HIPPO SIGNALING PATHWAY - Bio Cusa › uploadfile › pathway › Hippo... · 2018-06-05 · HIPPO...

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HIPPO SIGNALING PATHWAY CUSABIO TECHNOLOGY LLC Postal Address: 6161 Savoy Dr. Suite 1018 Houston, TX 77036, USA Tel : 301-363-4651Available 9 a.m. to 5 p.m. EST from Monday to FridayEmail: [email protected] Web: www.cusabio.com Protein Gene chemical molecule Other signal path diagram phosphorylation +P dephosphorylation -P Direct promotion ubiquitination +u Direct inhibition combination dissociation complex BTRC Antibody CSB-PA897464LA01HU ID2 Antibody CSB-PA010967LA01HU PARD6G Antibody CSB-PA863155LA01HU TGFBR1 Antibody CSB-PA023451LA01HU SMAD1 Antibody CSB-PA618998LA01HU TEAD1 Antibody CSB-PA023363DSR2HU CDH1 Antibody CSB-PA005034MA01HU MOB1A Antibody CSB-PA872519HA01HU Control IgG CCND3 Input 120KD90KD50KD25KD20KD35KD250KD130KD72KD95KD55KD36KDControl IgG CDH1 Input Control IgG MOB1A Input 120KD90KD50KD35KD25KD20KDMOB1B Antibody CSB-PA762574HA01HU 120KD90KD50KD35KD25KD20KDControl IgG MOB1B Input SAV1 Antibody CSB-PA875672ESR2HU CCND3 Antibody CSB-PA004814ESR2HU CSNK1D Antibody CSB-PA006067LA01HU-IP Control IgG CSNK1D Input 120KD90KD50KD35KD25KD20KD120KD90KD50KD35KD25KD20KDControl IgG SAV1 Input CSNK1D Antibody CSB-PA006067LA01HU NPHP4 Antibody CSB-PA015987LA01HU TGFB1 Antibody CSB-PA07309A0Rb YWHAB Antibody CSB-PA01544A0Rb SMAD3 Antibody CSB-PA021788ESR2HU YWHAQ Antibody CSB-PA026290ESR1HU FZD10 Antibody CSB-PA891782LA01HU A549 Hela HepG2 120KD90KD50KD25KD20KD35KDMCF-7 PARD6A Antibody CSB-PA878839LA01HU 120KD90KD35KD50KD25KD20KDHepG2 A549 Stomach Lung SAV1 Antibody CSB-PA875672ESR2HU 293T Pc3 A549 120KD90KD50KD35KD25KD20KDMCF-7 NIH/3T3 SMAD2 Antibody CSB-PA15557A0Rb 120KD90KD50KD35KD25KD20KDHela HepG2 Jurkat K562 Heart Liver Brain TEAD4 Antibody CSB-PA618010LA01HU Hela MCF-7 HepG2 120KD90KD50KD35KD25KD20KDK562 PPP2R2A Antibody CSB-PA018564LA01HU 120KD90KD50KD35KD25KD20KDBrain Liver Brain Kidney Par6 Par3 aPKC RASSF6 Lg1 Scnb Dlg YAP/TAZ Mob Lats1/2 SAV1 Mst1/2 Mer KIBRA FRMD F-actin PP2A ASPP2 Pp1 14-3-3 TGF-β signaling pathway Wnt signaling pathway RASSF1A YAP Smad1 Smad4 YAP/TAZ Smad2/3 Smad4 YAP/TAZ ? YAP/TAZ TEAD YAP/TAZ p73 -P -P -P +P +P +P Proapoptotic genes PUMA ? E-Cad Crb Tight junction Tight junction Adherens junction Adherens junction E-Cad E-Cad Crb E-Cad Adherens junction Adherens junction TCF/LEF YAP TEAD 14-3-3 YAP/TAZ Axin2 cycD Sox2 Birc2/5 Nkd1 myc Slug Id1 Id2 CTGF Pai-1 Smad7 AREG ITGB2 FGF1 Birc5 AFP Gh2 CTGF Anti-apoptotic genes, Pro-proliferation genes Pals1 PATJ AMOT YAP/TAZ Ajub

Transcript of HIPPO SIGNALING PATHWAY - Bio Cusa › uploadfile › pathway › Hippo... · 2018-06-05 · HIPPO...

