1210

Undefined

––

––

––

–Notassignedd

Cw*1211

Undefined

––

––

––

–Notassignedd

Cw*1212

Undefined

––

––

––

–Notassignedd

Cw*1213

Undefined

––

––

––

–Notassignedd

Cw*1214

Cw7

––

––

––

–Cw7

Cw*1215

Undefined

––

––

––

–Notassignedd

Cw*1216

Undefined

––

––

––

–Notassignedd

NN:Cw7

Cw*1217

Undefined

––

––

––

–Notassignedd

Cw*1218

Undefined

––

––

––

–Notassignedd

NN:Cw7

Cw*1219

Undefined

––

––

––

–Notassignedd

Cw*1220

Undefined

––

––

––

–Notassignedd

Cw*1221

Undefined

––

––

––

–Notassignedd

NN:Cw2,Cw5

Cw*1402

Cw1/blank

–Blank,noCw

antigen

reportedbymore

than5%

ofthe

laboratories

19a

Blank[93]

93

Cw1

36

Cw1

ihw13:shortCw1

Cw*1403

Cw1/blank

–Blank,noCw

antigen

reportedbymore

than5%

ofthe

laboratories

5a

Blank[100]b

11

Cw1

10

Notassignedd

ihw13:shortCw1;

NN:Cw1

Cw*1404

Undefined

––

–Blank[100]b

1–

–Notassignedd

NN:Cw4,Cw1

Cw*1405

Cw1

––

–Blank[100]b

1–

–Cw1

Cw*1406

Undefined

––

––

––

–Notassignedd

NN:Cw1

Cw*1407N

Notexpressed

Null

––

––

––

NT

Cw*1408

Cw1

––

––

––

–Cw1

Cw*1502

Undefined

–Blank

31a

Blank[90]

107

Blank

56

Notassignedd

NN:C

w10,C

w3,C

w2

Cw*1503

Undefined

––

–Blank[100]b

2–

–Notassignedd

NN:C

w10,C

w3,C

w2

Cw*1504

Undefined

––

–Blank[100]b

2Blank

2Notassignedd

NN:Cw3,Cw2

Cw*1505

Undefined

–Blanka

11a

Blank[62],Cw7[24],

Cw2[10]b

29

Blank

5Notassignedd

NN:Cw10,Cw3,

Cw2,Cw5

Cw*1506

Undefined

––

–Blank[100]b

1–

–Notassignedd

NN:C

w10,C

w3,C

w2

Cw*1507

Cw3

––

––

––

–Cw3f

NN:Cw10

Cw*1508

Undefined

––

––

––

–Notassignedd

NN:Cw10,Cw3,

Cw2,Cw5

Cw*1509

Undefined

–Blank

1Blank[100]b

8–

–Notassignedd

NN:Cw3,Cw2

Cw*1510

Undefined

––

––

––

–Notassignedd

Cw*1511

Undefined

––

–Blank[100]b

1–

–Notassignedd

NN:C

w2,C

w3,C

w10

Cw*1512

Undefined

––

––

––

–Notassignedd

NN:Cw3,Cw9,Cw2



Table

3Continued

HLAallele

Expert

assigned

WHO

assigned


CLA

NMDP

IHW

S13data

NN

Comments

Assignedtype[%

]

Cells

tested

Assignedtype[%

]

Cells

tested

Assignment

Cells

tested

Assigned

type>0.55

Cw*1513

Undefined

––

–Blank[100]b

1–

–Notassignedd

NN:C

w10,C

w3,C

w2

Cw*1514

Undefined

––

––

––

–Notassignedd

Cw*1515

Undefined

––

––

––

–Notassignedd

NN:C

w10,C

w3,C

w2

Cw*1516

Undefined

––

––

––

–Notassignedd

NN:Cw10,Cw3

Cw*1517

Undefined

––

––

––

–Notassignedd

NN:C

w10,C

w3,C

w2

Cw*1518

Undefined

––

––

––

–Notassignedd

NN:C

w10,C

w3,C

w2

Cw*1519

Undefined

––

––

––

–Notassignedd

NN:Cw3,Cw2

Cw*1520

Undefined

––

––

––

–Notassignedd

NN:Cw3,Cw2

Cw*1521

Cw3

––

––

––

–Cw3f

NN:Cw10

Cw*1601

Undefined

–Cw7[2–23]a

36

Blank[94]

276

Blank

57

Notassignedd

Cw*1602

Undefined

–Blanka

3Blank[97]

22

Blank

5Notassignedd

NN:Cw2,Cw6

Cw*1604

Undefined

––

–Blank[100]b

10

Blank

2Notassignedd

NN:Cw1

Cw*1606

Undefined

––

––

––

–Notassignedd

NN:Cw7

Cw*1607

Undefined

––

––

––

–Notassignedd

NN:Cw7

Cw*1608

Undefined

––

––

––

–Notassignedd

Cw*1609

Undefined

––

––

––

–Notassignedd

NN:Cw2,Cw6

Cw*1701

Cw7/blank

–C‘17’[27–43],Cw7

[6–22]a

25

Blank[82],Cw7[18]b

28

––

Notassignedd

Cw*1702

Undefined

––

––

––

–Notassignedd

Cw*1703

Cw7/blank

–C‘17’[31–44],Cw7

[10–20]a

3Blank[100]b

8–

–Notassignedd

Cw*1704

Undefined

––

––

––

–Notassignedd

Cw*1801

Cw6/blank

–Cw6[30–42]a

3Cw4[40],Cw6[40],

Cw7[20]b

5–

–Notassignedd

NN:Cw6,Cw4

Cw*1802

Cw6/blank

–Cw6[32–49],Cw4

[2–6]a

8Cw6[100]b

1–

–Notassignedd

NN:Cw6,Cw4

Cw*1803

Undefined

––

––

––

–Notassignedd

NN:Cw6,Cw4


etw



arrow

DonorProgram.


ellExchange,UCLA.

bUpdatedNMDPdata.Insomecases,theinform


ells



cWHO


data.

dNotassigned;seecommentcolumnforpredictions>0.20.

eTheallele


ative.

fIfaprimary


are

shownin

thecomments

column.

gRef14,58,59.



Table

4HLA-DRB1allelesandtheirserologicdesignations

HLAallele

Expertassigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]Cells

tested

Assignedtype>0.55

DRB1*0101

DR1

DR1

DR1[95–100]a

21

DR1[97]

6317

Training–DR1

DRB1*0102

DR1

DR1

DR1[86–95]

2DR1[95]

2035

Training–DR1

DRB1*0103

DR103/DR1

DR103

DR103[75–80],

DR1[9–17]a

5DR1[56],DR103

[12],blank[18]

1186

Training–DR1

DR103

DRB1*0104

DR1

DR1

––

––

DR1

DRB1*0105

DR1

––

–DR1[100]b

2DR1

DRB1*0106

DR1

––

––

–DR1

DRB1*0107

DR1

DR1

––

––

DR1

DRB1*0108

DR1

––

––

–DR1

DRB1*0109

DR1

DR1

––

––

DR1

DRB1*0110

DR1

––

––

–DR1

DRB1*0111

DR1

––

––

–DR1

DRB1*0112

DR1

––

––

–DR1

DRB1*0113

DR1

DR1

––

––

Notassignedc

NN:DR1

DRB1*0114

DR1

––

––

–DR1

DRB1*0115

DR1

––

––

–DR1

DRB1*0116

DR1

––

––

–DR1

DRB1*0301

DR17

DR17(3)

DR17[33–70],

DR3[20–50],

DR18[0–11]a

36

DR17[64],DR3

[33]

