HHS Combined FOIA Production

8/10/2019 HHS Combined FOIA Production

1/697

HARVARD MEDICAL SCHOOL

'. :

.

'

John E. Dahlberg, Ph.D., Director

Division of Investigative Oversight

Office for Research Integrity

1101 Wootton Parkway

Suite 750

Rockville, MD 20852

Re: DIO:

Matter

of

Dear Dr. Dahlberg:

CONFIDENTIAL

GRETCHEN BRODNICKI, J .D.

DEAN

FOR FACULTY AND

RESEARCH INTEGRITY

25 SHATTUCK STREET

BOSTON, MAsSACHUSETTS 02115

TEL:

(617) 432-2496

FAX:

(617) 432-7462

GRETCHEN_BRODNICICI@HMS:HARVARD.EDU

June

S

2012

Enclosed please find the fmal determination, final reports and documentary record in the

above-referenced investigation. As you will see, there was a fmding of research misconduct.

Please do not hesitate to contact me at 617-432-2496

or

Gretchen [email protected] if you have any questions or need any additional

information.

Enclosures

cc: Kristin Bittinger (w/o enclosures)

Ellen Berkman, J.D. (w/o enclosures)

Sincerely,

: J ~ 6 ~

Gretchen Brodnicki

Dean for Faculty and

Research Integrity

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (7)(A)

(b) (6), (b)(7)(C)

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MASSACHUSEITS GENERAL H O S P I T L ~ HARVARD MEDICAL

SCHOOL

Jeffrey Flier, M.D.

Dean

of

the Faculty of Medicine

Harvard Medical School

25 Shattuck Street

Boston,

MA

02115

Dear Dr. Flier:

PAUL

S

RUSSELL, MD

John Homans Professor

of

Surgery

Harvard

Visiting Surgeon and Chief, Transplantation Unil

Massachusetts General Hospital, Boslon, MA 02114

(617)

726-2801

May 22, 2012

\@V

On behalfof the Harvard Medical School Standing Committee on Facility Conduct, I am

writing to convey to you the recommendation

of the Standing Committee relating to an investigation

into allegations that

in the laboratory

of

, might

have conimitted research misconduct

This matter commenced in October 2007, when Margaret Dale, J.D., former Research

Integrity Officer and Dean for Faculty and Research Integrity at HMS, was notified by Gerianne

Sands, J.D., Associate General Counsel at Fred Hutchinson Cancer Research Center (FHCRC)

that might . The research

reported in was conducted at HMS while in

laboratory. , where

in the Division of Basic Sciences.

The allegations against were first brought forward

by

another former fellow in

laboratory at FHCRC, prepared a detailed

report setting forth allegations against related to . In

addition, provided a series

of

PowerPoint presentations supporting allegations.

After an initial assessment, and in accordance with institutional policies and federal

regulations, a joint inquiry panel was appointed to look into the matter and to report its findings and

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C) (b) (6), (b)(7)(C) (b) (6), (b)(7)(C)

(b)

(6)

,

(b)

(7)

(C

)

(b)

(6),

(b)

(7)

(C)

(b) (7)(A)

(b) (7)(A)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (7)(A) (b) (6), (b)(7)(C) (b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

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PAUL S. RUSSELL, M.D.

conclusions to the Chair of the Standing Committee on Faculty Conduct. The inquiry panel,

comprised

of

Professor ,

Professor and Professor

, reviewed the matter and recommended that it proceed to investigation in accordance

with institutional policies, Public Health Service regulations and the Department of Defense

directive. The Chair

of

the Standing Committee on Faculty Conduct, Paul S. Russell, M.D.,

John Romans Distinguished Professor of Surgery, accepted the recommendations

of

the inquiry

panel and his recommendations were accepted

by

you. The final determinations

of

the inquiry

panel were then forwarded to the respondent, the federal Office of Research Integrity and the

Department

of

Defense.

The members

of

the inquiry panel agreed to serve as members

of

an investigative panel.

The investigative panel was charged with applying the standard for review set forth in 42 CFR

Sec. 50.102 to determine whether committed research misconduct.

1

As detailed in the

attached investigation report, the panel met three times at the end

of

2010 and early 2011 to review

the written submissions

of

the respondent and complainant, to interview and

and to consider the evidence against While the panel reached

preliminary conclusions in March 2011, it held issuance of its draft

report pending its formal inquiry into allegations against a second respondent.

The conclusions of that review did not ultimately alter the findings of the investigative panel.

Consequently, on , a draft report was shared with declined

to comment in .

The panel issued its final report on They concluded that

Specifically, the panel concluded that

.

The Standing Committee met on March 22,2012 to consider the matter. At the meeting, we

reviewed the investigative panel's report and the accompanying documentation, met with the

investigation staff, and interviewed , a representative on behalf of the investigative paneL

1

42 CFR Sec. 50.102 was the regulation in effect when the alleged misconduct occurred. "Misconduct" or

"Misconduct in Science" is defined as fabrication, falsification, plagiarism or other practices that seriously deviate

from those that are commonly accepted within the scientific community for proposing, conducting or reporting

research. It does not include honest error or honest differences in interpretations or judgments of data. The

investigation was conducted in compliance with that standard, but the procedural requirements

of

42 CFR Part

93,

the revised regulation covering misconduct, were followed with respect to the panel's investigative process.

2

(b) (6), (b)

(7)(C)

(b) (6),

(b)(7)

(C)

(b) (6), (b)(7)(C) (b) (6), (b)(7)(C)

(b) (7)(A)(b) (7)(A)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C) (b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C) (b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C) (b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

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PAUL S. RUSSELL,

M.D.

Conclusions

Having reviewed and considered carefully the final report

of

the investigative panel,

including the accompanying documentation, we conclude that the work of the investigative panel

was thorough

and fair.

We agree with the conclusion

of

the investigative panel tha

Although we find

In particular, it

does

not

appear from the record that exercised primary data

results were

preliminary.

See

investigation report, exhibit 8,

p.

11). A careful review

of

all primary data

supporting the paper before submission might have

showing the reported This might have

inspired a more careful review of the

Recommendations

We agree with the recommendation of the investigative panel that the Office for Research

Integrity, Department

of

Defense and appropriate institutional officials at HMS be notified

of

the

outcome of this investigation.

We also agree with the panel that FHCRC, and be notified in writing

of the conclusion of this matter.

These are the conclusions and recommendations of the Standing Committee on Faculty

Conduct. Please feel free to call on us if we can be of further assistance.

Enclosures

SjJerel

y

, )

r

Jul

g

~ ~ u / r U J

Paul

S.

Russell, M.D.

Chairperson

3

(b) (6), (b)(7)(C)

(b) (6), (b)

(7)(C)

(b) (6), (b)

(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C) (b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

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May 29, 2012

Via Email

Dear

CONFIDENTIAL

JEFFREY

S.

FUER, MD

DEAN OF

THE FACULTY OF

MEDICINE

HARVARD MEDICAL

SCHOOL

25 SHATTUCK ST.

BOSTON, MA 02II5

I am writing to inform you of the determinations Harvard Medical School has reached after reviewing and

considering the final conclusions and recommendations of the HMS Standing Committee on Faculty Conduct, as

set forth in their letter to me of as well as the Investigation Panel's report, and the rest of

documentary record

in

this case.

After careful consideration, I have accepted the findings, conclusions, and recommendations of the Standing

Committee and the Investigation Panel.

I also agree with the panel that FHCRC, and be notified in writing

of

the conclusion of this

matter.

If you have any further questions conceming this matter, including any questions about the implementation of the

Standing Committee's recommendations, please contact Gretchen Brodnicki, the HMS Dean for Faculty and

Research Integrity, at Gretchen [email protected], or at 617-432-2496.

