Health Sciences and Well-being Research Beacon

NEWSLETTER Autumn / Winter 2013

Faculty of Applied Sciences

Health Sciences and Well-being Research Beacon:

High quality research into contemporary health issues

From the lab through to clinical practice

Multi-disciplinary research teams that span fundamental and applied sciences

2

Foreword from the HSWB Beacon team

The HSWB Research Beacon is located in the Sciences Complex, City Campus, University of Sunderland

Contacts

Health Improvement and Well-being

Dr Lyn Brierley-Jones, Beacon Research Fellow

T: 0191 515 3492

E: lyn.brierley-jones@sunderland.ac.uk

Drug Discovery and Application

Dr Peter Dawson, Beacon Research Fellow

Tel: 0191 515 2572, E: peter.dawson@sunderland.ac.uk

General enquiries

Ms Glenda Young, Faculty Admin Assistant

(Research Beacons), T: 0191 515 2527

E: glenda.young@sunderland.ac.uk

Website

http://www.sunderland.ac.uk/research/areasofresearch/

healthsciencesandwell-beingbeacon

Welcome to the Health Sciences and Well-being

Research Beacon newsletter, Autumn / Winter 2013.

HSWB Beacon research is focused around two key themes:

Pharmaceutical and biological sciences

Mental health, healthcare and health behaviours

Within these, research groups are looking at:

Common mental health problems: from prevention to novel therapeutic interventions

Infection and immunology: from pathogenesis to treatment

Pharmaceutical sciences: from disease to medicines use

Understanding health behaviours: the impact of the individual and society on health

Cross cutting all research, a further research group looks at Knowledge translation and exchange

3

Middle-class alcohol time bomb

RESEARCH NEWS from the Health Sciences and Well-being Research Beacon

Middle-class profession-

als are risking serious

health problems by using

alcohol as a means of

stress relief, reward for

looking after a family and

working full-time, new

research has revealed.

Despite the common

perception that young people are the section of society most

affected by alcohol, new research shows it’s actually white

collar workers who are most guilty of alcohol abuse.

The research concludes that a complete overhaul of public

health messages is needed to give a more realistic picture of

those affected by alcohol. The research analysed the drinking

habits and the reasons for drinking among five different

groups of workers in the public and private sectors, aged

between 21 and 55.

The groups discussed their drinking patterns, their perceived

norms and how much alcohol they consumed on a personal

level as well as professional situations, such as entertaining

clients.

They found that those middle-class workers who drank at

home viewed alcohol as a reward for everyday chores after

work hours, such as looking after their children and cooking

dinner for the family. Alcohol was also used to alleviate

stress and as a way of telling the individual that they had

fulfilled their commitments. One respondent said drinking

alcohol after the children had gone to bed “makes me feel

like an adult again”.

In light of the new evidence researchers feel public health

warnings are failing to resonate with white collar workers

and have instead “actively reinforced their view that their

own alcohol use was problem-free”.

Instead, the report says that in future public health messages

should focus on a typical person and the damages that can

happen to their long-term health, and not solely the crime or

disorder that alcohol abuse can result amongst younger

members of society.

Dr Jonathan Ling, Senior

Lecturer in Public Health said:

“One of the issues that people

tend to focus on in relation to

alcohol use is ‘problem drink-

ing’. Problem drinking is usually

thought of in terms of young

people binge drinking in city

centres, or people with alcohol

dependency. However, what is

starting to be recognised is that

regularly consuming alcohol at

lower levels than would cause intoxication is likely to be

harmful to health, and that the people that drink most regu-

larly aren’t young people, but those who live in households

where someone has a managerial or professional job.”

Dr Lyn Brierley-Jones, HSWB

Beacon Research Fellow,

added: “Our research showed a

common perception among

some middle-class groups that

regularly drinking at home,

particularly drinking wine, is

safe and sensible, even though

such drinking often takes them

over the recommended daily

guidelines. These home drink-

ers don’t see their drinking

pattern as problematic, but evidence suggests that such

drinking will lead to significant health problems later in life,

and a major health burden for the NHS.”

Ling J, Smith K, Crosland A, Kaner E F S, Haighton C A, Brierley-Jones L and Wilson G (2012) The 'other' in patterns of

drinking: A qualitative study of attitudes towards alcohol use among professional, managerial and clerical workers.

BMC Public Health, 12 (892).

Dr Lyn Brierley-Jones

Dept of Pharmacy, Health

and Well-being

Dr Jonathan Ling

Dept of Pharmacy, Health

and Well-being

4

In profile: New Beacon members

Dr Graeme O’Boyle, Senior Lecturer in Immunology,

Dept of Pharmacy, Health and Well-being

Chemokines are a family of proteins that

control the directional movement of cells

throughout the body.

