Histology for Pathology Hepatobiliary System (Accessory Digestive Organs)
Histology of Digestive System
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Transcript of Histology of Digestive System
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HISTOLOGY of DIGESTIVE SYSTEM
Ageng Brahmadhi
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Overview
GI tract/ alimentary canal
(± 9m in cadaver)
Accescory digestive organs
Mounth
Pharynx
Esophagus
Stomach
Small intestine Large intestine
Teeth
Tounge
Salivary glands
Liver
Gallbladder Pancreas
Digestive system
components:
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Overview
Basic process in digestive system: Ingestion
Secretion
Mixing & Propulsion
Motility Digestion
Mechanical
Chemical
Absorption Defecation
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Oral Cavity
Lips three regions:
the skin aspect,
the vermilion zone
the mucous aspect.
The mucous (internal) aspect of the lip is always wet and is lined
by stratified squamous
nonkeratinized epithelium
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Lip, oral Mucosa
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Teeth
Mineralized Components : Enamel
96% calcium hydroxyapatite
Dentin
70% calcium hydroxyapatite
Cementum
50% calcium hydroxyapatite
Pulp, a richly vascularized
and innervated loose
connective tissue
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stratified squamous
nonkeratinized
epithelium
Orthokeratinized
Parakeratinized
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Humans have two sets
of teeth
20 deciduous (milk)teeth
replaced by 32
permanent (adult) teeth
composed of 20succedaneous teeth and
12 molars (accessional
teeth).
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The Tongue
The tongue is a mass of striated muscle coveredby a mucous membrane
Mucosal folds lingual papillae
Lamina propria
Muscles: Intrinsic muscles
Originate in the tongue
Alter the shape of the tongue
Extrinsic muscles
Outside the tongue
Moving tongue in & out, side to side
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The Tongue
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The Tongue Muscle
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Papillae
Papillae are elevations of the oral epithelium andlamina propria
four types of lingual papillae:
filiform papillae
stratified squamous keratinized epithelium fungiform papilla
stratified squamous nonkeratinized
Fungiform papillae have taste buds
Foliate papillae circumvallate papillae
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Filiform Papilae
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Circumvalata papilae
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Fungiform papilae
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Foliata papilae
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Taste Bud
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Alimentary Canal
The esophagus, Stomach,
Small intestine (duodenum, jejunum, and ileum),
Large intestine (cecum, colon, rectum, anal canal,
and appendix).
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Alimentary canal Histology
Layers: mucosa,
submucosa,
muscularis externa,
and serosa (or adventitia). similar throughout the length of the digestive tract
but display regional modifications and
specializations.
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Alimentary canal Histology
Mucosa Epithelium
lamina propria
mucosa-associated lymphoid tissue (MALT) system
muscularis mucosae
Submucosa dense, irregular fibroelastic connective tissue layer
no glands except in the esophagus and duodenum
Muscularis Externa inner circular and outer longitudinal smooth muscle layers
Serosa and Adventitia Serosa surround by mesothelium
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Esophagus Muscular tubes
Mucosa stratified squamous epithelium
lamina propria
muscularis mucosae
Submucosa esophageal glands
Muscularis Externa andAdventitia inner circular and outer longitudinal
the upper third of the esophagushas mostly skeletal muscle
the middle third has both skeletaland smooth muscle;
and the lowest third has only smoothmuscle fibers
The esophagus is covered by anadventitia until it pierces thediaphragm, after which it iscovered by a serosa
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Esophagus-Gaster Junction
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Esophagus-Gaster Junction
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Gaster
Cardia: a narrow region atthe gastroesophageal
junction, 2 to 3 cm wide
Fundus: a dome-shapedregion to the left of theesophagus, frequently filledwith gas
Body (corpus): the largestportion, responsible for theformation of chyme
Pylorus (pyloric antrum): afunnel-shaped, constrictedportion equipped with a thick
pyloric sphincter thatcontrols the intermittentrelease of chyme into theduodenum
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Gastric Histology
All the gastric regionsdisplay rugae
longitudinal folds of themucosa andsubmucosa, but transverse
in the antrum the epithelial lining of
the stomach invaginatesinto the mucosa,
forming gastric pits(foveolae), shallowest in the cardiac
region
and deepest in the
pyloric region
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Gastric Histology
Mucosa Epithelia
simple columnar epithelium
Lamina Propria Connective tissue, fundic glands
Mucous Neck Cells Regenerative (Stem) Cells
Parietal (Oxyntic) Cells
Chief (Zymogenic) Cells
DNES Cells (APUD or Enteroendocrine Cells
Muscularis mucosa
Composed by three layers of muscle SubMucosa
Muscularis Externa
Serosa
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Fundic Mucosa
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Mucus Cells not Goblet cells
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A: Gastric Pit
B: gastric Glands
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Gastric Pit (Neck region)
Simple
columnar
epithelia
Neckmucous
cells
Parietal
cells
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Gastric Pit (Base Region)
A : Parietal
Cells
B: Chief cells
M f
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Mucosa of
the Cardiac Region VS Pyloric Regions
Cardiac Pyloric
the gastric pits are
shallower
the base of its glands ishighly coiled
composed mostly of
surface-lining cells
predominant cell type in
the pylorus is the
mucous neck cell the gastric pits of the
pyloric region are
deeper
Pyloric glands arehighly convoluted and
tend to branch
C di i
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Cardiac region
Pyloric Region
CardiacR i
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Region
PyloricRegion
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Muscularis Mucosa & SubMucosa
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Muscularis Externa
Inner oblique layer,
middle circular layer,
and
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Small Intestine
duodenum,
jejunum, and ileum.