Sincerely,

ean

of

the Faculty

of

Medicine

cc: Gretchen Brodnicki

Kristin Bittinger

Ellen Berkman, J.D. (Office

of

the General Counsel)

Enclosures

(

b

)

(

6

)

(b) (6)

(b) (6), (b)(7)(C) (b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

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CONFIDENTIAL

.

. Because the research in

question was conducted while , the HMS Office for Professional

Standards and Integrity (OPSI) took the administrative lead in staffing the matter? The

complainant in this matter is in

. prepared a very detailed report dated November

and provided these materials to the FHCRC panel

in the course of its related review. In addition,

FHCRC secured and sequestered all available

primary data relevant to the inquiry and, in view

of

the jurisdict ion

ofHMS

over the allegations

discussed in this report, provided these data and submissions to HMS.

In compliance with institutional policy and federal regulation,3 was notified

of

commencement

of

the inquiry and provided with our names as proposed members

of

the review

panel. raised no objection to our service on the inquiry panel or to our continued service on

this investigation panel. We are Professor ,

Professor , and

Professor Gretchen Brodnicki, J.D., Research Integrity Officer and

Dean for Faculty and Research Integrity,4 Mortimer Litt, M.D., HMS Senior Scientific

Investigator, Kristin Bittinger, HMS Director of Scientific Integrity,s and

of

the

OPSI also served as staffto the panel.

In

addition, a representative

ofthe

Harvard University

Office

of

General Counsel (Ellen Berkman, J.D.) was available to advise us throughout the

proceedings and attended both inquiry and investigative panel meetings.

3 The inquiry and subsequent investigation were conducted in accordance with the HMS Principles nd Procedures

for

Dealing with llegations ofFaculty Misconduct

and the Public Health Services Rule, 42 CFR Part 93, and the

Department of Defense INSTRUCTION 3210.7 (May 14,2004), which implements Dodd DIRECTIVE 3216.2.

4 Dean Brodnicki arrived at HMS in July 2008.

5 Ms. Bittinger arrived at HMS

in

April 2009.

2

(b) (6), (b)(7)(C)

(b) (6), (b)

(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C) (b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b)(6),(b)(7)(C)

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CONFIDENTIAL

Although we initially

met

in April 2008 for orientation and document review, the bulk of

the inquiry was conducted through the end

of2009

and early 2010.

6

This panel convened two

meetings

on

March 20,2009 and March

30,2009

to further discuss the allegations, the

documentation, and the available primary image data. Following these

meetings, we requested that

On July 29, 2009, we met in the laboratory of to

review relevant original slides.

7

Following our review

of

the available slides, we posed follow-

up questions with an additional opportunity to respond

that he had not previously addressed. Through counsel,

The allegations under review relate to paper, which reported

on

the

; (ii)

; (iii)

3

(b) (6),

(b)(7)

(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6),

(b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

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CONFIDENTIAL

In a previous paper, using the expressed by

.8 They observed

that the

.

Based on experience derived from this paper,

.

.

The authors reported, as expected, that

Furthermore,

.

. Upon joining group,

4

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)

(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C) (b)

(6),

(b)

(7)

(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6),

(b)(7)

(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

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CONFIDENTIAL

.

9

See Inquiry Report, Exhibit

8,

p.

8).

efforts to gather insight from regarding potential causes for difficulty with

the protocol,

r. Following regarding the discrepancies and the

challenges he encountered in his attempt to follow the protocol, including a trip by

, brought concerns to the attention of

immediately notified institutional officials at FRCRC .

alleges that that had been

. According to

, the real data did not demonstrate

.

set forth

one allegation with numerous subparts identifying specific

manipulations alleged

on

the figures in At the

conclusion

of

the inquiry, we found

.

The final inquiry report was provided to Paul Russell, M.D., Chair

of

the Standing

Committee on Faculty Conduct, for review and approval. Dr. Russell concurred with the

conclusions ofthis panel's inquiry and recommended to Jeffrey Flier, M.D., Dean ofthe Faculty

of

Medicine, Dr. Flier

concurred with Dr. Russell's recommendation (Exhibit 4).

5

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C) (b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C) (b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C) (b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C) (b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C) (b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

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CONFIDENTIAL

LLEG TIONS ND FINDINGS

The facts and findings set forth in the inquiry report regarding each allegation are

incorporated by reference into this report. We focus here on the additional information provided

by as each relates to the pending allegations.

however, , to fully understand their

experimental basis one must consider to

explore the

Briefly, the method is supposed to consist

of

the following steps:

13

7

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

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CONFIDENTIAL

A review

of

the literature among members

of this investigation panelled to the following conclusions as

14

15

.

8

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

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CONFIDENTIAL

In summary, to answer the

questions asked This contributed (i)

, (ii)

and (iii)

It must be emphasized that the above reconstruction describes potential sources of human

error, and does not, alone, describe events that fall within the definition

of

research misconduct.

It is very common for scientific assays to detect a combination

of

genuine signal and background

noise; this paper's use of a method that included background labeling does not constitute

scientific misconduct. Scientific research is always limited to the use

of

techniques that are

available at the time: a technique may initially seem promising yet difficult, and remedies may be

attempted that generate artifacts.

16

9

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

HHS-PSC000017


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CONFIDENTIAL

10

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

HHS-PSC000018


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CONFIDENTIAL

11

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

HHS-PSC000019


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CONFIDENTIAL

12

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

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CONFIDENTIAL

13

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

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CONFIDENTIAL

(A)

14

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

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CONFIDENTIAL

(

IS

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

HHS-PSC000023


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CONFIDENTIAL

In view

of

our review

ofthe

original sections,

Our review of the original slide that produced figure

21,

however, revealed

A review

of

By simply comparing the

16

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

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26/697

CONFIDENTIAL

.

(

CONCLUSIONS

We have reviewed the documentary record relating to against

the numerous submissions from ,

throughout this process, the slides that we were able to locate and review, and the

of

, and In reviewing these materials, we

have been mindful

of

our charge as an Investigation Panel. Mindful

of

that charge, we have

determined that

18

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C) (b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C) (b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

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CONFIDENTIAL

RECOMMEND TIONS

In accordance with the applicable institutional policies and federal regulations and for the

reasons stated above, we recommend this matter be referred to HMS officials with such finding

and a recommendation that OR and DoD be notified.

19

(b) (7)(A)

HHS-PSC000027


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List of Zou Exhibits

Exhibit 1:

Exhibit 2: .

Exhibit

3:

Letter

of

Dr. Paul Russell, Chair

of

he Standing Committee on Faculty Conduct,

affinning the decision

of

he Inquiry panel.

Exhibit 4: Deciding Official Letter, signedby Jeffrey Flier, M.D., Dean ofthe Faculty

of

Medicine, following inquiry.

Exhibit

5:

Notification to the Office of Research Integrity (ORI) of decision of Inquiry

Panel to proceed to investigation.

Exhibit 6: Notification to the Department

of

Defense (DoD)

of

decision

of

Inquiry Panel

to proceed to investigation.

Exhibit 7: Transcript

of

testimony of

Exhibit

8:

Transcript of testimony of

Exhibit 9: Transcript of testimony of

Exhibit 10:

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

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HHS-PSC000029


30/697

rticles

(b) (6), (b)(7)(C)

HHS-PSC000030


31/697


32/697

rticles

(b) (6), (b)(7)(C)

HHS-PSC000032


33/697

rticles

(b) (6), (b)(7)(C)

HHS-PSC000033


34/697

rticles

(b) (6), (b)(7)(C)

HHS-PSC000034


35/697

articles

(b) (6), (b)(7)(C)

HHS-PSC000035


36/697

rticles

(b) (6), (b)(7)(C)

HHS-PSC000036


37/697

HHS-PSC000037


38/697

RETRACTION

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

HHS-PSC000038


39/697

HHS-PSC000039


40/697

MASSACHUSETTS GENERAL HOSPITAL HARVARD

MEDICAL

SCHOOL

PAULS.RUSSELL,M.D. ,

I :

John Homans Distinguished Professor of Surgery .

