Histopathological Analysis of Periapical Granuloma and Radicular Cysts: A Comparative Study
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SANDRA TORRES. UNIVERSIDADE FEDERAL DO RIO DE JANEIRO. Oral manifestations are common in patients with chronic graft-versus-host disease (cGVHD). However, few studies present systematic results on the prevalence of its different clinical pre- sentations. This study evaluates the frequency of oral cGVHD features. Materials and Methods: Patients with symptomatic oral cGVHD were studied. Demographic and clinical data were taken from medical records. Oral features were assessed through Na- tional Institutes of Health (NIH) criteria. A descriptive analysis was performed. Results: Twenty-two patients were included, 43.8% of whom were male. Patients presented diagnostic (87.5%), distinctive (100%), and common (100%) features of oral cGVHD. The gingiva was the most commonly affected anatom- ical site. Ulceration was the most frequent type of oral lesion, which is related to the inclusion of patients with symptomatic cGVHD. Salivary gland dysfunction was observed in 87.5% of cases. Conclusions: Oral involvement was frequent in the popu- lation studied. The calibration of investigators is important for an adequate diagnosis of oral cGVHD. PE-397 - GLUT-1 AS A TOOL FOR THE CORRECT DIAGNOSIS OF HEMANGIOMAS: AN UPDATE OF ALL CASES DIAGNOSED AT AN ORAL PATHOLOGY SERVICE. TIAGO JOAO DA SILVA FILHO, DENISE HÉLEN IMACULADA PEREIRA DE OLIVEIRA, LUCIANA ELOÍSA DA SILVA CASTRO, ANDRÉIA FERREIRA DO CARMO, RODRIGO GADELHA VASCONCELOS, PATRÍCIA TEIXEIRA DE OLIVEIRA, LÉLIA MARIA GUEDES QUEIROZ. UNIVERSIDADE FEDERAL DO RIO GRANDE DO NORTE. This study analyzed the immunohistochemical expression of human glucose transporter proteins (GLUT-1) in all cases diag- nosed as hemangiomas from a service of Oral Pathology and reclassified such lesions according their immunoexpression. Study Design: A total of 79 cases histologically diagnosed as hemangiomas were retrieved from a total of 12,100 lesions diagnosed at the Division of Oral Pathology, Federal University of Rio Grande do Norte, between 1970 and 2013. For all those lesions, we assessed the immunohistochemical expression of GLUT-1. Some cases were reclassified as pyogenic granulomas (PG) and vascular malformations (VM). Results: This research showed that only 26 cases initially classified as hemangiomas presented immunopositivity for GLUT-1 and fit the initial diag- nosis. The remaining 53 cases were reclassified as PG (20 cases) and VM (33 cases). Conclusion: This study showed that the histological diagnosis alone is not always enough for the correct diagnosis of infantile hemangiomas. PE-398 - GRANULAR CELL TUMOR: HISTOPATHO- LOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF 25 NEW CASES. MARISOL MARTÍNEZ MARTÍNEZ, MARISOL MARTÍNEZ MARTÍNEZ, FELIPE PAIVA FONSECA, THAMYRES CAMPOS FONSECA, MICHELLE AGOSTINI, OSLEI PAES DE ALMEIDA, MÁRIO JOSÉ ROMAÑACH. DEPARTMENT OF ORAL DIAGNOSIS, PIRACICABA DENTAL SCHOOL, STATE UNIVERSITY OF CAMPINAS; DEPARTMENT. This study evaluated the clinical, histopathological, and immunohistochemical features of granular cell tumors of the oral cavity. Study Design: Granular cell tumors were retrieved from the files of two oral pathology laboratories in Brazil from 1975 to 2013. Twenty-five cases were included and subjected to immu- nohistochemical analysis through the streptavidin-biotin tech- nique. Results: Most patients were in