9698

Training–DR3

DR17

DRB1*0302

DR18

DR18(3)

DR18[62–67],

DR3[27–35]

10

DR18[66],DR3

[24],DR17[3]

317

Training–DR3

DR18

DRB1*0303

DR18

DR18(3)

––

DR18[50],DR17

[50]b

4DR18

DRB1*0304

DR17

DR17(3)

DR17[50],DR3

[44–50]a

3DR3[57],DR17

[29]b

7DR17

DRB1*0305

DR3

DR3

––

––

DR17

DRB1*0306

DR3

DR3

––

––

DR17

DRB1*0307

DR3

DR3d

––

DR3[100]b

1DR17

DRB1*0308

DR3

––

––

–DR17

DRB1*0309

DR3

––

––

–DR17

DRB1*0310

DR3

DR17(3)d

––

DR3[100]b

1DR17

DRB1*0311

DR3

DR17(3)d

––

DR3[100]b

1DR17

DRB1*0312

DR3

DR3

––

––

DR17

DRB1*0313

DR3

––

––

–DR17

DRB1*0314

DR3

DR3

––

––

DR17

DRB1*0315

DR17

DR3

DR3[38–40],

DR17[20–25],

DR18[0–10]a

2–

–DR17

DRB1*0316

DR3

––

––

–DR17



Table

4Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]Cells

tested

Assignedtype>0.55

DRB1*0317

DR3

––

–DR17[100]b

1DR3

DRB1*0318

DR3

––

––

–DR17

DRB1*0319

DR3

––

––

–DR17

DRB1*0320

DR3

––

––

–DR17

DRB1*0321

DR3

––

––

–DR17

DRB1*0322

DR3

––

––

–DR17

DRB1*0323

DR3

DR3

––

––

DR17

DRB1*0324

DR3

––

––

–DR17

DRB1*0325

DR3

––

––

–DR17

DRB1*0326

DR3

––

––

–DR17

DRB1*0327

DR3

––

––

–DR18

DRB1*0328

DR3

––

––

–DR17

DRB1*0329

DR3

––

––

–DR18

DRB1*0330

DR3

––

––

–DR17

DRB1*0331

DR3

––

––

–DR17

DRB1*0332

DR3

––

––

–DR17

DRB1*0333

DR3

––

––

–DR17

DRB1*0335

DR3

––

––

–DR18

DRB1*0401

DR4

DR4

DR4[100]a

13

DR4[98]

5118

Training–DR4

DRB1*0402

DR4

DR4

DR4[84–100]

4DR4[92]

1029

Training–DR4

DRB1*0403

DR4

DR4

DR4[97–100]a

9DR4[92]

748

Training–DR4

DRB1*0404

DR4

DR4

DR4[95–100]a

20

DR4[89]

2164

Training–DR4

DRB1*0405

DR4

DR4

DR4[94–100]a

13

DR4[91]

505

Training–DR4

DRB1*0406

DR4

DR4

DR4[89–100]

3DR4[89]

83

DR4

DRB1*0407

DR4

DR4

DR4[97–100]a

7DR4[86]

846

Training–DR4

DRB1*0408

DR4

DR4

DR4[100]a

1DR4[86]

258

DR4

DRB1*0409

DR4

DR4

––

DR4[100]b

11

DR4

DRB1*0410

DR4

DR4

DR4[100]

3DR4[84]

29

DR4

DRB1*0411

DR4

DR4

DR4[94–100]a

3DR4[93]

76

DR4

DRB1*0412

DR4

––

–DR4[100]b

1DR4

DRB1*0413

DR4

DR4

––

DR4[100]b

3DR4

DRB1*0414

DR4

DR4

––

DR4[100]b

1DR4

DRB1*0415

DR4

DR4

DR4[84–100],

DR11[20]a

4DR4[67]b

3DR4

DR4x11

DRB1*0416

DR4

DR4

DR4[100]

2DR4[100]b

1DR4

DRB1*0417

DR4

DR4

––

be

1DR4

DRB1*0418

DR4

––

––

–DR4

DRB1*0419

DR4

DR4

––

––

DR4

DRB1*0420

DR4

DR4

––

DR4[100]b

1DR4



Table

4Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]Cells

tested

Assignedtype>0.55

DRB1*0421

DR4

DR4

––

DR4[100]b

1DR4

DRB1*0422

DR4/DR3

DR4

––

––

DR4

DR4x3

DRB1*0423

DR4

DR4

––

––

DR4

DRB1*0424

DR4

DR4

––

––

DR4

DRB1*0425

DR4

DR4

––

––

DR4

ShortDR4

DRB1*0426

DR4

DR4

DR4[100]

3DR4[100]b

1DR4

DRB1*0427

DR4

––

––

–DR4

DRB1*0428

DR4

DR4

––

––

DR4

DRB1*0429

DR4

DR4

––

––

DR4

DRB1*0430

DR4

––

––

–DR4

DRB1*0431

DR4

DR4

DR4[100]a

2be

1DR4

DRB1*0432

DR4

DR4d

DR4[94–100]a

2–

–DR4

DRB1*0433

DR4

––

–DR4[100]b

1DR4

DRB1*0434

DR4

––

––

–DR4

DRB1*0435

DR4

––

–DR4[100]b

1DR4

DRB1*0436

DR4

––

––

–DR4

DRB1*0437

DR4

––

––

–DR4

DRB1*0438

DR4

––

––

–DR4

DRB1*0439

DR4

––

––

–DR4

DRB1*0440

DR4

––

––

–DR4

DRB1*0441

DR4

––

––

–DR4

DRB1*0442

DR4

DR4

––

––

DR4

DRB1*0443

DR4

––

––

–DR4

DRB1*0444

DR4

––

––

–DR4

DRB1*0445

DR4

––

––

–DR4

DRB1*0446

DR4

––

––

–DR4

DRB1*0447

DR4

––

––

–DR4

DRB1*0448

DR4

––

––

–DR4

DRB1*0449

DR4

––

––

–DR4

DRB1*0450

DR4

––

––

–DR4

DRB1*0451

DR4

––

––

–DR4

DRB1*0452

DR4

––

––

–DR4

DRB1*0453

DR4

––

––

–DR4

DRB1*0454

DR4

––

––

–DR4

DRB1*0455

DR4

––

––

–DR4

DRB1*0456

DR4

––

––

–DR4

DRB1*0457

DR4

––

––

–DR4

DRB1*0458

DR4

––

––

–DR4

DRB1*0459

DR4

––

––

–DR4



Table

4Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]Cells

tested

Assignedtype>0.55

DRB1*0460

DR4

––

––

–DR4

DRB1*0461

DR4

––

––

–DR4

DRB1*0462

DR4

––

––

–DR4

DRB1*0463

DR4

––

––

–DR4

DRB1*0464

DR4

DR4

––

––

DR4

DRB1*0701

DR7

DR7

DR7[93–100]a

43

DR7[99]

7390

Training–DR7

DRB1*0703

DR7

DR7

––

––

DR7

DRB1*0704

DR7

DR7

DR7[100]

2–

–DR7

DRB1*0705

DR7

––

––

–DR7

DRB1*0706

DR7

––

––

–DR7

DRB1*0707

DR7

––

––

–DR7

DRB1*0708

DR7

––

––

–DR7

DRB1*0709

DR7

DR7

––

––

DR7

DRB1*0710N

Notexpressed

Null

––

––

NT

DRB1*0711

DR7

––

––

–DR7

DRB1*0712

DR7

––

––

–DR7

DRB1*0713

DR7

––

––

–DR7

DRB1*0714

DR7

––

––

–DR7

DRB1*0801

DR8

DR8

DR8[91–100]a

7DR8[95]

