History of the History of the Dan L. Duncan Cancer CenterDan L. Duncan Cancer Center

1997 Strategic plan recommendation

2002 Successful P20 application

2003-2005 Programs, shared resources, organizational structure, infrastructure

2006 P30 CCSG submitted Duncan gift

2007 NCI Cancer Center grant awarded

Mission of the Mission of the Dan L. Duncan Cancer CenterDan L. Duncan Cancer Center

• To provide exceptional patient care

• To provide outstanding education for students

• To conduct innovative research into the causes, prevention and treatment of cancer

• To provide community outreach and education, especially to the underserved

To prevent and ultimately cure cancer in all of its forms

Hospital Partnerships and Hospital Partnerships and

Patient Care ProgramsPatient Care Programs

Harris CountyHospital District

BCM Affiliates & FacilitiesBCM Affiliates & Facilities

BCM Clinic

Rice Consortium

Texas Children’s Hospital

St. Luke’s Hospital

Alkek Research Tower

Baylor College of Medicine

Ben Taub General Hospital

Michael E. DeBakey VA Medical Center

Parkwood

RICE UNIVERSITY

VAMC

The Texas Medical CenterThe Texas Medical Center

Research ProgramsResearch Programs

Cancer Biology Franko DeMayo, PhD

Molecular Carcinogenesis Janet Butel, PhD

Nuclear Receptors Orla Conneely, PhD

Breast Cancer Dan Medina, PhD

Cell and Gene Therapy Malcolm Brenner, MD, PhD

Prostate Cancer Tim Thompson, PhD

Cancer Prevention Powel Brown, MD, PhD

Pediatric Cancer David Poplack, MD

Membership and Grant SupportMembership and Grant Support

Total members 270

NCI Grant Support ≈$ 40M

Total Cancer Funding ≈$100M

SPOREs 3

Program Projects 5

U01 Mouse Models 4

U54 2

U19 2

LLS SCOR 1

U01 Redes en Accion 1

Developing ProgramDeveloping ProgramWorking GroupsWorking Groups

Gastrointestinal Cancer

Pancreas Cancer

Lymphoma

Melanoma

Gene sequencing of human tumors

Shared ResourcesShared Resources Genetically Engineered Mouse Franco DeMayo, PhD

Integrated Microscopy Mike Mancini, PhD

Protein Expression/Proteomics

Genomic Profiling ………………………

Biostatistics/Data Management

Clinical Trials Support Unit

Cell Processing/Vector Production

Dean Edwards, PhD

Lisa White, PhD and Eastwood Leung, PhD

Sue Hilsenbeck, PhD

Martha Mims, MD, PhD

Adrian Gee, PhD

Cytogenetics Core

Flow Cytometry

Rizwan Naeem, MD

Dorothy Lewis, PhD

Tissue Acquisition/ Pathology Tom Wheeler, MD

Other Baylor Core FacilitiesOther Baylor Core Facilities

• Bioinformatics Research Center

• Blot Analysis

• DNA Sequencing

• Interdepartmental Deconvolution Microscope

• Vector Development

• Mouse Phenotyping

Clinical ResearchClinical Research

• 4,000 new cancer patients diagnosed annually in partner hospitals

• 40% minority; 55% female

• 90 Investigator-initiated trials

• NCI-funded cooperative group membership- SWOG - COG

- NSABP - PBTC

- ACOSOG - CALGB

Nanoshell Treatment of Nanoshell Treatment of U373 Glioma CellsU373 Glioma Cells

Bare-NS Anti-IL-13r-NS

Live

Dead

PEG-NS

In press, Neuro-Oncology, 2007

Future Plans of the DLDCC in Future Plans of the DLDCC in Nanotechnology & NanomedicineNanotechnology & Nanomedicine

• Continue ongoing collaborations on nanotechnology projects with Rice and UT

• High priority for ongoing/future research

• Encourage faculty participation in the Keck Center Nanobiology Training program

• Encourage trainees to participate in training programs/projects in nanotechnology

• Commitment to space in the Rice Consortium building