the third decade of life (mean age 36 years), and the lesions were observed mainly in the tongue of females. Microscopically, tumors were composed of clusters of polygonal cells with abundant granular cytoplasm in the connective tissue, which was covered by superficial epithe- lium with pseudoepitheliomatous hyperplasia. The tumor cells were positive for S-100, CD63, and CD68, and they were nega- tive for CD163 and Claudin-1. Conclusion: Granular cell tumors are uncommon neural tumors that mainly affect the tongue of adult patients. The neural granular cells probably exhibit histio- cytic differentiation and are not related to perineural cells. PE-399 - HISTOPATHOLOGICAL ANALYSIS OF PERI- APICAL GRANULOMA AND RADICULAR CYSTS: A COMPARATIVE STUDY. MARIA ALICE RAMALHO DE SÁ LEITE, RAFAELA ALBUQUERQUE MELO, LUIZ CARLOS ALVES JÚNIOR, BARBARA VANESSA DE BRITO MONTEIRO, THÂMARA MANOELA MARINHO BEZERRA, JOABE DOS SANTOS PEREIRA, MÁRCIA CRISTINA DA COSTA MIGUEL. UNIVERSIDADE FEDERAL DO RIO GRANDE DO NORTE. Periapical granulomas (PG) and radicular cysts (RC) are common inflammatory periapical lesions whose etiology is associated with the presence of bacteria in root canals. The study investigated and compared the histopathological features of PGs and RCs. Methods: Fifty specimens, including 25 PGs and 25 RCs, were evaluated histopathologically. Results: Analysis of the inflammatory infiltrate in PGs revealed 21 cases (84%) with in- flammatory infiltrate grade III, 3 cases (12%) grade II, and 1 case (4%) grade I. Among the RCs, 14 cases (56%) showed inflam- matory infiltrate grade III, 8 cases (32%) grade II, and 3 cases (12%) infiltrate grade I. Morphological analysis of the epithelial thickness in RCs revealed the presence of an atrophic epithelium in 14 cases (58%). Conclusion: There were more inflammatory cells in cases of PGs than in cases of RCs, suggesting higher antigenic stimulation in PGs. PE-400 - HYPOSALIVATION IN NEUROFIBROMA- TOSIS TYPE 1: A PRELIMINARY STUDY. ELOÁ BORGES LUNA, RAQUEL RICHELIEU LIMA DE ANDRADE PONTES, RAFAELA ELVIRA ROZZA DE MENEZES, ELIANE PEDRA DIAS, MARIA ELISA RANGEL JANINI, KARIN SOARES GONÇALVES CUNHA. UFF. Neurofibromatosis type 1 (NF1) is one of the most common genetic diseases and can affect many organic systems. No studies investigated the glandular function in NF1 individuals. This study evaluated the unstimulated (US) and stimulated salivary flow (SS) in 37 patients with NF1. Material and Methods: Whole saliva was measured between 8:00 and 12:00 AM using the spitting method (5 min). Salivary flow rates were classified as very low (US < 0.1 mL/min; SS < 0.7 mL/min), low (US 0.1 to 0.25 mL/min; SS 0.7 to 1.0 mL/min), and normal (US > 0.25 mL/min; SS >1.0 mL/min). Results: The prevalence of hyposalivation was high (US ¼ 62.1%; SS ¼ 78.4%) in NF1, and the majority presented very low rates (US ¼ 60.8%; SS ¼ 72.4%). There was no association with drugs that cause xero- stomia. Hyposalivation is common among individuals with NF1. Conclusion: Other studies are needed to investigate if NF1 is a predisposing disease for hyposalivation or if other factors are associated with hyposalivation in NF1. OOOO ABSTRACTS Volume 117, Number 2 Abstracts e209
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Transcript of Histopathological Analysis of Periapical Granuloma and Radicular Cysts: A Comparative Study
OOOO ABSTRACTS
Volume 117, Number 2 Abstracts e209
SANDRA TORRES. UNIVERSIDADE FEDERAL DO RIO DEJANEIRO.
