Healthcare Associated Infections: Is Targeting Zero a...
Transcript of Healthcare Associated Infections: Is Targeting Zero a...
HEALTHCARE ASSOCIATED INFECTIONS:
IS TARGETING ZERO A GLOBAL REALITY? SANTIAGO, CHILE
APRIL 2013
Mary Lou Manning, PhD, CRNP, CIC
Associate Professor
Thomas Jefferson University
Philadelphia, PA
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I have no disclosures/conflicts of interest related to
this talk
I’d like to acknowledge Denise M. Murphy, RN, MPH,
CIC, my colleague and friend for assisting in the
development of this talk
Objectives/Outline
• Review the scope of healthcare-associated Infections in
the U.S. and around the world.
• Discuss the concept and rational behind “Targeting Zero
Healthcare Associated Infections.”
• Describe successful local, national and international
Targeting Zero central line-associated bloodstream
infections (CLABSI) strategies.
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Healthcare-Associated Infections (HAIs)
United States
• Approximately 1.7 million HAIs occur annually (1 in every
20 hospitalized patients) resulting in up to 90,000 deaths
and costing up to $45 billion in added healthcare costs. Klevens et al, Public Health Reports 2007;122:160-166
Scott, CDC March 2009
Developing Countries
• Systematic review and meta-analysis showed overall HAI
prevalence of 15.5 infections per 100 patients (compared
to 7.1 in Europe and 4.5 in US). Pooled HAI density in
adult ICUs was 47.9 per 1000 patient days (compared to
13.6 in US) Allegranzi et al, The Lancet 2011;377:228-241
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Healthcare-Associated Infections (HAIs)
The International Nosocomial Infection Control Consortium (INICC) recently reported 2004-2009 surveillance data from 422 ICUs in 36 countries in Latin America, Asia, Africa, and Europe. Device-associated nosocomial infection rates were significantly higher compared to US. INICC US NHSN
Central line associated bloodstream infection 6.8 2.0
(per 1,000 central line days)
Ventilator associated pneumonia 15.8 3.3
(per 1,000 ventilator days)
Catheter associated UTI 6.3 3.3 (per 1,000 catheter days)
Rosenthal et al., Am J Infect Control 2012;40:396-407
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Impact of HAIs
• Increase length of stay (increasing risks for other events)
• Increased attributable mortality
• Increased resistance of micro-organisms to antimicrobials
• Increased financial cost
• Societal cost: lack of consumer trust, increased litigation,
legislation
• Personal cost to patient and families
Pittet et al, J Hosp Infect 2008; 68:285-292
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Why Target Zero HAIs?
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What is “Targeting Zero HAIs”
Targeting Zero is a culture, a goal, an attitude, and a
long term commitment
• Culture that holds everyone accountable for adhering to
proven infection prevention strategies and practices.
• Goal that each time a reduction is achieved…sustain
it…keep going until you get to zero or as close to zero as
possible.
• Attitude to treat every HAI as something that should
never happen, investigating root causes.
• Long term commitment
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Learning From Each HAI
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1. What happened?
2. Why did it happen?
3. What will you do to reduce the risk of recurrence?
4. How will you know the risk is reduced?
Targeting Zero HAIs
What is the challenge for today’s leaders?
Setting the goal – elimination of HAIs and
creating the infrastructure and partnerships for success.
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US Drivers to Target Zero HAIs
• Hospital reimbursement– as of October 2008, the Centers
for Medicare and Medicaid Services (CMS) no longer
reimbursed hospitals for certain preventable events
• Public reporting – as of January 2011 mandatory national
reporting of central line associated bloodstream infections
required
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Is Achieving Zero HAIs a Reality?
ABSOLUTELY!
Growing evidence that organizations have gone long periods of time without a particular type of nosocomial
infection
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Is Sustaining Zero HAI a Reality?
ABSOLUTELY!
The evidence indicates that organizations have sustained the gains
Up to 24 months without a CLABSI in adult ICUs
Pronovost et al., Health Affairs 2011;30:628-634
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Eliminating CLABSI
The Roads to Success
• The Patient Unit Level
• Michigan Keystone ICU Project (The Michigan Project)
• The Rhode Island ICU Collaborative
• England’s “Matching Michigan” project
• The INICC project
• The US National Plan to Prevent HAI
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Patient Unit Success
A NICU Example: Eliminating CLABSI
The Children’s Hospital of Philadelphia 2004
1. Teamwork and Safety Culture Survey
2. NICU Safe Passage Campaign
3. Institute for Healthcare Improvement (IHI) “Reducing
Complications from Central Lines in the ICU”
collaborative
4. Strategies to improve clinical communication among
the clinical team through skill building and structured
communication.