Wi

~ Harvard m

Senior Surgeon

Massachusetts General Hospital, Boston, MA 02114

(617) 726-2801

May 12,2010

Jeffrey S. Flier, M.D.

Dean

of he

Faculty

of

Medicine


25 Shattuck Street

Boston,

MA

02115

.Dear Dr. Flier:

On

behalfof the

Harvard

Medical

School

StandilJ.g Committee on

Faculty Conduct,

I

am

writing to convey

to

you my recommendation, as chair of he Standing

Committee,

relating to

. allegations former Harvard Medical School (HMS)

As

the attached inquiry report details,

the allegations

in this matter

were

first to HMS's

attention by at Fred Hutchinson Cancer

Research Center (FHCRC) conveyed to

. fonner Research Integrity Officer

and

Dean

for

Facility and Research Integrity

at

HMS

that

in

the _

laboratory of

laboratory moved to FHCRC in 2002. After an initial assessment and

in accordance

with

institutional policies, a joint

inqUlly

panel

was

appointed to look into the matter.

The

inquiry panel

was comprised of Professor

Professor

and

Professor of

The inquiry panel was charged with determining whether or not the

matter warranted a further investigative process. It was detennined that

National Institute of Health and the Department of Defense

and, therefore the matter was subject to the Public Health Services Rule, 42 CFR Part 93 and the

Department ofDefense INSTRUCTION 3210.7 (May 14,2004).

The inquiry panel met in person

on

four

occasions

to review

submitted in support several written responses submitted by

the

respondent and all available onginal

source documentation,

including original croscope slides

sequestered

and

provided through FHCRC. As

indicated

in their report,

the

inquiry

panel

members

concluded

that there was sufficient

evidence to wiimuit

proceeding

to i n v s t i g ~ o n

3

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C) (b) (6), (b)(7)(C)

(b) (6), (b)(7)(C) (b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C) (b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

HHS-PSC000040


41/697

PAUL S. RUSSELL, MD.

The report

of he

inquiry panel

was

submitted to

me, as chair

of

he

Standing

Committee, on

May

5, 2010 to

consider the matter.

I

reviewed

inquiry

panel's

report and

the

accompanying

documentation.

Conclusion

2

(b) (6), (b)(7)(C)

(b) (7)(A)

HHS-PSC000041


42/697

HHS-PSC000042


43/697


3

(b) (7)(A)

HHS-PSC000043


44/697


Recommendations

I agree with:the inquiry l that

Because NIH and

DOD fimding

was involved, the Office of

Research Integrity (OR ) of he Public Health Service

and

the Department ofDefense should

be .

notified of he decision.

These are the conclusions

and

recommendations

of

he chair, on behalfof he

Standing

Committee

on

Faculty Conduct

Enclosures

4

Sincerely,

P

lliL S w ~

Paul Russell, M.D.

Chair

(b) (7)(A)

(b) (7)(A)

HHS-PSC000044


45/697

HARVARD MEDICAL

SCHOOL

May

25,

2010

VIA ELECTRONIC DELIVERY

CONFIDENTIAL

JEFFREY S.

FLIER,

MD

DI AN 0[' THE FACULTY OF MEDICINE

HARvARD

MEDICAL ScHOOL

25

SHAITUCK ST.

BOSTON, W,A

02II5

I am.

writing to provide you with the

final

conclusions

of

he

HMS

Standing

Committee on

. Faculty Conduct

and

to inform you of he determinations reached by the Harvard Medical

School

after-

reviewing the reports and the documentaIy record in this case, including your

submissions.

After careful

o n s i d e ~ t i o ~

HMS has accepted the findings, conclusions,

and

recommendations

of

he

Chair of he

Standing Committee and the Inquiry

Panel. We

agree

that

further investigation is warranted in this matter

and, as

required by

institutioDal policy, we will be

commencing the investigative process.

Gretchen

Brodnicki, J.D., Dean for Faculty

arid

Research Integrity at the Medical

School,

will

be

in contact with you concerning the investigative process. Please let her know

if you have

any

questions.

Sincerely,

J J J ? ~

Dean of

he

Faculty of Medicine

Enclosure

cc: Gretchen Brodnicki, J.D.

Ellen e r l o n ~ J.D.

~ ~ ~

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

HHS-PSC000045


46/697

HHS-PSC000046


47/697

Harvard MedicalSchool .

John

E. Dahlberg, Ph.D., Director


Office for Research Integrity

.1101 Wootton Parkway

.

Suite 750

Rockville, MD

20852

Re:

DIO:

'

Dear Dr. Dahlberg:

CONFIDENTIAL

25

Shattuck

Street

Boston. Massachusetts 021 i 5

(617) 432-3191

FAX:

(617) 432-0566

Office for

Research

Issues

May 25, 2010

I enclose full inquiry panel report , Standing Committee report,

and

determination letter

in the inquiry

of he

allegation

As

you will see, we wil l be proceeding to

.

further

investigation.

Please

do

not hesitate to contact

me

at

617-432-2496 or .

Gretchen

Brodnicki(a),hms.harvard.edu i f

you

have any questions or need any-additional .

information.

Enclosures

cc:

Kristin Bittinger, J.D. (w/o enclosures)

Ellen Berkman, J.D. ( flo enclosures)

Sincerely?

r\..

()

&

~ ~

L . L _ ~ ~ - ~

Gretchen A. Brodnicki

h

Dean for Faculty and

Research Integrity

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

HHS-PSC000047


48/697

HHS-PSC000048


49/697

. _ ...- ............. .

25 Shattuck street

Harvard Medical. School

. .Boston. Massachusetts 02115

(617) 432-3191

CONFIDENTIAL

Mr. Jay Winchester -

Office

of

the

Staff

Judge Advocate .

Medical Research and Development Command

United States Army

Department ofDefense ..

504 Scott Street

Fort Detrick

Frederick, Maryland 21702-5012

FAX: 301-619-5034

FAX: (617) 432-0566

Office

for

Research Issues

May 25, 2010

Re: Research Misconduct Inquiry ofAllegations

Dear Mr. Winchester:

,

,I

I enclo'se the

fujI

inquiry panel report, Standing Committee report, and detennination letter

in the research misconduct inquiry of the allegation As you will see, we

will be proceeding to further investigation.

The data subject to the pending allegations were fimded,

in

part, through a Department of

Army Grant ) and

two

NllI grants The Office for Research

Integrity (ORl) is simultaneously being notified of he results of his inquiry.

Please do not hesitate to contact me at 617-432-2496 or

. Gretchen [email protected] if you have any questions or need any additional

information. . .

Sincerely,

- - 0

I ~ ~ ~ g ~

Gretchen A. Brodnicki

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

HHS-PSC000049


50/697

Enclosures

cc:

Kristin Bittinger, lD w/o enclosures

Ellen

Berkman,

J.D.

w/o

enclosures

2

HHS-PSC000050


51/697

HHS-PSC000051


52/697

7

HARVARD

M E D l ~ L

'SOHOOL

OFFICE FOR RESEARCH fSSUES

O

N

FiDENTJAL

(b) (6), (b)(7)(C)

HHS-PSC000052


53/697


Transcription of

the

Meeting with

Conducted on October 5,2010

InquiIy Panel Members Present:

Sta ff Members Present: Gretchen Brodnicki (GB), Kristin Bittinger (KB),

Pat Gilligan (PG), and Ellen Berkman (EB).

