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Hemolytic Disease in New-born due to Iso-immunization towards the A Group Antigen. R81e of the Agglutinins of Milk

BY

CHRISTIAENS and GOUDEMAND

(Lille, France)

A case of maternal iso-immunization to haemoagglutinogen A is reported as having led to a neo-natal haemolytic anemia with erythroblastosis a t the time of a second pregnancy. It seems that the same etiology should be called in t o explain the death in a state of icterus of the first child. The authors, while insist- ing on the rareness of such incidents, put forward the immunological arguments which permit supporting the diagnosis (high level of antibodies of anti A in the serum and above all in the milk, the presence of incomplete anti A antibodies, blockage of the red blood cells of the new born child).

They insist on the importance of transmission of the anti A antibodies by the mother's milk, these bzing a t a clearly higher level in the milk than in the serum, and more active on the red cells of a baby. This lacteous origin seems to explain the death of the first child who was fed by the mother, and the slight injury to the second for whom maternal breastfeeding was supressed.

Observations faites chez 19 malades soumis ii l'ascolitherapie Par

A. LACROIX, ANTOINE et P L A N E (Alger, France)

Expos6 des rbultats obtenus par l'ascolitherapie chez 19 malades algkriens dont un splhectomisd, soumis au traitement d'Ascoli pendant une trentaine de jours. Les r6actions furent frkquentes et gknkralement prkcoces. Chez le sujet splenectomise et chez 2 sujets A rate acinetique on ne nota pas de rkactionclinique. Dans un cas de paludisme, gukrison au 25e jour avec diminution du'volume de la rate. Enfin dans 15 cas de splknomkgalie algkrienne avec rates acinktiques, il y eut diminution de volume de la rate allant de 6 d 70%. Les hemogrammes montrkrent une augmentation des eosinophiles dans 7 cas, des mononucleaires dans 4 cas, et des lymphocytes dans 5 cas, enfin une augmentation successive des mononucleaires puis des lymphocytes dans 2 cas.