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Reducing Central Line Associated Infections
Vermont Oxford Collaborative
Random Safety Audits
Core Teams and
Unit Restructuring
Clinical
Consenses
22 May 2004 - June 2005
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5
10
15
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May '04 Jun Jul Aug Sep Oct Nov Dec Jan '05 Feb Mar Apr May Jun
Month
CL
AB
SI
per
1000 C
ath
Days
CLABSI Rate
Median
~IHI start *DGS
+SBAR"Finding Your Voice" nurse
coaching sessions
Teamwork & Safety
Culture Survey
RN bundle
education
completed
The Michigan Keystone ICU Project
In 2003, Agency for Healthcare Research and Quality
(AHRQ) funded a 2 year initiative to prevent CLABSI and to
improve the culture of safety in 127 intensive care units
across the state of Michigan. The initiative included:
Use evidence-based interventions (hand hygiene, catheter insertion using maximal sterile barrier precautions,
chlorhexidine-containing disinfectant for skin antisepsis, favoring subclavian
insertion site, and daily checks for catheter removal)
+ a patient safety model called the Comprehensive Unit-
based Safety Program (CUSP)
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The CUSP Model
Created through a collaborative effort of the AHRQ and
state and national-level innovators in patient safety
Supports, a range of quality and safety improvement
models
Encompasses a wide range of safety tools and
approaches
Based on the understanding that all culture is local, and
that work to improve culture must be owned at the unit
level
Believes that harm is not an acceptable “cost of doing
business”
Can be applied by anyone, anywhere
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The CUSP Model
The program is designed to:
• educate and improve awareness about patient safety
and quality of care
• empower staff to take charge and improve safety in their
work place
• partner units with a hospital executive to improve
organizational culture and provide resources for unit
improvement efforts
• provide tools to investigate and learn from defects
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CUSP Components
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Engage
(adaptive)
How does this make
the world a better
place?
Educate
(technical)
What do we need to
know?
Execute
(adaptive)
What do we need to do?
What can we do with our
resources and culture?
Evaluate
(technical)
How do we know we
improved safety?
Senior leaders
Staff
Team leaders
The Michigan Keystone ICU Project
• Purpose: improve patient safety in the adult ICUs in
Michigan by reducing the rate of catheter-related
bloodstream infections
• Methods: collaborative cohort of 103 adult ICUs
implemented an evidence-based change package to
prevent CLABSI and the CUSP framework and
monitor/measured the effect for 18 months
Pronovost et al N Engl J Med 2006;355:2725-32.
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The Michigan Keystone ICU Project
Results
• 103 ICUs reported data for 1981 ICU months and 375,757
catheter-days.
• CLABSI were reduced by 66% in the first 18 months
• The overall median rate of CLABSI decreased from 2.7
(mean 7.7) infections/1000 catheter days at baseline, to 0
(mean 2.3) at 3 months after implementation of the study
interventions, and was sustained at 0 (mean 1.4) during
18 months of follow-up. Pronovost et al N Engl J Med 2006;355:2725-32.
Follow-Up
60% of ICUs sustained zero CLABSI for 12 months or more
and 26% for 24 months or more. Pronovost et al., BMJ 2010;340:c309.
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The Rhode Island ICU Collaborative
• In 2005 implemented the “Michigan model” in 100% of 23
ICUs in 11 hospitals in the state of Rhode Island
• Funded by hospitals and insurers
• Results: The statewide mean CLABSI rate decreased
74% from 3.73 (median 1.95) infections per 1000 catheter
days to 0.97 (median 0)
DePalo et al Qual Saf Health Care 2010;19:555-561
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England
• The National Patient Safety Agency coordinated an
initiative known as “Matching Michigan” in adult and
pediatric ICUs from 2009-2011
• Methods: 2-year, four cluster, stepped non-randomized
study to prevent CLABSI.
• Results: 215/223 ICUs in England participated. Adult
ICU’s achieved a 60% CLABSI reduction. Pediatric ICU’s
a 48% reduction.