Oral manifestations are common in patients with chronicgraft-versus-host disease (cGVHD). However, few studies presentsystematic results on the prevalence of its different clinical pre-sentations. This study evaluates the frequency of oral cGVHDfeatures. Materials and Methods: Patients with symptomatic oralcGVHD were studied. Demographic and clinical data were takenfrom medical records. Oral features were assessed through Na-tional Institutes of Health (NIH) criteria. A descriptive analysiswas performed. Results: Twenty-two patients were included,43.8% of whom were male. Patients presented diagnostic(87.5%), distinctive (100%), and common (100%) features of oralcGVHD. The gingiva was the most commonly affected anatom-ical site. Ulceration was the most frequent type of oral lesion,which is related to the inclusion of patients with symptomaticcGVHD. Salivary gland dysfunction was observed in 87.5% ofcases. Conclusions: Oral involvement was frequent in the popu-lation studied. The calibration of investigators is important for anadequate diagnosis of oral cGVHD.
PE-397 - GLUT-1 AS A TOOL FOR THE CORRECTDIAGNOSIS OF HEMANGIOMAS: AN UPDATE OFALL CASES DIAGNOSED AT AN ORAL PATHOLOGYSERVICE. TIAGO JOAO DA SILVA FILHO, DENISEHÉLEN IMACULADA PEREIRA DE OLIVEIRA, LUCIANAELOÍSA DA SILVA CASTRO, ANDRÉIA FERREIRADO CARMO, RODRIGO GADELHA VASCONCELOS,PATRÍCIA TEIXEIRA DE OLIVEIRA, LÉLIA MARIAGUEDES QUEIROZ. UNIVERSIDADE FEDERAL DO RIOGRANDE DO NORTE.
This study analyzed the immunohistochemical expression ofhuman glucose transporter proteins (GLUT-1) in all cases diag-nosed as hemangiomas from a service of Oral Pathology andreclassified such lesions according their immunoexpression.Study Design: A total of 79 cases histologically diagnosed ashemangiomas were retrieved from a total of 12,100 lesionsdiagnosed at the Division of Oral Pathology, Federal Universityof Rio Grande do Norte, between 1970 and 2013. For all thoselesions, we assessed the immunohistochemical expression ofGLUT-1. Some cases were reclassified as pyogenic granulomas(PG) and vascular malformations (VM). Results: This researchshowed that only 26 cases initially classified as hemangiomaspresented immunopositivity for GLUT-1 and fit the initial diag-nosis. The remaining 53 cases were reclassified as PG (20 cases)and VM (33 cases). Conclusion: This study showed that thehistological diagnosis alone is not always enough for the correctdiagnosis of infantile hemangiomas.
PE-398 - GRANULAR CELL TUMOR: HISTOPATHO-LOGICAL AND IMMUNOHISTOCHEMICAL STUDYOF 25 NEW CASES. MARISOL MARTÍNEZ MARTÍNEZ,MARISOL MARTÍNEZ MARTÍNEZ, FELIPE PAIVAFONSECA, THAMYRES CAMPOS FONSECA, MICHELLEAGOSTINI, OSLEI PAES DE ALMEIDA, MÁRIO JOSÉROMAÑACH. DEPARTMENT OF ORAL DIAGNOSIS,PIRACICABA DENTAL SCHOOL, STATE UNIVERSITY OFCAMPINAS; DEPARTMENT.
This study evaluated the clinical, histopathological, andimmunohistochemical features of granular cell tumors of the oralcavity. Study Design: Granular cell tumors were retrieved fromthe files of two oral pathology laboratories in Brazil from 1975 to
2013. Twenty-five cases were included and subjected to immu-nohistochemical analysis through the streptavidin-biotin tech-nique. Results: Most patients were in the third decade of life(mean age 36 years), and the lesions were observed mainly in thetongue of females. Microscopically, tumors were composed ofclusters of polygonal cells with abundant granular cytoplasm inthe connective tissue, which was covered by superficial epithe-lium with pseudoepitheliomatous hyperplasia. The tumor cellswere positive for S-100, CD63, and CD68, and they were nega-tive for CD163 and Claudin-1. Conclusion: Granular cell tumorsare uncommon neural tumors that mainly affect the tongue ofadult patients. The neural granular cells probably exhibit histio-cytic differentiation and are not related to perineural cells.