Witness, by telephone:

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(a), (b)(7)(c)

(b) (6), (b)(7)(C)

HHS-PSC000053


54/697

2

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000054


55/697

3

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000055


56/697

4

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000056


57/697

5

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000057


58/697

6

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000058


59/697

7

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000059


60/697

8

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000060


61/697

9

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000061


62/697

10

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000062


63/697

11

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000063


64/697

12

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000064


65/697

13

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000065


66/697

14

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000066


67/697

15

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000067


68/697

16

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000068


69/697

17

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000069


70/697

HHS-PSC000070


71/697

HARVARD MEDICAL

SCHOOL

Transcription of the Meeting

with

Conducted on December 17, 2010

InquirY Panel Members Present:

StaffMembers Present: Gretchen Brodnicki (GB), Kristin Bittinger

(KB),

Pat Gilligan (PG), and Ellen Berkman (EB).

Witness, by telephone:

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(a), (b)(7)(c)

(b) (6), (b)(7)(C)

HHS-PSC000071


72/697

2

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000072


73/697

3

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000073


74/697

4

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000074


75/697

5

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000075


76/697

6

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000076


77/697

7

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000077


78/697

8

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000078


79/697

9

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000079


80/697

10

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000080


81/697

11

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000081


82/697


83/697

HHS-PSC000083


84/697

HARVARD

MEDICAL SCHOOL

Transcription of the

Meeting with

Conducted on

March

29, 2011

Inquiry Panel Members Present:

Staff Members Present: Kristin Bittinger, , Ellen Berkman, and Patrick Gilligan.

Witness.

by

web conference:

1

i

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(a), (b)(7)(c)

(b) (6), (b)(7)(C)

HHS-PSC000084


85/697

2

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000085


86/697

3

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000086


87/697

4

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000087


88/697


89/697

6

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000089


90/697

7

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000090


91/697

8

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000091


92/697

9

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000092


93/697

10

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000093


94/697

11

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000094


95/697

12

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000095


96/697

13

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000096


97/697


98/697

15

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000098


99/697

16

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000099


100/697

17

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000100


101/697


102/697

19

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000102


103/697

20

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000103


104/697

21

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000104


105/697

22

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000105


106/697

23

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000106


107/697

24

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000107


108/697

25

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000108


109/697


110/697

27

(b) (6), (b)(7)(a), (b)(7)(c)

HHS-PSC000110


111/697


112/697

Page 1 of 1

From:

Sent: Tuesday, January 24, 2012 2:44 PM

To: Bittinger, Kristin

L.

Subject: RE: Confidential: Draft report from HMS panel

Dear Kristin,

Thank you for giving me the opportunity to see the draft report. I do not have any comment

as

I have stated

my

viewes in all previous responses. I deeply apologize for the precious time spent on this by the committee

members.

Sincerely,

>

From: [email protected]

>

To:

>

CC:

[email protected]; [email protected];

[email protected]

> Date: Thu, 22 Dec 2011 17:22:21 -0500

>

Subject: Confidential: Draft report from

HMS

panel

>

>

,

>

> Attached please find a copy of a draft report of the Harvard Medical School Investigation Panel regarding the

allegations I believe

that

you

are

familiar with many of

the

documents referenced within this report,

however, we. are happy to provide you with copies of all of the documents. Harvard Medical School is on break

unti l January 3rd, however, and the hard copy materials will not be sent until

that

time. In view of this, we will

extend your time for review

of

this

draft

report.

>

> We invite you

to

comment and/or respond to the enclosed draft prior to February 3, 2012. Your response

and/or comments will be shared with the Investigation Panel, who may revise the report based on such additional

information. Regardless, all comments will be attached to the report when it is finalized and submitted to the

Standing Committee on Faculty Conduct

for

final recommendation regarding this matter. The Standing

Committee's final recommendations will go to

Dean

Flier, as the deciding official in this matter. You will have an

opportunity to speak directly with

the

Standing Committee if you desire.

>

> Please let me know

if

you have

any

questions. I am happy

to

discuss the process directly with you.

>

> Thank you again for your continued cooperation.

>

>

Regards,

> Kristin

>

> Kristin L Bittinger, M.S., J.D.

>

Director

of

Scientific

Integrity

>

Office for Professional Standards and Integrity

> Harvard Medical School

> 25 Shattuck Street

> Gordon Hall, Suite 210C

>

Boston, Massachusetts 02115

> (617) 432-7769

3/13/2012

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b)(6),(b)(7)(C)

HHS-PSC000112


113/697

ase

Tracking System

Page 1 of 1

FOIA 12-0452; Appeal 13-0118

Index

of

ORI Case

l

j

and 2011-29 -

CONFIDENTIAL

FOR FOIA

USE

ONLY

72

Case

Indexes

found.

DATE

FILE

TO

FROM

TYPE OF

ATTACHMENTS

SUMMARY OF DOCUMENTATION

DESIGNATION DOCUMENTATION

10102/2007

DALHBERG DALE

CONVERSATION

NONE

DOCUMENT

02/1612008

KRUEGER

PRICE

EMAIL

NONE

PUBLICATION

03/06/2008

KRUEGER

PRICE

EMAIL

RETRACTION AND

PUBLICATION

ARTICLE

12/10/2008

BRODNICKI

LlPSHULTZ

EMAIL

NONE

12/10/2008

LlPSHULTZ

BRODNICKI

EMAIL NONE

04/28/2009

BRODNICKI

LlPSHULTZ

EMAIL NONE

04/28/2009

LlPSHULTZ BRODNICKI

EMAIL

NONE

08/20/2009

BRODNICKI

LlPSHULTZ

EMAIL NONE

https:llori.hhs.gov/intranet/CaseTracking/caseindex _rpt. php

3/2312013

HHS-PSC000113

(b) (7)(A)(b) (7)(A)

(b) (7)(A)


114/697

Case Tracking System Page 2

o 1

DATE

FILE

TO

FROM

TYPE OF

ATTACHMENTS SUMMARY OF DOCUMENTATION

DESIGNATION

DOCUMENTATION

08/27/2009 LlPSHULTZ

BRODNICKI

EMAIL

NONE

11/18/2009 BRODNICKI

HOHMANN EMAIL

NONE

01/12/2010

BRODNICKI

LlPSHULTZ EMAIL

NONE

01/14/2010 LlPSHULTZ CC:BITTINGER

BRODNICKI

EMAIL

NONE


LlPSHULTZ

EMAIL

NONE


LlPSHULTZ EMAIL

NONE


LlPSHULTZ EMAIL

NONE

04/14/2010

LlPSHULTZ

BRODNICKI

EMAIL

NONE

"

05/25/2010

DAHLBERG CC:BITTINGER,

BRODNICKI

LETTER

INQUIRY REPORT

BERKMAN

WI ATTCHMNTS

&

DETERMINATION

https:llori.hhs.gov/intranet/CaseTracking/caseindexJPt.php

3/2312013

HHS-PSC000114

(b) (7)(A) (b) (7)(A)

(b) (7)(A)