They have a key role in the functioning of

the immune system where they direct

white blood cells to migrate from the

blood stream into inflamed tissues.

Chemokines are also involved in the

metastatic spread of cancers from their

initial site to other organs.

My work has focused on endogenous

mechanisms that regulate chemokine

biology with a view to understanding

how they might be targeted for thera-

peutic intervention.

My work has been translated to a num-

ber of inflammatory diseases such as

rheumatoid arthritis, transplant rejection

(both bone marrow and solid organ), and

inflammatory bowel disease.

I also work on the pathological migration

of breast and skin cancers to the lung and

liver. graeme.o’boyle@sunderland.ac.uk

My PhD, awarded from Teesside University in 2008, involved

the study of femoral neck fracture fixation techniques using

cannulated screws.

Through a combination of finite element computer

simulation and mechanical testing, optimal screw placement

and tension was identified to improve the stability at the

fracture site to improve bone healing.

Having a sport science background, my current research

focusses on strategies to reduce injuries in sport.

This includes examining the mechanics of contact situations

in rugby union, such as the scrum and tackles, and the

analysis of player posture.

This research involves community rugby clubs as it is

important that player welfare is considered at all levels,

especially those where the availability of medical care is

limited and the risk increased.

I am also interested in the level of physical activity in non-

standard situations.

This has involved using GPS and activity monitors to

measure the level and intensity of movement at outdoor

festivals, as this is an untapped market for health

promotion.

eddie.bradley@sunderland.ac.uk

Dr Eddie Bradley, Senior Lecturer in Biomechanics

Dept of Sport and Exercise Sciences

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In profile: New Beacon members

Dr Stephany Veuger, Senior Lecturer in Clinical Biochemistry

Dept of Pharmacy, Health and Well-being

A major focus of my research has been to evaluate DNA

repair inhibitors as potential drugs to be used in

combination with current therapies or as stand-alone

therapies in cancer treatment. I have supported anti-cancer

drug discovery projects by evaluating drugs to exploit

underlying molecular defects in a range of human cancers;

investigating interactive effects of proteins involved in the

sensing and responding to DNA damage; developing and

validating pharmacodynamic biomarkers for agents pro-

gressing to clinical trials.

My current research is focussed on the mechanisms of DNA

repair following ionising radiation/chemotherapeutic drugs

and the role of NFkappa B in mediating resistance. This is

important as by defining resistance mechanisms to ionising

radiation and clinically important DNA damaging agents, it

has important implications for the way in which cancer ther-

apies are used and how future regimens may be developed.

I have an

interest in both solid

tumours and

haematological

malignancies (AML,

CLL).

I am a Fellow of the

HEA. Previously, I

have held posts as an

associate lecturer at

Northumbria Universi-

ty teaching on the biomedical sciences programme and the

Open University where I continue to tutor the MSc in medic-

inal chemistry. I am a visiting practitioner on the global

scholars programme, St Georges University Grenada, and

was e-learning developer at Newcastle University.

stephany.veuger@sunderland.ac.uk

I am a pharmacist working with a

community pharmacy for about six years

now. I have always wanted to develop my

pharmaceutical career. I am really

interested in the formulation of drugs,

especially hydrophobic drugs, as more than

40% of the drugs used are poorly water sol-

uble.

So, during my PhD study I will be working on

the best techniques for the formulation of

oral lipophilic drugs. I think it is really

interesting how lipophilic drugs are

formulated in a way to be absorbed in the

aqueous environment of the

gastrointestinal system, because they are

easily excreted from GIT before they are

fully dissolved and absorbed into the

systemic circulation.

Hence in my PhD studies I am exploring the

techniques that enhance the drug

dissolution to get optimal absorption and

bioavailability of lipophilic drugs, using solid

dispersion, lyophilisation technique, and

combination with cyclodextrines.

Ashraf Saleh, PhD student under the supervision of Dr Amal Ali Elkordy, Dr Ken

McGarry and Dr Cheng Shu Chaw, Dept of Pharmacy, Health and Well-being

Ashraf Saleh

Pharmaceutics researcher

Spotlight on Beacon PhD researchers

6

How wearing red helps you win

RESEARCH NEWS from the Health Sciences and Well-being Research Beacon

MANCHESTER United, Ferrari’s

Formula 1 team and the Spanish

football team all have one thing in

common which may explain their

success.

New research has found evidence to

show that putting on a red shirt can

give individuals and teams a physical

and psychological advantage.

Previous research has shown that wear-

ing red can be an advantage in compe-

tition, either by inhibiting opponents or

by giving the wearers of red a form of

mental advantage.

Now research from the University of

Sunderland has shown for the first time

that an individual’s testosterone levels

are associated with the choice of col-

ours they make when taking part in

competition. In this study, it was found

that males who chose to wear red in a

competitive task had higher testos-

terone levels than other males who

chose to wear blue.