The Matching Michigan Collaborative & Writing Committee, BMJ Qual Saf 2012;0:1-14
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The INICC Initiative
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The INICC Project
• Purpose: improve patient safety in the neonatal ICUs in
Michigan focused on an intervention to reduce the rate of
catheter-related bloodstream infections
• Methods: collaborative cohort of 4 NICUs (El Salvador,
Mexico, Philippines, Tunisia). Implemented evidence-
based interventions (bundles, education, daily patient goal
sheet, comprehensive unit-based safety program to
improve the safety culture)and monitor the effect for 18
months
• Results: CLABSI rate decreased by 55% from 21.4 per
1000 CL days to 9.9.
Rosenthal et al Infect Control Hosp Epidemiol 2013;34(3):229-237.
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U.S. National Action Plan to Prevent
HAI: Roadmap to Elimination
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In 2008 the U.S. Department of Health & Human Services
(HHS) published the National Action Plan to Prevent
Healthcare –Associated Infections: Roadmap for
Elimination.
National targets for elimination include: • Central line-associated blood stream infections
• Catheter-associated urinary tract infections
• Surgical site infections
• MRSA bacteremia
• Clostridium difficile infections
U.S. National Action Plan to Prevent
HAI: Roadmap to Elimination
Partnerships for Patients
Three Phases of Focus
• Hospitals
• Ambulatory
• Long term care facilities
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Action Plan Tier 1:
Eliminating CLABSI Why start with CLABSI?
• In the U.S. central venous lines catheters cause an
estimated 82,000 bloodstream infections and up to 30,000
deaths among patients in ICUs, costing $2.3 billion
annually.
• Clear scientific evidence base from which key
interventions focused on a specific procedure (eg,
catheter insertion) could be effectively and efficiently
applied using innovative strategies to increase practice
compliance and a method to measure outcomes
accurately. Pronovost et al Clin Infect Diseases 2011;52:507-513
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Eliminating CLABSI (2008-2011) (www.safercare.net)
• The national initiative, called On the CUSP:Stop BSI,
started in 2008. It was organized and implemented as a
State or region-level collaborative, structured around the
hospital association in the State or region.
• Goal: reduction of CLABSIs to 1 per 1,000 central line day
and to improve unit safety culture in ICUs and non-ICUs.
• Participants: 44 States, the District of Columbia, and
Puerto Rico. Collectively, these States and regions
recruited more than 1,000 hospitals and 1,800 hospital
units to participate in the project, representing over 25
percent of all adult ICUs in the nation.
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Eliminating CLABSI
Results:
• States reduced their adult ICU CLABSI rate from 1.915
infections per 1,000 line days (baseline) to 1.133
infections, or a relative reduction of 41%.
• The percentage of units with zero CLABSIs increased
from 30% at baseline to 68%.
• Non-ICU and pediatric units had similar reductions in
CLABSI rates.
• States that started with low CLABSI rates achieved
additional improvements, again demonstrating that
“getting to zero” was possible
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Eliminating CLABSI
Summary of National Results
• Reduce the CLABSI rate from 1.9 infections per 1000
central line days to 1.1 infections (educed the rate of
CLABSI by 40%)
• Prevented 2000 infections
• Saved 500 lives
• Saved $34 million in health care costs
Kuehn JAMA 2012; 308:1617-1618
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Lessons Learned
1. Have well-defined, evidence-based interventions
2. Build a solid implementation structure and project plan
3. Collect and use timely, accurate, and actionable data to
improve performance
4. Tailor national program for local and unit audiences
5. Evolve project strategies and emphases over time
The lessons learned contributed to the project’s success
and can be applied to future large scale interventions.
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CUSP Toolkit
The CUSP toolkit includes training tools to make care safer
by improving the foundation of how your physicians,
nurses, and other clinical team members work together. It
builds the capacity to address safety issues by combining
clinical best practices and the science of safety.
http://www.ahrq.gov/legacy/cusptoolkit/
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Summary
• Although “targeting zero” may not seem a realistic goal,
the number of hospitals approaching this idealistic
threshold is growing. The evidence is now clear that
CLABSI can be reduced and even eliminated using a
multimodal approach within a patient safety framework.
The question today is not
‘what to do’ but ‘how to do it.”
Zingg et al Curr Opin Infect Dis 2011;24:377-384
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Reflection
• Where are you and your organization on the Targeting
Zero HAI journey?
• Do you have the organizational support and the tools to
help you along the journey?
• What additional skills do you need to take the lourney?
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Eliminating Healthcare Associated
Infections: It’s In Our Hands!
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