115/697

Case Tracking System

Page 3

o 1

DATE

FILE

TO

FROM

TYPE OF

ATTACHMENTS


DESIGNATION

DOCUMENTATION

LETTER

10107/2010

BRODNICKI LlPSHULTZ EMAIL

NONE

10/21/2010

BRODNICKI LlPSHULTZ EMAIL

NONE

10/21/2010

LlPSHULTZ

BRODNICKI

EMAIL

NONE

10/22/2010

BRODNICKI DAHLBERG EMAIL

NONE

11/19/2010

DAHLBERG EMAIL

NONE

11/24/2010

LlPSHULTZ

BRODNICKI EMAIL

NONE

01/27/2011

ASKORI

EMAIL

NONE

01/27/2011

ASKORI/MAHLER/ROCHEZITAYMAN EMAIL

NONE

01/2712011

ASKORIIDAH LBERG

EMAIL

NONE

https:llori.hhs.gov/intranet/CaseTracking/caseindex_rpt.php 3/2312013

HHS-PSC000115

(b) (7)(A)

(b) (7)(A)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (7)(A)


116/697


Page 4 o 1

DATE

FILE

TO FROM

TYPE OF

ATTACHMENTS


DESIGNATION

DOCUMENTATION

01/30/2011

DAHLBERG

EMAIL NONE

01/30/2011

DAHLBERG

EMAIL

NONE

02/24/2011

DAHLBERG CC:SPRUNG/PRICE

EMAIL

NONE

03/21/2011

DAHLBERG

EMAIL

NONE

SWEM(US

04/11/2011

DAHLBERG CC: EAST

DOJ

EMAIL NONE

ATTRNY)

04/11/2011

SWEM CC:DAHLBERG, ROCHEZ

DAHLBERG

EMAIL NONE

06/08/2011

BRODNICKI

LlPSHULTZ

EMAIL

NONE

07/06/2011

LlPSHULTZ

BRODNICKI

EMAIL

NONE

07/06/2011

BRODNICKI

LlPSHULTZ

EMAIL

NONE

https://ori.hhs.gov/intranet/Case Tracking/caseindex_rpt. php

312312013

HHS-PSC000116

(b) (7)(A)(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (7)(A)

(b) (7)(A)


117/697


Page 5 o 1

DATE

FILE

TO

FROM

TYPE OF

ATTACHMENTS


DESIGNATION

DOCUMENTATION

10/19/2011 LlPSHULTZ BRODNICKI EMAIL

NONE

10/19/2011 KABAK

BRODNICKI EMAIL

NONE


LlPSHULTZ

EMAIL NONE


KABAK

EMAIL

NONE

10/19/2011 KABAK

BRODNICKI EMAIL

NONE

10/24/2011

TABAK, ROCKEY, BAR DAHLBERG EMAIL NONE

10/25/2011

TABAK/ROCKEY/BAR

DIO/ORI MEMO NONE

01/24/2012

BRODNICKI

KABAK

EMAIL NONE

02/01/2012

Brodnicki

Kabak

Email none

02/01/2012

Kabak

Brodnicki Email none

https:llori.hhs.gov/intranet/CaseTracking/caseindexJPt.php

3/23/2013

HHS-PSC000117

(b) (7)(A) (b) (7)(A)

(b) (7)(A)


118/697


Page 6

o

1

DATE

FILE

TO FROM

TYPE OF

ATTACHMENTS


DESIGNATION

DOCUMENTATION

02/01/2012

Brodnicki Kabak

Email none

02/01/2012

Kabak Brodnicki

Email none

02/01/2012

SynanlFisher Kabak

Email none

02/27/2012

Rochez, East Cc: Dahlberg Dahlberg

Email None

02127/2012

Brodnicki; Bittinger Cc; Dahlberg Dahlberg

Email

NONE

02/27/2012

Dahlberg; Bittinger Brodnicki

Email NONE

02/27/2012

Brodnicki Cc: Dahlberg

Dahlberg

Email

NONE

05/17/2012

Dahlberg Cc:Swem/Puyce East

Email

none

05/17/2012

East Cc:Fleming/Morgan Dahlberg

Email

none

https:llori.hhs.gov/intranet/CaseTracking/caseindex_rpt. php

3/23/2013

HHS-PSC000118

(b) (7)(A)

(b) (7)(A)

(b) (7)(A)


119/697


Page 7

o

1

DATE

FILE

TO

FROM

TYPE OF

ATTACHMENTS



Dahlberg

05/17/2012

Cc: Flem ng/Morgan/Swem/Buyce

East

Email

none

06105/2012

Dahlberg

Brodnicki Letter

Investigation Report

Cc: Bittinger/Berkman/Godin/Kell

and Exhibits


06/07/2012 East Cc: Dahlberg

Dahlberg

Email

( NOT Attached to

FILE COPY)

06/07/2012

Dahlberg Cc: Swem

East

Email

NONE

06/07/2012 East Cc: Dahlberg

Dahlberg Email

NONE

https:llori.hhs.gov intranetlCaseTracking/caseindex_rpt. php 3123/2013

HHS-PSC000119

(b) (7)(A) (b) (7)(A)

(b) (7)(A)


120/697


Page 8

o

1

DATE

FILE

TO

FROM

TYPE OF

ATTACHMENTS



06/08/2012 Brodnicki Kabak

Email NONE

06/08/2012 Kabak Brodnicki Email NONE

06/08/2012

Brodnicki Kabak

Letter

NONE

Jan.27 and Jan.

30,2011 email

07/17/2012

Dahlberg

Email exchange between

DIO Director and

Complaint

08/24/2012

Dahlberg Email

https://ori.hhs.gov/intranet/CaseTracking/caseindexJPt.php

3123/2013

HHS-PSC000120

(b) (7)(A)

(b) (6), (b)(7)(C)

(b) (7)(A)

(b) (7)(A)

(b) (7)(A)


121/697


Page 9 o 1

DATE

FILE

TO

FROM

TYPE OF

ATTACHMENTS



082012.pdf

08/27/2012

Dahlberg Email

none

INQUIRY REPORT

05/25/2010

DAHLBERG CC:BITTINGER,

BRODNICKI

WI ATTACHMENTS

LETTER

BERKMAN

& DETERMINATION

LTR

06/05/2012

Dahlberg

Brodnicki Letter


Cc:Bittinger/Berkman/Godin/Kell and Exhibits

04/02/2012

Taymen Cc: Rochez Schwendinger

Email

NONE

04/10/2012

Dahlberg Cc: Mahler;Rochez; Szakaly

Taymen

Email

NONE

https:llori.hhs.gov/intranet/CaseTracking/caseindexJpt.php

3/23/2013

HHS-PSC000121

(b) (7)(A)

(b) (6), (b)(7)(C)

(b) (7)(A)

(b) (7)(A)


122/697


Page 1 o 1

DATE

FILE

TO

FROM

TYPE OF

ATTACHMENTS

DESIGNATION

DOCUMENTATION


04/10/2012

Taymen; Cc:Mahler, Rochez, Szakaly,

JD

Dahlberg

Email NONE

08/20/2012

Bradley\Kabak\Wright\Dahlberg

Garfinkel

Email

None

08/20/2012

Bradley, et

al

Garfinkel

Email None

https:llori.hhs.govlintranetICaseTracking/caseindex_rpt.php

312312013

HHS-PSC000122

(b) (7)(A) (b) (7)(A)

(b) (7)(A)


123/697

Dahlberg, John E (HHS/OASH)

From:

Sent:

To:

Cc:

Subject:


Monday, August

27,2012

11:42

AM


RE

HMS review panel decision

With the receipt of the Harvard report, DIO has initiated its separate oversight review of the investigation. During this

review, the records are not available to others. DIO staff may wish to discuss this matter

with

you as either a witness or

as the complain 'lnt,

but

we are not at a point where this has yet been discussed. Thank you for your offer

to

assist.

Sincerely,

John Dahlberg,

Ph.D.