1076

Training–DR8

DRB1*0802

DR8

DR8

DR8[100]a

4DR8[96]

265

Training–DR8

DRB1*0803

DR8

DR8

DR8[96–100]

12

DR8[88],DR12[3]

230

Training–DR8

DRB1*0804

DR8

DR8

DR8[88–100]a

9DR8[93]

186

Training–DR8

DRB1*0805

DR8

DR8

––

DR8[83]b

6DR8

DRB1*0806

DR8

DR8

DR8[96–100]

4DR8[95]b

21

DR8

DRB1*0807

DR8

DR8

DR8[89]

1DR8[100]b

3DR8

DRB1*0808

DR8

––

––

–DR8

DRB1*0809

DR8

DR8

––

DR8[100]b

2DR8

DR8variant

DRB1*0810

DR8

DR8

DR8[94–100]a

2DR8[67],DR12

[22]b

9DR8

DRB1*0811

DR8

DR8

DR8[89–94]a

2DR8[100]b

10

DR8

DRB1*0812

DR8

DR8

––

––

DR8

DRB1*0813

DR8

DR8

––

––

DR8

DRB1*0814

DR8

DR8

DR8[74–78]a

2–

–DR8

DRB1*0815

DR8

––

––

–DR8

DRB1*0816

DR8

DR8

DR8[85]a

1–

–DR8

DRB1*0817

DR8

DR8

––

––

DR8

DRB1*0818

DR8

DR8

––

DR8[100]b

2DR8

DRB1*0819

DR8

––

––

–DR8

DRB1*0820

undefined

––

––

–Notassignedc

NN:DR8



Table

4Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]Cells

tested

Assignedtype>0.55

DRB1*0821

DR8

––

––

–DR8

DRB1*0822

DR8

––

––

–DR8

DRB1*0823

DR8

––

––

–DR8

DRB1*0824

DR8

––

––

–DR8

DRB1*0825

DR8

––

––

–DR8

DRB1*0826

DR8

––

––

–DR8

DRB1*0827

DR8

––

––

–DR8

DRB1*0828

DR8

––

––

–DR8

DRB1*0829

DR8

––

––

–DR8

DRB1*0830

DR8

––

––

–DR8

DRB1*0831

DR8/DR11

DR11(5)

––

––

Notassignedc

NN:DR8,DR11

DRB1*0832

Undefined

––

––

–Notassignedc

NN:DR8,DR12

DRB1*0901

DR9

DR9

DR9[89–100]

19

DR9[95]

1058

Training–DR9

DRB1*0902

DR9

––

––

–DR9

DRB1*0903

DR9

––

––

–DR9

DRB1*0904

DR9

––

––

–DR9

DRB1*0905

DR9

DR9

––

––

DR9

DRB1*0906

DR9

––

––

–DR9

DRB1*1001

DR10

DR10

DR10[87–100]a

14

DR10[90],DR1

[4],blank[2]

894

Training–DR10

DRB1*1101

DR11

DR11(5)

DR11[88–100]a

15

DR11[92],DR5[5]

3474

Training–DR11

DRB1*1102

DR11

DR11(5)

DR11[89–100]

6DR11[89],DR5[3]

430

Training–DR11

DRB1*1103

DR11

DR11(5)

DR11[84–100]

2DR11[89],DR5[4]

397

Training–DR11

DRB1*1104

DR11

DR11(5)

DR11[87–100]a

13

DR11[87],DR5[4]

2119

Training–DR11

DRB1*1105

DR11

DR11(5)

DR11[90–100]a

2DR11[100]b

3DR11

DRB1*1106

DR11

DR11(5)

––

DR5[79],DR11

[21]b

14

DR11

DRB1*1107

DR11

DR11(5)d

––

DR11[100]b

3Notassignedc

DR11x3;NN:

DR17,DR3,DR11

DRB1*1108

DR11

DR11(5)

DR11[91–100]a

3be

1DR11

DRB1*1109

DR11

DR11(5)

DR11[100]

1DR11[75],DR5

[25]b

4Training–DR11

DRB1*1110

DR11

––

–DR11[100]b

2DR11

DRB1*1111

DR11

DR11(5)

DR11[87–90],

DR13[7–8],

DR5[4–5]

3DR11[90],DR5

[10]b

10

DR11

DR11x13

DRB1*1112

DR11

––

–DR11[100]b

5DR11

DRB1*1113

DR11

DR11(5)

DR11[93]a

2DR11[86]b

7DR11

DR11x14

DRB1*1114

DR11

DR11(5)

DR11[94–100]a

3DR11[100]b

2DR11



Table

4Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]Cells

tested

Assignedtype>0.55

DRB1*1115

DR11

––

–DR11[50],DR6

[50]b

2DR11

DRB1*1116

DR11/DR13

DR11(5)/DR13

(6)d

––

DR11[100]b

1DR11

DR11x13;DR11

(70),DR13(30)

DRB1*1117

DR14

––

––

–DR14f

NN:DR6

DRB1*1118

DR11

––

–be

1DR11

DRB1*1119

DR11

DR11(5)

DR11[100]

4be

1DR11

DRB1*1120

DR11

DR11(5)

––

––

DR11

DR11x13

DRB1*1121

DR11

DR11(5)

DR11[88–97],

DR13[12]a

2–

–DR11

DRB1*1122

Undefined

––

––

–Notassignedc

NN:DR11

DRB1*1123

DR11

DR11(5)

––

––

DR11

DRB1*1124

DR11

––

––

–DR11

DRB1*1125

DR11

DR11(5)

––

––

DR11

DRB1*1126

DR11

DR11(5)

––

––

DR11

DRB1*1127

DR11

DR11(5)

––

––

DR11

DRB1*1128

DR11

––

––

–DR11

DRB1*1129

DR11

DR11(5)

DR11[100]

2–

–DR11

DRB1*1130

DR11

––

––

–DR11

DRB1*1131

DR11

––

––

–DR11

DRB1*1132

DR11

––

––

–DR11

DRB1*1133

DR11

––

––

–DR11

DRB1*1134

DR11

––

––

–DR11

DRB1*1135

DR11

––

––

–DR11

DRB1*1136

DR11

––

––

–DR11

DRB1*1137

DR11

DR11(5)

––

––

DR11

DRB1*1138

DR11

––

––

–DR11

DRB1*1139

DR11

––

––

–DR11

DRB1*1140

DR11

––

––

–DR11

DRB1*1141

DR11

––

––

–DR11

DRB1*1142

DR11

––

––

–DR11

DRB1*1143

DR11

––

––

–DR11

DRB1*1144

DR11

––

––

–DR11

DRB1*1145

DR11

––

––

–DR11

DRB1*1146

DR11

––

––

–DR11

DRB1*1147

DR11

––

––

–DR11

DRB1*1148

DR11

––

––

–DR11

DRB1*1149

DR11

––

––

–DR11

DRB1*1150

DR11

––

––

–DR11



Table

4Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]Cells

tested

Assignedtype>0.55

DRB1*1151

DR11

––

––

–DR11

DRB1*1152

DR11

DR11(5)

––

––

DR14

DRB1*1153

DR11

––

––

–DR11

DRB1*1154

DR11

––

––

–DR11

DRB1*1155

DR11

––

––

–DR11

DRB1*1156

DR11

––

––

–DR11

DRB1*1157

DR11

––

––

–DR11

DRB1*1158

DR11

––

––

–DR11

DRB1*1159

DR11

––

––

–DR11

DRB1*1160

DR11

––

––

–DR11

DRB1*1161

DR11

––

––

–DR11

DRB1*1162

DR11

––

––

–DR11

DRB1*1201

DR12

DR12(5)

