HEALTH AND EHAVIOR IMPACT ON STOCKER AND EEDLOTSubclinical Disease: Iceberg Effect Wittum, JAVMA...
Transcript of HEALTH AND EHAVIOR IMPACT ON STOCKER AND EEDLOTSubclinical Disease: Iceberg Effect Wittum, JAVMA...
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HEALTH AND BEHAVIOR:IMPACT ON STOCKER AND FEEDLOT
Brad J. White, DVM, MSKansas State University
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Bovine Respiratory Disease
Bronchopneumonia (BRD)
Stressors-- Castration-- Weaning-- Commingling-- Ration Change-- Transport-- Dehydration
EnvironmentalChallenge-- Commingling-- Sick calf shedders-- Weather
Pathogen Infection / Proliferation-- IBR, BVD, PI3, BRSV-- MH, PM, MB, HS-- Others?
Decreased pulmonaryimmune defenses /
Pathogen proliferation
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Economic and performance consequences associated with the number of treatments for initial individual cases of bovine respiratory
disease in commercial feeder cattle
N. Cernicchiaro, B. White, D. Renter, A. Babcock
2012 Am J Vet Res 74(2):300-309
Objective:• Estimate cost of treating individual calf:
• Never(0X)• Once (1X)• Twice (2X)• Three or more times (3or>X)
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Data Analysis Individual calf performance, health, carcass data 212,867 hd 2001‐2006
Economic models: Standardized markets, feed costs (10 yr averages) Comparisons based on differences in performance Calculated net returns for each calf
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Net Returns by # Tx (fall only)
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BRD: Data based evaluation1. Refined classification of BRD events
a) Individual animal diagnosisb) Pen‐Level Events: Magnitude and Temporal
2. Managing BRD
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BRD in individuals
Find the sick calf Clinical diagnosis
Disease progression
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Time
Tiss
ue D
amag
e
Disease Detection Thresholds
No Clinical Signs / Minor performance loss
Mild Signs
Severe Clinical Signs
Point of No Return?
InterventionPoints
Outcome depends when intervene!
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Subclinical Disease: Iceberg Effect Wittum, JAVMA 1996 Survey 469 steers: birth to harvest 35% treated for BRD (78% had lung lesions) 65% not treated for BRD (68% had lung lesions)
Schneider et al, JAS 2009 1,665 calves: BRD Morb = 8.2%, Lung lesions = 62%
Reinhardt et al, JAS 2009 21,528 calves with individual performance data Morbidity & lung lesions negatively associated with initial BW, ADG, HCW Avg 0.12 treatments per calf w/ lung lesions (n=269) Avg 0.07 treatments per calf w/out lung lesions (n=6557)
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Serial progression of induced Mannheimia haemolytica pneumonia
Objective:To perform serial evaluations to quantify changes in behavior, physiologic, and pathologic parameters related to disease progression in experimentally induced Mannheimia haemolytica pneumonia calves.
Hanzlicek et al, 2010 AJVR
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Conclusions BRD Induction Model Rapid disease progression; all calves displayed clinical signs Clinical signs and lung lesions similar in appearance to field BRD cases (smaller lesions than fatal field cases)
Diagnostic Parameters: Measured parameters failed to predict level of lung lesions
Behavior and clinical scores useful
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Effect of Mannheimia haemolytica pneumonia on behavior and physiologic responses of calves
experiencing hyperthermal environmental conditions.
M.E. Theurer, D.E. Anderson, B.J. White, M.D. Miesner, D.A. Mosier, J.F. Coetzee, J. Lakritz, D.E. Amrine.