Director, Division

of

Investigative Oversight

Office of Research Integrity

240-453-8800

From

Sent Friday, August 24, 2012 2:30 PM

To:

Dahlberg, John E (HHSjOASH)

Subject HMS

review panel decision

Dear Dr. Dahlberg,

I received a note from the HMS review panel

I would like

to request to see the final report from the HMS review panel regarding the investigation in order to comment on

it and help OR conduct a thorough review process.

Regards,

Begin forwarded message:

From:

"Brodnicki, Gretchen A.

II

Subject: Confidential

Date:

August 20, 2012 1 13:05 PM GMT-05:00

To:

1

HHS-PSC000123

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (7)(A)(b) (7)(A)


124/697

I attach confidential correspondence

to

you for your review.

Thank you,

Gretchen Brodnicki, J.D.

Dean for Faculty and Research Integrity


25 Shattuck Street, Suite 108

Boston, MA 02115

(t) (617) 432-2496

(f) (617) 432-0566

Gretchen [email protected]

HHS-PSC000124


125/697

Dahlberg. John E (HHS/OASH)

From:

Sent:

To:

Subject:

Attachments:

Dear Dr. Dahlberg,

Friday, August 24,20122:30

PM


HMS review panel decision

I received a note from the HMS review panel

I would like

to request to see the fmal report from the HMS review panel regarding the investigation in order to comment on

it and help OR conduct a thorough review process.

Regards,

Begin forwarded message:

From:

"Brodnicki, Gretchen A."

Subject: Confidential

Date: August 20, 2012 1 13:05

PM

GMT-05:00

To:

,

I attach confidential correspondence to you for your review.

Thank you,

Gretchen Brodnicki, J.D.

Dean for Faculty and Research Integrity


25 Shattuck Street, Suite 108

Boston, MA 02115

(t) (617) 432-2496

f)

(617) 432-0566

Gretchen [email protected]

1

HHS-PSC000125

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(a), (b)(7)(c)

(b) (7)(A)


126/697


G R E T H ~ N BRODNICKI. J.D.

DEAN

FOR FAcul:n'

AND

RESEARCH INTEGnm

2 SHATTUCK STREET

BOSTON.

l\1ASSACHI1SF,nS 02115

Tn: (617) 432-2496

FAX: (617) 432-7462

[email protected]>.EI>ll

August 20,

20 12

I am writing

to

let you know the resolution of the concerns you raised

to

Harvard Medical

School (HMS) regarding possible research misconduct

A thorough investigation ofyolll' allegations was conducted by an HMS

The same

HMS

faculty panel also conducted a formal inquiry into

yoUI

allegations against

Confidentiality requirements preclude

me

ti OI11 giving you more information about ollr

findings, but I want to assure you that this was a thorough,

fail

and objective process.

review.

Thank

you

for bringing this matter to our attention

and

for

your cooperation with the detailed

Sincerely,

X"

) . v _ ~ t ~ 6 r u 7 J . - G - ~ k

Gl'etcnen Brodnicki

Dean

for

Faculty

and

Research Integrity

HHS-PSC000126

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (7)(A)


127/697

Garfinkel, usan

J

(HHS OASH)

From:

Sent:

To:

Cc:

Subject:

FYI on

case

Garfinkel, Susan J (HHS/OASH)

Monday, August 20, 2012 2:24

PM

Bradley, Ann (HHS/OASH)

Kabak, Shara (HHS/OPHS/ORI); Wright, David E (OS/OASH); Dahlberg,

John E (HHS/OASH)

Confidential:

I got a call from Gretchen Brodnicki at Harvard regarding this case. HMS has finished the investigation

The usual HMS process at

the

closure of a case is to inform

the

complainant of

the

outcome, very simply

that findings were made or not. Gretchen called because they are ready to send the complainant this

letter and wanted ORI to know that there may be a public backlash from complainant.

Susan

Susan Garfinkel,

Ph.D.



Phone: 240-453-8421

1

HHS-PSC000127

(b) (6), (b)(7)(a), (b)(7)(c)

(b) (7)(A)

(b) (7)(A)

(b) (7)(A)


128/697

Dahlberg. John E HHS/OASH)

From:

Sent:

To:

Subject:

Dear Dr. Dahlberg,

Tuesday, July 17, 20121 :31 PM


misconduct case

I am in contact with the d am aware that the Harvard investigation has a final report

I would also like to see the report from Harvard as soon as possible and offer comments

that may be useful for OR

in

the oversight review and final report. I hope that all the issues ofthis case in

particular are discussed with all relevant parties,

including the

Regards,

On

Jan 30,2011, at

11

:59 AM, Dahlberg, John E (HHS/OASH) wrote:

I will attempt to answer your questions for all of the recipients of this email, as quite likely I would have been

asked to do so in any event. I am sympathetic to your concerns as the complaint in these two cases that the

process has been protracted, and has not reached closure. However, 42 C.F.F

Part

93

is pretty clear that once

allegations are made and considered to meet the definition

of

research misconduct, the inquiry and investigation

process should be overseen by neutral unbiased institutional officials and scientists comprising the committees.

The complainant

mayor

may not be a useful fact witness, depending on circumstances, but has no special

status beyond being a possible fact witness.

f

you fell you have identified additional evidence of possible value

to an ongoing process, the institution is expected to consider it, and if not, OR would do so during its oversight

review that begins after receipt

of

the final investigation report.

You correctly note that the regulation does not require that the complainant be provided all of portions of either

the inquiry or investiqation report for review. It is not a complainant's responsibility to judge the merits

of

the

evidence for or against findings

of

misconduct. Such decisions are quite complex and based on far more that

simply demonstrating that a figure or statement is wrong or falsified.

Sincerely,

1

HHS-PSC000128

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(a), (b)(7)(c)

(b) (7)(A)(b) (7)(A)

(b) (7)(A)

(b) (6), (b)(7)(C)

b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (7)(A)

(b) (6), (b)(7)(a), (b)(7)(c)


129/697

John Dahlberg, Ph.D

Director, Divison oflnvestigative Oversight

Office

of

Research Integrity

Sent: Thursday, January 27, 2011 4:32 PM

To:

S

OPHS askORI (HHS/OPHS)

Subject: to Dr. John Dahlberg

This email is directed to the following individual:

John Dahlberg, Ph.D., Director

of

Division oflnvestigative Oversight,

I m writing to ask your opinion regarding PHS Policies on Research Misconduct, 42 CFR Part 93. It states that

a requirement

of

an institution that accepts PHS funds for research includes: A thorough, competent, objective,

and fair response to allegations of research misconduct consistent with, and within the time limits

of

the final

rule, including precautions to ensure that individuals responsible for carrying out any part of the research

misconduct proceeding do not have unresolved personal, professional, or financial conflicts

of

interest with the

complainant, respondent, or witnesses.

I have two questions regarding this policy and would like to hear your opinion.

The underlying presumption is that an institution is inherently biased against making determinations of research

misconduct against its members (or former members) and thus may not want to review all the evidence that

implicates that member. The institution therefore may do what it can to avoid consideration

of

additional

evidence that it becomes aware of, and also attempt to prevent the complainant from seeing the draft report.

Regards,

2

HHS-PSC000129

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)


130/697

CASE SUMMARY no names):

3

HHS-PSC000130

(b) (7)(A)


131/697

HHS-PSC000131

(b) (7)(A)


132/697

. 4 DEPARTMENT OF Illi LTII -

HUM N

SERVICES

+ ~ , . : : : : l .