Dr Daniel Farrelly, a Senior Lecturer in

Psychology believes this may explain

why teams as well as individual sports

stars in red could be much more suc-

cessful than those wearing other col-

ours.

Dr Farrelly, explains: “It has been

shown that in other primates such as

some species of monkeys, the redness

of skin relates to both the individual’s

testosterone levels

and also their domi-

nance. It is possible

that a similar innate

effect may occur in

humans. However it

may also be the result of cultural links

we make with the colour red, as it is

often used in warning signs such as

‘stop’ signs and traffic lights.

Researchers recruited 73 men who

were unaware of the study’s aims, and

told them they would be performing a

competitive task and their performanc-

es would be placed on a leaderboard.

Participants then chose either a red or

blue symbol to represent them in the

table and completed the competitive

tasks. They also answered question-

naires on whether personal reasons

affected their choice, to explain a num-

ber of characteristics about the colour

choice. Saliva samples were taken both

at the start of the study (before they

knew about the

competitive task)

and at the end, and

these were then

analysed for testos-

terone levels.

Dr Farrelly said:

“This is the first

study to look at whether

biological factors, specifical-

ly testosterone which has

been linked to characteris-

tics such as dominance,

aggression and competi-

tiveness, may affect the

choices we make in com-

petitive scenarios. Also by

allowing participants in a

test to choose their colour,

this study reveals that there

may be something intrinsi-

cally different about ‘red’ competitors,

that can give them an advantage.”

Farrelly, D, Slater, R, Elliott, H,

Walden, H and Wetherell, M (2013)

Competitors who choose to be red

have higher testosterone levels.

Psychological Science.

“Research shows for the

first time that an

individual’s testosterone

levels are associated with

the choice of colour in

competition”

Dr Daniel Farrelly, Dept of Psychology

7

Older drinkers need better alcohol advice

RESEARCH NEWS from the Health Sciences and Well-being Research Beacon

Joint research at the University of

Sunderland and University of

Newcastle has called for changes to be

made to the recommended safe levels

of drinking for over 65s and also

special alcohol advice to be made

available for older people.

The call comes as the team from

Newcastle and Sunderland Universities

publish a paper which looks at the

reasons why many older people

continue to drink to levels hazardous or

harmful to their health.

The paper found that many older

people may not recognise they are

heavy drinkers if they don’t see

themselves as dependent and

therefore having a problem.

As part of the study, organised through

Fuse, the Centre for Translational

Research in Public Health, the

academics carried out interviews and

conducted focus groups with 53 men

and women aged between 65 and 90.

They wanted to find out the reasons

why many in that age group drink to

unhealthy levels, and what their

attitudes are.

Many of those interviewed were blasé

about high alcohol intake and

questioned health practitioners who

cautioned them to drink less.

But heavy drinking in this age group is

strongly linked with depression and

anxiety and longer term health

problems.

Metabolism is slower in later life, and

older people are very likely to take

prescribed medicines that can interact

with alcohol. For these reasons heavy

drinking can have a bigger impact on

the lives of older people than the

younger generation.

And so far public health messages

about harmful drinking have not been

as effective for the older age group as

they have for the younger.

Older people saw drinking alcohol as a

positive way to relax and be sociable

with friends and family.

Chronic pain, loneliness and

bereavement were identified as likely

to lead to heavier drinking in later life.

The study was funded by Age UK.

University of Sunderland researchers pictured from L-R: Prof Ann Crosland and Dr Jonathan Ling

Department of Pharmacy, Health and Well-being

G.B. Wilson, E.F.S. Kaner, A. Cros-

land, J. Ling, K.E. McCabe, and

C.A. Haighton, 'A Qualitative

Study of Alcohol, Health and

Identities among UK Adults in

Later Life' PLOS ONE, 8 (2013),

8

New life into heart transplants

RESEARCH NEWS from the Health Sciences and Well-being Research Beacon

Human hearts which are not used each

year because they are deemed

unsuitable for an organ transplant

could get a second chance to save a

life, with the help of new research

taking place in the North East.

Organ shortage is one of the most

pressing issues concerning the field of

transplantation, with hundreds of

Britons a year dying while on the

transplant waiting list, and coronary

heart disease being one of the biggest

killers in the UK.

Some hearts are not retrieved from

potential donors due to their

unsuitability for organ transplantation.

Now new research at the University of

Sunderland, in collaboration with

Newcastle University to restart hearts

and develop tests to prove they are still

viable, could use more of the declined

donor hearts, potentially helping to

reduce transplant waiting lists.

As a result of successful pre-clinical

tests in the lab to get dead pigs’ hearts

beating once again, clinical trials are to

begin on human hearts that would not

otherwise have been used after ethical

approval was granted by National Re-

search Ethics service in Newcastle.