DR12[85–100],

DR13[5–12]

9DR12[83],DR5

[4],DR8[2],

DR11[2]

893

Training–DR12

DRB1*1202

DR12

DR12(5)

DR12[91–100]

17

DR12[89]

162

Training–DR12

DRB1*1203

DR12

DR12(5)

––

DR12[100]b

4DR12

DRB1*1204

DR12

––

––

–DR12

DR12x11

DRB1*1205

DR12

DR12(5)

––

––

DR12

DRB1*1206

DR12

DR12(5)

––

DR12[100]b

3DR12

DRB1*1207

DR12

––

––

–DR12

DRB1*1208

DR12

––

––

–DR12

DRB1*1209

DR12

––

––

–DR12

DRB1*1210

DR12

––

––

–DR12

DRB1*1211

DR12

––

––

–DR12

DRB1*1212

DR12

––

––

–DR12

DRB1*1213

DR12

––

––

–DR12

DRB1*1214

DR12

––

––

–DR12

DRB1*1215

DR12

––

––

–DR12

DRB1*1301

DR13

DR13(6)

DR13[90–100],

DR6[0–7]a

17

DR13[81],DR6

[14],DR14[1]

3788

Training–DR6DR13

DRB1*1302

DR13

DR13(6)

DR13[81–97],

DR6[7–11]a

17

DR13[74],DR6

[17],DR14[2]

3081

Training–DR6DR13

DRB1*1303

DR13

DR13(6)

DR13[50–93],

DR6[4–21],

DR‘1303’

[0–11],DR14

[0–17],DR3

[0–8]

11

DR13[69],DR6

[10],DR12[3],

DR11[3],DR5

[2],DR14[2]

948

Training–DR6DR13



Table

4Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]Cells

tested

Assignedtype>0.55

DRB1*1304

DR13

DR13(6)

––

DR13[87]

127

DR13

DRB1*1305

DR13

DR13(6)

DR13[48–62],

DR11[11–34],

DR6[5–20],

DR14[3–8]

3DR13[54],DR6

[12],DR11[7],

DR12[6],DR5

[4]

305

DR6

DRB1*1306

DR13

DR13(6)

DR13[95]

1DR13[88],DR6

[12]b

8DR13

DRB1*1307

DR13

DR13(6)

––

DR13[100]b

1Notassignedc

NN:DR11,DR6

DRB1*1308

DR13

DR13(6)

DR13[84],DR6[5]

1DR13[100]b

5DR13

DRB1*1309

DR13

––

–DR13[100]b

1DR6f

NN:DR13

DRB1*1310

DR13

DR13(6)

DR13[80–95],

DR6[7–15],

DR14[0–10]a

5DR13[100]b

4DR13

DRB1*1311

DR13

DR13(6)

DR13[72–90],

DR11[0–28],

DR14[0–10],

DR6[0–6]a

2DR6[50],blank

[50]b

2DR11

DRB1*1312

DR13

DR13(6)d

––

DR13[50],DR6

[13],DR12[13],

DR11[13]b

8DR13

DR13x12

DRB1*1313

DR13

DR13(6)d

DR13[83],DR6

[13]

1–

–DR6

DR52negative;

NN:DR13,DR8

DRB1*1314

DR13

DR13(6)

DR13[69–77],

DR11[0–15],

DR14[0–9],

DR6[0–5]a

3DR11[50],blank

[50]b

2DR11

DRB1*1315

DR13

––

––

–DR13

DRB1*1316

DR13

DR13(6)

––

––

DR13

DRB1*1317

DR13

DR13(6)

DR13[53],DR8

[41],DR11[6]a

1–

–Notassignedc

DR13x8;NN:DR8

DRB1*1318

DR13

DR13(6)

––

––

Notassignedc

NN:DR6,DR11

DRB1*1319

DR13

DR13(6)d

––

––

DR13

NN:DR14

DRB1*1320

DR13

DR13(6)

DR13[87–95],

DR6[0–5]a

2–

–DR13

DRB1*1321

DR13/DR11

––

–DR13[50],blank

[50]b

2DR11

DRB1*1322

DR13

DR13(6)d

––

DR13[100]b

1DR13f

NN:DR6

DRB1*1323

DR13

––

––

–DR13

NN:DR6

DRB1*1324

DR11

––

––

–DR11



Table

4Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]Cells

tested

Assignedtype>0.55

DRB1*1325

DR11

––

––

–DR11

DRB1*1326

DR14

––

––

–DR14

DRblankDR52

positive

DRB1*1327

DR13

DR13(6)

––

––

DR13

DRB1*1328

DR13

––

––

–DR13

DRB1*1329

DR13

DR13(6)d

DR13[72–90],

DR6[0–9]a

2–

–DR13

DRB1*1330

Undefined

––

––

–Notassignedc

NN:DR13,DR6,

DR11

DRB1*1331

DR13

–DR13[80],DR14

[10]a

1–

–DR13

DRB1*1332

DR13

––

––

–DR13

DRB1*1333

DR13

––

––

–DR13

DRB1*1334

DR13

––

––

–DR13

DRB1*1335

DR13

––

––

–DR13

DRB1*1336

DR13

DR13(6)

DR13[91–100],

DR6[0–5],

DR14[0–4]a

3DR6[100]b

1DR13

DRB1*1337

DR13

––

––

–DR13

DRB1*1338

DR13

––

––

–DR13

DRB1*1339

DR13

––

––

–DR13

DRB1*1340

DR13

––

––

–DR13

DRB1*1341

DR13

––

––

–DR13

DRB1*1342

DR6

DR13(6)

––

––

DR6

DRB1*1343

DR13

––

––

–DR13

DRB1*1344

Undefined

––

––

–Notassignedc

NN:DR11

DRB1*1345

DR13

––

––

–DR13

DRB1*1346

DR11

––

––

–DR11

DRB1*1347

Undefined

––

––

–Notassignedc

NN:DR8

DRB1*1348

DR13

––

––

–DR13

DRB1*1349

DR6

––

––

–DR6

DRB1*1350

DR11

––

––

–DR11

DRB1*1351

DR13

––

––

–DR13

DRB1*1352

DR13

DR13(6)

––

––

DR13

DRB1*1353

DR13

––

––

–DR13

DRB1*1354

DR14

DR14(6)

––

––

Notassignedc

NN:DR11

DRB1*1355

Undefined

––

––

–Notassignedc

NN:DR8,DR6

DRB1*1356

DR6

––

––

–DR6

NN:DR13

DRB1*1357

DR13

DR13(6)

––

––

DR13



Table

4Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]Cells

tested

Assignedtype>0.55

DRB1*1358

DR13

––

––

–DR13

DRB1*1359

DR13

––

––

–DR13

DRB1*1360

DR6

––

––

–DR6

DRB5*02

associated(60)

DRB1*1361

DR13

––

––

–DR13

DRB1*1362

DR11

––

––

–DR11

DRB1*1363

DR13

––

––

–DR13

DRB1*1364

DR13

––

––

–DR13

DRB1*1365

DR13

––

––

–DR13

DRB1*1366

DR13

DR13(6)

––

––

DR13

DRB1*1367

DR13

––

––

–DR13

DRB1*1368

DR13

––

––

–DR13

DRB1*1369

DR13

––

––

–DR13

DRB1*1370

DR13

––

––

–DR13

DRB1*1371

DR13

––

––

–DR13

DRB1*1372

DR13

––

––

–DR13

DRB1*1373

DR13

––

––

–DR13

DRB1*1374

DR13

––

––

–DR13

DRB1*1375

Undefined

––

––

–Notassignedc

NN:DR11,DR13,

DR6

DRB1*1376

DR13

––

––

–DR13

DRB1*1378

DR13

––

––

–DR13

DRB1*1379

DR13

––

––

–DR13

DRB1*1401

DR14

DR14(6)