Office

of

the Assistant Secretary for H

Office

of

Research Integrity

CONFIDENTIAL

June 8, 2012

Gretchen Brodnicki, i l l

Dean for Faculty Research and Research Integrity


25 Shattuck Street

Boston, MA 02115

RE:

Dear

Ms_

Brodnicki:

1101

Wootton Parkway, Suite

750

Rockville, MD 20852

Phone: 240-453-8800

FAX: 301-594-0043

Email: [email protected]

The Division

of

Investigative Oversight DIO), Office of Research Integrity ORl), has

received the report

of

the investigation with attachments, by Harvard Medical School

HHS-PSC000132

(b) (7)(A)

(b) (6), (b)(7)(a), (b)(7)(c)


133/697

Kabak, Shara HHS/OPHS/ORI)

From:

Sent:

Brodnicki, Gretchen A. [[email protected]]

Friday, June 08, 2012 1 07

PM

To:

Kabak, Shara (HHS/OPHS/ORI)

Subjec,:

RE: CONFIDENTIAL

Shara,

y apologies - my lette r indicated our internal account numbers, not the official NIH-assigned grant numbers. The two

NIH

grants are as follows:

Please do

not

hesitate to contact me with any further questions.

Thanks,

Gretchen

From:

Kabak, Shara (HHS/OPHS/ORI) [mailto:[email protected]]

Sent Friday, June 08, 2012 11:22 AM

To:

Brodnicki, Gretchen A.

Subject CONFIDENTIAL

Gretchen,

Thank you.

Regards,

Shara

Shara Kabak, PhD



Phone: 240-453-8800

1

HHS-PSC000133

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (7)(A)

(b) (7)(A)


134/697

Dahlberg, John E HHS/OASH)

From:

Sent:

To:

Dahlberg,

John

E

HHS/OASH)

Thursday, June 07, 2012 12:24 PM

East,

David USAWAW)

Cc:

Dahlberg,

John E HHS/OASH)

Subject:

RE: Scanned document from Fisher, Raymond HHS/OPHS)

raymond.fisher.os)

David,

with regard

to

ORI s system of records notice, the report can only be release following the

completion of ORI s oversight review and

case

closure.

At

that point, i the FOIA

office or

ORI) receives a

request,

a suitably redacted copy can be sent. For example, i

we

concur

that only

one

finding was

made,

all references to the

other

allegations, analyses, and

findings would

be redacted.

This

is

not

to

day

that

other

legal issues

might trump our

privacy issues, but aside from your interest,

that is how

we would handle a

direct

request.

And

Harvard could choose

to share part or all

of

the

report with the complainant but

is

unlikely to

do

so).

John

-----Original Message-----

From:

East,

David

USAWAW)

[mailto:[email protected]]

sent:

Thursday, June 87,

2812

12:89

PM

To: Dahlberg, John E HHS/OASH)

Cc:

Swem, Judy USAWAW)

Subject: Re: Scanned document from

Fisher,

Raymond HHS/OPHS) raymond.fisher.os)

Original Message

-----

From: Dahlberg, John E HHS/OASH) [mailto:[email protected]]

Sent: Thursday, June 87, 2812 11:59 AM

To: East, David USAWAW)

Cc: Dahlberg, John E HHS/OASH)

Subject:

FW: Scanned document from

Fisher,

Raymond HHS/OPHS) raymond.fisher.os)

Hello David,

Regards, John

John Dahlberg, Ph.D.

Director, Division of Investigative Oversight Office of

Research

Integrity 248-453-8888

248-453-8427 direct)

1

HHS-PSC000134

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)


135/697

Dahlberg.

John

E (HHS/OASH)

From:

Sent:

East, David (USAWAW) [[email protected]]

Thursday, May 17, 2012 5:43 PM

To:


Cc: Fleming, Sheila P (HHS/OASH); Morgan, Tracy S (HHS/OASH); Swem, Judy (USAWAW);

Buyce, Pat (USAWAW)

Subject:

RE: Harvard Investigation

Many

thanks

for

the quick response.

From:

Dahlberg, John E (HHSjOASH) [mailto:[email protected]]

Sent:

Thursday, May 17,

20122:34

PM

To:

East, David (USAWAW)

Cc:

Fleming, Sheila P (HHSjOASH); Morgan, Tracy S (HHSjOASH)

Subject RE: Harvard Investigation

Hello David,

I pinged Harvard

after

receiving

your

email,

as

the report

was due May

1.

I just heard

that

it

should

be

sent early next

week. I

will

be on leave next week,

but

I will ask

DIO staff to

immediately forward a copy of the report and its

attachments as

soon as

it

arrives.

This may be a

time to

be optimistic.

Regards, John

John Dahlberg, Ph.D.

Director, Division of Investigative Oversight


240-453-8800

From:

East, David (USAWAW) [mailto:[email protected]]

Sent:

Thursday, May 17,

2 ~ 2

2:33 PM

To: Dahlberg, John E (HHSjOASH)

Cc:

Swem, Judy (USAWAW); Buyce, Pat (USAWAW)

Subject Harvard Investigation

Hi Dr. Dahlberg,

Sorry

to

bother

you again,

but

I

wanted

to

see

if

you

have any updates on

the

status

of

the

Harvard investigation report.

Thanks.

David

David R. East

Assistant United States Attorney

United States At torney's Office

Western District of Washington

700 Stewart Street I Suite 5220 I Seattle Washington 98101-1271

a

206-553-1018 1,I;l, 206-553-4073 I [8J [email protected]

1

HHS-PSC000135


136/697

Confidentiality Notice: E-mails from the United States Attorney's Office normally contain confidential and privileged material,

and

are for the

sole

use of the intended recipient. Use or distribution

by

an unintended recipient is prohibited, and may be a violation of law. If you believe tha t you

received this e-mail in error, please do not read this e-mail or any attached items. Please delete the e-mail and all attachments, including any

copies thereof, and inform the sender that you

have

deleted the e-mail, all attachments

and

any copies thereof . Thank you.

HHS-PSC000136


137/697

Fisher, Raymond HHS/OPHS)

From:

Sent:

To:

Subject:


Wednesday, February

01,20123:19 PM

Synan, Kyle C (HHS/OASH); Fisher, Raymond (HHS/OPHS)

FW:

From: Brodnicki, Gretchen

A.

[mailto:Gretchen [email protected]

Sent Wednesday, February 01, 2012 10:29 AM

To:

Kabak,

Shara (HHS/OPHS/ORI)

Subject RE:

Thanks so much.

From: Kabak, Shara (HHS/OPHS/ORI) [mailto:[email protected]

Sent

Wednesday, February 01, 2012 10:28

AM

To: Brodnicki, Gretchen A.

Subject

RE:

Gretchen,

Your request

for

an extension is reasonable and we will expect the report on May 1, 2012.

Shara


A.


Sent Wednesday, February 01, 2012 10: 18 AM

To:

Kabak,

Shara (HHS/OPHS/ORI)

Subject RE:

Shara,

My apologies - I mis-calendared the due date for

our

update, and thought

it

wasn't due until February 20

Please

do not hesitate

to

contact me with any questions.

Thanks,

Gretchen

From: Kabak, Shara (HHS/OPHS/ORI) [mailto:[email protected]

Sent Wednesday, February 01, 20129:11 AM


Subject

1

HHS-PSC000137

(b) (7)(A)

(b) (7)(A)

(b) (7)(A)

(b) (7)(A)

(b) (7)(A)

(b) (7)(A)

(b) (7)(A)


138/697

Hi

Gretchen,

Regards,

Shara

Shara Kabak, PhD



Phone: 240-453-8428

HHS-PSC000138

(b) (7)(A)


139/697


140/697

Kabak, Shara HHS/OPHS/ORI)

From:

Sent:

Brodnicki, Gretchen A [[email protected]]

Wednesday, October 19, 2011 2:55 PM

To:


Subject:

RE:

Shara,

Thank you for the extension, and for

your

advice

with

respect

to

the need for two reports. We will handle accordingly.