Page 1: HIPPO SIGNALING PATHWAY - Bio Cusa › uploadfile › pathway › Hippo... · 2018-06-05 · HIPPO SIGNALING PATHWAY CUSABIO TECHNOLOGY LLC Postal Address: 6161 Savoy Dr. Suite 1018

HIPPO SIGNALING PATHWAY

CUSABIO TECHNOLOGY LLCPostal Address: 6161 Savoy Dr. Suite 1018 Houston, TX 77036, USA

Tel : 301-363-4651(Available 9 a.m. to 5 p.m. EST from Monday to Friday)Email: [email protected] Web: www.cusabio.com

Protein

Gene

chemical molecule

Other signal path diagram

phosphorylation+P

dephosphorylation-P

Direct promotion

ubiquitination+u

Direct inhibition

combination

dissociation

complex

BTRC AntibodyCSB-PA897464LA01HU

ID2 AntibodyCSB-PA010967LA01HU

PARD6G AntibodyCSB-PA863155LA01HU

TGFBR1 AntibodyCSB-PA023451LA01HU

SMAD1 AntibodyCSB-PA618998LA01HU

TEAD1 AntibodyCSB-PA023363DSR2HU

CDH1 AntibodyCSB-PA005034MA01HU

MOB1A AntibodyCSB-PA872519HA01HU

Control Ig

G

CCND3Input

120KD→

90KD→

50KD→

25KD→

20KD→

35KD→

250KD→

130KD→

72KD→

95KD→

55KD→

36KD→

Control Ig

G

CDH1Input

Control Ig

G

MOB1AInput

120KD→90KD→

50KD→

35KD→

25KD→

20KD→

MOB1B AntibodyCSB-PA762574HA01HU

120KD→

90KD→

50KD→

35KD→

25KD→

20KD→

Control Ig

G

MOB1BInput

SAV1 AntibodyCSB-PA875672ESR2HU

CCND3 AntibodyCSB-PA004814ESR2HU

CSNK1D AntibodyCSB-PA006067LA01HU-IP

Control Ig

G

CSNK1D

Input

120KD→90KD→

50KD→

35KD→

25KD→

20KD→

120KD→

90KD→

50KD→

35KD→

25KD→

20KD→

Control Ig

G

SAV1Input

CSNK1D AntibodyCSB-PA006067LA01HU

NPHP4 AntibodyCSB-PA015987LA01HU

TGFB1 AntibodyCSB-PA07309A0Rb

YWHAB AntibodyCSB-PA01544A0Rb

SMAD3 AntibodyCSB-PA021788ESR2HU

YWHAQ AntibodyCSB-PA026290ESR1HU

FZD10 AntibodyCSB-PA891782LA01HU

A549Hela

HepG2

120KD→

90KD→

50KD→

25KD→

20KD→

35KD→

MCF-7

PARD6A AntibodyCSB-PA878839LA01HU

120KD→

90KD→

35KD→

50KD→

25KD→

20KD→

HepG2

A549Stomach

Lung

SAV1 AntibodyCSB-PA875672ESR2HU

293TPc3 A549

120KD→90KD→

50KD→

35KD→

25KD→

20KD→

MCF-7NIH/3T3

SMAD2 AntibodyCSB-PA15557A0Rb

120KD→90KD→

50KD→

35KD→

25KD→

20KD→

HelaHepG2

JurkatK562

HeartLiver

Brain

TEAD4 AntibodyCSB-PA618010LA01HU

HelaMCF-7

HepG2

120KD→

90KD→

50KD→

35KD→

25KD→

20KD→

K562

PPP2R2A AntibodyCSB-PA018564LA01HU

120KD→

90KD→

50KD→

35KD→

25KD→

20KD→

BrainLiver

BrainKidney

Par6Par3

aPKC

RASSF6

Lg1Scnb

Dlg

YAP/TAZ

MobLats1/2

SAV1Mst1/2

Mer KIBRAFRMD

F-actin

PP2A

ASPP2Pp1

14-3-3

TGF-β signaling pathway

Wnt signaling pathway

RASSF1A

YAPSmad1Smad4

YAP/TAZSmad2/3

Smad4

YAP/TAZ? YAP/TAZ

TEAD YAP/TAZp73

-P

-P

-P

+P

+P+P

Proapoptotic genesPUMA

?

E-Cad

Crb

Tight junctionTight junction

Adherens junctionAdherens junction

E-CadE-Cad

Crb

E-Cad

Adherens junctionAdherens junction

TCF/LEFYAP

TEAD

14-3-3

YAP/TAZ

Axin2cycD

Sox2Birc2/5

Nkd1myc

SlugId1

Id2

CTGF

Pai-1

Smad7

AREG

ITGB2

FGF1

Birc5

AFP

Gh2

CTGF

Anti-apoptotic genes, Pro-proliferation genes

Pals1PATJAMOT

YAP/TAZ

Ajub