DR14[91–100],

DR6[0–7]a

18

DR14[74],DR6

[14],DR13[3]

1942

Training–DR6DR14

DRB1*1402

DR14

DR14(6)

DR14[50–83],

DR6[12–17],

DR17[8–15],

DR13[0–19]

9DR14[61],DR6

[13],DR13[9]

204

Training–DR6DR14

DRB1*1403

DR1403/DR14

DR1403

––

DR14[72],DR6

[12]

37

DR14

DRB1*1404

DR1404/DR14

DR1404

DR14[84–89],

DR1404[5–8],

DR6[3–7],DR8

[0–10]

8DR14[79],DR6

[8],DR1404[3]

80

DR14

DRB1*1405

DR14

DR14(6)

DR14[74–85],

DR6[11–15],

DR3[0–13]

2DR14[86],DR6

[10]

58

DR14



Table

4Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]Cells

tested

Assignedtype>0.55

DRB1*1406

DR14

DR14(6)

DR13[28],DR14

[26],DR6[19],

DR3[11]

1DR14[37],DR13

[22],DR6[15]

117

Training–DR6DR14

DRB1*1407

DR14

DR14(6)

DR14[87–96],

DR6[0–4]a

2DR14[94]b

16

DR14

DRB1*1408

DR14

DR14(6)d

DR14[94]

1DR14[50],DR6

[25]b

4DR14

DRB1*1409

DR14

––

––

–DR14

DRB1*1410

DR14

DR14(6)

DR14[76–83],

DR6[4–10]

2DR14[100]b

4Notassignedc

NN:DR4,DR14,

DR6

DRB1*1411

DR14

DR14(6)

DR14[59],DR6

[12],DR11[12],

DR‘14x11’[9]

1DR14[100]b

1Notassignedc

DR14x11;NN:

DR14

DRB1*1412

DR14

DR14(6)

––

––

DR14

NN:DR6

DRB1*1413

DR14

DR14(6)

DR14[59–86],

DR6[4–17],

DR13[0–10]

3DR6[100]b

1DR14

DRB1*1414

DR14

DR14(6)

DR14[88–89],

DR13[0–5]

2–

–DR14

DRB1*1415

DR8

DR8

DR8[50],DR14

[26],DR13[8]

1DR8[100]b

1DR8

DR81

DR52

DRB1*1416

DR6

DR6

––

DR14[100]b

1DR13

DR14x13

DRB1*1417

DR6

DR6

––

DR13[100]b

1DR6

DR14x13;DR13

weak,DR14

negative

DRB1*1418

DR14

DR6

––

DR14[100]b

1DR14

DRB1*1419

DR14

DR14(6)

––

––

DR14

DRB1*1420

DR14

DR14(6)

––

Blank[100]b

1DR14

DRB1*1421

DR14

DR14(6)

DR14[57–84],

DR13[8–29],

DR6[4–14],

DR17[0–6]a

3DR6[100]b

1DR6

Alsotypedas

DR13

DRB1*1422

DR14

DR14(6)d

––

––

DR14

DRB1*1423

DR14

––

–DR14[100]b

1DR14

DRB1*1424

DR14

––

––

–DR14

DRB1*1425

DR6

––

––

–DR6

DRB1*1426

DR14

DR14(6)

––

––

DR14

DRB1*1427

DR14

DR14(6)

––

––

DR6

NN:DR14

DRB1*1428

DR14

––

––

–DR14



Table

4Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]Cells

tested

Assignedtype>0.55

DRB1*1429

DR14

DR14(6)

––

––

DR14

DRB1*1430

DR6

––

––

–DR6

DRB1*1431

DR14

––

––

–DR14

DRB1*1432

DR14

––

––

–DR14

DRB1*1433

DR6

––

––

–DR6

NN:DR14

DRB1*1434

DR14

––

––

–DR14

DRB1*1435

DR14

––

––

–DR14

DRB1*1436

DR14

––

––

–DR14

DRB1*1437

DR14

––

––

–DR14

DRB1*1438

DR14

––

––

–DR14

DRB1*1439

DR14

––

––

–DR14

DRB1*1440

DR14

––

––

–DR14

DRB1*1441

DR14

––

––

–DR14

DRB1*1442

Undefined

––

––

–Notassignedc

NN:DR11

DRB1*1443

DR14

––

––

–DR14

DRB1*1444

DR14

––

––

–DR14

DRB1*1445

DR14

––

––

–DR14

DRB1*1446

DR14

––

––

–DR14

DRB1*1447

DR14

––

––

–DR14

DRB1*1448

DR14

––

––

–DR14

DRB1*1449

DR14

DR14(6)

––

––

DR14

DRB1*1450

DR14

DR14(6)

––

––

Notassignedc

NN:DR14,DR6

DRB1*1451

DR14

––

––

–DR14

DRB1*1452

DR14

––

––

–DR14

DRB1*1453

DR13/14

DR13(6)

––

––

DR11

DRB1*1454

DR14

–DR14[100]a

3DR14[89]b

9DR14

DRB1*1455

DR14

––

––

–DR14

DRB1*1456

DR14

––

––

–DR14

DRB1*1457

DR4/DR6

––

––

–DR4

NN:DR6

DRB1*1458

DR14

––

––

–DR14

DRB1*1459

DR14

––

––

–DR14

DRB1*1460

DR14

DR14(6)

––

––

DR14

DRB1*1461

DR14

––

––

–DR14

DRB1*1462

DR14

––

––

–DR14

DRB1*1463

DR6

––

––

–DR6f

NN:DR14

DRB1*1464

DR14

––

––

–DR14

DRB1*1465

DR6

––

––

–DR6f

NN:DR14

DRB1*1466

DR14

––

––

–DR14

DRB1*1467

DR6

––

––

–DR6f

NN:DR14



Table

4Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]Cells

tested

Assignedtype>0.55

DRB1*1468

DR14

––

––

–DR14

DRB1*1501

DR15

DR15(2)

DR15[75–90],

DR2[0–19],

DR16[0–13]a

31

DR15[76],DR2

[23]

6428

Training–DR2DR15

DRB1*1502

DR15

DR15(2)

DR15[82–100],

DR2[0–14]a

17

DR15[77],DR2

[16]

676

Training–DR2DR15

DRB1*1503

DR15

DR15(2)

DR15[81–94],

DR2[3–13],

DR16[0–6]a

8DR15[81],DR2

[13]

286

Training–DR2DR15

DRB1*1504

DR15

DR15(2)d

DR15[76–91],

DR2[0–18],

DR16[0–6]a

4DR15[100]b

1DR15

DRB1*1505

DR15

DR15(2)

––

DR15[100]b

1DR15

DRB1*1506

DR15

DR15(2)

––

DR15[100]b

2DR15

DRB1*1507

DR15

DR15(2)d

DR15[82–91],

DR2[5–9],

DR16[0–9]a

2–

–DR15

DRB1*1508

DR15

DR2

––

––

DR15

DRB1*1509

DR15

––

––

–DR15

DRB1*1510

DR2

––

––

–DR2

NN:DR15

DRB1*1511

DR15

––

––

–DR15

DRB1*1512

DR15

––

––

–DR15

DRB1*1513

DR2

––

––

–DR2

NN:DR15,DR16

DRB1*1514

DR15

––

–DR15[100]b

1DR15

DRB1*1515

DR15

––

––

–DR15

DRB1*1516

DR15

––

––

–DR15

DRB1*1517N

Notexpressed

Null

––

––

NT

DRB1*1518

DR15

––

––

–DR15

DRB1*1519

DR15

––

––

–DR15

DRB1*1520

DR15

––

––

–DR15

DRB1*1521

DR2

––

––

–DR2f

NN:DR15,DR16

DRB1*1522

DR15

––

––

–DR15

DRB1*1601

DR16

DR16(2)

DR16[31],DR15

[38],DR2[31]

1DR16[41],DR2

[29],DR15[19]

703

Training–DR2DR16

DRB1*1602

DR16

DR16(2)

DR16[56–82],

DR2[12–28],

DR15[6–22]a

13

DR16[47],DR2

[30],DR15[16]

239

Training–DR2DR16

DRB1*1603

DR16

DR2

––

––

DR16



NMDPdatabase; some individuals carried the allele but did

not have associated serologic typing. In some cases, the

number of cells tested is less than the number in the last

dictionary. In these cases, the typing assignment may have

changed or further data suggest that the typing result was

not informative.