Dr Noel Carter, senior lecturer in molec-

ular biology, explained: “We have

demonstrated enough evidence in our

results from restarting pigs’ hearts after

several hours of being clinically dead, to

be able to begin clinical testing on

human hearts that are considered too

marginal to be used for transplant or as

a source of heart valves.

“Heart surgeons have to be 100%

positive that this vital organ is going to

work before transplantation, which is

why a number of them end up not

being used. Our research wants to take

those rejected hearts, get them

restarted, carry out echocardiograms

and tests in a sterile environment to

check activity and show them to be in

perfect working order. We believe then

a proportion could be reconsidered for

transplantation.”

The research team has developed a

novel circulatory equipment and defib-

rillators to pump warm, oxygenated

blood through the hearts and used

dialysis to filter out unwanted products

from the circuit thereby restoring the

heart’s metabolic activity.

Dr Carter added: “We are devising a

series of parameters to test the hearts

and ensure that they would be viable if

a transplant goes ahead. We believe

this could offer new hope for patients

and see an increase in heart trans-

plants.”

Heart transplant is the only option for

patients with end-stage heart failure or

irreparable coronary artery disease.

During this procedure, doctors replace

the ailing heart with a healthy one from

a brain dead patient.

This latest research is in addition to

previous work by the same Sunderland

research group hoping to expand the

donor pool by looking at

non-heartbeating donors.

“We believe this could offer new hope for patients

and see an increase in heart transplants.”

Left to right: Dr Noel Carter, Dept of Pharmacy, Health and Well-being, with PhD student Omar Mownah

9

Football myth kicked into touch

RESEARCH NEWS from the Health Sciences and Well-being Research Beacon

Barcelona, Bayern Munich and the

Spanish football team might dominate

the beautiful game, but new research

has quashed the myth they tire the

opposition by keeping the ball.

For years, coaches, pundits and fans

believed teams should “let the ball do

the work” because the other team will

have to run further to regain posses-

sion. This is believed to enable world

class players to tire their opponents out

and help them conserve their energy.

However, research from the University

of Sunderland shows they cover the

same distances whether teams have the

ball or not.

Academics looked at 810 English

Premier League players in 54 matches

with an equal amount of players from

home and away sides, with the data

taken from the computerised tracking

system. Each individual player’s physical

and technical performance was

recorded, including how far they ran,

the varying levels of intensity and how

many passes they made.

The research has quashed the myth that

if you pass the ball more often than the

opposition then you would conserve

energy, tiring them out while doing so.

They found that no differences were

observed for total distance covered by

football teams with low percentage of

ball possession and those who had the

ball more often. This trend continued

when it came to high intensity running

and sprinting.

Research showed running with the ball

at a high-intensity was 31 per cent more

by teams with a high percentage of pos-

session than those with a low percent-

age. In contrast, those teams with a

high percentage of possession ran 22

per cent less at a high-intensity than

those with a low percentage when they

did not have the ball.

Dr Paul Bradley, senior lecturer in sport

and exercise science said: “We didn’t

find any statistical difference in their

physical exertions during the game.

However, as expected the technical

indicators did show superior differences

between those that keep the ball, and

those that don’t. The myth is that if you

cover a large amount of distance then

you tend to have a lower percentage of

possession, but these findings show it

isn’t the case at all.

“We always thought that there was

truth in the old adage of ‘let the ball do

the work’ and let the other team chase

after it, but it’s quite clearly not backed

up by the facts. There’s less than one

per cent difference between high and

low percentage of possession football

teams. They’re obviously superior in

terms of how many passes they make,

but not in distance.”

The research is the first to examine the

effects of high percentage of ball

possession and a low percentage on

physical and technical profiles during

elite football matches. The research

also looked at each different position

from each group for comparison.

Bradley P, Lago-Penas C, Rey E and Diaz A G (2013) The effect of high and low

percentage ball possession on physical and technical profiles in English FA

Premier League soccer matches. Journal of Sports Sciences, 31 (12).

Dr Paul Bradley

Dept of Sport and Exercise Sciences

10

Sunderland→London & Australia

Dr Jane Carr-Wilkinson, a senior lecturer in Physiological

Sciences in the Department of Pharmacy, Health and Well-

being gave a presentation at the House of Lords on cancer

research work taking place in the North East.

Dr Carr-Wilkinson was invited to the 25th Anniversary

Science Celebration of Children with Cancer UK, which held

its special reception to showcase the leading edge research

which the charity funds, in June 2013.

Dr Carr-Wilkinson presented a poster based on research,

which she has been working on in collaboration with

Newcastle University, developing a stem cell model that will

aid understanding of how common childhood tumour

neuroblastoma develops.

Dr Carr-Wilkinson said: “By understanding more about how

cancer develops, research may lead us to the development

of much-needed new therapies that may improve the

survival rates for cancer, including high risk neuroblastoma.”

