Hemodynamic And Oxidative Stress Profile After Exercise In
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Hemodynamic and Hemodynamic and oxidative stress profile oxidative stress profile after exercise in type 2 after exercise in type 2
diabetesdiabetesVILLA-CABALLERO L. ; NAVA-OCAMPO A. A. ; FRATI-MUNARI A. C. ; RODRIGUEZ DE LEON S. M. ; BECERRA-PEREZ A. R. ; CEJA
R. M. ; CAMPOS-LARA M. G. ; PONCE-MONTER H. A.
Diabetes Research and Clinical Practice , vol. 75, no3, pp. 285-291, 2007.
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IntroduçãoIntrodução
Steven E. Shoelson, Jongsoon Lee, and Allison B. GoldfineInflammation and insulin resistanceJ. Clin. Invest., Jul 2006; 116: 1793 - 1801.
HIPERGLICEMIA – Disfunção mitocondrialESTRESSE OXIDATIVO – Disfunção célula β
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ObjetivoObjetivo
Investigar efeito de uma única sessão de exercício (≥85% VO2Máx) no perfil hemodinâmico e marcadores de estresse oxidativo em diabéticos tipo 2 sedentários e fisicamente ativos.
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MateriaisMateriais e Métodos e Métodos
• Protocolo de Balke em esteira • 2 min / 0 a 20° de inclinação até ≥85% VO2Máx
• PAS, PAD e FC a cada 5 min
• Glicose, TBARS, GSH aos 5, 15, 30 e 60min
ANOVA, post hoc Bonferroni, SPSS 12.
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ResultadosResultados
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DiscussãoDiscussãoT2DA ativo – melhor resposta ao exercícioHPE – menor reatividade tônus parassimpático
Laaksonen et al (1996) e Davison et al (2002) ROS pós exercício em DM1 ?
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ConclusãoConclusão
T2DA (180min/sem) X T2DS – respostas metabólicas, hemodinâmicas e perfil antioxidante
T2DS – estresse oxidativo eventos cardiovasculares
Necessários mais estudos.