Neural network

An artificial NN was used to predict serologic assignments

for alleles lacking this information and to support serologic

assignments from other sources (7). The same set of alleles

used in previous iterations was used to train the NN. The

training alleles and the broad and split serologic assign-

ments used in the training are indicated in the tables. In this

2008 report, 10 NN were run instead of the five previously

run to increase accuracy of the predictions. After training of

10 independent NN for each locus, the NN were used to

predict the serologic types associated with polymorphic

amino acid sequences of the remaining allelic products and

results summarized from the 10 networks. Primary assign-

ments are listed in one column, secondary assignments in the

‘Comments’ column. The criteria used for inclusion are

described in the 2004 dictionary. Some allelic products with

unusual combinations of serologic epitopes did not receive

an assignment from the NN or have received varying

assignments in the different published iterations of the

network analysis. For example, A*0255, an allele evaluated

in all three iterations of the NN received varying assign-

ments from the NN. In the first NN (7), A2 was assigned as

the primary specificity with A28 and A69 as secondary

specificities; in the second NN (4), A28 was primary with

A69 as secondary; and in this iteration summarizing 10NN,

no specificity was assigned (serologic blank) and A2, A69,

and A28 were assigned as secondary specificities.

It should be noted that a few cases were observed where

the NN did not assign the same serologic specificity as

expected based on the validation data set. For example,

B*1529was assigned as B71 by theNNwhen previously this

allele had been assigned as B15 by serology. This

discrepancy could be because of limited serologic typing

data or because of limitations of the NN prediction. The

data from the NN can be viewed at http://bioinformatics.

nmdp.org/neuralnetwork2007.

The use of a NN to predict the serologic assignments of

antigens encoded by theHLA-C and -DQB1 loci is new. The

alleles with well-defined serology used to train the NN and

to validate the network assignments are indicated in

Tables 3 and 6.

Serology allele phenotype component of the 13th

International Histocompatibility Workshop

The data from the 13th IHWG were obtained by serologic

typing of cells with known HLA alleles. The cells wereTable

4Continued

HLAallele

Expertassigned

WHO

assigned

InternationalC

ellExchange,UCLA

NMDP

NN

Comments

Assignedtype[%

]Cells

tested

Assignedtype[%

]Cells

tested

Assignedtype>0.55

DRB1*1604

DR16

DR16(2)

DR16[53–64],

DR15[16–27],

DR2[9–31]a

2DR16[100]b

1DR16

DRB1*1605

DR16

DR16(2)d

––

DR16[100]b

1DR16

DRB1*1607

DR16

––

––

–DR16

DRB1*1608

DR16

––

––

–DR16

DRB1*1609

DR16

DR16(2)

––

––

DR16

DRB1*1610

DR16

––

––

–DR16

DRB1*1611

DR16

––

––

–DR16


etw



arrow

DonorProgram.


ellExchange,UCLA.

bUpdatedNMDPdata.Insomecases,theinform


ells



cNotassigned;seecommentcolumnforpredictions>0.20.

dWHO


data.

eTheallele


ative.

fIfaprimary


are

shownin

thecomments

column.



Table

5HLA-DRB3,DRB4,DRB5allelesandtheirserologicdesignations

HLAallele

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

Expert

assigned

WHO

assigned

InternationalC

ellExchange,UCLA

Comments

Assignedtype[%

]Cells

tested

Comments

HLAallele

Assignedtype[%

]Cells

tested

DRB3*0101

DR52

DR52

DR52[90–100]a

88

DRB3*0222

Undefined

––

DRB3*0102

DR52

–DR52[99]

1DRB3*0301

DR52

DR52

DR52[90–100]a

41

DRB3*0103

Undefined

––

–DRB3*0302

DR52

DR52

––

DRB3*0104

Undefined

––

–DRB3*0303

DR52

–DR52[100]a

1

DRB3*0105

Undefined

––

–DRB4*0101

DR53

DR53

DR53[94–100]a

44

DRB3*0106

DR52

DR52

––

DRB4*0102

Undefined

––

–

DRB3*0107

DR52

DR52

––

DRB4*0103

DR53

DR53

DR53[88–100]a

73

DRB3*0108

Undefined

––

–DRB4*01030102N

Notexpressed

Null

Referto

comments

23

DR53(20–54),false-

positiveassignments

DRB3*0109

Undefined

––

–DRB4*0104

Undefined

––

–

DRB3*0110

DR52

DR52

––

DRB4*0105

DR53

DR53

––

DRB3*0111

Undefined

–DRB4*0106

Undefined

––

–

DRB3*0201

DR52

DR52

DR52[97–100]a

3DRB4*0107

Undefined

–

DRB3*0202

DR52

DR52

DR52[90–100]

126

DRB4*0201N

Notexpressed

Null

––

DRB3*0203

DR52

DR52

DR52[100]

1DRB4*0301N

Notexpressed

Null

Referto

comments

1DR53(69)false-positive

assignments

DRB3*0204

Undefined

––

–DRB5*0101

DR51

DR51

DR51[82–100]a

41

DRB3*0205

Undefined

––

–DRB5*0102

DR51

DR51

DR51[86–100]a

10

DRB3*0206

DR52

–DR52[91]a

1DRB5*0103

Undefined

––

–

DRB3*0207

DR52

DR52

––

DRB5*0104

Undefined

––

–

DRB3*0208

DR52

DR52

––

DRB5*0105

Undefined

––

–

DRB3*0209

DR52

DR52

––

DRB5*0106

Undefined

––

–

DRB3*0210

DR52

DR52

––

DRB5*0107

DR51

DR51

––

DRB3*0211

DR52

DR52

––

DRB5*0108N

Notexpressed

Null

Referto

comments

a2

DR51(43–60),false-

positiveassignments

DRB3*0212

Undefined

––

–DRB5*0109

Undefined

––

–

DRB3*0213

Undefined

––

–DRB5*0110N

Notexpressed

Null

Referto

comments

a1

DR51(55),false-positive

assignments

DRB3*0214

Undefined

––

–DRB5*0111

Undefined

–

DRB3*0215

Undefined

––

–DRB5*0112

Undefined

–

DRB3*0216

Undefined

––

–DRB5*0113

Undefined

–

DRB3*0217

Undefined

––

–DRB5*0202

DR51

DR51

DR51[86–100]a

15

DRB3*0218

Undefined

––

–DRB5*0203

Undefined

––

–

DRB3*0219

Undefined

––

–DRB5*0204

Undefined

––

–

DRB3*0220

Undefined

––

–DRB5*0205

Undefined

––

–

DRB3*0221

Undefined

––

–


etw



arrow

DonorProgram.


ellExchange,UCLA.