Dr Jane Carr-Wilkinson takes cancer research

from Sunderland to the House of Lords

Linda Váradi’s PhD research to help in the fight against

infections, such as MRSA and E. coli, has led to a prestigious

placement ‘down under’.

Linda Váradi joined the University of Sunderland in 2009 and

began her project to design, make and test compounds to be

used in hospital laboratories to detect and identify the

bacteria responsible for causing infections in patients. This

research is being carried out in collaboration with global bio-

technology company bioMérieux and Newcastle’s Freeman

Hospital, as part of an on-going collaboration.

As a result of this work and her academic experiences at

Sunderland, Linda was offered a three-year postdoctoral

fellowship on a National Health and Medical Research

Council (NHMRC) funded project at the University of Sydney

in Australia.

Linda said: “I’m delighted to have been offered this post; it’s

working as part of a multi-national collaboration with

renowned researchers in their field. I am going to be working

on chemistry research, trying to enhance bacterial detection.

The main aim is to patent some of the applications and have

the research published. This has been made possible thanks

to the skills and scientific understanding I’ve developed at

Sunderland.”

Roz Anderson,

Professor of

Pharmaceutical

Chemistry, said:

“We are delighted

that Linda has been

offered this post,

which attracted

applications from

around the world.”

PhD student takes research ‘down under’

Linda Váradi (right) pictured with her

PhD supervisor Prof Roz Anderson

Dr Jane Carr-Wilkinson pictured outside House of Lords

11

Research funding news: Molplex

Molplex Pharmaceuticals has been conditionally selected to

receive government funding to help deliver new treatments

against the growing menace of drug resistant infections.

The company uses its innovative technology to identify and

optimise new treatments for infections and other serious

diseases.

An award from the Government’s Regional Growth Fund

(RGF) will help to build a new Optiplex drug discovery facility

that will speed up the delivery of new treatments at a radi-

cally lower cost.

Chief Executive Officer David Leahy was delighted to receive

the high level of financial support from the government:

“This success is a major breakthrough for Molplex in our

fight to deliver new drug treatments in a safer, more effec-

tive way and at a much lower cost.

“The award also recognises the hard work we have done

over many years to optimise the pharmaceutical research

and development and will trigger additional private invest-

ment, creating new jobs at Molplex, our suppliers and in the

local community.”

Mr Leahy also thanked other contributors who had helped

with the project.

“We thank our investors and Sunderland University for their

help in getting Optiplex production-ready.

“The University’s practical assistance and “can-do” attitude

has been critical in getting this important work off the

ground.”

The local SME Molplex Pharmaceuticals’ Optiplex platform

fuses in silico drug design and automated decision making

with microscale candidate synthesis and surface plasmon

resonance screening to optimise the drug discovery process,

providing results more quickly and at a significantly lower

cost.

Working alongside Dr Mark Ashton, Dr Peter Dawson and

Prof Roz Anderson at the University of Sunderland, Dr Tim

Blackburn is supported by Molplex to develop and validate

novel microfluidics technology for future Optiplex use.

This new collaboration is already producing interesting and

exciting results, with the promise of publication soon to be

realised.

We applaud Molplex for achieving this award and anticipate

the translation of an exciting concept into clinical products.

Molplex win UK Government funding to establish an Optiplex laboratory

to deliver new drugs for currently untreatable infections

12

Beacon Research Seminars

HSWB BEACON SEMINARS are open to everyone to attend

HSWB Beacon research seminars for 2013-4 include a variety of stimulating and diverse speakers and

topics around the five research themes of the Beacon. Seminars are open to all and refreshments

are served.

New seminars are being added to our series on a continuous basis, so do please check the Beacon

website for an up to date schedule at:

http://www.sunderland.ac.uk/research/areasofresearch/healthsciencesandwell-beingbeacon

If you would like to be added to the seminar email list to receive details of seminars by email, please

contact Glenda Young, FAS Admin Assistant (Research Beacons), email:

glenda.young@sunderland.ac.uk or ext. 2527.

Beacon Publications

May—September 2013

RESEARCH ARTICLES

Bradley PS, Carling C, Gomez Diaz A, Hood, P, Barnes C, Ade J, Boddy M, Krustrup P & Mohr M (2013) Match Performance

and Physical Capacity of Players in the Top Three Competitive Standards of English Professional Soccer. Hum Mov Sci.

Bradley PS, Di Mascio, M, Bangsbo, J & Krustrup, P. (2012b) The maximal and sub-maximal versions of the Yo-Yo inter-

mittent endurance test level 2 are simply reproducible, sensitive and valid. Eur J Appl Physiol 112, 1973-1975.