2013 J Anim Sci. 91:1-13.
Objectives:• Determine effects of inducing BRD
(Mannheimia) in high ambient temperatures
• Body temperature• Behavior• Inflammatory profile
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Mannheimia challenge Conducted during high ambient temperatures (July)
18 heifers randomly assigned to either Mannheimia haemolytica (n=10) or Control (n=8) group
Calves were group housed for 10 days after challenged
Directed endoscopic challenge: accessory bronchus
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0%10%20%30%40%50%60%70%80%90%
100%
Trial Day
Note: a CON calf classified CIS=2 on d 5 PM/6 AM (n=2)
% of MH calves sick (CIS 2) by Trial Day
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38.0
38.5
39.0
39.5
40.0
40.5
41.0
41.5
42.0
0 2 4 6 8 10 12 14 16 18 20 22 24
Rectal Tem
perature (°C)
Time of Day
Control Mannheimia
* ** *
**
** * *
* P value < 0.05
Rectal temperature: first 24 hours106.7 F
101.5 F
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38.0
38.5
39.0
39.5
40.0
40.5
0 1 2 3 4 5 6 7 8
Rectal Tem
perature (°C)
Trial Day
Control Mannheimia
* *
* P value < 0.05
Rectal temperature by trial day
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20%
25%
30%
35%
40%
45%
50%
55%
60%
65%
-1 0 1 2 3 4 5 6 7 8
Perc
enta
ge o
f Tim
e C
alve
s Spe
nt L
ying
D
own
Trial Day
Control Mannheimia
*
* * * *
* * * *
* P value < 0.05
Percent time calves spent lying down
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0.0%
1.0%
2.0%
3.0%
4.0%
5.0%
‐1 0 1 2 3 4 5 6 7 8
Mod
el adjusted pe
rcen
tage of tim
e calves sp
ent
with
in 1 fo
ot of g
rain bun
k
Trial Day
Control Mannheimia
* * *
*
* P value < 0.05
% Time spent within 1 foot of grain bunk
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Summary Rectal temperatures in MH calves extremely high early
Few clinical signs of BRD; lung lesions mild
MH calves spent more time lying down, less time at grain
MH calves had an initial shrink in body weight
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B. White, D. Anderson, D. Mosier, D. Renter, R. Larson, L. Kelly, B. Robert, M. Theurer
2012 AJVR Research sponsored by CEVA Biomune
Behavior following Mycoplasma bovischallenge in calves
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Behavioral Observations
• Calves equipped with a Ubisense ear tag to monitor behavior and activity during the trial
• Monitored to see if activity level is an indicator of illness
• Looked at calves proximityto water, feed, and shed
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Clinical illness scores
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Distance Traveled
250
300
350
400
450
-6 -4 -2 0 2 4 6 8 10 12 14 16 18 20
Dis
tanc
e Tr
avel
ed
Study Day
DistTraveled
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Comparison to Clinical Illness Scores
0%2%4%6%8%
10%12%14%16%18%
1 2 3
Perc
ent
of t
ime
Clinical Illness Score
Hayper1
0.0%
0.1%
0.2%
0.3%
0.4%
0.5%
0.6%
0.7%
1 2 3
Perc
ent
of t
ime
Clinical Illness Score
Waterper1
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Distance traveled and lung score Significant interaction: LS by trial day
100150200250300350400450500
-6 -4 -2 0 2 4 6 8 10 12 14 16 18 20
Dis
tanc
e Tr
avel
ed
Study Day
1Lessthan1 2Between1and10 3GreaterThan10
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Diagnostic Accuracy ofBRD Event Identification No perfect method to defining “cases”
Low specificity ‐> treat unnecessarily
Low sensitivity ‐> miss cases; resulting performance low
Prevention key to limiting losses
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BRD: Data based evaluation1. Refined classification of BRD events
a) Individual animal diagnosisb) Pen‐Level Events: Magnitude and Temporal
2. Managing BRD
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Pen‐level BRD Events Magnitude influences interventions
Performance impact influences interventions
Irsik et al. 2006 Bovine Practitioner Feed conversion: Increase 0.27 lb for each % death loss Average Daily Gain: Decrease 0.08 lb for each % death loss Added costs: Increase $1/hd for each % death loss Mortality: Estimate by multiplying percent treated by 0.14
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Risk Classification
LowRisk
HighRisk
Weight / Age Light / YoungHeavy / Older
Source MultipleSingle
Sex Bulls / PregnantSteers / Heifers
Precondition NoYes
Season Busy / WeatherSlow / Weather
Market Auction / DistantDirect / Local
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Lot Level Risk factors Transportation characteristics Distance traveled: entire period BRD morbidity / mortality
Cernicchiaro et al. J ANIM SCI 2012, 90:1929‐1939
Shrink: increased BRD incidence / performance losses Cernicchiaro et al. J ANIM SCI 2012, 90:1940‐1947
Weather conditions influence BRD risk Max wind speed, mean wind chill, temperature change
Cernicchiaro et al J ANIM SCI 2012, 90:1328‐1337
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Lot‐level cumulative morbidity risk
• Lots with between 30 and 500 hd• 23 feedyards• Between 2003 and 2008• n = 45,656
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Lot‐level cumulative morbidity risk
Median Risk: 5.1%
Mean Risk: 9.5%
3rd Quartile Risk: 12.6%
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Population Dynamics
Morbidity evaluation by lot
0%
2%
4%
6%
8%
10%
12%
14%
1 4 7 10 13 16 19 22 25 28 31 34 37 40 43 46
DOF
% o
f Tot
al P
ulls
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Population Diagnosis
Example data: 40% morbidity Calves, 1st 45 DOF
Differences by: Population Etiologic Agent
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Summary Individual BRD Events Costly Challenging to accurately diagnose Prevention important
Lot‐level BRD events Economically important Known, preventable risk factors
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Brad [email protected]