Hemophilia/ Royal Disease

Julia Bridges: Slides 1-4Scarlet Kim: Slides 5-6

Bailey Mooney: Slides 7-10

Table of Con.Intro/BackgroundPhysical Characteristics Mental CharacteristicsEmotional CharacteristicsGenetic Source or CauseTreatmentInteresting FactsReferences

Intro/BackgroundHemophilia is a medical disorder in which the person’s blood is unable to clot. This results in severe bleeding for even the smallest cuts. This disorder is usually inherited from parents to their children. Clotting Factors are proteins needed for normal blood clotting. These proteins work with platelets. When you are cut platelets work with clotting factors to help “plug” the cut, and then form a scab. You can either have type a or type b hemophilia. Type A is more common and results in you missing or having low levels of clotting factor VIII. People born with hemophilia lack these platelets and clotting proteins. Hemophilia is also called the royal disease because it affected the royal families of England, Germany, Russia and Spain in the 19th and 20th centuries.

Physical Characteristics ● Physical characteristics of hemophilia may include bruises (from internal

bleeding), heavy bleeding from a minor cut, nosebleeds, swelling in joints, etc.

Mental Characteristics ● Mental characteristics of Hemophilia include confusion, loss of balance,

and loss of coordination

Emotional Characteristics● According to a study, children with Hemophilia found more difficulties with

emotional well-being, including more depressive symptomatology and lower self-perceptions.

● According to the parents who has children with Hemophilia, they didn’t found any social or behavioral difficulties.

Genetic Source/CauseA defect in a gene that determines whether or not the blood can clot can cause Hemophilia. The gene is located on an X chromosome. If a male has this gene on his X chromosome, it means he has Hemophilia. If a female has it on one of her two X chromosomes, it means she has Hemophilia and can pass the genetic defect onto her offspring.

TreatmentThe most common treatment for Hemophilia is the Replacement Therapy. Using the Replacement Therapy, clotting factors can be concentrated from donor’s blood, or the clotting factor concentrates can be created in a laboratory without having to use donor’s blood. After the missing factor, or clotting factor, has been taken from the donor’s blood or made in a lab, it is injected into the affected person’s bloodstream, and the clotting factor is replaced inside the body, and the amount that person bleeds is now normal.

Interesting Facts● Over 400,000 people worldwide have hemophilia.● The disease occurs in 1 in 5,000 male births.● Queen Victoria of England carried Hemophilia and passed it down to her

son and some of her daughters. ● Although it is not entirely proven, lots of people believe that Abraham

Lincoln, Genghis Khan, and Mother Teresa all had Hemophilia. ● Until the 1960s, the life expectancy of someone with the disease was only

11 years.

Referenceswww.google.comwww.nhlbi.nih.govwww.hemophiliafed.orgwww.hemophilia.org

missingfactor.weebly.com

www.cdc.gov

http://www.medicalnewstoday.com/content/info/hemophilia/symptoms-and-

diagnosis.php

http://journals.lww.com/jrnldbp/Abstract/2003/08000/Social,_Emotional,

_and_Behavioral_Functioning_of.2.aspx