Thanks,

Gretchen

From: Kabak, Shara (HHS/OPHS/ORI) [mailto:[email protected]]

Sent:

Wednesday, October 19 2011 2:32 PM


Subject: RE:

Gretchen,

Thank you for the update. I appreciate the extra work you had to do after interviewing the complainant, and grant you a

9 day extension. We will expect

the

investigation report around January 16 2012.

Please feel free to contact me with any questions.

Regards,

Shara


A.

[mailto:Gretchen [email protected]]

Sent: Wednesday, October 19 2011 1:01 PM

To: Kabak, Shara (HHS/OPHS/ORI)

Subject: RE:

Dear Shara,

t

1

HHS-PSC000140

(b) (7)(A)

(b) (7)(A)

(b) (7)(A)

(b) (7)(A)

(b) (7)(A)


141/697

Thanks,

Gretchen

From: Kabak,

Shara

(HHS/OPHS/ORI) [mailto:[email protected]]

Sent:

Wednesday, October

19 2011 12:38 PM


Subject:

Hi

Gretchen,

Thank you,

Shara

Shara Kabak,

PhD

Office

of

Research

Integrity

Division

of


Phone:

240-453-8428

2

HHS-PSC000141

(b) (7)(A)

(b) (7)(A)


142/697

Lipshultz, Gary HHS/OASH)

From:

Sent:

To:

Subject:

Gretchen,

Lipshultz, Gary (HHS/OASH)

Wednesday, October 19,

2011

1 39

PM

'8rodnicki, Gretchen A.'

RE: Request for status of 010 Cases

Thank you for your

prompt

reply. The extensions you requested have been granted.

is

listed

as an

unknown

respondent which stemmed from a telephone call with Dr. Dahlberg and Ms. Bit tinge were allegations

of

plagiarism; falsification and fabrication in a presentation. The phone call took place on August

2,

2011.

Gary

From:

Brodnicki, Gretchen

A.


Sent

Wednesday, October

19

2 111:15 PM

To:

Lipshultz, Gary (HHS/OASH)

Cc: Dahlberg, John E (HHS/OASH)

Subject:

RE:

Request for status

of 1

Cases

Gary and John,

I sincerely apologize. In reviewing the case files, I thought I had responded

to

John about case number Instead,

however, I mistakenly updated Dr. Ambalavanar on case with data about the status

of

I apologize and will

be

correcting that immediately.

In

the meantime, here

is

information our status on these matters, and our requests

for

extensions where necessary:

1

HHS-PSC000142

(b) (7)(A)

(b) (7)(A)

(b) (7)(A)

Non-responsive

NR

NR(b) (7)(A)


143/697


144/697


From:

Sent:

To:

Subject:

Dear Mr. Dahlberg

Monday, March 21,20113:16 PM


request

Thanks

1

HHS-PSC000144

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)(b) (6), (b)(7)(C)

(b) (7)(A)


145/697


From:

Sent:

To:

Cc:

Subject:

Dear Dr. Dahlberg,

Thursday, February 24, 2011 3:52 PM


Jeff Sprung; Alan - Price

I would like to know whether Fred Hutchinson Cancer Research Center submitted to ORI (or another

government agency) the results

of

their preliminary assessment of

Regards,

On 30 Jan 2011, at 08:59, Dahlberg, John E (HHS/OASH) wrote:

I will attempt to answer your questions for all of the recipients of this email, as quite likely I would have been


process has been protracted, and has not reached closure. However,42 C.F.F Part 93 is pretty clear that once

allegations are made and considered to meet the definition of research misconduct, the inquiry and investigation


The complainant mayor may not be a useful fact witness, depending on circumstances, but has no special status

beyond being a possible fact witness. f you fell you have identified additional evidence ofpossible value to an

ongoing process, the institution is expected to consider it, and

if

not, ORI would do so during its oversight

review that begins after receipt of the final investigation report.

You correctly note that the regulation does not require that the complainant be provided all

of

portions

of

either

the inquiry or investiqation report for review. It is not a complainant s responsibility to judge the merits

of

the

evidence for or against findings

of

misconduct. Such decisions are quite complex and based on far more that

1 HHS-PSC000145

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (7)(A)


146/697

simply demonstrating that a figure or statement is wrong or falsified. I

Sincerely,

John Dahlberg, Ph.D

Director, Divison

of


Office

of

Research Integrity

Sent: Thursday, January 27,2011 4:32 P

To: S OPHS askORI (HHS/OPHS)



John Dahlberg, Ph.D., Director of Division oflnvestigative Oversight,

I am writing to ask your opinion regarding PHS Policies

on

Research Misconduct, 42 CFR Part 93.

It

states that

a requirement

of


and fair response to allegations

of

research misconduct consistent with, and within the time limits

of

the final

rule, including precautions to ensure that individuals responsible for carrying out any part

of

the research

misconduct proceeding do not have unresolved personal, professional, or financial conflicts

of

interest with the


Regards,

2

HHS-PSC000146

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)


147/697


3

HHS-PSC000147

(b) (6), (b)(7)(C)

(b) (7)(A)


148/697

HHS-PSC000148

(b) (7)(A)(b) (6), (b)(7)(C)


149/697


150/697

I will attempt to answer your questions for all of the recipients

of

this email, quite likely I would have been


process has been protracted, and has not reached closure. However, 42 C.F.F Part 93 is pretty clear that once

allegations are made and considered to meet the definition of research misconduct, the inquiry and investigation


The complainant mayor may not be a useful fact witness, depending on circumstances, but has no special status

beyond being a possible fact witness. If you fell you have identified additional evidence of possible value to an

ongoing process, the institution is expected to consider it, and

if

not, ORI would do so during its oversight

review that begins after receipt

ofthe

final investigation report.

You correctly note that the regulation does not require that the complainant be provided all of portions of either

the inquiry or investiqation report for review.

It

is not a complainant's responsibility to judge the merits of the

evidence for or against findings of misconduct. Such decisions are quite complex and based on far more that

simply demonstrating that a figure or statement is wrong or falsified.

Sincerely,

John Dahlberg, Ph.D

Director, Divison of Investigative Oversight

Office

of

Research Integrity

From

Sent: Thursday, January 27, 2 114:32 PM

To: OS OPHS askORI (HHS/OPHS)



John Dahlberg, Ph.D., Director

of

Division

of

Investigative Oversight,

I am writing to ask your opinion regarding PHS Policies on Research Misconduct, 42 CFR Part 93.

It

states that

a requirement

of


and fair response to allegations of research misconduct consistent with, and within the time limits

of

the final

rule, including precautions to ensure that individuals responsible for carrying out any part of the research

misconduct proceeding do not have unresolved personal, professional, or financial conflicts of interest with the


I have two questions regarding this policy and would like to hear your opinion.

2

HHS-PSC000150

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)


151/697

Regards,


3

HHS-PSC000151

(b) (6), (b)(7)(C)

(b) (6), (b)(7)(C)

(b) (7)(A)


152/697

HHS-PSC000152

(b) (7)(A)

(b) (6), (b)(7)(C)


153/697

Dahlberg, John E HHS/OASH)

From:

Sent:

To:

Cc:

Dahlberg,

John E

(HHS/OASH)

Sunday, January 30, 2011 12:00 PM

Subject:

Dahlberg,

John E (HHS/OASH)

RE:

to Dr

John

Dahlberg

I

will

attempt

to

HHS Combined FOIA Production

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Transcript of HHS Combined FOIA Production