PE-399 - HISTOPATHOLOGICAL ANALYSIS OF PERI-APICAL GRANULOMA AND RADICULAR CYSTS: ACOMPARATIVE STUDY. MARIA ALICE RAMALHO DESÁ LEITE, RAFAELA ALBUQUERQUE MELO, LUIZCARLOS ALVES JÚNIOR, BARBARA VANESSA DE BRITOMONTEIRO, THÂMARA MANOELA MARINHO BEZERRA,JOABE DOS SANTOS PEREIRA, MÁRCIA CRISTINA DACOSTA MIGUEL. UNIVERSIDADE FEDERAL DO RIOGRANDE DO NORTE.
Periapical granulomas (PG) and radicular cysts (RC) arecommon inflammatory periapical lesions whose etiology isassociated with the presence of bacteria in root canals. The studyinvestigated and compared the histopathological features of PGsand RCs. Methods: Fifty specimens, including 25 PGs and 25RCs, were evaluated histopathologically. Results: Analysis of theinflammatory infiltrate in PGs revealed 21 cases (84%) with in-flammatory infiltrate grade III, 3 cases (12%) grade II, and 1 case(4%) grade I. Among the RCs, 14 cases (56%) showed inflam-matory infiltrate grade III, 8 cases (32%) grade II, and 3 cases(12%) infiltrate grade I. Morphological analysis of the epithelialthickness in RCs revealed the presence of an atrophic epitheliumin 14 cases (58%). Conclusion: There were more inflammatorycells in cases of PGs than in cases of RCs, suggesting higherantigenic stimulation in PGs.
PE-400 - HYPOSALIVATION IN NEUROFIBROMA-TOSIS TYPE 1: A PRELIMINARY STUDY. ELOÁ BORGESLUNA, RAQUEL RICHELIEU LIMA DE ANDRADEPONTES, RAFAELA ELVIRA ROZZA DE MENEZES,ELIANE PEDRA DIAS, MARIA ELISA RANGEL JANINI,KARIN SOARES GONÇALVES CUNHA. UFF.
Neurofibromatosis type 1 (NF1) is one of the most commongenetic diseases and can affect many organic systems. Nostudies investigated the glandular function in NF1 individuals.This study evaluated the unstimulated (US) and stimulatedsalivary flow (SS) in 37 patients with NF1. Material andMethods: Whole saliva was measured between 8:00 and 12:00AM using the spitting method (5 min). Salivary flow rates wereclassified as very low (US < 0.1 mL/min; SS < 0.7 mL/min),low (US 0.1 to 0.25 mL/min; SS 0.7 to 1.0 mL/min), and normal(US > 0.25 mL/min; SS >1.0 mL/min). Results: The prevalenceof hyposalivation was high (US ¼ 62.1%; SS ¼ 78.4%) in NF1,and the majority presented very low rates (US ¼ 60.8%; SS ¼72.4%). There was no association with drugs that cause xero-stomia. Hyposalivation is common among individuals with NF1.Conclusion: Other studies are needed to investigate if NF1 is apredisposing disease for hyposalivation or if other factors areassociated with hyposalivation in NF1.
![Interdisciplinary management of large periapical … · Periapical pathology occurs as sequelae of microbial activity from ... granuloma.[2] The initial treatment for such pathology](https://static.fdocuments.in/doc/165x107/5ba7abce09d3f2eb658bcfef/interdisciplinary-management-of-large-periapical-periapical-pathology-occurs.jpg)