Bradley PS, C. Lago-Penas, E. Rey, and A.G. Diaz, The Effect of High and Low Percentage Ball Possession on Physical and

Technical Profiles in English FA Premier League Soccer Matches, J Sports Sci., 31 (2013 ), 1261-70.

Bradley, PS, and P. Krustrup, Counter-Point Number 3: Football-Specific Testing: Adding Value or Confirming the Evidence?,

The Journal of Sports Sciences, epub ahead of print (2013).

Bradley PS & Noakes TD (2013) Match running performance fluctuations in elite soccer: indicative of fatigue, pacing or situ-

ational influences? J Sports Sci.

Carling C, Nelson L, Wright M & Bradley PS (2013) Comment on ‘Performance analysis in football: A critical review and im-

plications for future research’ J Sports Sci. .

Di Mascio M & Bradley PS (2013) Evaluation of the most intense high-intensity running period in English FA premier league

soccer matches. J Strength Cond Res 27, 909-915

Gomez-Diaz A, Pallares JG, Diaz A & Bradley PS (2013). Cuantificación de la carga física y psicológica en fútbol profesional:

diferencias según el nivel competitivo y efectos sobre el resultado en competición oficial. Revista de Psicologia del Deporte.

22, 201-207.

13

Beacon Publications

RESEARCH ARTICLES continued

Bradley, P.S., Dellal, P.S., Mohr, M. Castellano, J & Wilkie, A. (2013 E-pub ahead of print). Gender Differences in Match Per-

formance Characteristics of Soccer Players Competing in the UEFA Champions League. Human Movement Science.

Brierley-Jones, L., Crawley, R.A., Ayers, S. and Lomax, S. (2014 in press) Stillbirth and Stigma: The Spoiling and Repair of

Multiple Social Identities, OMEGA the journal of death and dying

Coad, L, Carter, N and Ling, J (2013) Attitudes of young adults from the UK towards organ and tissue donation and trans-

plantation. Transplantation Research, 2:9.

Crawley, R., Lomax, S. and Ayers, S. (2013) Recovering from stillbirth: The effects of making and sharing memories on ma-

ternal mental health. Journal of Reproductive and Infant Psychology

Wilson, G B, Kaner, E F S, Crosland, A, Ling, J, Smith, K and Haighton, C A (2013) A Qualitative Study of Alcohol, Health and

Identities among UK Adults in Later Life. PLoS ONE 8(8): e71792.

Cuthill, F. (2013 in press) Understanding the ways in which health visitors manage anxiety in cross-cultural work: a qualita-tive study, Primary Health Care Research and Development.

Haj-Ahmad, R. R., Elkordy, AA, Chaw, CS, Moore, A. (2013). Compare and contrast the effects of surfactants (Pluronic®F-127

and Cremophor®EL) and sugars (β-cyclodextrin and inulin) on properties of spray dried and crystallised lysozyme. European

Journal of Pharmaceutical Sciences. 49: 519-534.

Elkordy, AA., Bhangale, U., Murle, N., Zarara, M. F. (2013). Combination of lactose (as a carrier) with cremophor® EL (as a

liquid vehicle) to enhance dissolution of griseofulvin. Powder Technology. 246: 182-186.

Farrelly, D. (2013) Altruism as an Indicator of Good Parenting Quality in Long Term Relationships: Further Investigations

Using the Mate Preferences Towards Altruistic Traits Scale, The Journal of Social Psychology, 153, 395-98.

Bedernjak, A., Groundwater, PW, Gray, M, Orenga, S, Perry, JD, Anderson, R. (2013) Synthesis and Evaluation of Halogenat-

ed Nitrophenoxazinones as Nitroreductase Substrates for the Detection of Pathogenic Bacteria Tetrahedron, 69, 8456–62.

Todd, A., Husband, A., Hurren, A., Kler, S. & Ling, J. (2013). Patients using antifungals following laryngectomy: A qualitative

study of community pharmacists in the North of England. International Journal of Pharmacy Practice 13 (1): 45 - 49.

Ling, J., McCabe, KE, Brent, S. & Crosland, A. (2013). Key workers in cancer care: Patient and staff attitudes and wider impli-

cations for role development in cancer services. European Journal of Cancer Care 22 (5), 691-698.

Vaideanu, D., Sandhu, S.S., Ling, J., Richardson, J. & Steel D.H.W. (2013 in press). The rate of diabetic vitrectomy in a defined geographical area of North East England. Ophthalmic Epidemiology.

M. Ahsan, H. Nazar. An investigation of how personal smoking habits affect a healthcare professional’s (HCPs) ability and

motivation to provide effective smoking cessation advice and consultation: Perspectives of undergraduate pharmacy stu-

dents. International Journal of Pharmacy Practice (2013) Supplement 2; 21:24-25.

I. Andrew, H. Nazar. A palliative care (PC) hospice placement: Students’ qualitative evaluation of experience-based learning.