Table 6 HLA-DQB1 alleles and their serologic designations

HLA allele

Expert

assigned

WHO

assigned

International Cell Exchange,

UCLA NMDP NN

CommentsAssigned type [%]

Cells

tested Assigned type [%]

Cells

tested

Assigned

type >0.55

DQB1*0201 DQ2 DQ2 DQ2 [87–100]a 30 DQ2 [98] 9175 Training – DQ2

DQB1*0202 DQ2 DQ2 DQ2 [75–100]a 23 DQ2 [87] 656 DQ2

DQB1*0203 DQ2 DQ2 – – DQ2 [67]b 3 DQ2

DQB1*0204 DQ2 – – – – – DQ2

DQB1*0205 DQ2 – – – – – DQ2

DQB1*0301 DQ7 DQ7(3) DQ7 [47–91], DQ3

[9–44], DQ8

[0–12]a

71 DQ7 [85], DQ3

[10], DQ8 [1]

12,220 Training – DQ3 DQ7

DQB1*0302 DQ8 DQ8(3) DQ3 [9–60], DQ8

[24–91], DQ7

[0–20], DQ9

[0–9]a

37 DQ8 [66], DQ3

[25], DQ7 [4]

6687 Training – DQ3 DQ8

DQB1*0303 DQ9 DQ9(3) DQ3 [22–60], DQ9

[20–67], DQ7

[0–11], DQ8

[0–9]a

23 DQ9 [67], DQ3

[12], DQ2 [11],

DQ8 [1], DQ7

[1]


DQB1*0304 DQ7 DQ7(3) DQ7 [60], DQ3

[34]

1 DQ7 [40], DQ3

[35], DQ8 [8]

111 DQ7

DQB1*0305 DQ8 DQ8(3)c – – DQ8 [34], DQ3

[30]

70 DQ8

DQB1*0306 DQ3 DQ3 – – DQ8 [100]b 1 DQ4

DQB1*0307 DQ8 – – – – – DQ8

DQB1*0308 DQ8 – – – – – DQ8

DQB1*0309 DQ7 – – – – – DQ7

DQB1*0310 DQ3 DQ8(3) – – DQ7 [100]b 1 DQ7

DQB1*0311 DQ8 – – – – – DQ8

DQB1*0312 DQ9 – – – – – DQ9

DQB1*0313 DQ7 – – – – – DQ7

DQB1*0314 DQ3 – – – – – DQ3d NN: DQ7, DQ8

DQB1*0315 DQ9 – – – – – DQ9

DQB1*0316 DQ7 – – – – – DQ7

DQB1*0317 DQ9 – – – – – DQ9

DQB1*0318 DQ8 – – – – – DQ8

DQB1*0319 DQ7 – DQ7 [91], DQ3 [9]a 1 – – DQ7

DQB1*0320 DQ9 – – – – – DQ9

DQB1*0401 DQ4 DQ4 DQ4 [88–89]a 3 DQ4 [71], DQ3

[10]

142 DQ4

DQB1*0402 DQ4 DQ4 DQ4 [77–100]a 22 DQ4 [86], DQ3 [2],

blank [7]

1085 Training – DQ4

DQB1*0501 DQ5 DQ5(1) DQ1 [25–67], DQ5

[20–63], DQ6

[0–13]a

27 DQ5 [69], DQ1

[20], DQ6 [2]


DQB1*0502 DQ5 DQ5(1) DQ1 [44–70], DQ5

[10–38], DQ6

[9–37]a

20 DQ5 [48], DQ1

[24], DQ6 [15]

919 DQ5

DQB1*0503 DQ5 DQ5(1) DQ1 [64–89], DQ5

[9–18], DQ6

[0–27]a

17 DQ5 [58], DQ1

[22], DQ6 [4]

1327 DQ5

DQB1*0504 DQ5 DQ5(1)c DQ1 [66], DQ5

[23], DQ6 [8]

1 DQ5 [58], DQ1

[17], DQ6 [2]

48 DQ5

DQB1*0505 DQ5 – – – – – DQ5

DQB1*0601 DQ6 DQ6(1) DQ6 [50–56], DQ1

[33–40], DQ5

[10–11]a

6 DQ6 [64], DQ1

[23]

675 DQ6



Table 6 Continued

HLA allele

Expert

assigned

WHO

assigned

International Cell Exchange,

UCLA NMDP NN

CommentsAssigned type [%]

Cells

tested Assigned type [%]

Cells

tested

Assigned

type >0.55

DQB1*0602 DQ6 DQ6(1) DQ1 [38–73], DQ6

[18–64], DQ5

[0–12]a

22 DQ6 [67], DQ1

[30], DQ5 [1]


DQB1*0603 DQ6 DQ6(1) DQ1 [31–64], DQ6

[22–63], DQ5

[0–10]a

18 DQ6 [62], DQ1

[23], DQ5 [2]

2807 DQ6

DQB1*0604 DQ6 DQ6(1) DQ1 [40–52], DQ6

[40–44], DQ5

[0–20]a

3 DQ6 [59], DQ1

[27], DQ5 [2]

1592 DQ6

DQB1*0605 DQ6 DQ6(1) – – DQ6 [76], DQ1

[13]

358 DQ6

DQB1*0606 DQ5 – – – DQ5 [100]b 1 DQ5

DQB1*0607 DQ6 – – – DQ1 [75], DQ6

[25]b4 DQ6

DQB1*0608 DQ6 DQ6(1)c – – DQ6 [50], DQ1

[25], DQ5 [25]b6 DQ6 DQ6

DQB1*0609 DQ6 DQ6(1) DQ6 [38–67], DQ1

[27–44], DQ5

[0–6]a

6 DQ6 [48], DQ1

[32], DQ5 [3]

149 DQ6

DQB1*0610 DQ1 – – – DQ1 [100]b 1 DQ6

DQB1*0611 DQ1 DQ1 – – – – DQ6

DQB1*0612 DQ1 DQ1 – – – – DQ6

DQB1*0613 DQ6 – – – be 1 DQ6

DQB1*0614 DQ6 DQ6(1) – – – – DQ6

DQB1*0615 DQ6 – – – – – DQ6

DQB1*0616 DQ6 – DQ6 [33–56], DQ1

[32–56], DQ5

[6–11]a

2 – – DQ6

DQB1*0617 DQ6 – – – be 1 DQ6

DQB1*0618 DQ6 – – – – – DQ6

DQB1*0619 DQ6 – – – – – DQ6

DQB1*0620 DQ6 – – – – – DQ6

DQB1*0621 DQ6 – – – – – DQ6

DQB1*0622 DQ6 – – – – – DQ6

DQB1*0623 DQ6 – – – – – DQ6

DQB1*0624 DQ6 – – – – – DQ6

DQB1*0625 DQ6 DQ6(1) – – – – DQ6

DQB1*0626N Not expressed Null – – – – NT

DQB1*0627 DQ6 – – – – – DQ6

DQB1*0628 DQ6 – – – – – DQ6

DQB1*0629 DQ6 – – – – – DQ6

DQB1*0630 DQ6 – – – – – DQ6

DQB1*0631 DQ6 – – – – – DQ6

DQB1*0632 DQ6 – – – – – DQ6

DQB1*0633 DQ6 – – – – – DQ6

NT, not tested; NN, neural network; HLA, human leukocyte antigen; WHO, World Health Organization; NMDP, National Marrow Donor Program.a Updated International Cell Exchange, UCLA.b UpdatedNMDPdata. In somecases, the information reported in previous dictionaries has changed. Cells have been excluded from this study in some

cases because their HLA typing has changed.c WHO assignment based on dictionary data.d If a primary specificity is provided by the NN, other specificities >0.4 are shown in the comments column.e The allele has been identified but serology not informative.



tested with a common set of well-characterized reagents

including mainly monoclonal antibodies (12) and supple-

mentary allosera. Tables 1–3 show the number of panel

cells for each allele included in the analysis, the assigned

specificity and, where appropriate, comments on the sero-

logical expression of that allele, as reported by the 13th

IHWS serology and HLA phenotype component (8, 9).