Layers:
Intestinal Mucosa
Sub Mucosa
Muscularis Externa
Serosa
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Intestinal Mucosa Epithelium
The simple columnar epithelium, Goblet cells , DNES cells
Lamina Propria
the crypts of Lieberkühn, lymphoid nodules
Muscularis Mucosae
inner circular layer and an outer longitudinal
Submucosa
Muscularis Externa inner circular layer and an outer longitudinal
Serosa
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Modifications of the Luminal Surface
Plicae circulares (valves of Kerckring)
transverse folds of the submucosa and mucosa
Villi
protrusions of the lamina propria
Microvilli modifications of the apical plasmalemma
crypts of Lieberkühn
Invaginations of the epithelium into the lamina propria
between the villi
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Plicae circulares
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Villi
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Villi
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Microvilli
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crypts of Lieberkühn
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Paneth Cells
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Histology of Small Intestine
Organ Epithelium
LaminaPropria
Muscularis Mucosa
Submucosa
Muscularis Externa
Serosa/adventitia
Duodenum Simple
columnar
(goblet
cells)
Crypts of
Lieberküh
n
Inner
circular,
outer
longitudinal
Brunner's
glands
Inner
circular,
outer
longitudinal
Serosa
and
adventitia
Jejunum Simple
columnar
(goblet
cells)
Crypts of
Lieberküh
n
Inner
circular,
outer
longitudina
l
No glands Inner
circular,
outer
longitudina
l
Serosa
Ileum Simple
columnar
(goblet
cells)
Crypts of
Lieberküh
n; Peyer's
patches
Inner
circular,
outer
longitudina
l
No glands
(Peyer's
patches
may
extend into
this layer)
Inner
circular,
outer
longitudina
l
Serosa
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Duodenum
Lumen Of DuodenumLumen Of Pyloric stomach
Pyloric Sphincter
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Duodenum
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Brunner's glands
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Jejunum
the longestsegment of the
small intestine
highly coiled
submucosa and
mucosa fold, called
plicae circulares
(or valves ofKerckring)
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Ileum
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Vermiform appendix
Lumen stellate/star-shaped
Mucosa:
Tidak punya villi
Epitel kolumner simpleks
Lamina propria: CT + banyak lymphoid nodule
Crypte Lieberkuhn
Muscularis mucosa, submucosa, muscularis externa,
serosa ~ small intestine
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Appendix vermiformis
Keterangan:
1. Lumen
2. Mukosa
3. Submukosa
4. Muskularis
eksterna
5. Serosa
6. Noduli limfatici
1
2
3
4
5
6
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Large Intestine
cecum, colon,rectum, and anus
No vili, Crypts of
Lieberkuhn (+),
paneth cell (-) Bundle of
muscularis
externa
Taenia coli
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The colon: 450X
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Muscularis externa
-Inner circular layer:
Submucosa
Mucosa
Muscularismucosa
Serosa & muscularis externa of the colon: 450X
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Inner circular layerOuter longitudinal layer
Serosa
Muscularis Externa
Muscularis Externa
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Rectum & Anal Canal
Rectum ~ colon
Anal Canal
simple columnar
epithelium
unkeratinized
stratified
squamousepithelium
Epitel squamous
kompleks keratin
Anal canal
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External anal sphincter
Internal anal sphincter
Anal canalRectum
Anal skin
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Glands
major salivary glands
parotid, submandibular, and sublingual glands),
the pancreas,
the liver
gallbladder
l f l l d
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Histology of Salivary Glands
Secretory Portions
Serous cells Mucous cells
Myoepithelial cells (basketcells)
Duct Portions
The smallest branches =
intercalated ducts = layer ofsmall cuboidal cells,myoepithelial cells
Several intercalated ductsmerge with each other to formstriated ducts = single layer ofcuboidal to low columnar cells
Striatedintralobular ductsinterlobar ducts. terminal (principal)duct
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Glandula Sublingualis secretory portion
P id l d
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Parotid glands
the largest of thesalivary glands
produces only
about 30%
saliva output• Ductus intercalaris
Ductus striatus
duktus excretorius
interlobularis
Serous secretion
S bli l Gl d
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Sublingual Gland
composed most ly of mucous acin i wi th serous demi lunes,
and prod uces a m ixed s aliva.
D il
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Demiluna serosa
S b dib l Gl d
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Submandibular Glands
produc es 60% of the total sal ivary outpu t
Mixed glands
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E i P
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Exocrine Pancreas
acinar cell
secretory granules
(zymogen granules)
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H
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Hepar
the liver has bothendocrine and
exocrine functions
Composed by
hepatocyte
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The Three Concepts of Li er Lob les
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The Three Concepts of Liver Lobules
The classical liver lobule
blood flows from theperiphery to the center of
the lobule into the central
vein
portal lobule all hepatocytes that deliver
their bile to a particular
interlobular bile duct
constitute a lobule
hepatic acinus (acinusof Rappaport).
blood flow from the
distributing arteriole
Portal Triad
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Portal Triad
Gallbladder
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Gallbladder
Layer:
epithelium, lamina
propria, smooth muscle,
and serosa/adventitia
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Questions ??
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Questions ??
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End of lecture