International Journal of Pharmacy Practice (2013) Supplement 2; 21:39.

N. Ahmad, H. Nazar. Investigating the views of undergraduate pharmacy students towards physician assisted suicide (PAS).

International Journal of Pharmacy Practice (2013) Supplement 2; 21:40.

A. Todd, H. Nazar, I. Andrew, L..Baker, A. Husband. Quantification of drug-related toxicity associated with the prescribing of

inappropriate medicines for patients with limited life expectancy. International Journal of Pharmacy Practice (2013) Supple-

ment 2;90-91.

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Beacon Publications

RESEARCH ARTICLES continued

Roberts J, Crosland A, Fulton J (2013 in press) “I think this is maybe our Achilles Heel....” Exploring GPs’ responses to young

people presenting with emotional distress in general practice. A qualitative study. Biomed Central.

Wilkie, S and Stavridou, A (2013) Influence of Environmental Preference and Environment Type Congruence on Judgments of

Restoration Potential. Urban Forestry & Urban Greening, 12. pp. 163-170

BOOKS, BOOK SECTIONS, EDITED BOOKS

Anderson, RJ and Todd, A. Chapter 3: Stereochemistry in Drug Action, , in ‘Integrated Foundations of Pharmacy: Pharma-

ceutical Chemistry’ by Barber and Rostron, Oxford University Press.

OTHER PUBLICATIONS

Alderton, W.K., Anderson, RJ, Collingwood, S.P., Pryde, D.C. Therapeutic Opportunities in Infectious Diseases: Highlights

from the Society of Medicines Research Symposium, held on March 14th 2013 at the National Heart & Lung Institute, Lon-

don, UK, Drugs of the Future, 2013, 38(5): 347.

Dodou K, Whiteley P (2013) In search of biomarkers - the science of metabolomics in pharmacy. The Pharmaceutical Jour-

nal; 290:512-513.

Dodou K and Whiteley P (2013) Lipidomics - the Science and Study of How Lipids Affect and Modify Our Health, Pharmaceu-

tical Journal, 291, 23-24.

Hayes, C. (2013) Dispelling myths about ageing for healthcare assistants, British Journal of Healthcare Assistants, 7,(7), 328-

334

Hayes, C. (2013) Mentorship in Action for Healthcare Assistants, British Journal of Healthcare Assistants, 7,(5), 252-255.

Nazar, H. (2013) Developing biomaterials for tissue engineering and regenerative medicine. Pharmaceutical Journal. Sept 2013.

Nazar, H. (2013) Using 'smart' biomaterials and systems for targeted drug delivery. Pharmaceutical Journal. June 2013.

CONFERENCE WATCH— PROCEEDINGS, PAPERS AND POSTERS

Brierley-Jones, L., Crawley, R.A., Ayers, S. and Lomax, S. (2013) Stillbirth and Stigma: The Spoiling and Repair of Multiple

Social Identities, in BSA 45th Medical Sociology Annual Conference, University of York, UK,

Jill Jobson, Noel Carter, Ken McGarry, Achim Treumann and Roz Anderson A Quantitative Proteomic Investigation of Cysti-

notic Fibroblasts and Proximal Tubule Epithelial Cells using SILAC, , Poster Presentation, Cystinosis Research Network Con-

ference (Washington D.C., USA), July 2013.

M. S. Chu, and C. S. Chaw, Ketoprofen Loaded Pellets Produced by Extrusion/ Spheronisation Using Avicel Cl611 as Spheron-

isation Aids in UKPharmSci conference, 4th September 2013 .

V. J. Li-Kwok-Cheong, and C.S. Chaw, The Behaviour of Xanthan Gum Matrix Systems, in UKPharmSci conference 2013.

Dodou, K. (2013) Surface dissolution imaging on Pluronic F127 gel formulations containing ibuprofen. 3rd Annual Dissolu-

tion Symposium, 3rd-4th June 2013 (University of Bath)

Eng, M., Haj-Ahmad, R.R., Elkordy, AA. (2012). Characterisation of DNA in the presence of excipients. Poster presentation at

the UK- PharmSci 2012 conference, September 12-14th, 2012 in Nottingham, UK.

15

Beacon Publications

CONFERENCE WATCH— PROCEEDINGS, PAPERS AND POSTERS continued

Elkordy, AA. (2012). When will liquisolid tablets as dosage forms for enhancement dissolution of hydrophobic drugs be

available in the market? Poster presentation at 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceuti-

cal Technology, Turkey, Istanbul, 19th – 22nd March 2012.

Elkordy, A.A. Evaluation of different Floating Tablets at Target meeting's Third World Drug Discovery Online Conference,

15th - 17th October 2013.