These data have not been updated from the 2004 edition of

the HLA data dictionary.

Information obtained from other sources

Data on the serological expression of new alleles have been

submitted fromHLA laboratories. However, because many

laboratories no longer perform serological typing or use

commercial monoclonal reagents, there are only a small

number of alleles that have been tested in this way. In this

edition of the dictionary, only 23 HLA class I alleles have

been submitted with serological information. The ‘Com-

ments’ column in the tables refers to information from

publications (listed at end of document) and other sources

that describe serologic expression of new alleles. It must be

noted, however, that some of these data are based on small

sample numbers tested by a single laboratory.

Expert assigned type

The expert assigned type for HLA-A, -B, -C, -DRB1, -DRB

3/4/5, and -DQB1 alleles is the combination of all serologic

equivalents information. This may help identify serologic

equivalents when there are differences with theWHOHLA-

designated serologic assignments (e.g. B*4005), or where

multiple assignments are possible such as hybrid molecules,

or where more antigen assignments are given (e.g. A* 3204,

Table 1 and B*1303, B*1304, Table 2). Occasionally, the

expert assigned type is based on the NN assignment;

however, while this should be considered with caution, the

NN may be the only information available.

Use of the dictionary in a HSC donor search

The HLA dictionary is a valuable tool in the search for

a matched unrelated stem cell source for a patient in need. It

contains the most current data, from multiple sources, on

the frequency of the phenotype detected for a particular

allele. An alternate patient phenotype can be identified to

assist with serologic types that may be potential matches for

a particular allele, for example B*4807 types as B48 (33%)

and B60 (42%). The search report for a patient with B*4807

will include B48-positive donors, but an alternate pheno-

type search using B60 would identify serologically typed

B60 donors with potential to match. In addition, some

alleles routinely type as blank by serology. The dictionary

can help determine whether donors with serologic blanks

(apparent homozygotes) carry the allele of interest.

Some alleles in the tables are listed with more than one

common serological assignment. This indicates that the

serological pattern is not clear, for example B*4416 has both

B47 and B44 reactivity. The ‘Comments’ section may

provide further information for serological reactivity in

some cases. In addition, many laboratories are not able to

identify many of the WHO-designated HLA specificities.

The International Cell Exchange, UCLA data show that

some of the newer specificities are rarely used but are often

designated by their antigen equivalents, for example A2

instead of A203. Although subsequent cell exchanges do

improve the detection rate, these assignments remain

difficult. It is useful to refer to the percentage recogni-

tion information when selecting alternative antigens for

alternative searches.

Searchable links between alleles and serologic

assignments

A searchable form of the dictionary is available through the

IMGT/HLA database (5) at http://www.ebi.ac.uk/imgt/

hla/. This information can then be used byHSC registries to

routinely update their matching algorithms and to support

other search and matching activities.

Acknowledgments

This work was supported in part by the US Office of Naval

Research N00014-05-1-0859 to the NMDP (MS, MM, and

JK) andN00014-06-1-0726 to the C.W. Bill YoungMarrow

Donor Recruitment and Research Program (CKH). The

participants of the International Cell Exchange, UCLA and

the Transplantation and Immunogenetics Laboratory of

the Welsh Transfusion Service are acknowledged for their

contribution.

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allele, B*3705, containing a Bw6 sequence motif. Tissue

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43. Voorter CEM, van den Berg-Loonen EM. Sequence based

typing of exons 1-5 of a new HLA-B allele, B*3927. Tissue

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44. Blanco PV, Theile G, Marcos C, et al. Novel HLA allele,

HLA-B*4013, identified from a potential bone marrow

recipient. Tissue Antigens 2001: 57: 380–3.

45. Voorter CEM, Hepkema BG, Lems SPM, van den

Berg-Loonen EM. Identification of a new HLA-B*40 variant

B*4035. Tissue Antigens 2003: 61: 89–91.

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HLA-B40 allele with serological Bw4 motif, HLA-B*4047, in

the Finnish population and confirmation of B*270503 allele.


47. Street J, Downing J, Darke C. Immunogenetics of the

rare HLA-B allele B*4408. Eur J Immunogen 2003:

30: 129–31.

48. Darke C, Street J, Downing J. Immunogenetics of two new

HLA-B alleles: B*4414 and B*5708. Tissue Antigens 2003:

62: 436–41.

49. Canossi A, Papola F, Liberatore G et al. Identification of the

novel allele B*4427 and a confirmatory sequence (B*44022).


50. Przemeck M, Elsner H-A, Sel S, Pastucha LT, Blasczyk R.

HLA-B*4431: a new HLA-B variant with a complex ancestral

history involving HLA-B*44, B*40 and B*07 alleles. Tissue

Antigens 2002: 60: 91–4.

51. Poli F, Longhi E, Frison S et al. Identification of a novel

HLA-B allele – HLA-B*4902.Tissue Antigens 2001: 57: 173–4.

52. Darke C, Street J, Guttridge MG. Sequence, genetics and

serology of a newHLA-B allele: B*4903.Tissue Antigens 2001:

57: 478–80.

53. Voorter CEM, Hepkema BG, Mulkers EMT, Lems SPM, van

den Berg-Loonen EM. Identification of two new HLA-B22

variants, HLA-B*5509 and B*5606. Tissue Antigens 2001:

58: 42–6.

54. Park H-S, Choi J-H, Lee KW. Identification of a novel

HLA-B*55 variant (B*5513) from a Korean family. Tissue

Antigens 2004: 64: 96–8.

55. Lyou J-Y, YangKL, Lee A, Lin PY, Lee TD. Confirmation of

a recombinant allele B*5603 and a hypothetical reciprocal

hybrid. Eur J Immunogen 2002: 29: 69–71.

56. Wu G-G, Cheng L-H, Zhou D et al. Identification of a novel

alleleHLA-B*5610 in aChinese potential bonemarrowdonor.


57. Poli F, Crespiatico L, Frison S, Longhi E, Marlianici E,

Scalamogna M. HLA-B*5808, a new HLA-B allele

characterized by sequence based typing. Tissue Antigens 2003:

62: 551–3.

58. Cantwell L, BoyleA,DivineyMet al. Identification of twonew

Cw alleles – implication for epitope recognition (ASHI

abstract). Hum Immunol 2002: 63: S37.

59. Voorter CEM, Fischer GF, van den Berg-Loonen EM.

Identification of a new HLA-C allele, Cw*0316, by SBT.


60. TestaGV, BunceM, SheldonMH,DunnPPJ,Day S,Marques

SBD. Identification of a new allele, HLA-DRB1*1360, on

a DRB5 haplotype in a Brazilian individual. Tissue Antigens

2004: 63: 617–8.

61. Hammond L, Bengtsson M, Street J et al. HLA-A*2312-a

novel allele found in testing for the UK NEQAS H & I DNA

HLA typing scheme. Tissue Antigens 2006: 68: 175–6.

62. Dubois V, Tiercy JM, Labonne MP, Dormay A, Gebuhrer L.

A new HLA-B44 allele (B*4402012S) with a splicing mutation

leading to a complete deletion of exon 5. Tissue Antigens 2004:

63: 173–80.



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