Elkordy, A.A. Folding reversibility of lysozyme in the presence of poly vinyl pyrrolidone at 2nd Central and Eastern European

Conference on Thermal Analysis and Calorimetry, 27th - 30th August 2013, Vilnius, Lithuania

Elkordy, AA. Correlation of folding reversibility with biological activity: Lysozyme and Trypsin in crystallised and dried forms

Presented on 10th April 2013 at the TAC 2013 conference “Modern Thermal Methods from an Industrial and Academic

Perspective” (9th - 10th April, 2013), University of Greenwich, Chatham, UK.

Haj-Ahmad, R.R., Chaw, C.S., Elkordy, A.A., Moore, A. (2013). Stabilizing effect of surfactants and saccharides on freeze

dried lysozyme. Poster presentation at the UK-PharmSci 2013 conference, September 2nd - 4th, 2013 in Edinburgh, UK.

Javaheri, H., Elkordy, A.A., Carter, P. (2013) Preparation and Evaluation of Liquisolid Compacts Containing Salbutamol Base

with PEG 400 and Synperonic® PE/L44. Poster presentation at the UK-PharmSci 2013 conference, September 2nd - 4th, 2013

in Edinburgh, UK.

Loh, Z., Elkordy, A.A. (2013). Preparation and Characterisation of Metronidazole Floating Tablets. Poster presentation at

the UK-PharmSci 2013 conference, September 2nd - 4th, 2013 in Edinburgh, UK.

Rusby, N., Elkordy, A.A. (2013). Influences of Poly-vinyl pyrrolidone and Pluronic® F127 on Lysozyme Folding Reversibility

and Biological Activity. Poster presentation at the UK-PharmSci 2013 conference, September 2nd - 4th, 2013 in Edinburgh,

UK.

G. O'Boyle, (2013) A Small Molecule Agonist of the Chemokine Receptor Cxcr3 Prevents Experimental Graft-Versus-Host

Disease, in “The Leading Edge of Leukocyte Migration”, the inaugural meeting of the British Society of Immunology Leuko-

cyte Migration Group, Glasgow.

C. Wassef, I. Andrew, T. Paget, H. Nazar. Sedative drug prescribing practices at a local Hospice at the end-of-life compared to current guidelines. UK Clinical Pharmacy Association 2013. Harrogate.

A. Todd, H. Nazar, I. Andrew, A. Husband Prescribing of inappropriate medication in patients with limited life expectancy: a prospective study in a specialist palliative care unit. UK Clinical Pharmacy Association 2013. Harrogate. Won Patient Safety Award.

A. Todd, H. Nazar, I. Andrew, A. Husband. Quantification of drug-related toxicity associated with the prescribing of inappro-priate medicines for patients with limited life expectancy. Royal Pharmaceutical Society Conference 2013. Birmingham.

N. Ahmad, H. Nazar. Investigating the views of undergraduate pharmacy students towards physician assisted suicide (PAS). Royal Pharmaceutical Society Conference 2013. Birmingham.

I. Andrew, H. Nazar. A palliative care (PC) hospice placement: Students’ qualitative evaluation of experience-based learn-ing. Royal Pharmaceutical Society Conference 2013. Birmingham

M. Ahsan, H. Nazar. An investigation of how personal smoking habits affect a healthcare professional’s (HCPs) ability and motivation to provide effective smoking cessation advice and consultation: Perspectives of undergraduate pharmacy stu-dents. Royal Pharmaceutical Society Conference 2013. Birmingham.

16

CONFERENCE WATCH— PROCEEDINGS, PAPERS AND POSTERS continued

Suliman, A.S., Anderson, R.J., Elkordy, A.A. (2013). Liquisolid Tablet Preparation for Norfloxacin Dissolution Enhancement.

Poster presentation at the UK-PharmSci 2013 conference, September 2nd - 4th, 2013 in Edinburgh, UK.

Wong, L.M., Elkordy, A.A. (2013). Improvement of dissolution of Ibuprofen via in-situ lyophilisation. Poster presentation at

the UK-PharmSci 2013 conference, September 2nd - 4th, 2013 in Edinburgh, UK.

Wilkie, S., Tan, Q., O’Lynn, J. (2013, June). More than bricks and mortar: Determining how the psychological qualities of

home places influence resident well-being. Environmental Design Research Association 44th Annual Conference, Provi-

dence R.I.

Wilkie, S., & Stavridou, A. (2013, June). Influence of environmental preference and environment type congruence on judge-

ments of restoration potential. Poster presented at the Environmental Design Research Association 44th Annual Confer-

ence, Providence R.I.

REPORTS

Cuthill, F., Abdalla, O.S. and Bashir, K. (2013) Between destitution and a hard place: finding strength to survive refusal from

the asylum system: a case study from the North East of England. Sunderland: University of Sunderland.

Health Sciences and Well-being Research Beacon

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